Rs6586282 of the CBS Gene: Its Lack of Eff ect on Homocysteine Concentrations, and Interaction Eff ects on Body Weight in Elderly Women

2016 ◽  
Vol 86 (5-6) ◽  
pp. 235-241
Author(s):  
Agata Chmurzynska ◽  
Anna M. Malinowska ◽  
Jolanta Twardowska-Rajewska ◽  
Jan Gawecki
Keyword(s):  
Body Weight ◽  
Folic Acid ◽  
Vitamin B6 ◽  
Elderly Women ◽  
Folic Acid Supplementation ◽  
B Vitamins ◽  
Folate Intake ◽  
Blood Biomarkers ◽  
Hip Circumference ◽  
Anthropometric Parameters

Abstract.The aim of the present study is to evaluate the effect of the rs6586282 polymorphism of the cystathionine-β-synthase (CBS) gene, and of the intake of B vitamins on anthropometric parameters, tHcy levels, and lipoprotein levels in women over 60 years of age. 122 volunteers were supplemented with 400 μg/day folic acid for 8 weeks. The intake of B vitamins above the median value was associated with lower levels of blood biomarkers: folate with tHcy post supplementation (6.21 ± 0.24 μM vs 7.11 ± 0.32 μM; p < 0.05), vitamin B6 with baseline triacylglycerol (TAG, 107.3 ± 5.5 mg/dL vs 127.2 ± 6.4 mg/dL; p < 0.05) and glucose (82.3 ± 1.1 mg/dL vs 86.9 ± 1.5 mg/dL; p < 0.05); and vitamin B12 with baseline TAG (106.8 ± 5.5 mg/dL vs 127.7 ± 6.3 mg/dL; p < 0.01). Women with a T allele consuming lower amounts of folate had higher body weight (72.3 ± 2.3 kg vs 64.0 ± 1.7 kg; p < 0.05), body mass index (28.7 ± 0.8 vs 25.2 ± 0.7; p < 0.05), waist (0.90 ± 0.02 m vs 0.82 ± 0.01 m; p < 0.01), and hip circumference (1.08 ± 0.02 vs 1.02 ± 0.01 m; p < 0.01) than the CC homozygotes. Intake of vitamin B6 or B12 may infl uence blood TAG and glucose concentrations in elderly women, but the rs6586282 polymorphism of the CBS gene does not alter either tHcy or the effectiveness of folic acid supplementation. The CBS SNP at rs6586282 may infl uence anthropometric parameters, though only in case of low folate intake.

Folic acid supplementation, dietary folate intake and risk of small for gestational age in China

2019 ◽  
Vol 23 (11) ◽  
pp. 1965-1973
Author(s):  
Huaqi Guo ◽  
Baohong Mao ◽  
Meng Wang ◽  
Qing Liu ◽  
Liping Yang ◽  
...  
Keyword(s):  
Folic Acid ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Folic Acid Supplementation ◽  
Folate Intake ◽  
Care Hospital ◽  
Dietary Folate ◽  
Acid Supplementation ◽  
Dietary Folate Intake ◽  
Reduced Risk

AbstractObjective:To investigate the hypothesis that folic acid supplementation and dietary folate intake before conception and during pregnancy reduce the risk of small for gestational age (SGA) and to examine the joint effect of folic acid supplementation and dietary folate intake on the risk of SGA.Design:Participants were interviewed by trained study interviewers using a standardized and structured questionnaire. Information on birth outcomes and maternal complications was abstracted from medical records and dietary information was collected via a semi-quantitative FFQ before conception and during pregnancy.Setting:A birth cohort data analysis using the 2010–2012 Gansu Provincial Maternity and Child Care Hospital.Participants:Women (n 8758) and their children enrolled in the study.Results:Folic acid supplementation was associated with a reduced risk of SGA (OR = 0·72, 95 % CI 0·60, 0·86), with the reduced risk seen mainly for SGA at ≥37 weeks of gestational age (OR = 0·70, 95 % CI 0·58, 0·85) and nulliparous SGA (OR = 0·67, 95 % CI 0·54, 0·84). There was no significant association between dietary folate intake and SGA risk.Conclusions:Our study suggested that folic acid supplementation was associated with a reduced risk of SGA and the risk varied by preterm status and parity.

scholarly journals Circulating Unmetabolized Folic Acid: Relationship to Folate Status and Effect of Supplementation

2012 ◽  
Vol 2012 ◽  
pp. 1-17 ◽  
Author(s):  
Carolyn Tam ◽  
Deborah O'Connor ◽  
Gideon Koren
Keyword(s):  
Folic Acid ◽  
Statistical Significance ◽  
Folic Acid Supplementation ◽  
The Body ◽  
Reproductive Age ◽  
Folate Intake ◽  
Women Of Reproductive Age ◽  
Metabolic Capacity ◽  
Acid Status ◽  
Status Of Women

There are increasing concerns that exposure to unmetabolized folic acid, which results from folic acid intakes that overwhelm the liver's metabolic capacity, may be associated with adverse effects. In this paper, we examined the folic acid status of women of reproductive age in relation to dietary intake and the effect of folic acid supplementation (1.1 mg or 5 mg). Plasma unmetabolized folic acid was not significantly correlated with folate intake estimated by food frequency questionnaire or biomarkers. The proportion of women with detectable levels of unmetabolized folic acid increased from 65% to 100% after twelve weeks of supplementation (P<0.05); however, the increase in concentrations did not reach statistical significance and the effect was not sustained. Moreover, there were no significant differences between the two doses. This suggests that there are mechanisms by which the body adapts to high folic acid intakes to limit exposure to unmetabolized folic acid.

scholarly journals The effect of folate fortification on folic acid-based homocysteine-lowering intervention and stroke risk: a meta-analysis

2014 ◽  
Vol 18 (8) ◽  
pp. 1514-1521 ◽  
Author(s):  
Rui Zeng ◽  
Chun-Hua Xu ◽  
Yuan-Ning Xu ◽  
Ya-Li Wang ◽  
Mian Wang
Keyword(s):  
Folic Acid ◽  
Randomized Controlled Trials ◽  
Stroke Risk ◽  
Meta Analysis ◽  
Folic Acid Supplementation ◽  
Folate Intake ◽  
Controlled Trials ◽  
Acid Supplementation ◽  
Randomized Controlled ◽  
Significant Difference

AbstractObjectiveFolate and vitamin B12 are two vital regulators in the metabolic process of homocysteine, which is a risk factor of atherothrombotic events. Low folate intake or low plasma folate concentration is associated with increased stroke risk. Previous randomized controlled trials presented discordant findings in the effect of folic acid supplementation-based homocysteine lowering on stroke risk. The aim of the present review was to perform a meta-analysis of relevant randomized controlled trials to check the how different folate fortification status might affect the effects of folic acid supplementation in lowering homocysteine and reducing stroke risk.DesignRelevant randomized controlled trials were identified through formal literature search. Homocysteine reduction was compared in subgroups stratified by folate fortification status. Relative risks with 95 % confidence intervals were used as a measure to assess the association between folic acid supplementation and stroke risk.SettingThe meta-analysis included fourteen randomized controlled trials,SubjectsA total of 39 420 patients.ResultsHomocysteine reductions were 26·99 (sd 1·91) %, 18·38 (sd 3·82) % and 21·30 (sd 1·98) %, respectively, in the subgroups without folate fortification, with folate fortification and with partial folate fortification. Significant difference was observed between the subgroups with folate fortification and without folate fortification (P=0·05). The relative risk of stroke was 0·88 (95 % CI 0·77, 1·00, P=0·05) in the subgroup without folate fortification, 0·94 (95 % CI 0·58, 1·54, P=0·82) in the subgroup with folate fortification and 0·91 (95 % CI 0·82, 1·01, P=0·09) in the subgroup with partial folate fortification.ConclusionsFolic acid supplementation might have a modest benefit on stroke prevention in regions without folate fortification.

scholarly journals Maternal Folic Acid Supplementation, Dietary Folate Intake and Low Birth Weight: A Birth Cohort Study

2021 ◽  
Author(s):  
LiPing Yang ◽  
Wenjuan Wang ◽  
Baohong Mao ◽  
Jie Qiu ◽  
Huaqi Guo ◽  
...  
Keyword(s):  
Folic Acid ◽  
Folic Acid Supplementation ◽  
Folate Intake ◽  
Care Hospital ◽  
Folic Acid Supplement ◽  
Dietary Folate ◽  
Acid Supplementation ◽  
Dietary Folate Intake ◽  
Reduced Risk ◽  
Joint Associations

Abstract ObjectivesTo investigate the independent and collective effects of maternal folic acid supplementation or dietary folate intake upon the risk of low birth weight (LBW), and to further comprehensively examine the joint associations of folic acid supplementation and dietary folate intake with LBW by various clinical subtypes.DesignParticipants were recruited in Gansu Provincial Maternity and Child Care Hospital. A standardized and structured questionnaire was distributed to collect demographic factors, reproductive and medical history, occupational and residential history, physical activity and diet. Data on pregnancy-related complications and birth outcomes were extracted from medical records. Unconditional logistic regression models were used to estimate odds ratio (OR) and 95% confidence interval (95%CI) for single and joint associations of folic acid supplementation and dietary folate intake with LBW. SettingA birth cohort data analysis using the 2010–2012 Gansu Provincial Maternity and Child Care Hospital in Lanzhou, China.Participants9231 pregnant women and their children were enrolled in the study. ResultsCompared to non-users, folic acid supplementation was associated with a reduced risk of LBW (OR: 0.80, 95%CI: 0.66-0.97), and the reduced risk was mainly seen for term-LBW (OR: 0.59, 95%CI: 0.41-0.85), and multiparous-LBW (OR: 0.72, 95%CI: 0.54-0.94). For dietary folate intake, there were no significant associations with LBW, and there was no interaction of folic acid supplement and dietary folate intake on LBW.ConclusionsOur study results indicated that folic acid supplementation was associated with a reduced risk of LBW, and there was not interaction of folic acid supplement and dietary folate intake on LBW.

scholarly journals B vitamins for stroke prevention

2018 ◽  
Vol 3 (2) ◽  
pp. 51-58 ◽  
Author(s):  
Graeme J Hankey
Keyword(s):  
Clinical Trials ◽  
Folic Acid ◽  
Stroke Prevention ◽  
Stroke Risk ◽  
Folic Acid Supplementation ◽  
Adverse Outcomes ◽  
B Vitamins ◽  
Vitamin B ◽  
Folate Supplementation ◽  
Acid Supplementation

Supplementation with B vitamins (vitamin B9(folic acid), vitamin B12 and vitamin B6) lowers blood total homocysteine (tHcy) concentrations by about 25% and reduces the relative risk of stroke overall by about 10% (risk ratio (RR) 0.90, 95% CI 0.82 to 0.99) compared with placebo. Homocysteine-lowering interventions have no significant effect on myocardial infarction, death from any cause or adverse outcomes. Factors that appear to modify the effect of B vitamins on stroke risk include low folic acid status, high tHcy, high cyanocobalamin dose in patients with impaired renal function and concurrent antiplatelet therapy. In regions with increasing levels or established policies of population folate supplementation, evidence from observational genetic epidemiological studies and randomised controlled clinical trials is concordant in suggesting an absence of benefit from lowering of homocysteine with folic acid for prevention of stroke. Clinical trials indicate that in countries which mandate folic acid fortification of food, folic acid supplementation has no significant effect on reducing stroke risk (RR 1.05, 95% CI 0.90 to 1.23). However, in countries without mandatory folic acid food fortification, folic acid supplementation reduces the risk of stroke by about 15% (RR 0.85, 95% CI 0.77 to 0.94). Folic acid alone or in combination with minimal cyanocobalamin (≤0.05 mg/day) is associated with an even greater reduction in risk of future stroke by 25% (RR 0.75, 95% CI 0.66 to 0.86), whereas the combination of folic acid and a higher dose of cyanocobalamin (≥0.4 mg/day) is not associated with a reduced risk of future stroke (RR 0.95, 95% CI 0.86 to 1.05). The lack of benefit of folic acid plus higher doses of cyanocobalamin (≥0.4 mg/day) was observed in trials which all included participants with chronic kidney disease. Because metabolic B12 deficiency is very common and usually not diagnosed, future randomised trials of homocysteine-lowering interventions for stroke prevention should probably test a combination of folic acid and methylcobalamin or hydroxocobalamin instead of cyanocobalamin, and perhaps vitamin B6.

Plane of nutrition and folic acid supplementation between birth and four months of age on mammary development of dairy heifers

1999 ◽  
Vol 79 (2) ◽  
pp. 227-234 ◽  
Author(s):  
D. Petitclerc ◽  
P. Dumoulin ◽  
H. Ringuet ◽  
J. Matte ◽  
C. Girard
Keyword(s):  
Growth Hormone ◽  
Body Weight ◽  
Folic Acid ◽  
Mammary Gland ◽  
Folic Acid Supplementation ◽  
Mammary Development ◽  
Acid Supplementation ◽  
Parenchymal Tissue ◽  
Dairy Heifers ◽  
Ad Libitum

Forty-seven dairy heifers of approximately 10 d of age were assigned randomly to a 2 × 2 factorial design to study the effects of folic acid supplementation (0 vs. 40 mg) administered weekly i.m. and levels of feed intake after weaning on mammary development. Folic acid treatment started immediately and all heifers were weaned 5 wk later. Heifers were then either fed ad libitum grass hay and concentrates or restricted to a body weight gain of approximately 700 g d−1 until slaughter at 4 mo of age. Average daily gain was affected by feed intake level after weaning (615 vs. 954 g d−1P < 0.01); however, folic acid supplementation increased weight gain only during the 5-wk period following weaning (P < 0.05). Heifers fed ad libitum were 33% heavier before slaughter (P < 0.001) but there was no effect due to folic acid supplementation (P > 0.05). There was no effect of treatments on serum prolactin and growth hormone concentrations (P > 0.05); overall, prolactin increased and growth hormone decreased over the 16-wk sampling period. However, serum IGF-1 concentrations were significantly higher in heifers fed ad libitum following weaning as compared with the feed-restricted animals (P < 0.001); overall, IGF-1 concentrations increased linearly between weeks 2 and 16 (P < 0.001). Plane of nutrition did not have any effect (P > 0.05) on the total volume of parenchymal tissue in the mammary gland (61.6 vs. 63.6 cm3); however, ad libitum feeding increased significantly (P < 0.001) the volume of extraparenchymal tissue in the gland (262.0 vs. 1067.6 cm3). After adjusting data for the difference in body weight at slaughter, the amount of parenchymal tissue was smaller in animals fed ad libitum (P < 0.05); this adjustment did not change the effect of plane of nutrition on mammary extraparenchymal tissue. In conclusion, a fast rate of gain after weaning up to 4 mo of age induced a large accumulation of mammary fat, but did not negatively affect the total amount of parenchymal tissue in the mammary gland of dairy heifers. Key words: Plane of nutrition, folic acid, mammary gland, IGF-1

The association of maternal dietary folate intake and folic acid supplementation with small-for-gestational-age births: a cross-sectional study in Northwest China

2019 ◽  
Vol 122 (04) ◽  
pp. 459-467 ◽  
Author(s):  
Shanshan Li ◽  
Danmeng Liu ◽  
Ruo Zhang ◽  
Fangliang Lei ◽  
Xin Liu ◽  
...  
Keyword(s):  
Folic Acid ◽  
First Trimester ◽  
Northwest China ◽  
Folic Acid Supplementation ◽  
Cross Sectional Study ◽  
Folate Intake ◽  
Sectional Study ◽  
Cross Sectional ◽  
Dietary Folate ◽  
Reduced Risk

AbstractThe effect of maternal folate intake on small-for-gestational-age (SGA) births remains inconclusive. The present study aimed to investigate the associations of maternal folate intake from diet and supplements with the risk of SGA births using data from a cross-sectional study in Shaanxi Province of Northwest China. A total of 7307 women who were within 12 months (median 3; 10th–90th percentile 0–7) after delivery were included. Two-level models were adopted to examine the associations of folate (dietary folate, supplemental folic acid and total folate) intake with the risk of SGA births and birth weight Z score, controlling for a minimum set of confounders that were identified in a directed acyclic graph. Results showed that a higher supplemental folic acid intake during the first trimester was negatively associated with the risk of SGA births (≤60 d v. non-use: OR 0·80; 95 % CI 0·66, 0·96; &gt;60 d v. non-use: OR 0·78; 95 % CI 0·65, 0·94; Ptrend = 0·010; per 10-d increase: OR 0·97; 95 % CI 0·95, 0·99). A higher total folate intake during pregnancy was associated with a reduced risk of SGA births (highest tertile v. lowest tertile: OR 0·77; 95 % CI 0·64, 0·94; Ptrend = 0·010; per one-unit increase in the log-transformed value: OR 0·81; 95 % CI 0·69, 0·95). A similar pattern was observed for the birth weight Z score. Our study suggested that folic acid supplementation during the first trimester and a higher total folate intake during pregnancy were associated with a reduced risk of SGA births.

Endothelial dysfunction by acute hyperhomocyst(e)inaemia: restoration by folic acid

1999 ◽  
Vol 96 (3) ◽  
pp. 235-239 ◽  
Author(s):  
Michiaki USUI ◽  
Hidehiro MATSUOKA ◽  
Hiroshi MIYAZAKI ◽  
Seiji UEDA ◽  
Seiya OKUDA ◽  
...  
Keyword(s):  
Body Weight ◽  
Risk Factor ◽  
Folic Acid ◽  
Endothelial Dysfunction ◽  
Endothelial Function ◽  
Plasma Levels ◽  
Folic Acid Supplementation ◽  
Non Invasive ◽  
Per Se ◽  
High Resolution Ultrasonography

Recent evidence demonstrates that hyperhomocyst(e)inaemia is a novel risk factor for cardiovascular diseases. In patients with chronic hyperhomocyst(e)inaemia, endothelial function is impaired. However, whether hyperhomocyst(e)inaemia per se is a cause or an epiphenomenon of endothelial dysfunction remains unknown. In this study, we examined the effects of methionine-induced acute hyperhomocyst(e)inaemia on human endothelial function. In healthy volunteers we administered methionine (0.1 ;g/kg body weight, per os), a substrate of homocyst(e)ine, with or without folic acid (20 ;mg, per os) and examined flow-mediated vasodilatation of the brachial artery by high-resolution ultrasonography as a non-invasive measure of endothelial function. We also measured plasma levels of homocyst(e)ine before and 3, 8 and 24 ;h after methionine loading. Methionine administration increased plasma levels of homocyst(e)ine by four times the basal level at 8 ;h (P< 0.0001, ANOVA). The plasma levels returned to baseline at 24 ;h. Flow-mediated vasodilatation was significantly decreased to half of the baseline value at 8 ;h and returned to baseline at 24 ;h (P< 0.0001, ANOVA), whereas endothelium-independent vasodilatation by glyceryl trinitrate was not affected by the methionine loading. Co-administration of folic acid did not attenuate methionine-induced hyperhomocyst(e)inaemia but completely prevented endothelial dysfunction. Our results suggest that in humans a methionine-rich diet may acutely impair endothelial function, which can be prevented by folic acid supplementation.

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