Controlled bioactive compound delivery systems based on double polysaccharide film-coated microparticles for liquid products and their release behaviors

This article reports the studies on bioactive (co)oligoesters towards their use as controlled delivery systems of p-anisic acid. The objects of the study were oligo[3-hydroxy-3-(4-methoxybenzoyloxymethyl)propionate], (p-AA-CH2-HP)n oligoester, and oligo[(3-hydroxy-3-(4-methoxybenzoyloxymethyl)propionate)-co-(3-hydroxybutyrate)] [(p-AA-CH2-HP)x-co-(HB)y (co)oligoesters containing p-anisic acid moiety (p-AA, as the bioactive end and side groups) connected to the polymer backbone through the susceptible to hydrolysis ester bonds. A thorough insight into the hydrolysis process of the bioactive (co)oligoesters studied has allowed us to determine the release profile of p-AA as well as to identify polymer carrier degradation products. The p-AA release profiles determined on the basis of high-performance liquid chromatography (HPLC) measurements showed that the release of the bioactive compound from the developed (co)oligoester systems was regular and no burst effect occurred. Biological studies demonstrated that studied (homo)- and (co)oligoesters were well tolerated by HaCaT cells because none of them showed notable cytotoxicity. They promoted keratinocyte growth at moderate concentrations. Bioactive (co)oligoesters containing p-anisic acid moiety had somewhat decreased cell proliferation at the highest concentration (100 µg/mL). The important practical inference of the current study is that the (co)oligoesters developed have a relatively large load of the biologically active substance (p-AA) per polymer macromolecule, which unlocks their potential application in the cosmetic industry.

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Plant Protein-Based Delivery Systems: An Emerging Approach for Increasing the Efficacy of Lipophilic Bioactive Compounds

Molecules ◽

10.3390/molecules27010060 ◽

2021 ◽

Vol 27 (1) ◽

pp. 60

Author(s):

Andresa Gomes ◽

Paulo José do Amaral Sobral

Keyword(s):

Bioactive Compounds ◽

Bioactive Compound ◽

Delivery Systems ◽

Raw Material ◽

Plant Protein ◽

Plant Proteins ◽

Rational Development ◽

Effective Delivery ◽

New Generation ◽

And Control

The development of plant protein-based delivery systems to protect and control lipophilic bioactive compound delivery (such as vitamins, polyphenols, carotenoids, polyunsaturated fatty acids) has increased interest in food, nutraceutical, and pharmaceutical fields. The quite significant ascension of plant proteins from legumes, oil/edible seeds, nuts, tuber, and cereals is motivated by their eco-friendly, sustainable, and healthy profile compared with other sources. However, many challenges need to be overcome before their widespread use as raw material for carriers. Thus, modification approaches have been used to improve their techno-functionality and address their limitations, aiming to produce a new generation of plant-based carriers (hydrogels, emulsions, self-assembled structures, films). This paper addresses the advantages and challenges of using plant proteins and the effects of modification methods on their nutritional quality, bioactivity, and techno-functionalities. Furthermore, we review the recent progress in designing plant protein-based delivery systems, their main applications as carriers for lipophilic bioactive compounds, and the contribution of protein-bioactive compound interactions to the dynamics and structure of delivery systems. Expressive advances have been made in the plant protein area; however, new extraction/purification technologies and protein sources need to be found Their functional properties must also be deeply studied for the rational development of effective delivery platforms.

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Therapeutic Efficacy of Herbal Formulations Through Novel Drug Delivery Systems

Advances in Medical Diagnosis, Treatment, and Care - Enhancing the Therapeutic Efficacy of Herbal Formulations ◽

10.4018/978-1-7998-4453-2.ch001 ◽

2021 ◽

pp. 1-42

Author(s):

Arvind Kumar Singh Chandel ◽

Nutan Bhingradiya

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Herbal Medicines ◽

Bioactive Compound ◽

Delivery Systems ◽

Bioactive Molecules ◽

Therapeutic Molecules ◽

Dose Accuracy ◽

The Many ◽

Novel Drug

The herbal-based drugs have been getting wide attention over the last few decades. The herbal drugs have been used from the ancient times, but the dose accuracy, efficacy, and treatment was just based on symptomatic observatory. Modern research is focused on pure bioactive compound instead of crude. The researchers are trying to apply the current advanced nanotechnology-based knowledge on the herbal medicines to improve efficacy and reduces the unwanted pharmacological actions' adverse effects of the therapeutic molecules. The many novel drug delivery systems available used for the herbal bioactive molecules include polymeric micelle, injectable hydrogel, nano gel, nano emulsions, microsphere, polymeric nanoparticles, nano capsules, liposomes, phytosomes, transferosomes, dendrimer, and ethosomes. This chapter highlights the existing research and development of current standing of the of various novel formulations especially for the herbal bioactive molecules and summarizes their active ingredients, commercial formulations, route of drug administration, and pharmacological activity.

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Understanding Users� Electronic Nicotine Delivery Systems Vaping Experience from Social Media Using Sentiment Opinion Summarization Techniques (Preprint)

10.2196/preprints.9373 ◽

2017 ◽

Author(s):

Qiudan Li ◽

Can Wang ◽

Ruoran Liu ◽

Lei Wang ◽

Daniel Dajun Zeng ◽

...

Keyword(s):

Application Programming Interface ◽

Delivery Systems ◽

Analysis Model ◽

Electronic Nicotine Delivery Systems ◽

Fine Grained ◽

Nicotine Delivery ◽

Opinion Summarization ◽

Positive Attitudes ◽

Liquid Products ◽

Main Components

BACKGROUND E-liquid is one of the main components in electronic nicotine delivery systems (ENDS). ENDS review comments could serve as an early warning on use patterns, and even function to serve as an indicator of problems or adverse events pertaining to the use of specific e-liquids – much like the types of responses that are tracked by the Food and Drug Administration (FDA) regarding medications. OBJECTIVE This paper aims to understand users’ vaping experience using sentiment opinion summarization techniques, which can help characterize how consumers, ENDS vendors, and others think about specific e-liquids and their characteristic (e.g. flavor, throat hit, vapor production, etc.). METHODS We collected e-liquid reviews on JuiceDB from June 27, 2013 to December 31, 2017 by using its public application programming interface (API). The dataset contains 27070 reviews for 8058 e-liquid products. Each review is accompanied by an overall rating and a set of four aspect ratings of an e-liquid, each on a scale of 1-5: flavor accuracy, throat hit, value and cloud production. An Iterative Dichotomiser 3 (ID3) based influential aspect analysis model was adopted to learn the key elements that impact e-liquid use. Then, fine-grained sentiment analysis was employed to mine opinions on various aspects of the vaping experience related to e-liquids. RESULTS We found that: (1) Flavor accuracy and value were the two most important aspects that influence users’ sentiments towards e-liquids. (2) 67.83% (18362/27070) of the reviews in JuiceDB were positive, while 12.67% (3430/27070) were negative. This indicates that users generally hold positive attitudes towards e-liquids. (3) Among the nine flavors, fruity and sweet were the two most popular flavors. (4) Great and sweet tastes, reasonable value, and strong throat hit made users satisfied with the fruity and sweet flavors, whereas weird tastes made users dislike these flavors. Meanwhile, users complained about steep/expensive price, bad quality and harsh throat hit of some e-liquids. (5) There were 2342 fruity e-liquids and 2049 sweet e-liquids. Positive sentiments towards fruity e-liquids and sweet e-liquids measured 55.81% and 59.83% respectively; negative sentiments were 13.62% and 12.88% respectively. Great flavors and good vapors contributed to positive reviews of fruity and sweet products. However, bad tastes such as “sour” or “bitter” resulted in negative reviews. These findings can help businesses and policy makers further improve product quality and formulate effective policy. CONCLUSIONS This is the first study to provide an effective mechanism to analyze users’ ENDS vaping experience based on sentiment opinion summarization techniques. Sentiment opinions on aspect and products can be found using our method, which is of great importance to monitor e-liquid products and improve work efficiency.

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Electrohydrodynamic Processing of Potato Protein into Particles and Fibers

Molecules ◽

10.3390/molecules25245968 ◽

2020 ◽

Vol 25 (24) ◽

pp. 5968

Author(s):

Ana C. Mendes ◽

Elena Saldarini ◽

Ioannis S. Chronakis

Keyword(s):

Vitamin B12 ◽

Protein Concentration ◽

Bioactive Compound ◽

Delivery Systems ◽

Electrospun Fibers ◽

Potato Protein ◽

Protein Particles

Potato protein particles and fibers were produced using electrohydrodynamic processing (electrospray and electrospinning). The effect of different solvents and protein concentration on the morphology of the potato protein particles and fibers was investigated. Electrosprayed particles with average diameters ranging from 0.3 to 1.4 µm could be obtained using water and mixtures of water: ethanol (9:1) and water:glycerol (9:1). Electrosprayed particles were also obtained using the solvent hexafluoro-2-propanol (HFIP) at a protein concentration of 5% wt/v. For protein concentrations above 10% wt/v, using HFIP, electrospun fibers were produced. The release of vitamin B12, as a model bioactive compound, from potato protein electrospun fibers, was also investigated, demonstrating their potential to be utilized as encapsulation and delivery systems.

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Peptide dendrimers: drug/gene delivery and other approaches

Canadian Journal of Chemistry ◽

10.1139/cjc-2017-0242 ◽

2017 ◽

Vol 95 (9) ◽

pp. 907-916 ◽

Cited By ~ 19

Author(s):

S.S. Santos ◽

R.V. Gonzaga ◽

J.V. Silva ◽

D.F. Savino ◽

D. Prieto ◽

...

Keyword(s):

Gene Delivery ◽

Bioactive Compounds ◽

Recent Trend ◽

Bioactive Compound ◽

Delivery Systems ◽

Bioactive Molecules ◽

Peptide Dendrimers ◽

Important Trend ◽

Covalently Linked ◽

Peptide Dendrimer

Dendrimers are versatile hyperbranched molecules, which have deserved attention especially for their potential in many applications, including biological. Peptide dendrimers comprise interesting classes of dendrimers, and their use has been emphasized as a drug/bioactive compound delivery system, mostly in the antineoplastic area. The bioactive molecules can be covalently linked or entrapped inside the peptide derivative. Self-assembled nanocarriers are a recent trend in the design of potential delivery systems, and pH-sensitive carriers, one of their methods, have been designed to control their systems. In addition, the use of targeting peptides or other specific groups that direct the drug/bioactive compounds to specific organs is an important trend in the search for better drug delivery systems. Recent examples have been given in the literature, showing that gene delivery as another important peptide dendrimer application. It is worth emphasizing that some peptide dendrimers show activity per se, without bioactive compounds. Immune compounds and vaccines are presented herein, as well as uses of other peptide dendrimers are briefly discussed in this review, which encompasses around 10 years of work.

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Techniques For The Preparation of Tissue Samples Containing Injectable Polymer Microcapsules

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100120242 ◽

1985 ◽

Vol 43 ◽

pp. 710-711

Author(s):

G.E. Visscher ◽

R. L. Robison ◽

G. J. Argentieri

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Gastrocnemius Muscle ◽

Degradation Process ◽

Delivery Systems ◽

Tissue Reaction ◽

Electron Microscopic ◽

Tissue Samples ◽

Injectable Polymer ◽

Microscopic Techniques

The use of various bioerodable polymers as drug delivery systems has gained considerable interest in recent years. Among some of the shapes used as delivery systems are films, rods and microcapsules. The work presented here will deal with the techniques we have utilized for the analysis of the tissue reaction to and actual biodegradation of injectable microcapsules. This work has utilized light microscopic (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques. The design of our studies has utilized methodology that would; 1. best characterize the actual degradation process without artifacts introduced by fixation procedures and 2. allow for reproducible results.In our studies, the gastrocnemius muscle of the rat was chosen as the injection site. Prior to the injection of microcapsules the skin above the sites was shaved and tattooed for later recognition and recovery. 1.0 cc syringes were loaded with the desired quantity of microcapsules and the vehicle (0.5% hydroxypropylmethycellulose) drawn up. The syringes were agitated to suspend the microcapsules in the injection vehicle.

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