Bacteria associated with Ulva prolifera: a vital role in green tide formation and migration

MicroRNA (miRNA) has been widely suggested to play a vital role of in the pathogenesis of gestational diabetes mellitus (GDM). We have previously demonstrated that miR-657 can regulate macrophage inflammatory response in GDM. However, the role of miR-657 on M1/M2 macrophage polarization in GDM pathogenesis is not clear yet. This study is aimed at elucidating this issue and identifying novel potential GDM therapeutic targets based on miRNA network. miR-657 is found to be upregulated in placental macrophages demonstrated by real-time PCR, which can enhance macrophage proliferation and migration in vitro. Luciferase reporter assay shows the evidence that FAM46C is a target of miR-657. In addition, miR-657 can promote macrophage polarization toward the M1 phenotype by downregulating FAM46C in macrophages. The present study strongly suggests miR-657 is involved in GDM pathogenesis by regulating macrophage proliferation, migration, and polarization via targeting FAM46C. miR-657/FAM46C may serve as promising targets for GDM diagnosis and treatment.

Download Full-text

Ulva prolifera green-tide outbreaks and their environmental impact in the Yellow Sea, China

National Science Review ◽

10.1093/nsr/nwz026 ◽

2019 ◽

Vol 6 (4) ◽

pp. 825-838 ◽

Cited By ~ 26

Author(s):

Yongyu Zhang ◽

Peimin He ◽

Hongmei Li ◽

Gang Li ◽

Jihua Liu ◽

...

Keyword(s):

Yellow Sea ◽

Red Tide ◽

Abiotic Factors ◽

Management Strategies ◽

Ulva Prolifera ◽

The Yellow Sea ◽

Green Tide ◽

Biological Interactions ◽

Green Tides ◽

Carbon Cycles

Abstract The Ulva prolifera green tides in the Yellow Sea, China, which have been occurring since 2007, are a serious environmental problem attracting worldwide attention. Despite extensive research, the outbreak mechanisms have not been fully understood. Comprehensive analysis of anthropogenic and natural biotic and abiotic factors reveals that human activities, regional physicochemical conditions and algal physiological characteristics as well as ocean warming and biological interactions (with microorganism or other macroalgae) are closely related to the occurrence of green tides. Dynamics of these factors and their interactions could explain why green tides suddenly occurred in 2007 and decreased abruptly in 2017. Moreover, the consequence of green tides is serious. The decay of macroalgal biomass could result in hypoxia and acidification, possibly induce red tide and even have a long-lasting impact on coastal carbon cycles and the ecosystem. Accordingly, corresponding countermeasures have been proposed in our study for future reference in ecosystem management strategies and sustainable development policy.

Download Full-text

Long non-coding RNA AGER-1 inhibits colorectal cancer progression through sponging miR-182

The International Journal of Biological Markers ◽

10.1177/1724600819897079 ◽

2020 ◽

Vol 35 (1) ◽

pp. 10-18 ◽

Cited By ~ 1

Author(s):

Mingzhu Lin ◽

Yinyan Li ◽

Jianfeng Xian ◽

Jinbin Chen ◽

Yingyi Feng ◽

...

Keyword(s):

Colorectal Cancer ◽

Cancer Progression ◽

Ectopic Expression ◽

Tumor Development ◽

Vital Role ◽

Normal Tissues ◽

Non Coding Rna ◽

Colorectal Cancer Progression ◽

And Migration ◽

Long Non Coding Rna

Objective: Abundant evidence has illustrated that long non-coding RNA (lncRNA) plays a vital role in the regulation of tumor development and progression. Ectopic expression of a novel lncRNA, termed lnc-AGER-1, has been discovered in cancers, and this lncRNA was reported to exert an anti-tumor effect. However, its biological mechanism remains unelucidated in colorectal cancer. Methods: A total of 159 paired colorectal cancer specimens and adjacent tissues was applied to detect the expression of lnc-AGER-1 by the quantitative Real-time PCR (qRT-PCR), and a series of functional assays was executed to uncover the role of this lncRNA on colorectal cancer. Results: We found that the expression of lnc-AGER-1 in the tumor tissues was significantly down-regulated, while compared with adjacent normal tissues (0.0115 ± 0.0718 vs. 0.0347 ± 0.157; P < 0.0001). Also, lnc-AGER-1 was observably associated with clinical T status (r = −0.184, P = 0.024). Patients with advanced T status exerted a significantly lower level of lnc-AGER-1 than those with early T status (20.0% vs. 40.7%, P = 0.021). Over-expression of lnc-AGER-1 inhibited cell proliferation and migration efficiency, and induced cell cycle arrest at the G0/G1 phase, and promoted cell apoptosis. Further research proved that lnc-AGER-1 altered the expression of its neighbor gene, AGER, through acting as a competing endogenous RNA for miR-182 in colorectal cancer. Conclusion: lnc-AGER-1 has a suppressive role in colorectal cancer development via modulating AGER, which may serve as a target for colorectal cancer diagnosis and treatment.

Download Full-text

Characterization of a broad substrates specificity acyl-CoA: diacylglycerol acyltransferase 1 from the green tide alga Ulva prolifera

Acta Oceanologica Sinica ◽

10.1007/s13131-020-1659-0 ◽

2020 ◽

Vol 39 (10) ◽

pp. 42-49

Author(s):

Xiaowen Zhang ◽

Xiaoyuan Chi ◽

Yitao Wang ◽

Jian Zhang ◽

Yan Zhang ◽

...

Keyword(s):

Diacylglycerol Acyltransferase ◽

Ulva Prolifera ◽

Green Tide

Download Full-text

Spatiotemporal Patterns and Morphological Characteristics of Ulva prolifera Distribution in the Yellow Sea, China in 2016–2018

Remote Sensing ◽

10.3390/rs11040445 ◽

2019 ◽

Vol 11 (4) ◽

pp. 445 ◽

Cited By ~ 10

Author(s):

Yingzhi Cao ◽

Yichen Wu ◽

Zhixiang Fang ◽

Xiaojian Cui ◽

Jianfeng Liang ◽

...

Keyword(s):

Yellow Sea ◽

Vegetation Index ◽

Morphological Changes ◽

Surface Wind ◽

Morphological Characteristics ◽

Ulva Prolifera ◽

Spatiotemporal Patterns ◽

The Yellow Sea ◽

Green Tide ◽

Sea Surface Wind

The world’s largest macroalgal blooms, Ulva prolifera, have appeared in the Yellow Sea every summer on different scales since 2007, causing great harm to the regional marine economy. In this study, the Normalized Difference of Vegetation Index (NDVI) index was used to extract the green tide of Ulva prolifera from MODIS images in the Yellow Sea in 2016–2018, to investigate its spatiotemporal patterns and to calculate its occurrence probability. Using the standard deviational ellipse (SDE), the morphological characteristics of the green tide, including directionality and regularity, were analyzed. The results showed that the largest distribution and coverage areas occurred in 2016, with 57,384 km2 and 2906 km2, respectively and that the total affected region during three years was 163,162 km2. The green tide drifted northward and died out near Qingdao, Shandong Province, which was found to be a high-risk region. The coast of Jiangsu Province was believed to be the source of Ulva prolifera, but it was probably not the only one. The regularity of the boundary shape of the distribution showed a change that was opposite to the variation of scale. Several sharp increases were found in the parameters of the SDE in all three years. In conclusion, the overall situation of Ulva prolifera was still severe in recent years, and the sea area near Qingdao became the worst hit area of the green tide event. It was also shown that the sea surface wind played an important part in its migration and morphological changes.

Download Full-text

Role of Anillin in Tumour: From a Prognostic Biomarker to a Novel Target

Cancers ◽

10.3390/cancers12061600 ◽

2020 ◽

Vol 12 (6) ◽

pp. 1600

Author(s):

Nguyen Minh Tuan ◽

Chang Hoon Lee

Keyword(s):

Prognostic Biomarker ◽

Tumour Microenvironment ◽

Vital Role ◽

Actin Binding ◽

Cell Proliferation And Migration ◽

Novel Target ◽

And Migration ◽

The Impact ◽

Proliferation And Migration

Anillin (ANLN), an actin-binding protein, reportedly plays a vital role in cell proliferation and migration, particularly in cytokinesis. Although there have been findings pointing to a contribution of ANLN to the development of cancer, the association of ANLN to cancer remains not fully understood. Here, we gather evidence to determine the applicability of ANLN as a prognostic tool for some types of cancer, and the impact that ANLN has on the hallmarks of cancer. We searched academic repositories including PubMed and Google Scholar to find and review studies related to cancer and ANLN. The conclusion is that ANLN could be a potent target for cancer treatment, but the roles ANLN, other than in cytokinesis and its influence on tumour microenvironment remodeling in cancer development, must be further elucidated, and specific ANLN inhibitors should be found.

Download Full-text

Composition variations and spatiotemporal dynamics of dissolved organic matters during the occurrence of green tide (Ulva prolifera blooms) in the Southern Yellow Sea, China

Marine Pollution Bulletin ◽

10.1016/j.marpolbul.2019.07.021 ◽

2019 ◽

Vol 146 ◽

pp. 619-630 ◽

Cited By ~ 3

Author(s):

Xiuzhu Li ◽

Conghe Li ◽

Ying Bai ◽

Xiaoyong Shi ◽

Rongguo Su

Keyword(s):

Yellow Sea ◽

Spatiotemporal Dynamics ◽

Ulva Prolifera ◽

Green Tide ◽

Southern Yellow Sea ◽

Organic Matters ◽

The Southern Yellow Sea ◽

Dissolved Organic Matters

Download Full-text

First Record of the Harmful Raphidophyte Chattonella marina Bloom in Rushan Coast, China in 2008 after the Occurrence of the Green Tide

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.663.911 ◽

2013 ◽

Vol 663 ◽

pp. 911-921

Author(s):

Xiu Kai Song ◽

Ya Jun Shi ◽

Yu Zeng Sun ◽

Yang Jin ◽

Xiang Yang Jiang ◽

...

Keyword(s):

Red Tide ◽

First Record ◽

Ulva Prolifera ◽

Green Tide ◽

Chattonella Marina ◽

Shandong Peninsula ◽

Sea Temperature ◽

Average Cell ◽

Routine Monitoring ◽

First Time

The red tide of Chattonella marina (Subrahmanyan) Hara & Chihara occurred in Rushan coast, Shandong Peninsula, China, in August 2008. Based on the four cruises of routine monitoring and four cruises of monitoring of the red tide in Rushan, the process of the red tide and possible mechanism were analyzed. During the bloom, the maximum area of the red tide was about 100 km2; the maximum average cell abundance of C. marina reached 1.46×106 cells/L; surface water temper-ature ranged between 26.1 °C and 27.2 °C, and salinity between 26.6 ‰ and 30.3 ‰. The material released from the decayed green tide species Ulva prolifera could provide a chance for the bloom of C. marina, combined the optimum sea temperature, light and nutrient condition. It was the first time to link a red tide event with the consequence of the green tide in Yellow Sea, which could give an attention on our future monitoring and management.

Download Full-text

Assessing Herbivorous Impacts of Apohale sp. on the Ulva prolifera Green Tide in China

Frontiers in Plant Science ◽

10.3389/fpls.2021.795560 ◽

2021 ◽

Vol 12 ◽

Author(s):

Xiaoxiang Miao ◽

Jie Xiao ◽

Shiliang Fan ◽

Yu Zang ◽

Xuelei Zhang ◽

...

Keyword(s):

Yellow Sea ◽

Algal Biomass ◽

Large Scale ◽

Algal Growth ◽

Ulva Prolifera ◽

The Yellow Sea ◽

Green Tide ◽

Species Identity ◽

Green Tides ◽

The Southern Yellow Sea

An epiphytic gammarid species, Apohyale sp., was abundant in the floating Ulva prolifera (U. prolifera), which forms large-scale green tides in the Yellow Sea (YSGT). Field observation and laboratory experiments were subsequently conducted to study the species identity, abundance, and grazing effects on the floating algal biomass. The abundance of Apohyale sp. showed great spatial variation and varied from 0.03 to 1.47 inds g−1 in the YSGT. In average, each gram of Apohyale sp. body mass can consume 0.43 and 0.60 g algal mass of U. prolifera per day, and the grazing rates varied among the algae cultured with different nutritional seawaters. It was estimated that grazing of Apohale sp. could efficiently reduce ~0.4 and 16.6% of the algal growth rates in Rudong and Qingdao, respectively. The U. prolifera fragments resulting from gnawing of Apohyale sp. had a higher growth rate and similar photosynthetic activities compared to the floating algae, indicating probably positive feedback on the floating algal biomass. This research corroborated the significant impact of Apohyale sp. on the floating algal mass of YSGT through the top-down control. However, further research is needed to understand the population dynamics of these primary predators and hence their correlation with the expansion or decline of YSGT, especially under the complex food webs in the southern Yellow Sea.

Download Full-text