84 ROLE OF uCTX-I uCTX-II GLUCOSAMINE, CHONDROITINSULPHATE AND TYPE II COLLAGEN IN OSTEOARTHRITIS FOLLOW-UP: AN ITALIAN OBSERVATIONAL STUDY

Abstract Background Outpatient medical follow-up post-stroke is not only crucial for secondary prevention but is also associated with a reduced risk of rehospitalization. However, being voluntary and non-urgent, it is potentially determined by both healthcare needs and the socio-demographic context of stroke survivor-caregiver dyads. Therefore, we aimed to examine the role of caregiver factors in outpatient medical follow-up (primary care (PC) and specialist outpatient care (SOC)) post-stroke. Method Stroke survivors and caregivers from the Singapore Stroke Study, a prospective, yearlong, observational study, contributed to the study sample. Participants were interviewed 3-monthly for data collection. Counts of PC and SOC visits were extracted from the National Claims Database. Poisson modelling was used to explore the association of caregiver (and patient) factors with PC/SOC visits over 0–3 months (early) and 4–12 months (late) post-stroke. Results For the current analysis, 256 stroke survivors and caregivers were included. While caregiver-reported memory problems of a stroke survivor (IRR: 0.954; 95% CI: 0.919, 0.990) and caregiver burden (IRR: 0.976; 95% CI: 0.959, 0.993) were significantly associated with lower early post-stroke PC visits, co-residing caregiver (IRR: 1.576; 95% CI: 1.040, 2.389) and negative care management strategies (IRR: 1.033; 95% CI: 1.005, 1.061) were significantly associated with higher late post-stroke SOC visits. Conclusion We demonstrated that the association of caregiver factors with outpatient medical follow-up varied by the type of service (i.e., PC versus SOC) and temporally. Our results support family-centred care provision by family physicians viewing caregivers not only as facilitators of care in the community but also as active members of the care team and as clients requiring care and regular assessments.

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The role of rehabilitation measures in reintegration of children with brain tumours or leukaemia and their families after completion of cancer treatment: a study protocol

BMJ Open ◽

10.1136/bmjopen-2016-014505 ◽

2017 ◽

Vol 7 (8) ◽

pp. e014505 ◽

Cited By ~ 5

Author(s):

Mona Leandra Peikert ◽

Laura Inhestern ◽

Corinna Bergelt

Keyword(s):

Observational Study ◽

Cancer Treatment ◽

Childhood Cancer ◽

Quantitative Study ◽

Prospective Observational Study ◽

Daily Life ◽

Oncological Rehabilitation ◽

Rehabilitation Measures

IntroductionFor ill children as well as for their parents and siblings, childhood cancer poses a major challenge. Little is known about the reintegration into daily life of childhood cancer survivors and their families. The aim of this prospective observational study is to further the understanding of the role of rehabilitation measures in the reintegration process of childhood leukaemia or brain tumour survivors and their family members after the end of cancer treatment.Methods and analysisThis prospective observational study consists of three study arms: a quantitative study in cooperation with three German paediatric oncological study registries (study arm 1), a quantitative study in cooperation with a rehabilitation clinic that offers a family-oriented paediatric oncological rehabilitation programme (study arm 2) and a qualitative study at 12-month follow-up including families from the study arms 1 and 2 (study arm 3). In study arm 1, children, parents and siblings are surveyed after treatment (baseline), 4–6 months after baseline measurement and at 12-month follow-up. In study arm 2, data are collected at the beginning and at the end of the rehabilitation measure and at 12-month follow-up. Families are assessed with standardised questionnaires on quality of life, emotional and behavioural symptoms, depression, anxiety, fear of progression, coping and family functioning. Furthermore, self-developed items on rehabilitation aims and reintegration into daily life are used. Where applicable, users and non-users of rehabilitation measures will be compared regarding the outcome parameters. Longitudinal data will be analysed by means of multivariate analysis strategies. Reference values will be used for comparisons if applicable. Qualitative data will be analysed using thematic analysis.Ethics and disseminationThis study has been approved by the medical ethics committee of the Medical Chamber of Hamburg. Data will be published in peer-reviewed journals and presented at conferences.

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Outcome of 116 cases of pleuropulmonary blastoma type I and type Ir (regressed): A report from the International PPB Registry (IPPBR).

Journal of Clinical Oncology ◽

10.1200/jco.2012.30.15_suppl.9522 ◽

2012 ◽

Vol 30 (15_suppl) ◽

pp. 9522-9522 ◽

Cited By ~ 3

Author(s):

Yoav H. Messinger ◽

Gretchen M Williams ◽

John R. Priest ◽

Anne Harris ◽

Leslie Ann Doros ◽

...

Keyword(s):

Lung Neoplasm ◽

Pleuropulmonary Blastoma ◽

Type I ◽

High Grade ◽

Type Ii ◽

Exact Test ◽

Risk Of Progression ◽

High Grade Sarcoma

9522 Background: Pleuropulmonary blastoma (PPB) is a rare dysembryonic lung neoplasm of early childhood with progression from a purely cystic Type I (T-I) lesion to cystic solid and solid high grade sarcoma (Type II and Type III). A regressed form of PPB (T-Ir) has been recognized pathologically. The outcome of both T-I and T-Ir has been only partially described. Methods: Retrospective analysis of 345 IPPBR cases showed 116 T-I or T-Ir. In all cases the PPB diagnosis was made on surgically removed cysts. The treating physician decided whether to use chemotherapy after surgery. Results: The pathologic diagnosis of the 91 PPB T-I and 25 T-Ir is now confirmed by central review (LPD and DAH). Patients with T-I were younger than T-Ir (median: 8 months vs. 48 months).Diagnosis after age 6 years included only one T-I compared to 10 T-Ir patients. Therapy is not known for 28 T-I and 2 T-Ir. Surgery was followed by chemotherapy in 31 T-I and 2 T-Ir. Six (5%) recurred with the same type, all were alive at last follow-up: 5 (5.5%) T-I, 1 (4%) T-Ir. Progression to high-grade Type II or III occurred in 9/91 (10%) T-I and 2/25 (8%) T-Ir. The addition of chemotherapy did not significantly reduce progressions (Fisher’s exact test). All of the tumor progressions were seen by 75 months of age; this finding is similar to broader IPPBR data: > 95% of patients are diagnosed with Type II/III by 72 months of age. Of the 9 patients with T-I who progressed, 5 ultimately died, whereas the 2 T-Ir who progressed were alive. At last follow-up 111/116 (95.6%) were alive. Conclusions: A cyst in an older individual most likely will be Type Ir. Type I and Type Ir are clinically similar with a small risk of progression to the advanced Type II/III up to 6 years of age. Outcome for those whose cystic PPBs progressed is poor. The role of chemotherapy remains uncertain for the prevention of progression in the pure cystic PPB Type I or Ir. [Table: see text]

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Expression of extracellular matrix genes during skeletogenesis : the role of type II collagen

10.5353/th_b3123757 ◽

1997 ◽

Author(s):

Ling-jim Ng

Keyword(s):

Extracellular Matrix ◽

Type Ii Collagen ◽

Type Ii

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An observational study into the management of arteriomegaly: a call for a revised classification system

Annals of The Royal College of Surgeons of England ◽

10.1308/003588412x13171221498505 ◽

2012 ◽

Vol 94 (4) ◽

pp. 250-255 ◽

Cited By ~ 2

Author(s):

JV Barandiaran ◽

TC Hall ◽

I Glaves ◽

N El-Barghouti ◽

EP Perry

Keyword(s):

Observational Study ◽

Critical Limb Ischaemia ◽

Limb Ischaemia ◽

Type I ◽

Type Ii ◽

Type Iii ◽

Cerebrovascular Events ◽

Progression Of Disease ◽

Artery Disease

INTRODUCTION Arteriomegaly is the diffuse ectasia of arteries with or without aneurysmal disease. Patients with arteriomegaly have a higher incidence of morbidity including limb loss compared to patients with other arteriopathies. The aim of this observational study was to review the management of these patients in our institution. METHODS Radiologists and surgeons prospectively reviewed aortofemoral angiography. Patients with arteriomegaly were identified. Data relating to demographics, mode of presentation, risk factors, type of arteriomegaly, management and progression of disease were analysed. RESULTS Arteriomegaly was identified in 1.3% of patients (n=69) undergoing lower limb angiography in the study period. Of these, the majority (n=67) were men. The mean age was 74 years (range: 60–89 years) and 76% were smokers. Co-morbidities included coronary artery disease (55%), diabetes mellitus (20%), hypertension (45%) and cerebrovascular events (6%). Fortynine patients presented with critical limb ischaemia and eighteen patients were seen electively in the outpatients department with symptoms of intermittent claudication. Data were incomplete for two male patients and were therefore not included. At presentation, 22 patients were classified as Hoi lier type I, 5 were type II and 9 were type III. Thirty-one patients had arteriomegalic vessels but no aneurysmal disease. After a median follow-up duration of 76 months (range: 6–146 months), 34 patients progressed to type I, 2 to type II and 18 to type III. Thirteen remained without aneurysmal disease. Twenty-nine patients required angioplasty and twenty-eight required bypass surgery during this time. In total, 102 procedures were required for complicated disease. The limb salvage rate was 92%. Although 8 patients in our series died, the remaining 59 are under regular follow up. CONCLUSIONS This study illustrates the progressive nature of arteriomegaly. Results of the management of these patients in our institution are similar to those in the literature. We suggest an additional fourth category to Hollier’s classification that describes arteriomegalic disease without aneurysmal degeneration as this, too, deserves special management. Regular follow-up visits and early intervention for patients with arteriomegaly is advocated to reduce the high incidence of morbidity.

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Time Course of Antibodies against IgG and Type II Collagen in Adjuvant Arthritis. Role of Mycobacteria Administration in Antibody Production

Immunobiology ◽

10.1016/s0171-2985(11)80285-8 ◽

1994 ◽

Vol 190 (1-2) ◽

pp. 93-104 ◽

Cited By ~ 5

Author(s):

Angels Franch ◽

Salvador Cassany ◽

Cristina Castellote ◽

Margarida Castell

Keyword(s):

Antibody Production ◽

Adjuvant Arthritis ◽

Time Course ◽

Type Ii Collagen ◽

Type Ii

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Born Again: Recurrent Hepatic Encephalopathy in an Adult without Cirrhosis

Journal of Gastrointestinal and Abdominal Radiology ◽

10.1055/s-0039-1686966 ◽

2019 ◽

Vol 02 (01) ◽

pp. 039-040

Author(s):

Tom George ◽

Sasidharan Rajesh ◽

Cyriac Abby Philips

Keyword(s):

Hepatic Encephalopathy ◽

Systemic Circulation ◽

Portosystemic Shunt ◽

Type Ii ◽

Adult Onset ◽

Significant Clinical Improvement ◽

Congenital Extrahepatic Portosystemic Shunt ◽

Born Again

AbstractCongenital extrahepatic portosystemic shunt (CEPS) develops between the por-to-mesenteric and systemic veins. The splanchnic venous system drains directly to systemic circulation in this condition. We present a case of an adult onset Type II CEPS presenting with hepatic encephalopathy. The patient underwent PARTO (plug-assisted retrograde transvenous obliteration) and had a significant clinical improvement on subsequent follow-up. Our case highlights the importance of imaging and the role of an interventional radiologist in the management of the condition.

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Norepinephrine Inhibits Synovial Adipose Stem Cell Chondrogenesis via α2a-Adrenoceptor-Mediated ERK1/2 Activation

International Journal of Molecular Sciences ◽

10.3390/ijms20133127 ◽

2019 ◽

Vol 20 (13) ◽

pp. 3127 ◽

Cited By ~ 3

Author(s):

Karima El Bagdadi ◽

Frank Zaucke ◽

Andrea Meurer ◽

Rainer H. Straub ◽

Zsuzsa Jenei-Lanzl

Keyword(s):

Stem Cells ◽

Type Ii Collagen ◽

Collagen Content ◽

Type Ii ◽

Adipose Stem Cell ◽

Future Studies ◽

Knee Oa ◽

Sulfated Glycosaminoglycan ◽

Resident Stem Cells

In recent years, first evidences emerged that sympathetic neurotransmitters influence osteoarthritis (OA) manifestation. Joint-resident stem cells might contribute to cartilage repair, however, their chondrogenic function is reduced. The neurotransmitter norepinephrine (NE) was detected in the synovial fluid of trauma and OA patients. Therefore, the aim of this study was to analyse how NE influences the chondrogenesis of synovial adipose tissue-derived stem cells (sASCs). sASCs were isolated from knee-OA patients synovia. After adrenoceptor (AR) expression analysis, proliferation and chondrogenic differentiation in presence of NE and/or α- and β-AR antagonist were investigated. Cell count, viability, chondrogenic and hypertophic gene expression, sulfated glycosaminoglycan (sGAG) and type II collagen content were determined. Key AR-dependent signaling (ERK1/2, PKA) was analyzed via western blot. sASC expressed α1A-, α1B-, α2A-, α2B-, α2C-, and β2-AR in monolayer and pellet culture. NE did not affect proliferation and viability, but 10−7 and 10−6 M NE significantly reduced sGAG and type II collagen content as well as ERK1/2 phosphorylation. These effects were fully reversed by yohimbine (α2-AR antagonist). Our study confirms the important role of NE in sASC chondrogenic function and provides new insights in OA pathophysiology. Future studies might help to develop novel therapeutic options targeting neuroendocrine pathways for OA treatment.

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Granulomatous inflammation and organizing pneumonia: Role of computed tomography-guided lung fine needle aspirations, touch preparations and core biopsies in the evaluation of common non-neoplastic diagnoses

CytoJournal ◽

10.4103/1742-6413.126223 ◽

2014 ◽

Vol 11 ◽

pp. 2 ◽

Cited By ~ 9

Author(s):

Anjali Saqi ◽

Shana M. Coley ◽

John P. Crapanzano

Keyword(s):

Computed Tomography ◽

Granulomatous Inflammation ◽

Cytological Diagnosis ◽

Type Ii ◽

Organizing Pneumonia ◽

Site Assessment ◽

Fine Needle ◽

Type Ii Pneumocytes

Background: Fine-needle aspirations (FNAs) and core biopsies (CBs), with or without touch preparations (TPs), are performed to characterize pulmonary lesions. Although a positive (P) or suspicious report is sufficient for further management, the significance of unsatisfactory (U), negative (N) and atypical (A) cytological diagnoses remains uncertain. The aims of the study were to correlate U, N and A cytological diagnoses with histological and/or clinical/radiological follow-up and evaluate the utility of FNAs, TPs and CBs. Materials and Methods: We performed a retrospective search and examined 30 consecutive computed tomography-guided transthoracic U, N and A lung FNAs (n = 23) and TPs (n = 7) with surgical pathology (SP) (n = 17) and/or clinical/radiological follow-up (n = 13) and compared them to 10 SP-confirmed P FNAs, which served as controls. Results: The 30 FNAs and TPs were from 29 patients. All 6 U specimens were scantly cellular. Granulomas, the most common specific benign cytological diagnosis, were evident in 8 (of 13) and 7 (of 11) N and A cytology cases, respectively. Histology corroborated the presence of granulomas identified on cytology. Organizing pneumonia was the second leading benign specific diagnosis (5/17), but it was rendered on histology (n = 5) and not FNAs or TPs. Evaluation of the A cases revealed that type II pneumocytes were the source of “atypical”, diagnoses often associated with granulomas or organizing pneumonia and lacked 3-D clusters evident in all P cases. Discussion: U, N and A FNAs and TPs lacked 3-D clusters seen in carcinomas and were negative on follow-up. Granulomas and organizing pneumonia were the most common specific benign diagnoses, but the latter was recognized on histology only. In the absence of a definitive FNA result at the time of on-site assessment, a CB with a TP containing type II pneumocytes increases the likelihood of a specific benign diagnosis.

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Interleukin-1 potentiates the development of collagen-induced arthritis in mice

Clinical Science ◽

10.1042/cs0760535 ◽

1989 ◽

Vol 76 (5) ◽

pp. 535-538 ◽

Cited By ~ 36

Author(s):

L. M. Killar ◽

C. J. Dunn

Keyword(s):

Immune Response ◽

Interleukin 1 ◽

Subcutaneous Administration ◽

Type Ii Collagen ◽

Interleukin 1Β ◽

Type Ii ◽

Collagen Induced Arthritis

1. The subcutaneous administration of recombinant human interleukin-1β (rhIL-1β) was found to induce an increased incidence and earlier onset of collagen-induced arthritis in mice. 2. The rhIL-1β had different effects, depending on when it was administered after collagen-immunization. 3. The effect of rhIL-1β may be due, in part, to augmentation of the immune response to type II collagen. 4. Interleukin-1-accelerated, collagen-induced arthritis will provide a useful model for investigating the role of interleukin-1 in the regulation of arthritic diseases, and the development of anti-arthritic therapeutics.

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