The influence of two lucerne-based forage feeds, FiberProtect® and FiberEdge® on Equine Gastric Ulcer Syndrome in horses

2013 ◽  
Vol 2 ◽  
Author(s):  
N.L. Stowers ◽  
L.A. Waldron ◽  
I.D. Pryor ◽  
S.R. Hill ◽  
J. O'Brien
Keyword(s):  
Gastric Ulcer ◽  
High Energy ◽  
Current Treatment ◽  
Gastric Ulceration ◽  
Gastric Ulcers ◽  
Treatment Techniques ◽  
Related Risk ◽  
Healing Phase ◽  
Feed Costs ◽  
The Impact

SummaryEquine Gastric Ulcer Syndrome (EGUS) is extremely prevalent in both racing and non-racing horse populations. The exact aetiology of EGUS is unclear but many stress related risk factors have been implicated including the feeding of grain-based diets. Current treatment techniques often necessitate drug therapy which, when added to feed costs, can be expensive and may have a detrimental effect on digestion due to the mode of action of these therapies. The following experiment set out to investigate if feeding fermented, forage-based feeds (Modified Bio-Fermentation (MBF) lucerne feeds treated with Xanotyde®, registered as FiberProtect® and FiberEdge®; Fiber Fresh Feeds Ltd, Reporoa, New Zealand), could assist in the healing and prevention of ulceration. Nine adult horses with demonstrable and sustained gastric ulceration (diagnosed by gastric endoscopy), were used in a two part study. The first 42 d healing phase investigated the impact of feeding FiberProtect® (FPT) or FiberEdge® (FED) on established gastric ulcers. After 14 d on these diets 44% (4/9) of horses had no ulceration or hyperaemia (inflammation) (EGUC grade 0) and all horses were ulcer free (EGUC grade 0) at d 42. A significant (P < 0.01) relationship was determined between length of time fed and disappearance of ulcers (R2 = 0.9004; DF = 2). The prevention phase utilised the same horses, ulcer-free at d 42, and fed them a grain-based high energy racing diet alongside FPT at 40% and 60% of the total diet (DM basis). The horses were monitored for a further 28 d (d 42 – d 70), and only three showed a recurrence of ulceration throughout this period. At d 70, eight out of nine horses were ulcer free (EGUC grade 0). The findings suggest that FPT and FED can be used to heal and prevent gastric ulceration, and that FPT can be fed alongside a high grain diet to prevent recurrence of gastric ulcers.

scholarly journals Intensity of growth and development of rainbow trout using feeds Aller Aqua and Aquafeed Fischfutter

2017 ◽  
Vol 19 (79) ◽  
Author(s):  
J. I. Pivtorak ◽  
I. Y. Bobel
Keyword(s):  
Rainbow Trout ◽  
Oxygen Content ◽  
High Energy ◽  
Appropriate Technology ◽  
The Body ◽  
Energy Value ◽  
Feed Costs ◽  
German Producer ◽  
The Impact ◽  
Content Of Oxygen

Due to the rapid development of feed since the early 1990's, efficiency has increased dramatically. The effectiveness is achieved by increasing energy levels, reducing the level of carbohydrates and balancing various nutrients that meet the needs of fish. Improvement of efficiency should be taken into account when determining the amount of ration feeding. The economic efficiency of growing fish depends largely on proper feeding. The feed should be dosed depending on its formulation and size, the physiological state of the fish, the temperature of water and the content of oxygen in it. Salmon fish are demanding oxygen treatment. The content of oxygen in water should be at least 7 mg/l. At a lower oxygen level, the growth of fish is suppressed, and the effectiveness of food is reduced. The optimum temperature of water for growing salmon fish is 14–18 °С. Excessive feeding leads to unproductive feed costs and water pollution, insufficient  feeding leads to incomplete realization of potential opportunities for the rate of growth of fish. The quantity of the daily ration is established taking into account the temperature of water and the mass of fish. Depending on their state, activity and conditions of maintenance, it can fluctuate within ± 20% of the norm. In addition, high fertility densities, unsanitary conditions, illness, low water exchange rates, low oxygen content in water affect the efficiency of feeding in trout farms. Due to the fact that the cost of forage for trout is up to 60% of all costs for its cultivation, the problem of it rational use and saving is at the forefront. When feeding trout it is necessary to take into account that the size of granules for young fish in the length of 4–20 cm should be from 2.2 to 2.6% of the body length (according to Smith), which corresponds to the size of the mouth and the distance between the gill stamens in rainbow trout. Fish is best fed often in small portions. The smaller the fish, the more often feeding. Going on a feed of another size or type should be gradually over 3–5 days. If necessary, it is necessary to use special therapeutic granulated food or a mixture of therapeutic ingredients to add to the wet granules. It is necessary to create optimal conditions for growing and to carry out constant monitoring of water temperature and its fluctuations, oxygen content in water, pH, atmospheric pressure, etc. It is necessary to follow the rules of storage of forages, taking into account that the quality of feed after being stored for more than 3 months is deteriorating. This happens. It may be caused by poor water quality or disease. In order for the fish to get used to a particular feeding regime, it is recommended to do feed it at the same time. Today, the diversity of feeds allows you to get a better feed rate, fast growth and a minimal impact on the environment under different conditions, since the need of  fish in nutrients is fully covered by feeds (energy, protein, minerals and vitamins). The use of Aller Aqua feed guarantees receiving of a strong, healthy fish, thus providing good economic performance to farms. The basis of the research is the analysis of the nutritional value of the feeds of the company Aquafeed Fishsfutter of the German producer and Aller Aqua of the Danish company in the production conditions on the farm of the Western Fish Company PP of Peremyshlyany district, Lviv region. Also we should study fodder, their composition and carry out an objective assessment. It is known that fodder of foreign producers are characterized by higher energy value due to increased fat content, which is achieved by application of the appropriate technology and equipment for vacuum desiccation. For example, Aller Aqua's salmon-based compound feed for protein levels 40–46% contains 15 to 32% lipids and 23–24 MJ/kg of gross energy. Due to the high energy value, these feeds allow to provide the growth of fish at low feed costs. The aim of the work was to analyze the impact of different producers of feed fodder for commodity groups of trout on their growth and the development and receipt of quality commodity products in short terms.

Clinical management of gastroduodenitis and equine gastric ulcer syndrome grade IV of unknown origin in an Arabian mare

2019 ◽  
Vol 88 (6) ◽  
pp. 327-334
Author(s):  
S. Alonso-Sousa ◽  
M. De Rijck ◽  
M. Lores ◽  
J. Brunsting
Keyword(s):  
Gastric Ulcer ◽  
Small Intestine ◽  
Case Report ◽  
Clinical Management ◽  
Unknown Origin ◽  
Gastric Ulceration ◽  
Gastric Ulcers ◽  
Gastroscopic Examination ◽  
First Case ◽  
Severe Degree

A two-year-old Arabian filly was referred with symptons of colic. Clinical examination revealed signs associated with endotoxemia. Ultrasonographic examination of the abdomen demonstrated severe distention of the stomach and distended loops of small intestine with reduced motility. With nasogastric intubation, eight liters of hemorrhagic reflux were retrieved. Gastroscopic examination showed a severe degree of gastric ulceration scored as equine gastric ulcer syndrome (EGUS) grade IV. Based on these findings, EGUS and gastroduodenitis (GD) were diagnosed. Initially, the horse was treated using parenteral pantoprazole, which was supplemented by adding enteral ranitidine and sucralfate when the horse ceased refluxing. The horse was discharged eleven days after presentation with a 75%-healing of the gastric ulcers. A control gastroscopic examination was performed thirty days after discharge showing a 90%-healing (EGUS Grade I). To the authors’ knowledge, this is the first case report in which pantoprazole in combination with ranitidine and sucralfate has been used to treat a severe degree of gastric ulceration.

Protective Role of Casuarinin from Melaleuca leucadendra against Ethanol-Induced Gastric Ulcer in Rats

Planta Medica ◽  
2019 ◽  
Vol 86 (01) ◽  
pp. 32-44 ◽  
Author(s):  
Eman Al-Sayed ◽  
Haidy E. Michel ◽  
Mohamed Abdelrazik Khattab ◽  
Mohamed El-Shazly ◽  
Abdel Nasser Singab
Keyword(s):  
Gastric Ulcer ◽  
Health Problem ◽  
Treatment Options ◽  
Protective Role ◽  
Current Treatment ◽  
Gastric Ulcers ◽  
Major Health Problem ◽  
Histamine H2 Receptor ◽  
Ulcer Group ◽  
Melaleuca Leucadendra

AbstractGastric ulcer is a major health problem. Current treatment options of gastric ulcer, including antagonists of histamine H2 receptor and inhibitors of the proton pump, do not cure gastric ulcers, but only provide temporary relief of symptoms and can be associated with severe side effects. The lack of effective and safe medications for this global health problem urges for the discovery of novel classes of compounds with potent activity and an acceptable safety profile. Ethanol-induced ulceration in rats was used to evaluate the gastroprotective activity of casuarinin, an ellagitannin isolated from Melaleuca leucadendra. Casuarinin (25, 50, and 100 mg/kg) reduced the ulcer area by 45, 78, and 99%, respectively, compared with the ulcer group. Casuarinin (100 mg/kg) increased mucin content by 1.8-fold and reduced acidity by 42%. At the same dose, it also increased the levels of reduced glutathione by 194%, catalase by 586%, and prostaglandin E2 to its normal level. In contrast, it attenuated the ethanol-increased levels of malondialdehyde by 56%, TNF-α by 58%, and caspase-3 by 87%. Histological findings demonstrated that casuarinin exhibited a protective effect against tissue alterations in response to the ethanol-induced ulcer. Casuarinin suppressed the immunoexpression of nuclear factor-kappa B, cyclooxygenase-2, and inducible nitric oxide synthase to their normal values. It also induced the expression of heat shock protein-70, reaching up to 4.9-fold in comparison with the ulcer group. The potent gastroprotective effect of casuarinin was thus attributed to its anti-inflammatory, antioxidant, and antiapoptotic effects. Our results suggest the potential application of casuarinin as an antiulcer agent from natural sources.

scholarly journals Gastric Ulceration, Appetite and Feeding Practices in Standardbred Racehorses in the Czech Republic

2008 ◽  
Vol 77 (4) ◽  
pp. 603-607 ◽  
Author(s):  
B. Bezděková ◽  
P. Jahn ◽  
M. Vyskočil
Keyword(s):  
Gastric Ulcer ◽  
Czech Republic ◽  
Feeding Practices ◽  
Gastric Ulceration ◽  
Gastric Ulcers ◽  
Feeding Frequency ◽  
The Czech Republic ◽  
Poor Appetite ◽  
Feeding Management ◽  
Standardbred Racehorses

The objective of our study was to determine the prevalence of poor appetite and its correlation with the prevalence of gastric ulceration, and to evaluate relation between feeding management (feeding frequency and feeding regularity) and gastric ulceration in a group of 54 Standardbred racehorses in training. Prevalence of gastric ulceration in the group of horses with poor general appetite was 94.8%. Prevalence of gastric ulceration in the group of horses with good general appetite was 48.6%. Significant association between poor general appetite and squamous gastric ulcer presence was observed (p < 0.001). Gastric ulceration was found in 75.0% of horses fed twice daily and in 57.9% horses fed three times a day. Fifty seven point nine per cent of regularly fed horses had gastric ulcers. Irregularly fed horses were ulcer-positive in 75.0%. Thus no significant association between feeding frequency or regularity and the occurrence of gastric ulcers was found.

scholarly journals Equine gastric ulcer syndrome (EGUS). Prevalence, etiology, diagnostic

2018 ◽  
Vol 20 (83) ◽  
pp. 156-161
Author(s):  
O. Stefanyk ◽  
L. Slivinska
Keyword(s):  
Gastric Ulcer ◽  
Clinical Signs ◽  
Poor Performance ◽  
Gastric Ulceration ◽  
Gastric Ulcers ◽  
Common Disease ◽  
Protective Mechanisms ◽  
Anatomy And Physiology ◽  
Loss Of Appetite ◽  
Specific Species

The analysis of scientific literature and different studies of recent years concerning diseases of the stomach in horses has been conducted in the article. The analysis of literature data indicates that the Equine gastric ulcer syndrome is a common disease especially among racehorses. This term is a condition in horses, characterized by ulcers in the terminal esophagus; proximal (squamous) stomach; distal (glandular) stomach; and proximal duodenum. The anatomy and physiology of the stomach, with particular reference to secretion of acid and mucosal protective mechanisms, are reviewed as well as the differing theories relating to the aetiopathogenesis of gastric ulceration. The prevalence of the disease in racehorses has been reported from 60 to 90%. In general, horses that are in active training for racing tend to have a prevalence of around 90%, whereas horses for pleasure in full work have a reported prevalence of approximately 60%. The recent years data indicate the influence of microorganism Helicobacter genus on ulceration in equine stomach, a new specific species of H. Equorum was identified by the PCR assay in horse faeces, but the relationship between different species of Helicobacter and stomach ulcers remains controversial. Recently, nutritional and dietary management factors, the features of the anatomical structure of the stomach, dental problems, nonsteroidal anti-inflammatory drugs etc. have been identified to play an important role in gastric ulceration in horses. Clinical signs of EGUS are not always noticeable. Depending on the degree of damage, сlinical signs in horses with EGUS include: acute and recurrent colic, poor body condition, partial anorexia, poor appetite, poor performance and attitude changes, diarrhea,, the disease is accompanied by weight loss, loss of appetite and decreased ability to work. This disease affects the physical condition of horses, slows the growth and development of foals. The introduction of new diagnostic tests and methods in veterinary practice, including gastroscopy, allows to diagnose ulcers on early stages, investigate and explore the causes of EGUS. The diagnosis requires a thorough treatment history, physical examination, and a minimum database. Identifying risk factors and clinical signs are also helpful in making a diagnosis. However, gastroscopy is the only definitive diagnosis for gastric ulcers currently available. in more detail. The article presents a 0‒5 gastric ulcer scoring system to determine a lesion prevelence.

Melatonin promotes gastric healing by modulating the components of matrix metalloproteinase signaling pathway: a novel scenario for gastric ulcer management

2021 ◽  
Vol 4 (2) ◽  
pp. 213-231
Author(s):  
Romit Majumder ◽  
Madhuri Datta ◽  
Aindrila Chattopadhyay ◽  
Debasish Bandyopadhyay
Keyword(s):  
Gastric Ulcer ◽  
Gastric Ulceration ◽  
Gastric Ulcers ◽  
Protective Effects ◽  
Therapeutic Tool ◽  
The Past ◽  
The Matrix ◽  
Endogenous Antioxidant ◽  
Substantial Decline

Over the past few decades, since the induction of antibiotics and proton pump inhibitors (PPI) as a therapeutic tool in controlling gastropathy, a substantial decline in the incidence of gastric ulcer and its related manifestations has been achieved globally. However, there are a lot of skeptics on the steady rise in the list of complications following long-term use of these drugs, especially in chronic and elderly patients. Hence, the search for a sustainable cure for these gastropathies has never actually ended; this let us consider that melatonin, an endogenous antioxidant, might have a utility in this respect. Although researchers have linked melatonin with accelerated post ulcerative wound healing, many of these studies have failed to identify the confounding factors and plausible healing mechanisms. In this review, we attempt to identify the underline mechanisms as to the protective effects of melatonin on a variety of gastropathies.  Based on the evidence, we select the matrix metalloproteinases (MMPs) to be the main targets of melatonin. MMPs play a key role in maintaining the balance between extracellular matrix degradation and tissue remodeling, therefore, they act as the integral connection between the ulcer manifestation and healing. Thus, gastric ulceration occurs where this balance is disrupted. Melatonin can preserve this balance during the onset of gastric ulcers. In this review, we have also discussed the effects of melatonin on the different isoforms of MMPs and their roles in gastric ulceration, respectively. We hope that this will bestow us with a better understanding of the development of the gastric ulcer, as well as its cure.

scholarly journals The Meniscus in Normal and Osteoarthritic Tissues: Facing the Structure Property Challenges and Current Treatment Trends

2019 ◽  
Vol 21 (1) ◽  
pp. 495-521 ◽  
Author(s):  
Caroline A. Murphy ◽  
Atul K. Garg ◽  
Joana Silva-Correia ◽  
Rui L. Reis ◽  
Joaquim M. Oliveira ◽  
...  
Keyword(s):  
Paradigm Shift ◽  
Biological Function ◽  
Treatment Strategies ◽  
Meniscal Repair ◽  
Current Treatment ◽  
Structure Property ◽  
Biological Structure ◽  
Treatment Techniques ◽  
Treatment Trends ◽  
Meniscus Injuries

The treatment of meniscus injuries has recently been facing a paradigm shift toward the field of tissue engineering, with the aim of regenerating damaged and diseased menisci as opposed to current treatment techniques. This review focuses on the structure and mechanics associated with the meniscus. The meniscus is defined in terms of its biological structure and composition. Biomechanics of the meniscus are discussed in detail, as an understanding of the mechanics is fundamental for the development of new meniscal treatment strategies. Key meniscal characteristics such as biological function, damage (tears), and disease are critically analyzed. The latest technologies behind meniscal repair and regeneration are assessed.

scholarly journals Shock interactions in inviscid air and $$\hbox {CO}_2$$–$$\hbox {N}_2$$ flows in thermochemical non-equilibrium

Shock Waves ◽  
2021 ◽  
Author(s):  
C. Garbacz ◽  
W. T. Maier ◽  
J. B. Scoggins ◽  
T. D. Economon ◽  
T. Magin ◽  
...  
Keyword(s):  
Chemical Species ◽  
High Energy ◽  
Ideal Gas ◽  
Shock Interaction ◽  
Interaction Patterns ◽  
Shock Interactions ◽  
Wave Interference ◽  
Type V ◽  
The Impact ◽  
Non Equilibrium

AbstractThe present study aims at providing insights into shock wave interference patterns in gas flows when a mixture different than air is considered. High-energy non-equilibrium flows of air and $$\hbox {CO}_2$$ CO 2 –$$\hbox {N}_2$$ N 2 over a double-wedge geometry are studied numerically. The impact of freestream temperature on the non-equilibrium shock interaction patterns is investigated by simulating two different sets of freestream conditions. To this purpose, the SU2 solver has been extended to account for the conservation of chemical species as well as multiple energies and coupled to the Mutation++ library (Multicomponent Thermodynamic And Transport properties for IONized gases in C++) that provides all the necessary thermochemical properties of the mixture and chemical species. An analysis of the shock interference patterns is presented with respect to the existing taxonomy of interactions. A comparison between calorically perfect ideal gas and non-equilibrium simulations confirms that non-equilibrium effects greatly influence the shock interaction patterns. When thermochemical relaxation is considered, a type VI interaction is obtained for the $$\hbox {CO}_2$$ CO 2 -dominated flow, for both freestream temperatures of 300 K and 1000 K; for air, a type V six-shock interaction and a type VI interaction are obtained, respectively. We conclude that the increase in freestream temperature has a large impact on the shock interaction pattern of the air flow, whereas for the $$\hbox {CO}_2$$ CO 2 –$$\hbox {N}_2$$ N 2 flow the pattern does not change.

scholarly journals Cost-effectiveness of new MDR-TB regimens: study protocol for the TB-PRACTECAL economic evaluation substudy

BMJ Open ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. e036599
Author(s):  
Sedona Sweeney ◽  
Gabriela Gomez ◽  
Nichola Kitson ◽  
Animesh Sinha ◽  
Natalia Yatskevich ◽  
...  
Keyword(s):  
Economic Evaluation ◽  
Cost Effectiveness ◽  
Best Practice ◽  
Current Treatment ◽  
Outcome Data ◽  
London School ◽  
Main Trial ◽  
Ethical Approval ◽  
Mdr Tb ◽  
The Impact

IntroductionCurrent treatment regimens for multidrug-resistant tuberculosis (MDR-TB) are long, poorly tolerated and have poor outcomes. Furthermore, the costs of treating MDR-TB are much greater than those for treating drug-susceptible TB, both for health service and patient-incurred costs. Urgent action is needed to identify short, effective, tolerable and cheaper treatments for people with both quinolone-susceptible and quinolone-resistant MDR-TB. We present the protocol for an economic evaluation (PRACTECAL-EE substudy) alongside an ongoing clinical trial (TB-PRACTECAL) aiming to assess the costs to patients and providers of new regimens, as well as their cost-effectiveness and impact on participant poverty levels. This substudy is based on data from the three countries participating in the main trial.Methods and analysisPrimary cost data will be collected from the provider and patient perspectives, following economic best practice. We will estimate the probability that new MDR-TB regimens containing bedaquiline, pretomanid and linezolid are cost-effective from a societal perspective as compared with the standard of care for MDR-TB patients in Uzbekistan, South Africa and Belarus. Analysis uses a Markov model populated with primary cost and outcome data collected at each study site. We will also estimate the impact of new regimens on prevalence of catastrophic patient costs due to TB.Ethics and disseminationEthical approval has been obtained from the London School of Hygiene & Tropical Medicine and Médecins Sans Frontières. Local ethical approval will be sought in each study site. The results of the economic evaluation will be shared with the country health authorities and published in a peer-reviewed journal.Trial registration numberClinicalTrials.gov Registry (NCT04207112); Pre-results.

scholarly journals Coir Fibers Treated with Henna as a Potential Reinforcing Filler in the Synthesis of Polyurethane Composites

Materials ◽  
2021 ◽  
Vol 14 (5) ◽  
pp. 1128
Author(s):  
Sylwia Członka ◽  
Anna Strąkowska ◽  
Agnė Kairytė
Keyword(s):  
Mechanical Properties ◽  
High Energy ◽  
Dynamic Mechanical Properties ◽  
Milling Process ◽  
Coir Fiber ◽  
Lawsonia Inermis ◽  
Coir Fibers ◽  
Mechanical Performances ◽  
The Impact ◽  
Reinforcing Filler

In this study, coir fibers were successfully modified with henna (derived from the Lawsonia inermis plant) using a high-energy ball-milling process. In the next step, such developed filler was used as a reinforcing filler in the production of rigid polyurethane (PUR) foams. The impact of 1, 2, and 5 wt % of coir-fiber filler on structural and physico-mechanical properties was evaluated. Among all modified series of PUR composites, the greatest improvement in physico-mechanical performances was observed for PUR composites reinforced with 1 wt % of the coir-fiber filler. For example, on the addition of 1 wt % of coir-fiber filler, the compression strength was improved by 23%, while the flexural strength increased by 9%. Similar dependence was observed in the case of dynamic-mechanical properties—on the addition of 1 wt % of the filler, the value of glass transition temperature increased from 149 °C to 178 °C, while the value of storage modulus increased by ~80%. It was found that PUR composites reinforced with coir-fiber filler were characterized by better mechanical performances after the UV-aging.

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