Development of a functional product for the prevention of iodine deficiency

Author(s):  
L. V. Antipova ◽  
A. O. Daryin

Iodine belongs to the most important elements that are responsible for the full working condition of the body. Iodine deficiency is a very acute problem, its elimination is an important task of the world communities, reflected in the Doctrine of Food security of the Russian Federation, regional target programs of Russia. In the modern world, the proposed measure for the prevention of iodine deficiency is the consumption of iodized salt and some foods containing an inorganic form of iodine, or the use of a variety of biologically active additives. However, according to the observed statistics of diseases that are associated with a lack of iodine, the presented measures are not very effective. The article presents studies of the process of bioconversion of inorganic iodine into organic – bioavailable, capable of reaching the target organ, for example, during the germination of lentil grains in the appropriate nutrient medium. The possibility of obtaining an organic form of iodine from sprouted lentils in an iodized medium with subsequent production of food products, such as vegetable milk, is proved. The organoleptic, physico-chemical parameters of the milk obtained, as well as vitamin and amino acid compositions that increase the nutritional and biological value of the product were studied, the safety indicators were analyzed and meet the requirements for use in food systems. In the course of the work carried out, we obtained a product with a balanced composition of nutrients for the human body. These developments open up prospects for the creation of functional products for functional purposes with a bioavailable form of iodine.

Author(s):  
O.V. Belashova ◽  
◽  
A.V. Zaushintsena ◽  
N.V. Fotina

One of the ways to eliminate population diseases and increase the body is resistance to adverse environmental factors is the systematic use of functional food products enriched with a complex of biologically active substances with a wide range of therapeutic effects. The creation of a new, unique functional dairy product was preceded by long-term comparative biochemical studies of Scutellaria baicalensis Georgi and Scutellaria galericulata L. In the grass and roots, biologically active substances of a phenolic nature, such as baicalin, vogonin, scutellarin, etc., were found useful for medicinal purposes. The use of extracts from the of Scutellaria galericulata L. in the development of a functional product based on sour-milk fractions made it possible to obtain curd mass enriched with the biologically active substance of this plant. The functional product meets the organoleptic, physico-chemical, tasting requirements for new functional products and is recommended for introduction into the diet of different population groups by age and functional activity.


Author(s):  
S. L. Gribanova ◽  
М. О. Sinegovskiy ◽  
S. P. Prisyazhnaya

In the enrichment of fermented milk ice cream with beekeeping products, preference is given to pollen from royal jelly to bee adsorbed on the basis of their high biological value, sufficient raw material availability and low cost. The resulting product with improved structural mechanical properties: an increase in the viscosity and air saturation of the mixture at the stage of its preparation, as well as resistance to melting of the finished product. The product has improved organoleptic characteristics, milky taste, having a delicate honey-floral shade and high biological value. In addition, due to the increased content in the resulting functional product of proteins, fats, carbohydrates, vitamins, amino acids and fatty acids and the consortium of bifidobacteria and lactic acid microorganisms (Bifidobacterium bifidum, Lactobacillus delbruecki subsp. Bulgaricus, Streptococcus thermophilus), there will be, the activity of the cardiovascular system, the gastrointestinal tract, is a preventive, tonic effect on the body, the immune system is stimulated. The influence of the stabilizer on the formation of the structure and consistency of ice cream. With optimal doses of pollen, royal jelly adsorbed and the use of lactic acid microorganisms, the developed product can compensate for the deficiency of biologically active components in the diet for all age and social groups. When organizing and conducting research, a set of generally accepted, standard techniques and research methods, including physicochemical, biochemical and rheological, were used. The technology has been developed, the content of nutrients has been determined, the production method ice cream enriched with beekeeping products – flower pollen and royal jelly adsorbed, has been received a for invention RF Patent No. 2614797


2021 ◽  
Vol 17 (5) ◽  
pp. 448-452
Author(s):  
T.V. Sorokman ◽  
O.V. Makarova

Background. The consequence of iodine deficiency is a decrease in the secretion of thyroid hormones, which adversely affects the immune system with the development of somatic and predisposition to frequent respiratory diseases. The purpose was to investigate the iodine supply of the body of children with recurrent respiratory infections (RRI) by studying the organification and inorganic fractions of iodine in the serum and excretion of iodine in the urine. Materials and methods. The study was conducted by simple sampling, taking into account the characteristics of the clinic course of respiratory disease. Clinical and laboratory and instrumental examination was performed in 60 children aged 3 to 11 years with a diagnosis of RRI. The concentration of iodine in urine, the level of inorganic and organification iodine in the blood were studied. Results. The clinical picture presented with the symptoms of intoxication, fever, and catarrhal symptoms typical of RRI. In children with severe RRI experienced a clear decrease in the iodine level to 57.34 μg/l (p < 0.05) and a decline in the blood content of total iodine and iodine organification by 31.12 and 39.11 % (p < 0.001), respectively. The concentration of inorganic iodine was significantly higher (p < 0.001). Such results indicate a “wrong” subcellular distribution of iodine into fractions in the inflammatory process caused by RRI. The children with detected iodine deficiency demonstrated a more severe course of RRI. There was a moderately negative relationship between the levels of organification and inorganic iodine (r = –0.515; p < 0.05) and a direct relationship between the blood concentrations of total and organification iodine (r = 0.899; p < 0.05). Conclusions. The course of RRI in patients with iodine deficiency is characterized by an increase in the level of inorganic iodine, a decrease in organification iodine and total iodine, the deepening of these changes correlates with the severity of the respiratory disease.


2021 ◽  
Vol 32 ◽  
pp. 04002
Author(s):  
Alexey Yevglevsky ◽  
Andrey Gostev

One of the global, vital problems of humanity is iodine deficiency. According to the World Health Organization (WHO), more than 2 billion people live in conditions of iodine deficiency. people: among them, 740 million have endemic goiter, 43 million have mental retardation, more than 6 million. they suffer from cretinism (an extreme degree of mental retardation). Currently, iodine deficiency diseases are the most common non-infectious diseases in the world. What about mammalian animals? In animals, iodine performs the same functions as in humans. Animals, especially agricultural animals, are just as sensitive to iodine deficiency as humans. With a lack of iodine in the body of animals, the biosynthesis of thyroid hormones is disrupted, which leads to a decrease in the intensity of redox processes, as a result of which all types of metabolism are disrupted:-protein, fat, carbohydrate, macro – and microelement, energy. In this regard, the failure of the thyroid gland is accompanied by the development of severe pathobiochemical processes, which, in the end, leads to the clinical manifestation of pathophysiological conditions. Taking into account the fact that in conditions of constant iodine deficiency it is very problematic to ensure the health of productive animals, the issues of prevention of iodine deficiency conditions are economically significant for industrial animal husbandry. It is no accident that in countries experiencing natural iodine deficiency, state programs have been developed that provide for the use of iodine-containing additives in the diets of productive animals. Despite the fact that the simplest and most affordable method of eliminating iodine deficiency in humans and animals is the inclusion of iodized salt in the diet, however, this method can not be used for veterinary purposes. First of all, the feed method of using biologically active additives eliminates the possibility of dosed therapeutic or preventive treatment. On the pages of this article, we draw attention to the emerging prospects for the use of a new iodine-metabolic composition in non-infectious and infectious pathology, based on an iodine polymer complex known in pharmacology as iodinol and succinic acid.


2020 ◽  
Vol 11 (6) ◽  
pp. 5091-5104 ◽  
Author(s):  
Joscelin T. Diaz ◽  
E. Allen Foegeding ◽  
Mary Ann Lila

Consumers are demanding healthy nutritious foods rich in protein (both plant and animal) and biologically-active phytochemicals from plants, which can help the body to sustain a stronger immune system and fight against oxidative stress.


2020 ◽  
Vol 6 (1) ◽  
pp. 43-55
Author(s):  
A. I. Andriyanov ◽  
E. V. Kravchenko ◽  
S. G. Kuz’min ◽  
L. P. Lazarenko ◽  
O. G. Korosteleva ◽  
...  

At present time, the compliance of energy costs and the chemical composition of foods in the daily diet with physiological needs of the body gains a particular relevance. Particular attention is paid to the use of functional food products - special products intended for systematic use by all age groups of a healthy population. Functional nutrition compensates for the deficiency of essential amino acids, polyunsaturated fatty acids (PUFA), vitamins, macro- and microelements, etc., as well as protects the body from the effects of pesticides and herbicides, antibiotics, dyes and preservatives, widely used in conventional products, and is used to strengthen health and prevent diseases caused by deficiencies in traditional nutrition. Such diseases include: obesity, non-insulin-dependent diabetes mellitus, hypertension, atherosclerosis, mental depression and others. In some professional groups, for example, in military athletes, the use of functional foods has been practiced for a long time. Currently, a fairly wide range of this group of products has been developed and is being produced. When developing a functional product, environmentally friendly raw materials of animal and vegetable origin, biologically active additives that improve functional and consumer qualities should be used. The high content of amino acids, proteins, carbohydrates, minerals, vitamins and other necessary biologically active substances, as well as good organoleptic characteristics and high consumer properties justify the feasibility of including functional products in the diet of military personnel, whose professional activity is characterized by high physical activity, requiring maximum use of functional resources organism. At the same time, military personnel are capable of completing official tasks at the limit of their physical capabilities, while maintaining relatively constant biochemical constants of the internal environment of the body. The information presented in the paper will be useful to the logistics and medical service specialists of the Russian Army and Navy and will serve as the basis for further development of the direction for the use of functional products for feeding military personnel.


Author(s):  
D. Ya. Dalievska ◽  
O. S. Pokotylo

Iodine is a natural trace element that is necessary for the human body. The function of iodine in the human body is the synthesis of thyroid hormones. Iodine deficiency has many negative consequences for the human body. Iodine deficiency is especially dangerous for pregnant women and children. Insufficient iodine in pregnant women increases the risk of miscarriage and birth of a child with cognitive impairment. Iodine deficiency in children has the following consequences: delayed physical development, delayed intellectual development, decreased mental activity, drowsiness, lethargy. Expanding food with iodine is a necessary step to overcome the problem of iodine deficiency.The quality of dairy products in Ukraine is very high. Due to the mandatory implementation of the HACCP system, manufacturers are improving equipment and production technologies. Accordingly, the requirements for the quality of raw materials increase in proportion to the competitiveness of the enterprise. That is why it is important to develop dairy products that will be in demand among consumers.Kefir with a biologically active additive “Iodis-concentrate” is a source of the required amount of iodine for the body. Jodis-concentrate is a certified biologically active additive that is widely used in the food industry. It has already found application in water production and the meat industry. The article presents a comparative analysis of changes in titrated acidity and active acidity (pH) in control and experimental samples of kefir during fermentation with the addition of biologically active iodine. The source of iodine was a biologically active additive "Iodis-concentrate". It is shown that the titrated acidity in both samples of kefir – control and experimental – had the same dynamics before growth during fermentation, which indicates no effect of the addition of biologically active iodine on the dynamics of titrated acidity. The same tendency to decrease the active acidity (pH) in control and experimental samples of kefir during fermentation with a difference within the significant error, indicating no effect of adding biologically active iodine to kefir on active acidity (pH).


Author(s):  
Yu. S. Alikin ◽  
M. V. Alekseeva ◽  
V. V. Ermolaev ◽  
V. P. Klimenko ◽  
L. R. Lebedev ◽  
...  

A proposal is being considered for the use of BAS preparations developed in the Institute of medical biotechnology OF the FBU SSC VB «Vector» in the programs of ensuring the country’s security in the field of medicine, veterinary medicine and obtaining environmentally friendly food products. On the basis of biotechnological methods, a technology for obtaining a complex of biologically active preparations of double-stranded and single-stranded RNA from yeast and phages that can provide a solution to the above problems has been created. The» ideology «of the development consisted in a deep study of the EN-Dogen induction of interferons by the organism itself using evolutionarily formed mechanisms. The basis was taken of inter-veronicaceae mechanisms of action of viruses. Such drugs when injected into the human body and animals can act as viruses, inducing the synthesis of interferons and other proteins-cytokines in the body, but unlike viruses, they do not produce destructive effects. Activation of the endogenous cytokine network in this case at the systemic level can form a state of non-specific resistance against viruses, bacteria and their toxins. Injectable and ointment forms of these drugs based on RNA were developed, tested and approved by the Ministry of health of the Russian Federation and the Department of veterinary medicine of the Russian Federation. Introduction of effective methods of application of the developed preparations allows to use them as etiotropic means of emergency prevention and treatment of viral diseases of the person, calves, pigs, carnivores, birds and fishes, correction of immunodeficiency, strengthening of protective properties of vaccines.


2021 ◽  
Vol 100 (9) ◽  
pp. 980-984
Author(s):  
Irina V. Bereznyak ◽  
Leonora I. Lipkina ◽  
Nataliya E. Fedorova ◽  
Natalia G. Zavolokina ◽  
Natalia I. Nikolayeva

The basis of safety for working with chemicals, including pesticides, is to minimize contact with them and prevent them from entering the body by inhalation and dermal route, sometimes in actual production conditions, the skin pathway can be more dangerous. The most studied inhalation route of harmful substances entering the body of a working person is confirmed by an extensive evidence base, the presence of regulatory and methodological documents, experimentally established and approved MPC in the air of the occupational area for 2484 substances, and 601 substances included in SanPiN 1.2.3685-211. The maximum permissible levels (MPL) on the skin are presented for only 26 substances in the same document. Identification and evaluation of the skin-resorptive effect of xenobiotics have methodological features due to the properties of the skin, which performs a barrier-protective function, and the physico-chemical, toxic properties of substances. The main stages of development in the domestic hygienic science and practice of research on the study and assessment of the skin-resorptive effect of xenobiotics in industrial contact with them are presented. The continuity of research on the study and evaluation of the skin-resorptive impact of chemicals used in various industries and agriculture is shown, making it possible to develop methodological approaches to the identification and risk assessment of dermal absorption of xenobiotics, including pesticides, within the organisms of workers. Evaluating the risk of skin contamination is the main argument for the development of measures for the primary prevention of skin resorptive action. Establishing the priority of the dermal route of toxicant intake is an evidence-based justification for making decisions about the possibility of using, for example, pesticides on the territory of the Russian Federation. The literature review is based on open sources hosted on virtual database platforms: Scopus, Web of Science, MedLine, Global Health, e-LIBRARY, Electronic Fund of Legal and Regulatory Documents, etc.


2016 ◽  
Vol 18 (3(71)) ◽  
pp. 174-177
Author(s):  
T.V. Farionik

Iodine deficiency in the biosphere, mainly in the soil, leading to the development of endemic goiter and other iodine deficiency disorders. As shown by numerous studies of this disease tend to over 1 billion world population. Endemic goiter and much of the territory of Ukraine, including the Vinnitsa region. Presented current research study of recipes and technologies on system cooked sausages.Currently boiled sausage enjoys fairly high demand among the population, due to the fact that a large for most of the population gives it an advantage.Innovation activity represents one of the most effective directions.It should facilitate the development of innovative activity that promotes penetration into new markets, growth in production.Today the most important and effective innovative organizational and technical measures introduced in sausage production can be considered are:–The use of new recipes for manufacturing products;– Installation of new equipment, which can significantly reduce the cost of manual labor and power inputs, and improve product quality and reduce the share of marriage. Sausage production is seen as thermochemical method of preserving meat products. For each type of sausages set a production process approved technological instructions and recipes.Strict adherence to recipes and technological instructions and sanitary regime over the course of the process is a prerequisite for obtaining high–quality sausages.Crucial in the production of sausages is raw. The main raw materials are beef and pork. Occasionally use lamb, horsemeat.Equally important is the creation of a new generation of products that have general strengthening and preventive action. The components of these products can protect the body from the harmful effects of the environment and the emergence in the human diseased cells. The constant lack of iodine leads, first, to reduce the synthesis and secretion of primary thyroid hormone – thyroxine. The role of thyroid hormones in the body is extremely high, most of the vital functions performed by their participation. The main physiological effects of thyroid hormone is to stimulate synthesis, growth, development and differentiation of tissues.Developed products to include microorganisms that can synthesize biologically active structures (antibodies, receptors, hormones) that contribute to the removal or destruction of harmful decay and systems, thereby prevents human disease. 


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