scholarly journals GP.01 The relationship between carotid stenosis, cerebral cortex thickness and cognitive function in community dwelling older individuals

2018 ◽  
Vol 45 (s2) ◽  
pp. S8-S8
Author(s):  
S Alhusaini ◽  
S Karama ◽  
JM Star ◽  
ME Bastin ◽  
JM Wardlaw ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Carotid Stenosis ◽  
Cortical Thickness ◽  
Fluid Intelligence ◽  
Negative Impact ◽  
Brain Mri ◽  
Significant Risk ◽  
Negative Association ◽  
Community Dwelling ◽  
The Relationship

Background: Carotid atherosclerosis is a significant risk factor for stroke and has been associated with cognitive decline and dementia. Methods: We assessed 554 community-dwelling subjects from the Lothian Birth Cohort of 1936 (LBC1936) who underwent brain MRI and carotid Doppler ultrasound studies at age 73 years. The relationship between carotid stenosis and cerebral cortical thickness was examined cross-sectionally, controlling for gender, extensive vascular risk factors (VRFs), and IQ at age 11 (IQ-11). The association between carotid stenosis and a composite measure of fluid intelligence was also investigated. Results: A widespread negative association was identified between carotid stenosis and cerebral cortical thickness at age 73 years, independent of the side of carotid stenosis, other carotid measures, VRFs, or IQ-11. This association increased in an almost dose-response relationship from mild to severe degrees of carotid stenosis. A negative association was also noted between carotid stenosis and fluid intelligence, which appeared partly mediated by carotid stenosis-related thinning of the cerebral cortex. Conclusions: Carotid stenosis is associated with thinner cerebral cortex and lower fluid cognitive abilities at age 73. The findings suggest that carotid stenosis represents a marker of vascular processes that accelerate cortical aging with a negative impact on cognition, independent of measurable VRFs.

scholarly journals 344 The Relationship between Late Life Depressive Symptoms and Cerebral White Matter Disease is Modified by Systemic and Orthostatic Blood Pressure

2019 ◽  
Vol 48 (Supplement_3) ◽  
pp. iii1-iii16
Author(s):  
Robert Briggs ◽  
Anne Buckley ◽  
Silvin Knight ◽  
Jim Meaney ◽  
Sean Kennelly ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Depressive Symptoms ◽  
White Matter ◽  
Brain Mri ◽  
Depression Scale ◽  
Late Life ◽  
Community Dwelling ◽  
Cerebral White Matter ◽  
White Matter Disease ◽  
The Relationship

Abstract Background Cerebral white matter hyperintensity (WMH) burden is a key biological risk factor underpinning late life depression (LLD) and cerebral hypoperfusion has been identified as an important cause of WMH. The aim of this study therefore is to clarify if orthostatic hypotension (OH) and lower systemic blood pressure (BP), both of which cause reduced cerebral blood flow, modify the relationship between depression and cerebral white matter disease in a cohort of community-dwelling older people aged ≥70 years. Methods This study uses data from wave 3 of TILDA. Participants were included if they were aged ≥70 years and had undergone assessment for depressive symptoms, brain MRI and cardiovascular measures. Depressive symptoms were measured using the 8-item Centre for Epidemiological Studies Depression Scale. Scheltens Score was used by a trained radiologist to calculate overall WMH burden. Orthostatic BP was measured by active stand. OH was defined as a drop in Systolic BP≥20 mmHg or drop in diastolic BP≥10 mmHg at 30, 60 or 90 seconds post standing. Results Participants with depressive symptoms (8%, 16/202) had a significantly higher burden of WMH measured by Scheltens Score (14.6 (95% CI:11.0–18.2) vs. 11.0 (95% CI:10.1–11.8); p=0.0211). Two-way interaction models demonstrated that the association between depressive symptoms and WMH burden is significant only in those with co-existing OH. Similarly, the two-way interaction between depressive symptoms and systolic BP shows that this association remains statistically significant only in those with both depressive symptoms and lower BP, i.e. <130 mm Hg. Conclusion This study demonstrates that depressive symptoms are associated with cerebral WMH in a cohort of community-dwelling people aged ≥70 years but this relationship is modified by co-existing OH or lower BP. Identifying the processes that lead to WMH accumulation and progression in depression is crucial in order to inform strategies aimed at preventing and ameliorating LLD.

scholarly journals How family background shapes the relationship between human capital and fertility

2021 ◽  
Author(s):  
Francis Kramarz ◽  
Olof Rosenqvist ◽  
Oskar Nordström Skans
Keyword(s):  
Human Capital ◽  
Cognitive Abilities ◽  
Negative Impact ◽  
Family Background ◽  
Negative Association ◽  
Register Data ◽  
Background Factors ◽  
The Relationship

AbstractMany previous studies have shown that skilled and educated women have fewer children. By comparing twins and close siblings in Swedish register data, we show that the negative association between human capital and fertility mostly reflects family background factors. For males, human capital measures are unrelated to fertility in the overall population, but this again masks the influence of family background factors as high-skilled males tend to have more children than their less-skilled twins or siblings. Hence, family background factors have a strong negative impact on the overall association between human capital measures and fertility for both women and men. Non-cognitive abilities deviate from these patterns—these abilities remain strongly complementary to fertility both within and across families. Our results can be reconciled with a stylized model where family-specific preferences for fertility are shared across generations and shape investments in skills and traits when children are young.

scholarly journals What is the Relationship between Functional Limitations, Pain, and Self-Perceptions of Aging?

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 607-608
Author(s):  
Jillian Minahan ◽  
Ashley Blasi
Keyword(s):  
Older Adults ◽  
Negative Impact ◽  
Functional Limitations ◽  
Interactive Effect ◽  
Community Dwelling ◽  
Negative Stereotypes ◽  
Older Adulthood ◽  
Self Perceptions ◽  
Perceptions Of Aging ◽  
The Relationship

Abstract Self-perceptions of aging (SPA) influences health and mortality during older adulthood (e.g., Kotter-Grühn et al., 2009; Sargent-Cox et al., 2012). Westerhof and Wurm (2015) found that increasing functional limitations (FL) worsened older adults’ SPA. Additional research is needed to identify other factors that influence SPA. Although pain is common among older adults and is a frequent cause of disability (e.g., Brooks et al., 2019), it has not been examined as a factor influencing SPA. Pain is often misperceived as an inevitable part of aging because of widely held negative stereotypes about aging (Thielke et al., 2012). The experience of pain may activate internalized negative stereotypes about aging, which may worsen SPA. Thus, this study investigated: 1) the relationship between chronic and recent pain, FL, and SPA, and 2) the interactive effect of FL and pain on SPA within a sample of community-dwelling adults aged 65 years and older. This study included 5,126 participants from the 2014 wave of the Health and Retirement Study. Controlling for covariates, chronic pain (β = .09, p &lt; .001) and recent pain (β = .12, p &lt; .001) were associated with negative SPA and were stronger than FL (β = .04, p &lt; .01). There was also a small interaction between FL and recent pain on SPA (β = -.03, p &lt; .01) such that the negative impact of FL on SPA was stronger among individuals who reported low pain. These findings highlight the importance of pain in older adults’ evaluation of their own aging.

scholarly journals Relationship between maximum occlusal force and gastrointestinal cancer in community-dwelling older Japanese adults

2022 ◽  
Vol 12 (1) ◽  
Author(s):  
Takamasa Komiyama ◽  
Takashi Ohi ◽  
Wakana Ito ◽  
Yoshitada Miyoshi ◽  
Takako Hiratsuka ◽  
...  
Keyword(s):  
Gastrointestinal Cancer ◽  
Age Groups ◽  
Significant Risk ◽  
Risk Difference ◽  
Community Dwelling ◽  
Occlusal Force ◽  
Cox Proportional Hazard ◽  
Japanese Adults ◽  
Using Data ◽  
The Relationship

AbstractGlobally, the cancer burden is expected to increase as populations are ageing. Therefore, cancer prevention among older age groups is important. This prospective cohort study examined the relationship between the number of remaining teeth, maximum occlusal force, and incidence of gastrointestinal cancer in community-dwelling older Japanese individuals using data from the Tsurugaya project; 847 participants were included. The exposure variables were the number of remaining teeth and the maximum occlusal force, with the outcome being the incidence of gastrointestinal cancer. Covariates were age, sex, medical history, smoking, alcohol consumption, educational attainment, and physical function. The Cox proportional hazard model was used to examine the relationship between the number of remaining teeth, maximum occlusal force, and incidence of gastrointestinal cancer. With a median follow-up of 7.6 years, 63 participants were confirmed to have gastrointestinal cancer. The risk of gastrointestinal cancer was significantly higher in those with an occlusal force lower than the median (hazard ratio, 2.80; 95% confidence interval, 1.54–5.10). No significant risk difference was found according to the number of remaining teeth. Low maximum occlusal force was associated with the incidence of gastrointestinal cancer in community-dwelling older Japanese adults.

scholarly journals Corticosteroids and Regional Variations in Thickness of the Human Cerebral Cortex across the Lifespan

2019 ◽  
Vol 30 (2) ◽  
pp. 575-586 ◽  
Author(s):  
Nadine Parker ◽  
Didac Vidal-Pineiro ◽  
Leon French ◽  
Jean Shin ◽  
Hieab H H Adams ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Cortical Thickness ◽  
Brain Structure ◽  
Pyramidal Cells ◽  
Brain Atlas ◽  
Variable Degree ◽  
Human Cerebral Cortex ◽  
Age Related ◽  
The Relationship ◽  
Age Related Changes

Abstract Exposures to life stressors accumulate across the lifespan, with possible impact on brain health. Little is known, however, about the mechanisms mediating age-related changes in brain structure. We use a lifespan sample of participants (n = 21 251; 4–97 years) to investigate the relationship between the thickness of cerebral cortex and the expression of the glucocorticoid- and the mineralocorticoid-receptor genes (NR3C1 and NR3C2, respectively), obtained from the Allen Human Brain Atlas. In all participants, cortical thickness correlated negatively with the expression of both NR3C1 and NR3C2 across 34 cortical regions. The magnitude of this correlation varied across the lifespan. From childhood through early adulthood, the profile similarity (between NR3C1/NR3C2 expression and thickness) increased with age. Conversely, both profile similarities decreased with age in late life. These variations do not reflect age-related changes in NR3C1 and NR3C2 expression, as observed in 5 databases of gene expression in the human cerebral cortex (502 donors). Based on the co-expression of NR3C1 (and NR3C2) with genes specific to neural cell types, we determine the potential involvement of microglia, astrocytes, and CA1 pyramidal cells in mediating the relationship between corticosteroid exposure and cortical thickness. Therefore, corticosteroids may influence brain structure to a variable degree throughout life.

Investment Traits and Intelligence in Adulthood

2013 ◽  
Vol 34 (2) ◽  
pp. 82-89 ◽  
Author(s):  
Sophie von Stumm
Keyword(s):  
Individual Differences ◽  
Personality Traits ◽  
Fluid Intelligence ◽  
Need For Cognition ◽  
Openness To Experience ◽  
Intelligence Tests ◽  
Crystallized Intelligence ◽  
New Knowledge ◽  
The Relationship ◽  
Over Time

Intelligence-as-knowledge in adulthood is influenced by individual differences in intelligence-as-process (i.e., fluid intelligence) and in personality traits that determine when, where, and how people invest their intelligence over time. Here, the relationship between two investment traits (i.e., Openness to Experience and Need for Cognition), intelligence-as-process and intelligence-as-knowledge, as assessed by a battery of crystallized intelligence tests and a new knowledge measure, was examined. The results showed that (1) both investment traits were positively associated with intelligence-as-knowledge; (2) this effect was stronger for Openness to Experience than for Need for Cognition; and (3) associations between investment and intelligence-as-knowledge reduced when adjusting for intelligence-as-process but remained mostly significant.

HUBUNGAN KEPADATAN BIVALVIA DENGAN PARAMETER LINGKUNGAN DI PESISIR TANJUNG PURA KABUPATEN BANGKA TENGAH

2020 ◽  
Vol 13 (2) ◽  
pp. 112-121
Author(s):  
Sudiyar . ◽  
Okto Supratman ◽  
Indra Ambalika Syari
Keyword(s):  
Negative Impact ◽  
Principal Component ◽  
Environmental Parameters ◽  
Data Retrieval ◽  
Distribution Patterns ◽  
Random System ◽  
System Method ◽  
Relationship Of ◽  
The Relationship ◽  
Anadara Granosa

The destructive fishing feared will give a negative impact on the survival of this organism. This study aims to analyze the density of bivalves, distribution patterns, and to analyze the relationship of bivalves with environmental parameters in Tanjung Pura village. This research was conducted in March 2019. The systematic random system method was used for collecting data of bivalves. The collecting Data retrieval divided into five research stasions. The results obtained 6 types of bivalves from 3 families and the total is 115 individuals. The highest bivalve density is 4.56 ind / m², and the lowest bivalves are located at station 2,1.56 ind / m²,  The pattern of bivalve distribution in the Coastal of Tanjung Pura Village is grouping. The results of principal component analysis (PCA) showed that Anadara granosa species was positively correlated with TSS r = 0.890, Dosinia contusa, Anomalocardia squamosa, Mererix meretrix, Placamen isabellina, and Tellinella spengleri were positively correlated with currents r = 0.933.

Work Stress and Organisational Citizenship Behaviours (OCBs) in Call Centers Employees

2015 ◽  
Vol 3 (1) ◽  
Author(s):  
Sunita ◽  
Urvashi Singh ◽  
Shalini Singh ◽  
Rajnee Sharma
Keyword(s):  
Negative Impact ◽  
Call Centers ◽  
Negative Relationship ◽  
Married Couples ◽  
Call Centre ◽  
Simple Correlation ◽  
Nuclear Families ◽  
Set Up ◽  
Stress At Work ◽  
The Relationship

The present study was conducted to examine the relationship between organisational stress and organisational citizenship behaviours (OCBs) in employees of call centers. The study also further explored as how stress at work set-up has negative impact on OCBs. A sample of 250 employees working in call centre of Gurgaon belonging to an age group of 25-30 years were selected on availability basis. All were working married couples living in nuclear families. Job stress survey (Spielberger & Vagg, 1999) and Organisational Citizenship Behaviour (Bateman & Organ, 1983) were administered. Data was analysed by using simple correlation and multiple regression. Results showed the negative relationship between organisational stress and OCBs. Results of regression analysis also exhibited the negative impact of stress on OCBs. The implications for the employees are discussed.

Is There Racial Discrimination in Police Stop-and-Searches of Black Youth? A Toronto Case Study

2015 ◽  
Vol 7 (1) ◽  
pp. 115 ◽  
Author(s):  
Yunliang Meng ◽  
Sulaimon Giwa ◽  
Uzo Anucha
Keyword(s):  
Racial Profiling ◽  
Negative Impact ◽  
Black Youth ◽  
White People ◽  
Neighbourhood Level ◽  
Neighbourhood Characteristics ◽  
The Relationship ◽  
Race And Place ◽  
Stop And Search

Our study investigated racial profiling of Black youth in Toronto and linked this racial profiling to urban disadvantage theory, which highlights neighbourhood-level processes. Our findings provide empirical evidence suggesting that because of racial profiling, Black youth are subject to disproportionately more stops for gun-, traffic-, drug-, and suspicious activity-related reasons. Moreover, they show that drug-related stop-and-searches of Black youth occur most excessively in neighbourhoods where more White people reside and are less disadvantaged, demonstrating that race-and-place profiling of Black youth exists in police stop-and-search practices. This study shows that the theoretical literature in sociology on neighbourhood characteristics can contribute to an understanding of the relationship between race and police stops in the context of neighbourhood. It also discusses the negative impact of racial profiling on Black youth.

Has Aid Helped in Pakistan?

1997 ◽  
Vol 36 (4II) ◽  
pp. 947-957 ◽  
Author(s):  
Shahrukh Rafi Khan
Keyword(s):  
Economic Growth ◽  
Negative Impact ◽  
Negative Association ◽  
Causal Impact ◽  
The Impact ◽  
Over Time

This paper has a two-fold objective: first, to examine the terms on which Pakistan receives aid and whether its debt situation is sustainable, and second, to examine the impact of aid and debt on economic growth. It is found that there is little encouraging that can be said about how the terms on which Pakistan has received aid over time have changed, and its current debt situation is not sustainable. Also reported is the analysis done elsewhere which shows that aid has a negative (Granger) causal impact on GDP, and aid has a robust negative impact on economic growth after controlling for supplyside shocks. We provide various reasons for this negative association.

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