Background - Perceived stress experiences differ amongst individuals due to psychological, physical and socio-economic factors and with the outbreak of COVID-19, the impact on mental health has been unavoidable. Another dimension of understanding stress is also put forth by Ayurveda, an ancient medicine system of India. Aim – Aims to find the association of bio-social parameters including prakriti body types with perceived stress levels amidst COVID -19 pandemic. Material and Methods – Data were collected from 390 individuals aged ranging from 18 – 45 years through an online survey. Prakriti were determined by prakriti assessment questionnaire. Stress level was assessed by using Perceived Stress Scale (PSS 10) and relevant statistical analysis were carried out. Results - Significant association (p < 0.05) is found in body mass index (BMI), prakriti body types, sex, and effects of COVID–19 on mental and physical well – being with perceived stress levels. Vata prakriti (19.71%), underweight individuals (12.65%), and females (11.44%) are significantly more prone to develop high stress. Salaried individuals are significantly less likely to be affected by moderate stress. VIF is less than 5 and Tolerance is greater than 0.2. And, Nagelkerke value is found to be 29.3%. Conclusion – The study concludes that there is a significant association of biosocial parameters including prakriti body types with perceived stress levels amidst COVID–19 pandemic.