scholarly journals Dietary composition is associated with one-carbon metabolites and B-vitamin status in patients with stable angina – a cross-sectional study

2020 ◽  
Vol 79 (OCE2) ◽  
Author(s):  
Vegard Lysne ◽  
Anthea van Parys ◽  
Thomas Olsen ◽  
Ingvild Marienborg ◽  
Johnny Laupsa-Borge ◽  
...  
Keyword(s):  
Plasma Concentration ◽  
Energy Intake ◽  
Carbon Metabolism ◽  
Stable Angina ◽  
Protein Intake ◽  
Dietary Composition ◽  
Cross Sectional ◽  
Vitamin Status ◽  
One Carbon Metabolism ◽  
B Vitamin

AbstractIntroduction:Peroxisome Proliferator-Activated Receptor α (PPARα) is a known regulator of lipid and energy metabolism. In animal experiments of PPARα activation, we have reported on altered plasma concentration of metabolites related to one-carbon metabolism and B-vitamin status. Several of these metabolites, e.g. homocysteine and dimethylglycine, have been associated with increased cardiovascular disease risk. Diet can influence one-carbon metabolism, and this may partly be mediated through altered PPARα activity as dietary fatty acids can activate PPARα. As diet is a modifiable life style factor, the aim of this investigation is to explore potential associations between dietary composition and plasma concentration of one-carbon metabolites and markers of B-vitamin status.Materials and methods:The study population consisted of 1977 patients with stable angina (geometric mean age 61 years, 80% male) from the Western Norway B-vitamin Intervention Trial (WENBIT), who completed a self-administered food frequency questionnaire at baseline. Data on outcome variables were obtained from the baseline blood samples (35% fasting). Outcome variables of interest were metabolites related to one-carbon metabolism and B-vitamin status. Cross-sectional associations between protein, carbohydrate and fat intake with the outcome metabolites were analysed with linear regression, adjusted for age, sex, fasting status, BMI and reported energy intake. Estimates are given as % change in the outcome variable per isoenergetic increment of 1 energy % (E%) in the exposure nutrient.Results:The average distribution [95% prediction interval] of energy intake (E%) in the population was 48.5 (37.1, 63.4) from carbohydrate, 31.4 (21.9, 44.9) from fat and 16.5 (12.2, 22.3) from protein.The strongest associations were seen for increasing protein intake, while the associations with fat and carbohydrate intake were weaker. The most pronounced associations (% change [95% confidence interval]) with increasing protein intake were higher cobalamin (2.9 [2.1, 3.7]), PLP (2.7 [1.7, 3.7]) and riboflavin (2.3 [1.0, 3.6]), and lower tHcy (-1.4 [-1.9, -0.9]) and MMA (-1.3 [-1.9, -0.7]).Discussion:The current observations indicate that dietary macronutrient composition may influence plasma concentration of one-carbon metabolites and markers of B-vitamin status. The strongest associations are observed with increasing protein intake, but elucidating the importance of the nutrient substituted remains. Whether the observed associations are due to macronutrients per se, or reflect differences in food choices/nutrient intakes, or effects on physiological factors, i.e. inflammation or PPARα activation, is not known.

scholarly journals Effect of a Tailored Dietary Intervention with High or Standard Protein Intake on B-Vitamin and One Carbon Metabolism Status in Healthy Older Males: A 10 Week Randomised Controlled Trial

Proceedings ◽  
2019 ◽  
Vol 8 (1) ◽  
pp. 19
Author(s):  
Nicola Gillies ◽  
Amber M. Milan ◽  
Pankaja Sharma ◽  
Brenan Durainayagam ◽  
Sarah M. Mitchell ◽  
...  
Keyword(s):  
Randomised Controlled Trial ◽  
Carbon Metabolism ◽  
Protein Intake ◽  
Dietary Intervention ◽  
Controlled Trial ◽  
One Carbon Metabolism ◽  
Randomised Controlled ◽  
B Vitamin ◽  
Standard Protein ◽  
Older Males

Background: Maintaining optimal status of folate and metabolically [...]

scholarly journals Effect of a Tailored Dietary Intervention with High or Standard Protein Intake on B-Vitamin and One Carbon Metabolism Status in Healthy Older Males: A 10 Week Randomised Controlled Trial

Proceedings ◽  
2019 ◽  
Vol 8 (1) ◽  
pp. 36
Author(s):  
Nicola Gillies ◽  
Amber M. Milan ◽  
Pankaja Sharma ◽  
Brenan Durainayagam ◽  
Sarah M. Mitchell ◽  
...  
Keyword(s):  
Older Adults ◽  
Carbon Metabolism ◽  
Protein Intake ◽  
Dietary Intervention ◽  
Controlled Trial ◽  
One Carbon Metabolism ◽  
Randomised Controlled ◽  
B Vitamin ◽  
Standard Protein ◽  
Older Males

Background: Maintaining optimal status of folate and metabolically related vitamins (riboflavinand vitamins B6 and B12) is increasingly important for older adults [...]

Early pregnancy B vitamin status, one carbon metabolism, pregnancy outcome and child development

Biochimie ◽  
2016 ◽  
Vol 126 ◽  
pp. 91-96 ◽  
Author(s):  
Pol Solé-Navais ◽  
Pere Cavallé-Busquets ◽  
Joan D. Fernandez-Ballart ◽  
Michelle M. Murphy
Keyword(s):  
Child Development ◽  
Pregnancy Outcome ◽  
Early Pregnancy ◽  
Carbon Metabolism ◽  
Vitamin Status ◽  
One Carbon Metabolism ◽  
B Vitamin

scholarly journals Education Level, Energy Intake and Protein With Nutritional Status Of Pregnant Women In Bungoro Health Center Work Area

2019 ◽  
Vol 25 (2) ◽  
pp. 38
Author(s):  
Khaeriya Megauleng ◽  
Mustamin Mustamin ◽  
Sunarto Sunarto
Keyword(s):  
Nutritional Status ◽  
Pregnant Women ◽  
Health Center ◽  
Energy Intake ◽  
Protein Intake ◽  
Education Level ◽  
Level Energy ◽  
Cross Sectional ◽  
Work Area ◽  
The Relationship

Education influences a changes in knowledge, attitudes, and lifestyle patterns in the selection of the type and amount of food consumed. The health of a pregnant women affects the fetus in her womb. Nutrient content consumed by the mother will be absorbed by the fetus which is important for the growth of the fetus itself. This study aims to determine the relationship of education level, energy intake and protein nutritional status of pregnant women in the Bungoro Health Center Work Area of Bungoro District, Pangkep Regency. This research is an analytical study with cross-sectional design. Samples were pregnant women, amount to 40 people. The level of education is obtained through a questionnaire. Energy and protein intake was obtained through 2x24 hours recall and then processed using menu A software. To find out the relationship between variables of education level, energy and protein intake with nutritional status, Chi-Square was tested using the SPSS program. Data is presented in the form of tables and narratives. The results showed that 77.5% of the sample education level was high. Sample energy intake was classified as less than 82.5% and 17.5% classified as good. Sample protein intake of 95% classified as poor and 5% classified as good. Nutritional status of pregnant women is 70% experiencing KEK and 30% normal. Statistical test results show that there is no relationship between education level, energy and protein intake and nutritional status of pregnant women in the Bungoro Health Center Work Area, Bungoro District, Pangkep Regency.

scholarly journals B-Vitamin Intake, One-Carbon Metabolism, and Survival in a Population-Based Study of Women with Breast Cancer

2008 ◽  
Vol 17 (8) ◽  
pp. 2109-2116 ◽  
Author(s):  
Xinran Xu ◽  
Marilie D. Gammon ◽  
James G. Wetmur ◽  
Patrick T. Bradshaw ◽  
Susan L. Teitelbaum ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Carbon Metabolism ◽  
Population Based ◽  
Population Based Study ◽  
Vitamin Intake ◽  
One Carbon Metabolism ◽  
B Vitamin

scholarly journals Nutritional intakes and associated factors among tuberculosis patients: a cross-sectional study in China

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Zhewen Ren ◽  
Fei Zhao ◽  
Hui Chen ◽  
Dongmei Hu ◽  
Wentao Yu ◽  
...  
Keyword(s):  
Energy Intake ◽  
Protein Intake ◽  
Associated Factors ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Daily Energy Intake ◽  
Cross Sectional ◽  
Female Patients ◽  
Daily Energy ◽  
Males And Females

Abstract Background The objectives of this study were to examine nutrient intakes of tuberculosis (TB) patients and to identify their associated factors. Methods In this cross-sectional study, 300 adult TB patients were surveyed in two impoverished counties in China. Nutrient intakes were evaluated through two consecutive 24-h dietary recalls and compared with the Chinese Dietary Reference Intakes (DRIs) 2013. The potential socio-demographic and behavioral factors were analyzed using multivariate logistic model to identify strong influential factors. Results We found that mean daily energy intake was 1655.0 kcal (SD: 619.3 kcal) and 1360.3 kcal (SD: 552.1 kcal) for male and female patients, respectively. The mean daily energy intake was significantly lower than that has been recommended by DRI (i.e., 2250 and 1800 kcal for males and females, respectively), with 87.4% of the male patients and 59.9% of female patients failed to consume adequate energy. The protein intakes were 44.6 g (SD: 18.2 g) and 35.9 g (SD: 12.3 g) for male and female patients, respectively, which were lower than the recommended values by DRI (i.e., 65 and 55 g for males and females, respectively). Most male (90.8%) and female (58.4%) TB patients had insufficient daily protein intake. Further analyses suggested that mean daily intakes of many micronutrients, were insufficient, while for most of patients, intakes of vitamin E and sodium were sufficient. We identified that unemployment was a risk factor for low energy intake (p < 0.05) and out-home-eating was a protective factor for low protein intake (p < 0.01). Conclusions In impoverished areas in China, intakes of macronutrients and most micronutrients in TB patients were inadequate compared with DRIs, especially for unemployed patients and patients eating at home. These findings suggested that public health actions are needed to promote education on TB patients about significance of nutritional support, and, further interventions in TB patients’ nutritional intakes are also required.

The role of one-carbon metabolism and homocysteine in Parkinson’s disease onset, pathology and mechanisms

2019 ◽  
Vol 32 (2) ◽  
pp. 218-230 ◽  
Author(s):  
Lauren K. Murray ◽  
Nafisa M. Jadavji
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Carbon Metabolism ◽  
Animal Studies ◽  
B Vitamins ◽  
Present Review ◽  
Increased Risk ◽  
One Carbon Metabolism ◽  
B Vitamin

AbstractParkinson’s disease (PD) is the second most common neurodegenerative disorder. It is characterised by the progressive degeneration of dopaminergic (DA) neurons. The cause of degeneration is not well understood; however, both genetics and environmental factors, such as nutrition, have been implicated in the disease process. Deficiencies in one-carbon metabolism in particular have been associated with increased risk for PD onset and progression, though the precise relationship is unclear. The aim of the present review is to determine the role of one-carbon metabolism and elevated levels of homocysteine in PD onset and pathology and to identify potential mechanisms involved. A search of PubMed, Google Scholar and Web of Science was undertaken to identify relevant human and animal studies. Case–control, prospective cohort studies, meta-analyses and non-randomised trials were included in the present review. The results from human studies indicate that polymorphisms in one-carbon metabolism may increase risk for PD development. There is an unclear role for dietary B-vitamin intake on PD onset and progression. However, dietary supplementation with B-vitamins may be beneficial for PD-affected individuals, particularly those on l-DOPA (levodopa or l-3,4-dihydroxyphenylalanine) treatment. Additionally, one-carbon metabolism generates methyl groups, and methylation capacity in PD-affected individuals is reduced. This reduced capacity has an impact on expression of disease-specific genes that may be involved in PD progression. During B-vitamin deficiency, animal studies report increased vulnerability of DA cells through increased oxidative stress and altered methylation. Nutrition, especially folates and related B-vitamins, may contribute to the onset and progression of PD by making the brain more vulnerable to damage; however, further investigation is required.

scholarly journals Kinetic Modeling of Storage Effects on Biomarkers Related to B Vitamin Status and One-Carbon Metabolism

2012 ◽  
Vol 58 (2) ◽  
pp. 402-410 ◽  
Author(s):  
Steinar Hustad ◽  
Simone Eussen ◽  
Øivind Midttun ◽  
Arve Ulvik ◽  
Puck M van de Kant ◽  
...  
Keyword(s):  
Amino Acids ◽  
Carbon Metabolism ◽  
Room Temperature ◽  
Nonlinear Models ◽  
Methionine Sulfoxide ◽  
Flavin Mononucleotide ◽  
Storage Effects ◽  
One Carbon Metabolism ◽  
Accumulation Kinetics ◽  
B Vitamin

Abstract BACKGROUND Biomarkers and metabolites related to B vitamin function and one-carbon metabolism have been studied as predictors of chronic diseases in studies based on samples stored in biobanks. For most biomarkers, stability data are lacking or fragmentary. METHODS Degradation and accumulation kinetics of 32 biomarkers were determined at 23 °C in serum and plasma (EDTA, heparin, and citrate) collected from 16 individuals and stored for up to 8 days. In frozen serum (−25 °C), stability was studied cross-sectionally in 650 archival samples stored for up to 29 years. Concentration vs time curves were fitted to monoexponential, biexponential, linear, and nonlinear models. RESULTS For many biomarkers, stability was highest in EDTA plasma. Storage effects were similar at room temperature and at −25 °C; notable exceptions were methionine, which could be recovered as methionine sulfoxide, and cystathionine, which decreased in frozen samples. Cobalamin, betaine, dimethylglycine, sarcosine, total homocysteine, total cysteine, tryptophan, asymetric and symmetric dimethyl argenine, creatinine, and methylmalonic acid were essentially stable under all conditions. Most B vitamins (folate and vitamins B2 and B6) were unstable; choline increased markedly, and some amino acids also increased, particularly in serum. The kynurenines showed variable stability. For many biomarkers, degradation (folate and flavin mononucleotide) or accumulation (pyridoxal, riboflavin, choline, amino acids) kinetics at room temperature were non–first order. CONCLUSIONS Data on stability and deterioration kinetics for individual biomarkers are required to optimize procedures for handling serum and plasma, and for addressing preanalytical bias in epidemiological and clinical studies.

scholarly journals B Vitamins and Cognitive Performance in Older Adults: Review

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
J. L. Reay ◽  
M. A. Smith ◽  
L. M. Riby
Keyword(s):  
Cognitive Function ◽  
Carbon Metabolism ◽  
Optimal Dose ◽  
Epidemiological Studies ◽  
B Vitamins ◽  
Therapeutic Window ◽  
Vitamin Therapy ◽  
One Carbon Metabolism ◽  
B Vitamin ◽  
The Impact

A copious amount of scientific scrutiny has been dedicated to documenting typical and atypical human ageing, with a substantial body of work focusing upon the impact of lifestyle choices. One such lifestyle choice is that of diet and, in particular, micronutrient ingestion. Epidemiological studies have reported positive associations between B vitamin status and cognitive function, including negative associations between biological markers (i.e., homocysteine) of dysregulated one-carbon metabolism and cognitive function. This has led to a surge of randomised control trials (RCTs) investigations into B vitamin therapy. However, results have continuingly failed to show beneficial behavioural effects. Despite this, results reliably show treatment-related increases in B vitamin level and decreases in homocysteine level—both of which have been identified as risk factors for atypical ageing. In this paper we argue that it would be premature to conclude that B vitamin therapy has no potential and that more research is needed to systematically investigate the optimal dose, the therapeutic “window,” and individual differences in therapy responders and nonresponders. We start with a brief look at one-carbon metabolism and then consider the evidence from epidemiological studies and RCTs in relation to three specific B vitamins: folic acid (B9), pyridoxine (B6), and cobamides (B12).

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