Can genetics deliver?

2004 ◽  
Vol 31 ◽  
pp. 39-48
Author(s):  
J Webb

For the past thirty years pig genetics has enjoyed a clear message from its end–users: reduce backfat and production costs. During that period, genetics, nutrition and health have together delivered improvements of some 60% in lean growth rate and feed efficiency. To compound the recent misfortunes of the UK industry, meat is now slipping further behind everything else on the supermarket shelf in quality, uniformity, and above all predictability. The notion of quality stretches far beyond the product into responsibility for animal welfare, human nutrition and food safety.The industry's present dilemma arises from five factors:1.uncertain market conditions with cyclical profitability2.poor communication of what constitutes good quality3.payment systems that no longer reflect what the market requires4.independent management of the different steps in the pork value chain5.possible effects of animal health on quality and uniformity.Meanwhile the understanding of gene function and the ability to detect potentially useful genetic variation is gathering momentum. This paper examines the role that genetics can play in adding value, reducing risk and differentiating the product, from the perspective of a large vertically coordinated pork producer.

1967 ◽  
Vol 71 (677) ◽  
pp. 344-348
Author(s):  
J. V. Connolly

During the past two years, there has been a sharp acceleration to the interest which industry has displayed in the subject of management education. This can be attributed to these factors: —(a) A more widespread realisation of the gap developing between the UK and a number of foreign economies, as manifested by diverging rates of the major economic indicators.(b) The attainment of top-management responsibilities by a younger generation of managers, many of whom had been given some earlier training and who were more conscious of its value than the incumbents of the job from earlier generations.(c) The publication of the Franks, Robbins and (in the aerospace industry) the Plowden reports.(d) The impact of the Industrial Training Boards making it manifest, in terms of serious levies, that training was an economic necessity and therefore must be investigated thoroughly.Notwithstanding the widespread awakening of interest, it is very belated and sets numerous problems. The problems are in two areas—scale and quality.


2017 ◽  
pp. 104-111
Author(s):  
Frederik Botha

In general, few productivity improvements in sugarcane have occurred during the past three decades. At the same time, production costs have increased and production statistics reflect decreased yields globally. In comparison to the ‘golden years’ of new technology and improved germplasm in the second half of the previous century, little more than optimisation of existing practises has emerged from the past two decades. Given the slowdown in new technology delivery, it is not surprising that many industries have placed more scrutiny on how they manage their Research & Development institutions and investments. The result of this ‘slowdown’ has created a perception that poor management of research projects and programs by scientists is at the core of the problem. This has led to the introduction of ‘real’ managers with the subsequent management of R&D as if it is a ‘normal’ production and sales business through well established ‘business models’. Strong emphasis has been placed on project selection, project management and minimising risk. Research, especially in the discovery phase, is a very high-risk endeavour and a high proportion of all projects fail. Institutions that have a low appetite for risk quickly run out of new technology innovation. Because of the inability to predict, a discovery project cannot easily accommodate management issues such as budgeting, milestone definition and timeframes. Managers generally prefer D and Extension over R because of the higher predictability and lower perceived failure rate. The key to proper management of R&D is a recognition that researchers and managers operate under very different codes of conduct. If this is not properly managed, then conflict between researchers and the rest of the business follows. It has become customary to view RD&E as a unit following a ‘systems’ approach. Despite obvious advantages of this approach, it often fails to recognise the most significant shortfall(s) in the value chain. This practice can unnecessarily inflate the cost, slow project progress and is dependent on consensus that tends to favour the lowest common denominator or more vocal team members. Consensus and innovation tend to be opposing objectives, as innovation requires thinking with an ‘outside the box’ mindset. Consequently, innovation can be stifled using this approach. Peer review is a great tool to measure progress in projects and selecting projects for development. It is not suited for selection of new innovative ideas. With no obvious improvement in technology delivery and adoption, it is timely to ask whether the current approaches are achieving their objectives. In addressing this question it is important to look at the global evolution of R&D models and modern trends in highly innovative businesses. Instead of trying to ensure that every research project entering the technology funnel delivers a product, a greater emphasis is needed to create an innovative environment where all role players are focussed on key strategic objectives, and all research results are seen as key learnings for future deployment.


2014 ◽  
Vol 20 (5) ◽  
pp. 350-358 ◽  
Author(s):  
Harvey Gordon ◽  
Vivek Khosla

SummaryMental disorder and criminality are separate entities but some people with a mental disorder commit criminal offences and some criminals have a mental disorder. Before 1800 there was no separate category of mentally disordered offenders (referred to as criminal lunatics until 1948) in UK legislation. The provision of facilities for mentally disordered offenders in Britain and Ireland overlapped with, but was also separate from, provision for the mentally ill generally. The interface between general and forensic psychiatry is an area of tension and of collaboration. To understand how contemporary general and forensic psychiatry interact, it is useful to have an understanding of how factors have evolved overtime.Learning Objectives•Have an understanding of the evolution of general and forensic psychiatry in the UK over the past 200 years.•Comprehend the similarities and differences between general and forensic psychiatry.•Be aware of some of the roots of conflict between general and forensic psychiatry.


1969 ◽  
Vol 73 (706) ◽  
pp. 916-922
Author(s):  
P. R. Openshaw

Although an interest in electric propulsion has existed in the UK for a considerable time, it is only in the past few years that it has been considered worthwhile to undertake the development of hardware and produce detailed systems studies. The practical developments can be divided into two categories: — 1. The development of comparatively large thrusters (in the region of ½ kW power, giving 10-20 milli Newtons of thrust), for producing major movements in a satellite's position. 2. The development of micro-thruster systems for the maintenance of a satellite's attitude and position against the small disturbing forces and torques it normally experiences in orbit.


2013 ◽  
Vol 10 (4) ◽  
pp. 769-784 ◽  
Author(s):  
Estella Tincknell

The extensive commercial success of two well-made popular television drama serials screened in the UK at prime time on Sunday evenings during the winter of 2011–12, Downton Abbey (ITV, 2010–) and Call the Midwife (BBC, 2012–), has appeared to consolidate the recent resurgence of the period drama during the 1990s and 2000s, as well as reassembling something like a mass audience for woman-centred realist narratives at a time when the fracturing and disassembling of such audiences seemed axiomatic. While ostensibly different in content, style and focus, the two programmes share a number of distinctive features, including a range of mature female characters who are sufficiently well drawn and socially diverse as to offer a profoundly pleasurable experience for the female viewer seeking representations of aging femininity that go beyond the sexualised body of the ‘successful ager’. Equally importantly, these two programmes present compelling examples of the ‘conjunctural text’, which appears at a moment of intense political polarisation, marking struggles over consent to a contemporary political position by re-presenting the past. Because both programmes foreground older women as crucial figures in their respective communities, but offer very different versions of the social role and ideological positioning that this entails, the underlying politics of such nostalgia becomes apparent. A critical analysis of these two versions of Britain's past thus highlights the ideological investments involved in period drama and the extent to which this ‘cosy’ genre may legitimate or challenge contemporary political claims.


2021 ◽  
Vol 4 (1) ◽  
pp. 60-71
Author(s):  
Donovan Guttieres ◽  
Anthony J Sinskey ◽  
Stacy L Springs

Abstract Background Neutralizing antibodies (nAbs) against SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) can play an important role in reducing impacts of the COVID-19 pandemic, complementing ongoing public health efforts such as diagnostics and vaccination. Rapidly designing, manufacturing and distributing nAbs requires significant planning across the product value chain and an understanding of the opportunities, challenges and risks throughout. Methods A systems framework comprised of four critical components is presented to aid in developing effective end-to-end nAbs strategies in the context of a pandemic: (1) product design and optimization, (2) epidemiology, (3) demand and (4) supply. Quantitative models are used to estimate product demand using available epidemiological data, simulate biomanufacturing operations from typical bioprocess parameters and calculate antibody production costs to meet clinical needs under various realistic scenarios. Results In a US-based case study during the 9-month period from March 15 to December 15, 2020, the projected number of SARS-CoV-2 infections was 15.73 million. The estimated product volume needed to meet therapeutic demand for the maximum number of clinically eligible patients ranged between 6.3 and 31.5 tons for 0.5 and 2.5 g dose sizes, respectively. The relative production scale and cost needed to meet demand are calculated for different centralized and distributed manufacturing scenarios. Conclusions Meeting demand for anti-SARS-CoV-2 nAbs requires significant manufacturing capacity and planning for appropriate administration in clinical settings. MIT Center for Biomedical Innovation’s data-driven tools presented can help inform time-critical decisions by providing insight into important operational and policy considerations for making nAbs broadly accessible, while considering time and resource constraints.


Livestock ◽  
2021 ◽  
Vol 26 (4) ◽  
pp. 176-179
Author(s):  
Chris Lloyd

The Responsible Use of Medicines in Agriculture Alliance (RUMA) was established to promote the highest standards of food safety, animal health and animal welfare in the British livestock industry. It has a current focus to deliver on the Government objective of identifying sector-specific targets for the reduction, refinement or replacement of antibiotics in animal agriculture. The creation and roll out of sector specific targets in 2017 through the RUMA Targets Task Force, has helped focus activity across the UK livestock sectors to achieve a 50% reduction in antibiotic use since 2014. This has been realised principally through voluntary multi-sector collaboration, cross sector initiatives, codes of practice, industry body support and farm assurance schemes. This article provides an overview of RUMA's work to date providing insight into the methods used to create the targets, why they are so important, the impact they are having and how ongoing support and robust data are vital components in achieving the latest set of targets.


2021 ◽  
pp. 095792652199215
Author(s):  
Charlotte Taylor

This paper aims to cast light on contemporary migration rhetoric by integrating historical discourse analysis. I focus on continuity and change in conventionalised metaphorical framings of emigration and immigration in the UK-based Times newspaper from 1800 to 2018. The findings show that some metaphors persist throughout the 200-year time period (liquid, object), some are more recent in conventionalised form (animals, invader, weight) while others dropped out of conventionalised use before returning (commodity, guest). Furthermore, we see that the spread of metaphor use goes beyond correlation with migrant naming choices with both emigrants and immigrants occupying similar metaphorical frames historically. However, the analysis also shows that continuity in metaphor use cannot be assumed to correspond to stasis in framing and evaluation as the liquid metaphor is shown to have been more favourable in the past. A dominant frame throughout the period is migrants as an economic resource and the evaluation is determined by the speaker’s perception of control of this resource.


2020 ◽  
Vol 30 ◽  
pp. 77-96
Author(s):  
Sujit Sivasundaram

AbstractThe Pacific has often been invisible in global histories written in the UK. Yet it has consistently been a site for contemplating the past and the future, even among Britons cast on its shores. In this lecture, I reconsider a critical moment of globalisation and empire, the ‘age of revolutions’ at the end of the eighteenth century and the start of the nineteenth century, by journeying with European voyagers to the Pacific Ocean. The lecture will point to what this age meant for Pacific islanders, in social, political and cultural terms. It works with a definition of the Pacific's age of revolutions as a surge of indigeneity met by a counter-revolutionary imperialism. What was involved in undertaking a European voyage changed in this era, even as one important expedition was interrupted by news from revolutionary Europe. Yet more fundamentally vocabularies and practices of monarchy were consolidated by islanders across the Pacific. This was followed by the outworkings of counter-revolutionary imperialism through agreements of alliance and alleged cessation. Such an argument allows me, for instance, to place the 1806 wreck of the Port-au-Prince within the Pacific's age of revolutions. This was an English ship used to raid French and Spanish targets in the Pacific, but which was stripped of its guns, iron, gunpowder and carronades by Tongans. To chart the trajectory from revolution and islander agency on to violence and empire is to appreciate the unsettled paths that gave rise to our modern world. This view foregrounds people who inhabited and travelled through the earth's oceanic frontiers. It is a global history from a specific place in the oceanic south, on the opposite side of the planet to Europe.


Author(s):  
Ellen Gordon-Bouvier

The restrained state has always sought to devalue socially reproductive work, often consigning it to the private family unit, where it is viewed as a natural part of female relational roles. This marginalisation of social reproduction adversely affects those performing it and reduces their resilience to vulnerability. The pandemic has largely shattered the liberal illusions of autonomous personhood and state restraint. The reality of our universal embodied vulnerability has now become impossible to ignore, and society’s reliance on socially reproductive work has therefore been pushed into public view. However, the pandemic has also exacerbated harms and pressures for those performing paid and unpaid social reproduction, creating a crisis that demands an urgent state response. As it is argued in this paper, the UK response to date has been inadequate, illustrating an unwillingness to abandon familiar principles of liberal individualism. However, the pandemic has also created a climate of exceptionality, which has prompted even the most neoliberal of states to consider measures that in the past would have been dismissed. In this paper, it is imagined how the state can use this opportunity to become more responsive and improve the resilience of social reproduction workers, both inside and outside the home.


Sign in / Sign up

Export Citation Format

Share Document