KCl-CaCO3 nanoclusters armored with Pt Nanocrystals for Enhanced Electro-driven Tumor Inhibition

AbstractGas breakdown in the millimetre-wave frequency band is an interesting phenomenon in nonlinear dynamics such as self-organized structure formation. We observed the transition between two types of filamentary plasma arrays in air discharge driven by a 303-GHz millimetre wave. Plasma is ignited at a parabolic mirror’s focal point in the overcritical condition. One array parallel to the electric field vector appears with a spacing of λ/4 at the focal point. Filaments then separate into plasma lumps ~10 μs after ignition. At 20 μs, a new comb-shaped array grows in the subcritical condition. Filaments are parallel to the incident beam with spacing of 0.96 λ and elongate towards the incident beam. This comb-shaped array appears only in the electric field plane; bulk plasma with a sharp vertex forms in the magnetic field plane. This array is created by a standing wave structure generated by waves diffracted from the plasma surface. Filamentary plasma array formations can influence the energy absorption by the plasma, which is important for engineering applications such as beamed energy propulsion.

Download Full-text

A Low Dose of Hydrous Icaritin Nano-Formulation with Remarkable Efficacy and Tumor Targeting in Cancer Therapy

Journal of Biomedical Nanotechnology ◽

10.1166/jbn.2021.3176 ◽

2021 ◽

Vol 17 (10) ◽

pp. 2003-2013

Author(s):

Jingxin Fu ◽

Yian Wang ◽

Haowen Li ◽

Likang Lu ◽

Hui Ao ◽

...

Keyword(s):

Cancer Therapy ◽

Tumor Targeting ◽

Low Dose ◽

Drug Loading ◽

Tumor Therapy ◽

High Dose ◽

Inhibition Rate ◽

Tumor Inhibition ◽

Nano Formulation ◽

Tumor Inhibition Rate

Background: The use of chemotherapeutic drugs is restricted in the tumor-therapy because of the severely toxic and side effects among most important factors. The active herbal extracts are always used as a high dose while in the tumortherapy to achieve good anti-tumor effects. Hydrous icaritin has a high activity while there are few existing dosage forms as a result of low solubility in water and poor bioavailability. Results: The prepared hydrous icaritin nanorods (DP-HICT NRs) using mPEG2000-DSPE as a stabilizer, presented a narrow distribution of particle size with of 217 nm and a properly high drug-loading content of approximately 65.3±1.5%. A low dose of hydrous icaritin nano-formulation shows remarkable efficacy in cancer therapy (tumor inhibition rate: 61.36±10.80%) compared with the same dose of Paclitaxel injection (tumor inhibition rate: 66.80±4.43%), which approved as medicaments. Not only that, DP-HICT NRs can escape the clearance of the immune system and enhance targeting ability to the tumor site with only one excipient and such a low dose. Conclusions: This kind of nanoparticles contain a low dose of HICT used mPEG2000-DSPE as a stabilizer, while can achieve good tumor targeting as some active targeting agents and an anti-tumor effect as the PTX injection. There are broad prospects in drug safety, anti-tumor efficacy and even prognosis.

Download Full-text

SCIENTIFIC AND THEORETICAL VALIDATION OF DEVELOPMENT OF PERSONALIZED ANTI-CANCER CELL PREPARATION ONTHE BASES OF CLINICAL ONCOPROTEOMICS TECHNOLOGY

Clinical Practice ◽

10.17816/clinpract5144-60 ◽

2014 ◽

Vol 5 (1) ◽

pp. 44-60

Author(s):

I S Bryukhovetskiy ◽

A S Bryukhovetskiy

Keyword(s):

Stem Cell ◽

Cancer Stem Cell ◽

Information Structure ◽

Malignant Tumors ◽

Tumor Therapy ◽

Malignant Neoplasms ◽

Alternative Approach ◽

Anti Cancer ◽

Main Target ◽

A Cell

In the article the authors present analysis of current conventional methodological and technological approaches to contemporary therapy of cancer and certain malignant neoplasms. Based upon the revision of available concepts of clinical oncology, the scientific and theoretical validation of novel approaches to the development of innovative technologies of proteomebased regulatory tumor therapy was attempted. The authors defined their original viewpoint on the development of the preparations for personalized therapy of cancer and proposed a new methodology and alternative approach to the malignant tumors therapy when a cancer stem cell becomes the main target of anticancer therapy. The authors showed that proteome of a cancer stem cell is the most stable information structure of a cell and can be perceived as the main therapeutic target.

Download Full-text

Improving Tumoral Acidic pH-Responsive Drug Efficiency Based on GO@Au Nanocomposite

10.21203/rs.3.rs-57457/v1 ◽

2020 ◽

Author(s):

Mingqing Tang ◽

Pengliang Xin ◽

Hongjun Lin ◽

Huangen Li

Keyword(s):

Drug Delivery ◽

Controlled Release ◽

Tumor Cells ◽

Drug Delivery System ◽

Delivery System ◽

Near Infrared ◽

Tumor Therapy ◽

Infrared Light ◽

Tumor Inhibition ◽

Release Drug

Abstract Background: to accurately deliver drugs to the lesion site and realize its timed and quantitative release is the focus of tumor therapy. In this paper, a tumor targeted near-infrared light controlled release drug delivery system integrating hyperthermia and chemotherapy was successfully constructed by combining tumor hyperthermia and chemotherapy. Results: by hydrothermal method, Au nanoparticles were firstly loaded onto the GO surface to obtain GO@Au nanocomposites, then PEG was loaded onto the GO@Au by pH sensitive hydrazone bond to obtain GO@Au-PEG, and DOX is finally loaded onto the GO surface via π-π stacking. The target controlled release drug delivery system showed good tumor targeting property, can be the efficient transfer of drug to the tumor cells, and the tumor cells in near-infrared light control of DOX release. In vivo tumor inhibition experiments in mice, the targeted drug delivery system showed obvious tumor inhibition characteristics and had good effects of hyperthermia and chemotherapy. Conclusions: therefore, this tumor targeted near-infrared controlled release drug delivery system has great potential in tumor therapy.

Download Full-text

Resistive Memory Utilizing Ferritin Protein with Nano Particle

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.470.92 ◽

2011 ◽

Vol 470 ◽

pp. 92-97 ◽

Cited By ~ 1

Author(s):

Mutsunori Uenuma ◽

Kentaro Kawano ◽

Bin Zheng ◽

Masahiro Horita ◽

Shigeo Yoshii ◽

...

Keyword(s):

Electric Field ◽

Pt Nanoparticles ◽

Memory Cell ◽

Switching Behavior ◽

Stable Operation ◽

Nano Particle ◽

Resistive Memory ◽

Conductive Path ◽

Power Operation ◽

State Resistance

This study reports on the controlled single conductive path in ReRAM formed by embedding Pt nanoparticles (Pt NPs) in NiO film. Homogenous Pt NPs produced and placed by ferritin protein produce electric field convergence which leads to the controlled conductive path formation. The ReRAM with Pt NPs shows stable switching behavior. A Pt NP density decrease results in an increase of OFF state resistance and decrease of forming voltage, whereas ON resistance was independent from the Pt NP density, which indicates that a single metal NP in a memory cell will achieve extremely high-on/off resistance ratio, low power operation and stable operation.

Download Full-text

An Alternative Approach to Solutions of the MGECSC Potential in Presence of External Electric Field

Advances in High Energy Physics ◽

10.1155/2015/807417 ◽

2015 ◽

Vol 2015 ◽

pp. 1-9

Author(s):

M. K. Bahar

Keyword(s):

Schrödinger Equation ◽

Electric Field ◽

External Electric Field ◽

Schrodinger Equation ◽

Mathematical Structure ◽

Wave Functions ◽

Electric Field Effect ◽

Electric Field Effects ◽

Alternative Approach ◽

First Time

For the first time the Schrödinger equation with more general exponential cosine screened Coulomb potential in the presence of external electric field is solved approximately and analytically by applying an ansatz to eigenfunction of corresponding Hamiltonian and then energy values and wave functions are obtained. Since this potential turns into four different potential cases when considering different cases of the parameters in the potential, energies and eigenfunctions for these four different potentials are already to be found by solving Schrödinger equation with MGECSC potential. Energy values and wave functions obtained by using different values of potential parameters for each of these four different potential are compared with the results of other studies. Since the obtained general solutions in this study have been found in the presence of external electric field, the external electric field effects on systems with the mentioned four different potentials are also easily investigated. One of advantages of the present results and method is that if external electric field is equal to zero, general mathematical structure of corresponding equations does not change and then electric field effect can be eliminated. The presence or absence of electric field does not prevent solving the Schrödinger equation analytically.

Download Full-text

Cytokine gene transfer in tumor inhibition and tumor therapy: where are we now?

Immunology Today ◽

10.1016/0167-5699(94)90131-7 ◽

1994 ◽

Vol 15 (2) ◽

pp. 48-51 ◽

Cited By ~ 176

Author(s):

Mario P. Colombo ◽

Guido Forni

Keyword(s):

Gene Transfer ◽

Tumor Therapy ◽

Cytokine Gene ◽

Tumor Inhibition

Download Full-text

Comparing two different descriptions of the I-V characteristic of graphene: theory and experiment

EPJ Web of Conferences ◽

10.1051/epjconf/201920406008 ◽

2019 ◽

Vol 204 ◽

pp. 06008 ◽

Cited By ~ 3

Author(s):

Anatolii Panferov ◽

Stanislav Smolyansky ◽

David Blaschke ◽

Narine Gevorgyan

Keyword(s):

Electric Field ◽

Strong Field ◽

Constant Electric Field ◽

Detailed Comparison ◽

Effective Lifetime ◽

Klein Tunneling ◽

Alternative Approach ◽

Static Conditions ◽

Ballistic Conductivity ◽

Good Coincidence

The formalism of the nonperturbative description of transport phenomena in graphene in the framework of the quantum kinetic equation for the Schwinger-like process is compared with the description on the basis of Zener- Klein tunneling. The regime of ballistic conductivity in a constant electric field is considered. In the latter case the interaction of carriers with electric field is described in terms of the spatial dependence of their potential energy (x-representation). The presented kinetic formalism uses an alternative method of describing the interaction with a field through the introduction of a quasimomentum P = p – (e/c)A(t), where A(t) is the vector potential (t-representation). Both approaches should lead to the same physical characteristics of the described process. The measurement of the current in experiments is realized in static conditions determined by the potential difference between the electrodes and the distance between them. These parameters are native for the x-representation. On the contrary, in the approach based on the t-representation it is necessary to consider the situation in dynamics and introduce the effective lifetime of the generated carriers. In the ballistic regime this time depends on the distance between the electrodes. We give a detailed comparison of these two descriptions of the current and demonstrate a good coincidence with the experimental data of the alternative approach based on the t-representation. It provides a reliable foundation for the application of nonperturbative methods adopted from strong field QED, that allows one to include in the consideration more general models of the field (arbitrary polarization and time dependence) and extend the scope of the theory.

Download Full-text