scholarly journals Born this way? A review of neurobiological and environmental evidence for the etiology of psychopathy

2019 ◽  
Vol 2 ◽  
Author(s):  
Annabelle Frazier ◽  
Patricia A. Ferreira ◽  
Joseph E. Gonzales
Keyword(s):  
Traumatic Stress ◽  
Brain Function ◽  
Life Experiences ◽  
Future Research ◽  
Future Directions ◽  
Relevant Evidence ◽  
Current Review ◽  
Multidimensional Trajectories ◽  
Biological Etiology ◽  
Epigenetic Research

Abstract Across a significant body of research, psychopathy has often been conceptualized as a biologically based malady. In this research, genetic and neurobiological differences have been conceptualized to underlie psychopathy, while affected individuals’ life experiences only influence expressed psychopathic features and their severity. Psychopathy research has largely ignored developmental evidence demonstrating significant influences of environment on both biological and behavioral processes, resulting in several prominent criticisms (Edens & Vincent, 2008; Loeber, Byrd, & Farrington, 2015). The current review was conducted with two main aims: (a) to collect and consider etiological evidence from the extant body of research on genetic and neurobiological factors in psychopathy; and (b) to evaluate findings from genetic, neurotransmitter, brain structure, and brain function studies in the context of relevant evidence from developmental research. Examples from research on adversity and traumatic stress, a common correlate of psychopathy, were used to highlight current research gaps and future directions to aid in the integration of developmental and neurobiological research agendas. While some promising evidence exists regarding possible underlying neurobiological processes of psychopathic traits, this evidence is insufficient to suggest a largely biological etiology for the disorder. Further, information from developmental and epigenetic research may suggest complex, multidimensional trajectories for individuals experiencing psychopathy. Based on these observations, the authors make several recommendations for future research, as well as for current clinical application and practice.

Brain Function in Pediatric PTSD

2017 ◽  
Author(s):  
Victor G. Carrión ◽  
John A. Turner ◽  
Carl F. Weems
Keyword(s):  
Brain Development ◽  
Children And Adolescents ◽  
Traumatic Stress ◽  
Brain Function ◽  
Treatment Strategies ◽  
Development Research ◽  
Critical Periods ◽  
Theoretical Frameworks ◽  
Future Directions ◽  
Neuroscience Research

Previous chapters established that many of the symptoms of PTSD in children and adolescents are associated with structural and functional abnormalities of fronto-limbic pathways. The current chapter reviews the scope of the book and discusses general implications that result from these findings, suggests other areas of investigation, and discusses applicability of this neuroscience research to treatment and policy. This includes a survey of current research into critical periods of brain development that may affect the trajectory of PTSD’s development, research into whole-brain networks exhibiting vulnerability to traumatic stress, and innovative treatment strategies based on these emerging theoretical frameworks. Future directions for the ever-growing field of traumatic stress science, as well as miscellaneous findings not otherwise included within this book’s framework, are discussed.

Inagaki (in press). Neural mechanisms of the link between giving social support and health. Ann NY Acad Sci

2018 ◽  
Author(s):  
Tristen Inagaki
Keyword(s):  
Social Support ◽  
Social Relationships ◽  
Neural Mechanisms ◽  
Future Research ◽  
Future Directions ◽  
Current Review ◽  
Current Perspective ◽  
Health Promoting ◽  
The Individual ◽  
Individual Giving

Giving social support to others has emerged as an additional route by which social ties influence health. Thus, giving support to others not only influences the health of the individual receiving support, but also the health of the individual giving the support. However, the neural mechanisms by which giving support leads to health are only beginning to be explored. In hopes of consolidating and guiding future research on giving support and health, the current review considers why, how, and when giving support is health-promoting. Special emphasis is placed on neural regions known to contribute to parental care in animals that both reinforce giving support behavior (ventral striatum (VS) and septal area (SA)) and reduce stress-related responding (e.g., amygdala) to facilitate care. Hypothesized links between neural regions involved in giving support and peripheral physiology (sympathetic nervous system (SNS), hypothalamic-pituitary-adrenal (HPA) axis, and related inflammatory responding) are considered as well as the conditions under which giving support should be most beneficial for health. Finally, the implications of the current perspective for understanding how social relationships, more broadly, contribute to health and suggestions for future directions are offered.

Mix Networks: Existing Scenarios and Future Directions on Security and Privacy

2019 ◽  
Vol 14 ◽  
Author(s):  
Khaleel Ahmad ◽  
Afsar Kamal
Keyword(s):  
Security And Privacy ◽  
Research Progress ◽  
Future Research ◽  
Future Directions ◽  
Practical Solution ◽  
Research Gap ◽  
The Web ◽  
Privacy Enhancing Techniques

Background: Privacy enhancing techniques are developed in order to provide strong protection to cyberspace. These techniques aim to allow users to keep their identities hidden during the communication when they are sending email, making payments online, browsing the Web or posting to newsgroups. MixNet is the most practical solution for concealing identities of message and sender’s identities. Objective: It provides sender and receiver anonymity as well as message security. The main goal of MixNet is to overcome vulnerability and enhance the performance of communication. It can efficiently handle the messages of various length and produce desirable results with privacy. The main objective of this paper is to acquire information and concepts regarding MixNet. We also provide guidelines for future research and references. Methods : The designing of MixNet depends on what cryptosystem method is used. Symmetric and Asymmetric both are used. Other methods could be also used such as PIR, CSP and FDR model, RPC, Token-based approach or others. Result: In this paper we provide an overview of MixNet approaches and presented a survey on MixNet based techniques and different models. We also constructed the comparison tables as per our requirements for better understanding. For this purpose, we found a total of 120 articles related to the MixNet published between 1990 and 2018 from the most relevant scientific resources. However, only 86 papers were analyzed due to comprehensiveness and relevancy to this article. Conclusion: Focused on the security and privacy of communication and how it can be achieved. This survey also reveals research progress and research gap on MixNet.

Alcohol Use Disorder

2018 ◽  
Author(s):  
Igor Ponomarev
Keyword(s):  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Critical Discussion ◽  
Epigenetic Mechanisms ◽  
Future Directions ◽  
Clinically Significant ◽  
Early Life Exposures ◽  
The Brain ◽  
Epigenetic Research

Alcohol use disorder (AUD) is characterized by clinically significant impairments in health and social function. Epigenetic mechanisms of gene regulation may provide an attractive explanation for how early life exposures to alcohol contribute to the development of AUD and exert lifelong effects on the brain. This chapter provides a critical discussion of the role of epigenetic mechanisms in AUD etiology and the potential of epigenetic research to improve diagnosis, evaluate risks for alcohol-induced pathologies, and promote development of novel therapies for the prevention and treatment of AUD. Challenges of the current epigenetic approaches and future directions are also discussed.

Conclusions and Future Directions for the Study of Accurate Personality Judgment

2020 ◽  
Author(s):  
Tera D. Letzring
Keyword(s):  
Standardized Tests ◽  
Personality Trait ◽  
Training Programs ◽  
Future Research ◽  
Research Topics ◽  
Theoretical Frameworks ◽  
Future Directions ◽  
Personality Judgment ◽  
Exciting Time ◽  
And Training

This chapter identifies several well-established findings and overarching themes within personality trait accuracy research, and highlights especially promising directions for future research. Topics include (1) theoretical frameworks for accuracy, (2) moderators of accuracy and the context or situation in which judgments are made, (3) the important consequences of accuracy, (4) interventions and training programs to increase judgmental ability and judgability, (5) the generalizability of previous findings, and (6) standardized tests of the accuracy of judging personality traits. The chapter ends by stating that it is an exciting time to be a researcher studying the accuracy of personality trait judgments.

scholarly journals Efficacy of Phytocannabinoids in Epilepsy Treatment: Novel Approaches and Recent Advances

2021 ◽  
Vol 18 (8) ◽  
pp. 3993
Author(s):  
Aaron M. Farrelly ◽  
Styliani Vlachou ◽  
Konstantinos Grintzalis
Keyword(s):  
Therapeutic Potential ◽  
Significant Proportion ◽  
Future Research ◽  
Specific Reference ◽  
Undesirable Side Effect ◽  
Treatment Resistant ◽  
Current Review ◽  
Epilepsy Treatment ◽  
Clinical Environments

Epilepsy is a neurological disorder mainly characterised by recurrent seizures that affect the entire population diagnosed with the condition. Currently, there is no cure for the disease and a significant proportion of patients have been deemed to have treatment-resistant epilepsy (TRE). A patient is deemed to have TRE if two or more antiepileptic drugs (AEDs) fail to bring about seizure remission. This inefficacy of traditional AEDs, coupled with their undesirable side effect profile, has led to researchers considering alternative forms of treatment. Phytocannabinoids have long served as therapeutics with delta-9-THC (Δ9-THC) receiving extensive focus to determine its therapeutic potential. This focus on Δ9-THC has been to the detriment of analysing the plethora of other phytocannabinoids found in the cannabis plant. The overall aim of this review is to explore other novel phytocannabinoids and their place in epilepsy treatment. The current review intends to achieve this aim via an exploration of the molecular targets underlying the anticonvulsant capabilities of cannabidiol (CBD), cannabidavarin (CBDV), delta-9-tetrahydrocannabivarin (Δ9-THCV) and cannabigerol (CBG). Further, this review will provide an exploration of current pre-clinical and clinical data as it relates to the aforementioned phytocannabinoids and the treatment of epilepsy symptoms. With specific reference to epilepsy in young adult and adolescent populations, the exploration of CBD, CBDV, Δ9-THCV and CBG in both preclinical and clinical environments can guide future research and aid in the further understanding of the role of phytocannabinoids in epilepsy treatment. Currently, much more research is warranted in this area to be conclusive.

scholarly journals Selective Harvesting Robotics: Current Research, Trends, and Future Directions

2021 ◽  
Author(s):  
Gert Kootstra ◽  
Xin Wang ◽  
Pieter M. Blok ◽  
Jochen Hemming ◽  
Eldert van Henten
Keyword(s):  
Review Paper ◽  
Production Systems ◽  
Future Research ◽  
Limiting Factor ◽  
Future Directions ◽  
Research Directions ◽  
Selective Harvesting ◽  
Important Solution ◽  
Future Research Directions ◽  
Current Systems

Abstract Purpose of Review The world-wide demand for agricultural products is rapidly growing. However, despite the growing population, labor shortage becomes a limiting factor for agricultural production. Further automation of agriculture is an important solution to tackle these challenges. Recent Findings Selective harvesting of high-value crops, such as apples, tomatoes, and broccoli, is currently mainly performed by humans, rendering it one of the most labor-intensive and expensive agricultural tasks. This explains the large interest in the development of selective harvesting robots. Selective harvesting, however, is a challenging task for a robot, due to the high levels of variation and incomplete information, as well as safety. Summary This review paper provides an overview of the state of the art in selective harvesting robotics in three different production systems; greenhouse, orchard, and open field. The limitations of current systems are discussed, and future research directions are proposed.

scholarly journals Artificial imine reductases: developments and future directions

2020 ◽  
Vol 1 (5) ◽  
pp. 369-378
Author(s):  
Rosalind L. Booth ◽  
Gideon Grogan ◽  
Keith S. Wilson ◽  
Anne-Kathrin Duhme-Klair
Keyword(s):  
Future Research ◽  
Future Directions ◽  
Artificial Metalloenzymes

This review surveys the development of this class of artificial metalloenzymes and provides a perspective on existing and future research in the area.

scholarly journals Recent Advances in Nanotechnology with Nano-Phytochemicals: Molecular Mechanisms and Clinical Implications in Cancer Progression

2021 ◽  
Vol 22 (7) ◽  
pp. 3571
Author(s):  
Bonglee Kim ◽  
Ji-Eon Park ◽  
Eunji Im ◽  
Yongmin Cho ◽  
Jinjoo Lee ◽  
...  
Keyword(s):  
Cancer Progression ◽  
Animal Studies ◽  
Molecular Mechanisms ◽  
Future Research ◽  
Clinical Implications ◽  
Research Perspectives ◽  
Current Review ◽  
Gold Silver ◽  
Significant Efficacy ◽  
Rapid Clearance

Biocompatible nanoparticles (NPs) containing polymers, lipids (liposomes and micelles), dendrimers, ferritin, carbon nanotubes, quantum dots, ceramic, magnetic materials, and gold/silver have contributed to imaging diagnosis and targeted cancer therapy. However, only some NP drugs, including Doxil® (liposome-encapsulated doxorubicin), Abraxane® (albumin-bound paclitaxel), and Oncaspar® (PEG-Asparaginase), have emerged on the pharmaceutical market to date. By contrast, several phytochemicals that were found to be effective in cultured cancer cells and animal studies have not shown significant efficacy in humans due to poor bioavailability and absorption, rapid clearance, resistance, and toxicity. Research to overcome these drawbacks by using phytochemical NPs remains in the early stages of clinical translation. Thus, in the current review, we discuss the progress in nanotechnology, research milestones, the molecular mechanisms of phytochemicals encapsulated in NPs, and clinical implications. Several challenges that must be overcome and future research perspectives are also described.

scholarly journals Creatine Supplementation and Brain Health

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 586 ◽  
Author(s):  
Hamilton Roschel ◽  
Bruno Gualano ◽  
Sergej M. Ostojic ◽  
Eric S. Rawson
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Cognitive Function ◽  
Cognitive Processing ◽  
Brain Function ◽  
Creatine Supplementation ◽  
Short Review ◽  
Future Research ◽  
Brain Health

There is a robust and compelling body of evidence supporting the ergogenic and therapeutic role of creatine supplementation in muscle. Beyond these well-described effects and mechanisms, there is literature to suggest that creatine may also be beneficial to brain health (e.g., cognitive processing, brain function, and recovery from trauma). This is a growing field of research, and the purpose of this short review is to provide an update on the effects of creatine supplementation on brain health in humans. There is a potential for creatine supplementation to improve cognitive processing, especially in conditions characterized by brain creatine deficits, which could be induced by acute stressors (e.g., exercise, sleep deprivation) or chronic, pathologic conditions (e.g., creatine synthesis enzyme deficiencies, mild traumatic brain injury, aging, Alzheimer’s disease, depression). Despite this, the optimal creatine protocol able to increase brain creatine levels is still to be determined. Similarly, supplementation studies concomitantly assessing brain creatine and cognitive function are needed. Collectively, data available are promising and future research in the area is warranted.

Sign in / Sign up

Export Citation Format

Share Document