Formulation of protein–polyphenol particles for applications in food systems

2020 ◽  
Vol 11 (6) ◽  
pp. 5091-5104 ◽  
Author(s):  
Joscelin T. Diaz ◽  
E. Allen Foegeding ◽  
Mary Ann Lila
Keyword(s):  
Oxidative Stress ◽  
Immune System ◽  
Food Systems ◽  
The Body ◽  
Biologically Active

Consumers are demanding healthy nutritious foods rich in protein (both plant and animal) and biologically-active phytochemicals from plants, which can help the body to sustain a stronger immune system and fight against oxidative stress.

scholarly journals POTENTIAL USE OF SULFORAPHANE AS A NEUROPROTECTOR

2021 ◽  
pp. 125-136
Author(s):  
S. A. Tsiumpala ◽  
K. M. Starchevska ◽  
V. I. Lushchak
Keyword(s):  
Oxidative Stress ◽  
Neurodegenerative Diseases ◽  
Old Age ◽  
Neurodegenerative Disorders ◽  
Therapeutic Potential ◽  
The Body ◽  
Biologically Active ◽  
Inflammatory Processes ◽  
The Brain ◽  
Potential Use

Introduction. Under normal conditions, oxidative stress and proinflammatory processes are tightly controlled. However, during neuroinflammation and overproduction of reactive oxygen species (ROS), homeostasis is disrup­ted, which may lead to development of Alzheimer’s disease, Parkinson’s disease and other neurodegenerative disorders. Inflammatory processes may result in neurodegenerative disorders. Sulforaphane is an isothiocyanate compound which has potential for treatment of neurodegenerative disorders. Its therapeutic potential is based on the ability to activate transcription of genes, that regulate protective cellular mechanisms. The importance of stu­dying sulforaphane as a neuroprotector is based on the fact, that dementias are the seventh leading cause of death glo­bally and actively progress due to aging of human population. In this review, the anti-inflammatory effects of sulforaphane in the brain and its use as a potential neuroprotector in the treatment of neurodegenerative diseases are discussed. The aim of the study – to review available literature sources on the potential use of sulforaphane to prevent or mitigate neuroinflammation. Conclusions. Economic and technological development of mankind and the improvement of the general qua­lity of life leads to prolongation of human life. But, achievements of longevity give new challenges to humanity. In young age and early adulthood, the organisms can relatively easily maintain homeostasis, then in old age intensification of oxidative stress and inflammatory processes can lead to the development of dementias and mental disorders. What should we do now to save clear mind in old age? In this review, sulforaphane is considered to be a potential neuroprotector. Biologically active supplements and drugs containing sulforaphane can weaken up inflammatory processes in the brain and in the body in general, and therefore they can be used for prevention and treatment of neurodegenerative diseases.

scholarly journals Oxidative Stress, Antioxidant Defenses, COVID-19 and Pollution

2020 ◽  
Vol 8 (10) ◽  
Author(s):  
Selva Rivas-Arancibia ◽  
Jennifer Balderas-Miranda ◽  
Lizbeth Belmont-Zúñiga ◽  
Martín Martínez-Jáquez ◽  
Eduardo Hernández-Orozco ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Trace Elements ◽  
Immune System ◽  
Inflammatory Response ◽  
Inflammatory Responses ◽  
The Body ◽  
Antioxidant Defenses ◽  
Cochrane Library ◽  
Antioxidant Systems ◽  
Low Levels

Patients with degenerative diseases present a chronic oxidative stress state, which puts them at a disadvantage when facing viral infections such as COVID-19. This is because there is a close relationship between redox signaling and this inflammatory response. Therefore, chronic changes in the redox balance cause alterations in the regulation of the immune system. An inflammatory response that must be reparative and self-limited loses its function and remains over time. In a chronic state of oxidative stress, there is a deficiency of antioxidants. This results in low levels of hormones, vitamins and trace elements, which are essential for the regulation of these systems. Furthermore, low levels of antioxidants imply a diminished capacity for a regulated inflammatory responses are much more vulnerable to a cytokine storm that mainly attacks the lungs, since they present a vicious circle between the null or diminished response of the antioxidant systems and the loss of regulation of the inflammatory process. Therefore, these patients are at a disadvantage in counteracting the response of defense systems to infection from SAR-COV19. A plausible option may be to restore the levels of Vitamins A, B, C, D, E and of essential trace elements such as manganese, selenium, zinc, in the body, which are key to either preventing or reducing the severity of the response of the immune system to the disease caused by SAR-CoV2. For the present review, we searched the specific sites of the Cochrane library database, PubMed and Medscape. The inclusion criteria were documents written in English or Spanish, published during the last 10 years.

Effects of Antioxidants on CD4 and Viral Load in HIV-Infected Women in Sub-Saharan Africa - Dietary Supplements vs. Local Diet

2012 ◽  
Vol 82 (1) ◽  
pp. 63-72 ◽  
Author(s):  
N. Nkengfack ◽  
N. Torimiro ◽  
Englert
Keyword(s):  
Oxidative Stress ◽  
Viral Load ◽  
Immune System ◽  
Dietary Supplements ◽  
Micronutrient Deficiency ◽  
The Body ◽  
Sub Saharan Africa ◽  
Hiv Positive ◽  
Natural Food ◽  
Nutritional Education

In sub-Sahara Africa, micronutrient deficiency, especially of antioxidant micronutrients including vitamins A, C, and E, beta-carotene, selenium, zinc, and polyphenols is very common in HIV-positive patients. Amongst adults, women are the most vulnerable. Antioxidants are known to play a vital role in the immune system, reducing oxidative stress. Oxidative stress is induced by excess production of reactive oxygen species (ROS), due to the HIV infection. Such damage may be prevented or moderated through adequate oral intake of antioxidants, scavenging ROS, as well as protecting cells and tissues against oxidative stress. Antioxidants can be provided to the body through locally available antioxidant rich-diets such as fruit-and-vegetable-based diets and/or dietary supplements. Provision of antioxidants through local diets or dietary supplements exercise beneficial effects on biological markers of the immune system (CD4 and viral load). However, while dietary supplements represent a costly and short-term strategy to limiting antioxidant deficiency, local diets, combined with adequate nutritional education, can provide a low-cost and long-term strategy to reduce oxidative stress, prevent micronutrient deficiency, and slow down HIV disease progression. The former can be applicable in countries around the West, Central, and South coast of Africa, which are rich in natural food resources. In contrast with significant evidence that dietary supplements confer benefits in HIV patients, fewer data are available relating to the benefits of local diets. Thus the need to do more research in this area arises. This review compares available data on effects of antioxidants on CD4 and viral load in HIV-positive women noneligible for antiretroviral therapy. Intake of antioxidants though dietary supplements and local diet, associated with nutritional education, is compared. Studies conducted in sub-Sahara Africa are considered.

Development of a functional product for the prevention of iodine deficiency

2020 ◽  
Vol 82 (3) ◽  
pp. 45-49
Author(s):  
L. V. Antipova ◽  
A. O. Daryin
Keyword(s):  
Iodine Deficiency ◽  
Food Systems ◽  
The Body ◽  
Biologically Active ◽  
Modern World ◽  
Physico Chemical ◽  
Functional Product ◽  
The Russian Federation ◽  
Vegetable Milk ◽  
Inorganic Iodine

Iodine belongs to the most important elements that are responsible for the full working condition of the body. Iodine deficiency is a very acute problem, its elimination is an important task of the world communities, reflected in the Doctrine of Food security of the Russian Federation, regional target programs of Russia. In the modern world, the proposed measure for the prevention of iodine deficiency is the consumption of iodized salt and some foods containing an inorganic form of iodine, or the use of a variety of biologically active additives. However, according to the observed statistics of diseases that are associated with a lack of iodine, the presented measures are not very effective. The article presents studies of the process of bioconversion of inorganic iodine into organic – bioavailable, capable of reaching the target organ, for example, during the germination of lentil grains in the appropriate nutrient medium. The possibility of obtaining an organic form of iodine from sprouted lentils in an iodized medium with subsequent production of food products, such as vegetable milk, is proved. The organoleptic, physico-chemical parameters of the milk obtained, as well as vitamin and amino acid compositions that increase the nutritional and biological value of the product were studied, the safety indicators were analyzed and meet the requirements for use in food systems. In the course of the work carried out, we obtained a product with a balanced composition of nutrients for the human body. These developments open up prospects for the creation of functional products for functional purposes with a bioavailable form of iodine.

scholarly journals Anti-Idiotypic Agonistic Antibodies: Candidates for the Role of Universal Remedy

Antibodies ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 19 ◽  
Author(s):  
Aliya K. Stanova ◽  
Varvara A. Ryabkova ◽  
Sergei V. Tillib ◽  
Vladimir J. Utekhin ◽  
Leonid P. Churilov ◽  
...  
Keyword(s):  
Immune System ◽  
The Body ◽  
Biologically Active ◽  
Medical Applications ◽  
Cell Functions ◽  
Treatment And Prevention ◽  
Biologic Activity ◽  
Structural And Functional Properties ◽  
New Treatments

Anti-idiotypic antibodies (anti-IDs) were discovered at the very beginning of the 20th century and have attracted attention of researchers for many years. Nowadays, there are five known types of anti-IDs: α, β, γ, ε, and δ. Due to the ability of internal-image anti-IDs to compete with an antigen for binding to antibody and to alter the biologic activity of an antigen, anti-IDs have become a target in the search for new treatments of autoimmune illnesses, cancer, and some other diseases. In this review, we summarize the data about anti-IDs that mimic the structural and functional properties of some bioregulators (autacoids, neurotransmitters, hormones, xenobiotics, and drugs) and evaluate their possible medical applications. The immune system is potentially able to reproduce or at least alter the effects of any biologically active endogenous or exogenous immunogenic agent via the anti-idiotypic principle, and probably regulates a broad spectrum of cell functions in the body, being a kind of universal remedy or immunacea, by analogy to the legendary ancient goddess of universal healing Panacea (Πανάκεια, Panakeia in Greek) in the treatment and prevention of diseases, possibly including non-infectious somatic and even hereditary ones.

scholarly journals The logit model as a way of integral assessment of oxidative stress induced by mechanical eye injury

2021 ◽  
Vol 273 ◽  
pp. 12029
Author(s):  
Olga Pavlova ◽  
Olga Gulenko ◽  
Konstantin Krupin ◽  
Victor Leonov ◽  
Svetlana Palevskaya
Keyword(s):  
Oxidative Stress ◽  
Practical Interest ◽  
Resistance Mechanisms ◽  
The Body ◽  
Biologically Active ◽  
Regression Equations ◽  
Eye Injury ◽  
Muscle Tissues ◽  
Integral Assessment ◽  
Radical Processes

The eyes are exposed to aggressive environmental influences. The blood-ophthalmic barrier is one of the resistance mechanisms serving to protect the body. Mechanical eye trauma violates the integrity of the hematoophthalmic barrier and induces oxidative stress on the background of general inflammatory process with cellular structures disturbances. The aim of our study was to investigate the peculiarities of free radical processes and antioxidant protection of the organism under induced oxidative stress by mechanical eye injury. The experiment was conducted on males of six months of age in an amount of 150. In blood, liver, brain, heart and skeletal muscle tissues we studied the state of enzyme indicators of oxidative stress in the dynamics in intact animals and in rats with violation of the blood-ophthalmic barrier by mechanical eye injury and different types of therapy. Based on the data obtained, we performed an integral assessment of oxidative homeostasis in injured animals using a logistic model. The resulting logistic regression equations allow modifying the redox processes in the body by applying biologically active compounds as additional therapy, but are of more fundamental than practical interest, as they illustrate the interrelationships of lipid peroxidation-antioxidant system enzymes in the tissues under study.

scholarly journals Boosting the immune system with antioxidants: where are we now?

2019 ◽  
Vol 41 (1) ◽  
pp. 42-44 ◽  
Author(s):  
Luca Pangrazzi
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Immune System ◽  
System Performance ◽  
Oxygen Radicals ◽  
The Body ◽  
Oxygen Species ◽  
Immune Systems ◽  
Inflammatory Molecules ◽  
Fight Against Cancer

A strong immune system doesn't have to be just a dream. Over the last few decades, several strategies for boosting the immune system have been studied, with the aim of reducing the incidence and severity of infectious diseases. Furthermore, investigations into the possibility of improving the fight against cancer continue. Simple and powerful tools are already in our hands: the antioxidants. As we get older, or when we are particularly stressed, high levels of reactive oxygen species (ROS) accumulate, promoting oxidative stress and inflammation throughout the body. In this situation, normal body functions, in particular the immune systems, are severely impaired by an excess of oxygen radicals and pro-inflammatory molecules. For this reason, blocking the side effects of ROS with antioxidants may help us improve our immune system performance.

MECHANISMS AND FEATURES OF IMMUNE STATUS AND "OXIDATIVE STRESS - ANTIOXIDANT PROTECTION" SYSTEM IN PATIENTS WITH TUBERCULOSIS

2020 ◽  
pp. 16-20
Author(s):  
I. I. Hrek ◽  
Maryna Mykolayivna Kochuieva
Keyword(s):  
Oxidative Stress ◽  
Immune System ◽  
Immune Status ◽  
The Body ◽  
Lymphoid Cells ◽  
Protection System ◽  
Natural Resistance ◽  
Antioxidant Protection ◽  
Humoral Factors ◽  
Antioxidant Protection System

The study of the human immune system state in infection with M. tuberculosis is relevant because the course and outcome of this disease are largely determined by the immune status of the patient. However, 98 % of patients with pulmonary tuberculosis have an immune imbalance. It is known that in the protection against tuberculosis an important role belongs to the body's natural resistance, which is provided by a variety of cellular and humoral factors, physicochemical characteristics of tissues, lymphoid cells, leukocyte and macrophage responses and genetic resistance. When mycobacteria enter the body, polymorphonuclear leukocytes, monocytes and macrophages are the main phagocytic cells. Optimally high level of resistance to the pathogen develops only in the coordinated interaction of T−lymphocytes with macrophages. Studies of cellular immunity and genetic markers have shown that the course of tuberculosis infection is associated with suppression of their functional activity. Immune response deregulation is closely related to oxidative stress, which results from an imbalance between free reactive oxygen species and antioxidant mechanisms, with a higher risk of developing it rather in lungs than other organs. Many studies have presented the results of studying the state of the immune system and the "oxidative stress − antioxidant protection" system in tuberculosis. This is an important component, because the clinical course and outcome of treatment is largely determined by the status of these systems. A number of experts point out that the study of immunological and oxidative parameters in tuberculosis is of a great importance for deciding on the tactics of treatment and the choice of direction of influence on the course of the disease. Key words: M. Tuberculosis, immunity in tuberculosis, oxidative stress, antioxidant protection.

Iron Metabolism in the Human Body and Setting its Hygienic Limits for Drinking Water. Review. Part 2

2020 ◽  
Vol 99 (5) ◽  
pp. 504-508
Author(s):  
Natalija A. Egorova ◽  
N. V. Kanatnikova
Keyword(s):  
Oxidative Stress ◽  
Drinking Water ◽  
Iron Overload ◽  
Iron Metabolism ◽  
Subcutaneous Tissue ◽  
Allergic Diseases ◽  
The Body ◽  
Urogenital System ◽  
High Iron Content ◽  
Labile Iron Pool

Iron is an assential element for the growth, division, differentiation and functioning of any cell in the body. Iron is virtually important for human and danger at the same time, because with excessive accumulation it causes oxidative stress with formation of highly active oxygen radicals and reactive form of nitrogen that can destroy cell membranes, proteins, nucleic acids, reduce cell viability, with, according to modern concepts, can contribute to the development of many diseases (cardiovascular, rheumatic, gastrointestinal, neurodegenerative, oncological, metabolic and others), and also accelerate the aging process. Part 1 of this review discussed the issues of iron metabolism in human, including its regulation at the cellular and systemic levels, the intake, transport, use, accumulation and export of iron in cells, the role of the labile iron pool in the cytoplasm of cells and plasma non-transferrin bound iron. Data are provided on the causes, frequency and significance of iron overload in the formation of free radicals and the development of oxidative stress. Part 2 of the review provides information on diseases associated with iron overload as well as information on ferroptosis - a new type of iron-dependent regulated cell death. Attention is paid to the works of domestic authors, where it was found that prolonged use of drinking water with a high iron content is unfavorable for the population and leads to an increase in the overall incidence, the development of the diseases of the blood, skin and subcutaneous tissue, musculoskeletal system, digestive system, urogenital system, and allergic diseases. Separate publications are cited on the possibility of a negative effect of iron at concentrations in water of 0.3 mg/l and lower. The material of the review emphasizes the preventive significance of caution attitude to regulating iron in the water in the Russian Federation, where 1/3 of the population uses iron-containing water for drinking, and substantiate the feasibility of establishing a hygienic limit for iron in water not higher than 0.3 mg/l.

Neutral Lipids of Oats Fruit (Avena Sativa L.)

2020 ◽  
Vol 9 (4) ◽  
pp. 40-43
Author(s):  
N. K. Yuldasheva ◽  
S. D. Gusakova ◽  
D. Kh. Nurullaeva ◽  
N. T. Farmanova ◽  
R. P. Zakirova ◽  
...  
Keyword(s):  
Avena Sativa ◽  
Neutral Lipids ◽  
The Body ◽  
Biologically Active ◽  
Absorption Bands ◽  
Vital Functions ◽  
The Republic ◽  
Living Organisms ◽  
Main Components ◽  
Active Substances

Introduction. Lipids are a widespread group of biologically active substances in nature, making up the bulk of the organic substances of all living organisms. They accumulate in plants in seeds, as well as in fruits and perform a number of vital functions: they are the main components of cell membranes and the energy reserve for the body.Aim. Study of neutral lipids of sown oats (Avena sativa L.).Materials and methods. The objects of the study were fruits (grains) of oats of the sown variety "Tashkent 1," harvested in the Republic of Uzbekistan. Results and discussions. Neutral lipids of oat grains have been found to contain 13 fatty acids with a predominance of the sum of oleic, linolenic and linoleic acids. The total degree of unsaturation was almost 78%. Absorption bands characteristic of these substances were observed in the IR spectrum of MEGC.Conclusion. According to the results of the NL analysis, oat grains consisted of triacylglycerides and free LCDs, which were accompanied by hydrocarbons, phytosterols, triterpenoids and tocopherols.

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