scholarly journals Publisher Correction: Characterisation of factors contributing to the performance of nonwoven fibrous matrices as substrates for adenovirus vectored vaccine stabilisation

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Pawan Dulal ◽  
Robabeh Gharaei ◽  
Adam Berg ◽  
Adam A. Walters ◽  
Nicholas Hawkins ◽  
...  

The original version of this Article contained an error.

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Pawan Dulal ◽  
Robabeh Gharaei ◽  
Adam J. Berg ◽  
Adam A. Walters ◽  
Nicholas Hawkins ◽  
...  

AbstractAdenovirus vectors offer a platform technology for vaccine development. The value of the platform has been proven during the COVID-19 pandemic. Although good stability at 2–8 °C is an advantage of the platform, non-cold-chain distribution would have substantial advantages, in particular in low-income countries. We have previously reported a novel, potentially less expensive thermostabilisation approach using a combination of simple sugars and glass micro-fibrous matrix, achieving excellent recovery of adenovirus-vectored vaccines after storage at temperatures as high as 45 °C. This matrix is, however, prone to fragmentation and so not suitable for clinical translation. Here, we report an investigation of alternative fibrous matrices which might be suitable for clinical use. A number of commercially-available matrices permitted good protein recovery, quality of sugar glass and moisture content of the dried product but did not achieve the thermostabilisation performance of the original glass fibre matrix. We therefore further investigated physical and chemical characteristics of the glass fibre matrix and its components, finding that the polyvinyl alcohol present in the glass fibre matrix assists vaccine stability. This finding enabled us to identify a potentially biocompatible matrix with encouraging performance. We discuss remaining challenges for transfer of the technology into clinical use, including reliability of process performance.


Author(s):  
Bairon Oswaldo Vélez

This paper comments on the first Spanish translation of João Guimarães Rosa's short story "Páramo", which narrates the exile of a Brazilian lost with mountain sickness in a cold and hostile Bogotá. This translation is briefly explained in the following pages, giving special emphasis to some prominent features of the original version, in addition to the cultural context, critical and theoretical readings and the translation strategy evident in the translator‘s intervention. Finally, it is made clear how a certain perspective of the other – present in the original version as well – passes through the translation process and indicates the conditions of its presentation in the target language. The original article is in Portuguese.


Author(s):  
Olga Teush

The article is devoted to the names of the shrubs and bushes in the dialects of European North of Russia. The whole complex of lexemes is analyzed in relation to the origin and semantic connections of the words. The article determines the etymological origins of the key lexeme in the group – «a bush» with a reconstructed meaning «to stand, to stick out of the ground» . The research describes dialect derivatives of the root «kust-«. The author identifies contaminated words on the basis of the seme «dense». Northern Russian dialect names of the bush or shrub are considered in the onomasiological, semasiological, and lexical aspects. The article performs analysis of collective forms derived from «vitsa» as a flexible man-made rod, a branch, and «prut» as «a thin broken or cut branch without leaves» with Slavic origin. The active use of Russian roots like «ros- / rost- / rast-» of Indo-European antiquity is noted. Moreover, the article describes numerous species names. The largest number of nominations is discovered for the willow shrub: five roots are involved. The root «iv-« in dialects appears both in the original version and with metathesis (>«vi-«). In Northern Russian dialect zone the most active word formations are derived from the proto-Slavic origin of the root «bred-«. They form an extensive word-formation nest. The author interprets species appellative names of juniper, cherry bush, rose hip, hawthorn, gooseberry, hazel bushes. The article points out a wide use of names used to describe a dense bush with a root «chap- / tsap-» in the dialects of European North of Russia. The article analyzes the lexemes used to name the shrubs growing on the hills. The most numerous words are the names of water-bushes. Secondary names of shrubs and bushes growing on the hills or in the forests and marshlands are more rarely used. Descriptive names of scrup in abandoned fields are used in only one context. Pragmatic and metaphorical names are infrequent.


Author(s):  
Vered Noam

This chapter examines the story of the internecine struggle between the two Hasmonean brothers, Hyrcanus II and Aristobulus II, which brought the Hasmonean commonwealth to its end. Only in Josephus is the story of the murder of a righteous man, Onias, juxtaposed to the central tradition regarding the siege of the temple during this war, although this too was clearly an early Jewish tradition. In the rabbinic sources, the story of the siege and the sacrificial animals underwent multiple reworkings, and it is the Babylonian Talmud that reflects the more original version and message of the story. If in Chapter 2, we saw the “rabbinization” of the figure of John Hyrcanus, here the story itself underwent this process and its original moral message was replaced by multiple halakhic implications. In both corpora, this dissension between brothers is seen as the leading cause of the downfall of the Hasmonean dynasty. This was in contradistinction to the political stance represented in the Dead Sea Scrolls, which interpreted the Roman occupation as proof of the sinfulness of the Hasmonean state from its very inception.


2020 ◽  
Vol 129 (10) ◽  
pp. 1020-1029
Author(s):  
Andrea Nacci ◽  
Luca Bastiani ◽  
Maria Rosaria Barillari ◽  
Jerome R. Lechien ◽  
Massimo Martinelli ◽  
...  

Objectives: To investigate the psychometric properties of the reflux symptom index (RSI) as short screening approach for the diagnostic of laryngopharyngeal reflux (LPR) in patients with confirmed diagnosed regarding the 24-hour multichannel intraluminal impedance-pH monitoring (MII-pH). Methods: From January 2017 to December 2018, 56 patients with LPR symptoms and 71 healthy individuals (control group) were prospectively enrolled. The LPR diagnosis was confirmed through MII-pH results. All subjects (n = 127) fulfilled RSI and the Reflux Finding Score (RFS) was performed through flexible fiberoptic endoscopy. The sensitivity and the specificity of RSI was assessed by ROC (Receiver Operating Characteristic) analysis. Results: A total of 15 LPR patients (26.8%) of the clinical group met MII-pH diagnostic criteria. Among subjects classified as positive for MII- pH diagnoses, RSI and RFS mean scores were respectively 20 (SD ± 10.5) and 7.1 (SD ± 2.5), values not significantly different compared to the negative MII-pH group. The metric analysis of the items led to the realization of a binary recoding of the score. Both versions had similar psychometric properties, α was 0.840 for RSI original version and 0.836 for RSI binary version. High and comparable area under curve (AUC) values indicate a good ability of both scales to discriminate between individuals with and without LPR pathology diagnosis. Based on balanced sensitivity and specificity, the optimal cut-off scores for LPR pathology were ≥ 5 for RSI binary version and ≥ 15 for RSI original version. Both version overestimated LPR prevalence. The original version had more sensitivity and the RSI Binary version had more specificity. Conclusions: It would be necessary to think about modifying the original RSI in order to improve its sensitivity and specificity (RSI binary version, adding or changing some items), or to introduce new scores in order to better frame the probably affected of LPR patient.


2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Alexandra J. Spencer ◽  
Paul F. McKay ◽  
Sandra Belij-Rammerstorfer ◽  
Marta Ulaszewska ◽  
Cameron D. Bissett ◽  
...  

AbstractSeveral vaccines have demonstrated efficacy against SARS-CoV-2 mediated disease, yet there is limited data on the immune response induced by heterologous vaccination regimens using alternate vaccine modalities. Here, we present a detailed description of the immune response, in mice, following vaccination with a self-amplifying RNA (saRNA) vaccine and an adenoviral vectored vaccine (ChAdOx1 nCoV-19/AZD1222) against SARS-CoV-2. We demonstrate that antibody responses are higher in two-dose heterologous vaccination regimens than single-dose regimens. Neutralising titres after heterologous prime-boost were at least comparable or higher than the titres measured after homologous prime boost vaccination with viral vectors. Importantly, the cellular immune response after a heterologous regimen is dominated by cytotoxic T cells and Th1+ CD4 T cells, which is superior to the response induced in homologous vaccination regimens in mice. These results underpin the need for clinical trials to investigate the immunogenicity of heterologous regimens with alternate vaccine technologies.


Viruses ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1046
Author(s):  
Gerardo Casucci ◽  
Domenico Acanfora

In recent weeks, adverse reactions have been reported after administration of Oxford–AstraZeneca chimpanzee adenovirus vectored vaccine ChAdOx1 nCoV-19 (AZD1222), in particular thrombus formation, which has led several European Countries to discontinue administration of this vaccine. On March 8, 2021, the European Medicines Agency Safety Committee did not confirm this probable association. We report the case of a patient who developed disseminated intravascular coagulation after the first dose of Oxford-Astra Zeneca vaccine, which resolved in a few days with the administration of dexamethasone and enoxaparin. This work demonstrates the safety of the Oxford-Astra Zeneca vaccine and that any development of side effects can be easily managed with a prompt diagnosis and in a short time with a few commonly used drugs.


Pituitary ◽  
2020 ◽  
Author(s):  
Eliza B. Geer ◽  
Roberto Salvatori ◽  
Atanaska Elenkova ◽  
Maria Fleseriu ◽  
Rosario Pivonello ◽  
...  

The original version of the article unfortunately contained an error in the first name and the surname of one of the authors in the author group. The last author name was incorrectly published as ‘F. Pecori Giraldi’ and the corrected name is ‘Francesca Pecori Giraldi’ (First name: Francesca; Surname: Pecori Giraldi).


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