Regular training has a greater effect on aerobic capacity, fasting blood glucose and blood lipids in obese adolescent males compared to irregular training

Objective: To study the effects of continuous epidural injection of dexamethasone on blood glucose, blood lipids, plasma cortisol, and adrenocorticotropic hormone (ACTH) in patients with neuropathic pain.Methods: Thirty patients with cervical spondylotic radiculopathy, lumbar disc herniation, herpes pain or postherpetic neuralgia were randomly divided into three groups and were treated with different doses of epidural injection of dexamethasone (Group S with a concentration of 25 μg/mL; Group M with a concentration of 50 μg/mL; Group L with a concentration of 100 μg/mL). Epidural catheterization placement was guided by computed tomography (CT), and was connected to the analgesic pump for 10 days. Visual Analog Score (VAS), fasting blood glucose (FBG), total cholesterol (CHOL), triglyceride (TG), 2 h postprandial blood glucose (2hPG) and the concentrations of cortisol, ACTH were measured before injection (T0), 2, 4, 6, 8, and 10 days during injection (D2, D4, D6, D8, D10), and 7, 14, 21, 28 days (W1, W2, W3, W4) after injection.Results: During and after the treatment, VAS score was significantly decreased, and group M and L had the lowest VAS score. The concentrations of cortisol and ACTH were significantly lower during the treatment, but all of them recovered to the normal level after stopping the injection. The treatment did not affect the CHOL and TG concentrations.Discussion: Epidural injection of dexamethasone at the concentration of 50 μg/mL is recommended for patients with neuropathic pain because of its good analgesic effect and less adverse effect on blood glucose, plasma cortisol, and ACTH.

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The Correlation Analysis Between the Blood Lipids, Glycosylated Protein Level and Inflammatory Factors of Pregnant Women with GDM During Pregnancy and the Weight of Newborn

10.21203/rs.3.rs-896430/v1 ◽

2021 ◽

Author(s):

Changhua Hu ◽

Lirong Wu ◽

Juan Fang

Keyword(s):

Blood Glucose ◽

Pregnant Women ◽

Research Group ◽

Blood Lipids ◽

Fasting Blood Glucose ◽

Blood Lipid ◽

Adverse Outcomes ◽

Inflammatory Factors ◽

Control Group ◽

Inflammatory Factor

Abstract The study was carried to explore the correlation between blood lipids, blood glucose levels, inflammatory factor and weight of newborn, to provide reference for control of blood glucose in pregnant women with gestational diabetes mellitus (GDM) and early screening of macrosomia. Fifty pregnant women (give birth to newborn) with GDM were selected as research group, and 55 normal pregnant women (give birth to newborn) as control group. Blood lipid levels of TC, TG, HDL-C, LDL-C, the fasting blood glucose (FPG), HbAlc, glycosylated albumin (GA), and expression of inflammatory factor TLR4 of pregnant women in the two groups were monitored. The levels of TG, FPG, HbA1c and GA in pregnant women, the levels of TLR4 in cord blood of newborn, the relative expression of TLR4 protein and TLR4mRNA in the placenta were higher than in control group, and level of HDL-C was lower than the control group. The levels of TC and LDL-C of pregnant women were higher than in control group. Weight of newborn was positively correlated with these all except HDL-C levels (negatively correlated) and no correlation was found with TC and LDL-C. The weight of newborn and incidence of macrosomia in research group were higher compared to control group, and scores of newborns at 1 min and 5 min were lower compared to control group. The results revealed that strengthening the detection of blood lipid and blood glucose during pregnancy can prevent adverse outcomes such as giant babies and improve the quality of birth.

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Beneficial effects of diacerein on adipokines and pro-inflammatory cytokines involved in diet-induced nonalcoholic steatohepatitis in rats

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20171085 ◽

2017 ◽

Vol 6 (4) ◽

pp. 811 ◽

Cited By ~ 1

Author(s):

Omaima M. Abd Allah

Keyword(s):

Insulin Resistance ◽

Blood Glucose ◽

Inflammatory Cytokines ◽

Blood Lipids ◽

Fasting Blood Glucose ◽

Liver Weight ◽

Serum Levels ◽

Beneficial Effects ◽

Tnf Α ◽

Pro Inflammatory Cytokines

Background: Non-alcoholic steatohepatitis (NASH) is considered as a progressive liver disease, so effective therapies are needed to ameliorate hepatic steatosis, inflammation and fibrosis, and to prevent the progression to cirrhosis and hepatocellular carcinoma. Diacerein is an anti-inflammatory drug that inhibits the synthesis and activity of pro-inflammatory cytokines. The present study was designed to investigate the effect of diacerein on pro-inflammatory cytokines as well as adipokines involved in diet-induced NASH rat model.Methods: Thirty-two adult male rats were divided into four groups: control, diacerein-treated, NASH-untreated and NASH+diacerein-treated groups. NASH was induced by feeding rats with high-fat and high-cholesterol diet for 12 weeks. Body weight, liver weight, fasting blood glucose and insulin levels for estimation of insulin resistance, blood lipids, alanine transaminase, and aspartate aminotransferase were evaluated. Serum levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), adiponectin, visfatin and leptin were also detected. Histopathological examination of liver sections was performed.Results: Diacerein significantly reduced liver weight, fasting blood glucose, insulin level, transaminases and ameliorates insulin resistance with favourable effects on blood lipids. These results were accompanied with a significant reduction in serum levels of TNF-α, IL-1β, IL-6, and visfatin, while, adiponectin was significantly increased and leptin was insignificantly affected. Liver sections revealed that diacerein reduced steatosis and lobular inflammatory grades.Conclusions: These data suggest that diacerein administration may have a potential usefulness in the prevention of NASH as a possible result of inhibition of pro-inflammatory cytokines and the beneficial effects on adipokines especially adiponectin and visfatin.

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Elevation of serum E-selectin in Thai hyperlipidemia adults

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20214702 ◽

2021 ◽

Vol 9 (12) ◽

pp. 3520

Author(s):

Apinya Michuea ◽

Somsak Fongsupa ◽

Thaval Rerksngarm ◽

Sudawadee Kongkhum

Keyword(s):

Uric Acid ◽

Blood Glucose ◽

Endothelial Dysfunction ◽

Total Cholesterol ◽

Blood Lipids ◽

Low Density Lipoprotein ◽

Fasting Blood Glucose ◽

Density Lipoprotein ◽

Serum Levels ◽

Specific Marker

Background: Hyperlipidemia is an important risk factor of cardiovascular diseases (CVD), whose pathogenesis involves vascular endothelial dysfunction. Therefore, a specific marker of endothelial dysfunction, serum E-selectin, was assessed in Thai hyperlipidemia adults.Methods: Subjects who had no history of hypertension, diabetes and other serious illness were recruited and classified as normolipidemia (n=100) and hyperlipidemia (n=100), by using the levels of blood lipids (hyperlipidemia: total cholesterol >200 mg/dl, low density lipoprotein cholesterol (LDL-C) >130 mg/dl, and triglyceride >150 mg/dl). Clinical data were collected, and laboratory analysis was done. Serum levels of uric acid, fasting blood glucose (FBS), blood urea nitrogen (BUN), and creatinine were measured by the dry chemistry automate analyzer. Serum E-selectin was measured by using the enzyme-linked immunosorbent assay.Results: The hyperlipidemia subjects had significantly higher serum E-selectin levels than the normolipidemia subjects (18.98±11.58.56 versus 8.85±4.02 ng/ml). E-selectin was significantly correlated with blood lipids; total cholesterol, triglyceride, LDL-C, and HDL-C (r=0.477, 0.441, 0.453, and -0.191, respectively). Moreover, significant correlations of E-selectin with uric acid and fasting blood glucose were also found (r=0.155 and 0.166, respectively).Conclusions: Serum E-selectin levels increased in hyperlipidemia and correlated with uric acid and fasting blood glucose, reflecting the association between hyperlipidemia and pathogenesis of CVD, Therefore, it emphasizes the importance of hyperlipidemia management.

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Associations Of Betatrophin Levels With Fasting Blood Glucose In Obese Females

STRADA JURNAL ILMIAH KESEHATAN ◽

10.30994/sjik.v9i1.271 ◽

2020 ◽

Vol 9 (1) ◽

pp. 78-84

Author(s):

Pradika Gita Baskara ◽

Lilik Herawati ◽

Purwo Sri Rezeki

Keyword(s):

Blood Glucose ◽

Pearson Correlation ◽

Fasting Blood Glucose ◽

Cross Sectional Study ◽

Fat Percentage ◽

Cross Sectional ◽

Obese Adolescent ◽

Analysis Techniques ◽

Obese Female ◽

Pearson Correlation Test

This study aims to analyze the correlation between the levels of betatrophin and fasting blood glucose (FBG) in obese females. This study used a cross sectional study method of 26 obese female aged 18-23 years old, body mass index (BMI) 25-35 kg/m2 and body fat percentage (PBF) above 30%. Betatrophin levels were measured by ELISA method, while FBG measurements used ACCU-CHEK® Performance. The data analysis techniques used the Pearson Correlation test with the Statistical Package for Social Sciences (SPSS). The results obtained the average of betatrophin level (165.707 ± 96.124) pg / mL and the average of FBG (90.576 ± 7.094) g / dL (p = 0.021). Based on the results of the study it can be concluded that there is a correlation between levels of betatrophin and FBG in obese adolescent girls with a negative correlation direction

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Metabolic Syndrome and Cardiovascular Risk Factors in Obese Adolescent

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2016.037 ◽

2016 ◽

Vol 4 (1) ◽

pp. 118-121 ◽

Cited By ~ 11

Author(s):

Manal Mansour ◽

Yasser E. Nassef ◽

Mones Abu Shady ◽

Ali Abdel Aziz ◽

Heba A. El Malt

Keyword(s):

Risk Factors ◽

Metabolic Syndrome ◽

Cardiovascular Risk ◽

Blood Glucose ◽

Total Cholesterol ◽

Blood Lipids ◽

Density Lipoprotein ◽

P Value ◽

Lipid Levels ◽

Obese Adolescent

BACKGROUND: Childhood and adolescent obesity is associated with insulin resistance, abnormal glucose metabolism, hypertension, dyslipidemia, inflammation, liver disease, and compromised vascular function. The purpose of this study was to determine the prevalence of cardiovascular risk factor abnormalities and metabolic syndrome in a sample of obese adolescent as prevalence data might be helpful in improving engagement with obesity treatment in future. The high blood lipid levels and obesity are the main risk factors for cardio vascular diseases. Atherosclerotic process begins in childhood.AIM: This study aimed to investigate the relationship between obesity in adolescent and their blood lipids levels and blood glucose level.METHODS: This study was conducted with 100 adolescents of both gender age 12-17 years and body mass index (BMI) greater than 95th percentiles and 100 normal adolescents as control group. The blood samples were collected from all adolescents after overnight fasting (10 hours) to analyze blood lipids (Total cholesterol, high density lipoprotein, low density lipoprotein) and hematological profile (Hemoglobin, platelets and red blood cell, C reactive protein and fasting blood glucose.RESULTS: There were statistical difference between the two groups for red blood cells (P<0.001), Hemoglobin (P < 0.001) and platelets (P = 0.002), CRP (P = 0.02). Positive correlation was found between the two groups as regards total cholesterol (P = 0.0001), P value was positive for HDL (P = 0.005 and Atherogenic index P value was positive (P = 0.002). Positive correlation was found between the two group as regards fasting blood glucose (P = 0.001).CONCLUSION: Saturated fat was associated with elevated lipid levels in obese children. These results reinforce the importance of healthy dietary habits since child-hood in order to reduce the risks of cardiovascular diseases in adulthood.

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Treatment with astragaloside IV reduced blood glucose, regulated blood lipids, and protected liver function in diabetic rats

Journal of International Medical Research ◽

10.1177/0300060519841165 ◽

2021 ◽

Vol 49 (3) ◽

pp. 030006051984116

Author(s):

Dong Han

Keyword(s):

Blood Glucose ◽

Liver Function ◽

Liver Tissue ◽

Blood Lipids ◽

Serum Alkaline Phosphatase ◽

Fasting Blood Glucose ◽

Diabetic Rats ◽

Metformin Hydrochloride ◽

Astragaloside Iv ◽

Serum Aspartate Aminotransferase

Objectives To investigate the effects of astragaloside IV on blood glucose, blood lipids, and liver function in diabetic rats. Methods Fifty diabetic rats were randomly placed into five groups (n = 10 each): the diabetes mellitus (DM) group received intragastric saline, the metformin hydrochloride group received intragastric metformin hydrochloride, and the astragaloside-30, -60, and -120 groups received intragastric astragaloside 30 mg/kg, 60 mg/kg, and 120 mg/kg for 28 days, respectively. Ten non-diabetic rats received intragastric saline as controls. Results Relative to the DM group, fasting blood glucose, triglyceride, total cholesterol, serum alanine transaminase, and serum aspartate aminotransferase levels decreased in the astragaloside-60 and astragaloside-120 groups; serum alkaline phosphatase decreased solely in the astragaloside-120 group. Serum superoxide dismutase (SOD), glutathione (GSH-Px), and catalase (CAT) levels were elevated, while maleic dialdehyde (MDA) decreased in the astragaloside-120 group, relative to the DM group. Relative to the DM group, the liver index and liver cell apoptosis rate were reduced, while histopathological changes in liver tissue were ameliorated in the astragaloside groups; moreover, liver tissue SOD, GSH-Px, and CAT levels were increased, while liver tissue MDA was reduced. Conclusions Astragaloside IV can lower blood glucose, regulate blood lipids, and protect liver function in diabetic rats.

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Blood Glucose Relationship to Fasting Blood Lipids, Acylated Ghrelin, and Response to Carbonated and Flavored Beverage Consumption

Current Developments in Nutrition ◽

10.1093/cdn/nzaa049_005 ◽

2020 ◽

Vol 4 (Supplement_2) ◽

pp. 612-612

Author(s):

Joleen Barnett ◽

Emily Heying ◽

Alexa Evenson ◽

Annaliese Widmer

Keyword(s):

Blood Glucose ◽

Total Cholesterol ◽

Repeated Measures ◽

Blood Lipids ◽

Fasting Blood Glucose ◽

Blood Lipid ◽

Acylated Ghrelin ◽

Glucose Response ◽

Beverage Consumption ◽

Blood Glucose Concentrations

Abstract Objectives The objective was to 1) determine if carbonation, flavor, and sweetness in beverages impact blood glucose response after consumption and 2) to determine if there is a relationship between fasting glucose concentrations, acylated ghrelin, and blood lipid concentrations. Methods Participants (males n = 11, females n = 14) aged 23–65, BMI < 30 kg/m2, and no reported chronic disease participated in a single-blinded randomized crossover design. Participants completed six data collections, arriving four hours fasted and consuming one of six different beverages (water, carbonated-no flavor [CNF], carbonated lime flavor [CL], degassed lime flavor [DL], carbonated lime flavor with aspartame [CLS], and degassed lime flavor with aspartame [DLS]). Blood was collected via finger stick at 0 (baseline), followed by beverage consumption, and then collected at 10 and 45 minutes post consumption into EDTA microtainers. A cholestec machine, ELISA assay, and glucometer were used to measure blood lipids, acylated ghrelin, and blood glucose concentrations, respectively. A repeated measures ANOVA was used to determine differences in glucose response. Spearman rank-order correlation coefficients were used to determine the relationships between variables. Results Blood glucose concentrations did not differ based on beverage, time, or an interaction between the two (P > 0.05). The average blood glucose concentration among beverage and time points was 96.68 + 7.76 mg/dL (mean ± SD). There was no correlation between fasting blood glucose (0 min), acylated ghrelin, or any blood lipid measurements (P > 0.05). There was a correlation between LDL and total cholesterol concentrations (r = .780, P = < 0.0001) and between HDL and LDL concentrations (r = –.417, P = 0.038). Conclusions HDL and LDL were negatively correlated and LDL and total cholesterol were positively correlated in adults with BMI < 30 kg/m2. Carbonation, flavor, and artificially sweetened beverages have limited impact on blood glucose change after beverage consumption. Funding Sources This work was funded by the College of Saint Benedict/Saint John's University Faculty Development Grant and CSB/SJU Undergraduate Research Grant.

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