Disaggregated control of blood vessels over platelets in milk piglets

The important element in the functioning of hemostasis in the body of a piglet is platelet aggregation activity. The degree of its severity in piglets largely controls the functional state of primary hemostasis and the severity of microcirculation in their tissues, determining the formation of many functional mechanisms. The aggregation activity of platelets in early ontogenesis significantly determines the growth and development of the animal in the future and ultimately the level of its productivity. The examination of 36 healthy piglets of milk nutrition showed a decrease in the content of peroxidation products in their blood as a result of increased activity of their antioxidant potential in plasma. This led to their weak platelet alteration, contributing to their optimal aggregation activity. In piglets during the phase of milk feeding, a gradual increase in the aggregation properties of platelets is noted, regulating blood flow in vessels of the smallest caliber.

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Изменение функциональной активности тромбоцитов при длительном световом воздействии в эксперименте

Оптика и спектроскопия ◽

10.21883/os.2021.06.50981.11-21 ◽

2021 ◽

Vol 129 (6) ◽

pp. 711

Author(s):

О.В. Злобина ◽

В.Ф. Киричук ◽

С.С. Пахомий ◽

А.Н. Иванов ◽

А.Ю. Каретникова ◽

...

Keyword(s):

Platelet Aggregation ◽

Light Exposure ◽

White Male ◽

The Body ◽

Male Rats ◽

Light Transmittance ◽

Laboratory Animals ◽

Transmittance Curve ◽

Microcirculatory Disturbances ◽

Aggregation Activity

We studied the effect of intensive light exposure on the aggregation activity of white male rats' platelets using the experimental Light-Dark (18:6) lighting model. Analysis of platelet aggregation activity was carried out using a computerized 230LA "Biola" aggregation analyzer using the method of V.A. Gabbasov. It was established that in case of prolonged light exposure in the body of laboratory animals there was a disturbance of aggregation activity accompanied by an increase in the parameters of the curve of the average weighted radius of platelets and the parameters of the light transmittance curve. Violation of the daytime regime in the form of artificial prolongation of illumination causes increase of platelet aggregation activity and provokes development of microcirculatory disturbances. Forming changes in the hemostasis system increase in proportion to the duration of the experiment. The most pronounced changes in the vascular-platelet mechanism of hemostasis are formed on the 21st day of the experiment, indicating the development of processes of maladaptation followed by exhaustion of the organism.

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Effect of Rheology of Blood and Haemostasis of the Cows on the Viability of the Offspring and Reproduction

Bulletin of Sumy National Agrarian University. The series: Veterinary Medicine ◽

10.32845/bsnau.vet.2021.1.1 ◽

2021 ◽

pp. 3-11

Author(s):

Марія Камбур ◽

Андрій Замазій ◽

Олександр Нечипоренко ◽

Олександр Калашник ◽

Денис Матвуйчук ◽

...

Keyword(s):

Body Weight ◽

Growth And Development ◽

Reproductive Function ◽

The Body ◽

Viscosity Reduction ◽

Animal Blood ◽

The Third ◽

Service Period ◽

The Given ◽

Increased Activity

The Results of the studies indicate that in 45.44% of cows-the initial duration of the third period of genera was more than 9 hours, and in cows of the second - third lactation only in 27.28% of animals. Morphometry indicators of a body mass of newborns calves and placenta show the conditions of growth and development of fetal, which are connected with functional activity of the feto-placental complex and on average, the body weight of the calves of the first subgroups (animals derived from cows with the duration of the third period of genera up to six hours) proved by20.80%-21.20% more than the calves of the fourth subgroups. Below the mass proved and placenta of calves, fourth subgroups (in 1.25 by Times – 1.18 by Times, (P < 0.05), compared to this indicator of the first subgroups of calves. Increased activity of the factors of hemostasis and rheology of blood is set in animals in which the duration of time of the third period of genera was up to 12 and more hours. Under these conditions, the viscosity of animal blood in 1.39-1.40 by Times, (P < 0.05) and 1.30-1.40 by times (P < 0.05), the content of Fibrinogen in 2,47-2,04 by Times<0.01). The given data indirectly indicate the increase of blood viscosity, reduction of its blood flow, especially in the capillary system vessels. In our opinion, this is the cause of the birth of animals with low viability as evidenced by the coefficients of the catabolism factor, oxygenic homeostasis, samples of Mack Klur Aldrich, "immature" surfactant system. Recovery of the reproductive function of cows after calving and duration service period in animals of the first subgroups was in 1.17 – 1.14 by times shorter than in cows of the fourth subgroups

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The Inhibition of Platelet Aggregation by an Aorta Intima Extract

Thrombosis and Haemostasis ◽

10.1055/s-0038-1647710 ◽

1974 ◽

Vol 32 (02/03) ◽

pp. 417-431 ◽

Cited By ~ 14

Author(s):

A. du P Heyns ◽

D. J van den Berg ◽

G. M Potgieter ◽

F. P Retief

Keyword(s):

Platelet Aggregation ◽

Degradation Products ◽

Adenosine Diphosphate ◽

Inhibitory Effect ◽

Protective Role ◽

Vascular Trauma ◽

Wear And Tear ◽

Sequential Addition ◽

Aggregation Activity

SummaryThe platelet aggregating activity of extracts of different layers of the arterial wall was compared to that of Achilles tendon. Arterial media and tendon extracts, adjusted to equivalent protein content as an index of concentration, aggregated platelets to the same extent but an arterial intima extract did not aggregate platelets. Platelet aggregation induced by collagen could be inhibited by mixing with intima extract, but only to a maximum of about 80%. Pre-mixing adenosine diphosphate (ADP) with intima extracts diminished the platelet aggregation activity of the ADP. Depending on the relationship between ADP and intima extract concentrations aggregating activity could either be completely inhibited or inhibition abolished. Incubation of ADP with intima extract and subsequent separation of degradation products by paper chromatography, demonstrated a time-dependent breakdown of ADP with AMP, adenosine, inosine and hypoxanthine as metabolic products; ADP removal was complete. Collagen, thrombin and adrenaline aggregate platelets mainly by endogenous ADP of the release reaction. Results of experiments comparing inhibition of aggregation caused by premixing aggregating agent with intima extract, before exposure to platelets, and the sequential addition of first the intima extract and then aggregating agent to platelets, suggest that the inhibitory effect of intima extract results from ADP breakdown. It is suggested that this ADP degradation by intima extract may play a protective role in vivo by limiting the size of platelet aggregates forming at the site of minimal “wear and tear” vascular trauma.

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COMPARISON OF ANTIHYPERTENSIVE EFFECT OF MOXONIDINE VERSUS CLONIDINE IN RENAL FAILURE PATIENTS.

Journal of Drug Discovery and Therapeutics ◽

10.32553/jddt.v6i9.440 ◽

2018 ◽

Vol 6 (9) ◽

Author(s):

DR.MATHEW GEORGE ◽

DR.LINCY JOSEPH ◽

MRS.DEEPTHI MATHEW ◽

ALISHA MARIA SHAJI ◽

BIJI JOSEPH ◽

...

Keyword(s):

Blood Pressure ◽

Renal Failure ◽

Blood Flow ◽

Blood Vessel ◽

Blood Vessels ◽

High Blood Pressure ◽

Antihypertensive Effect ◽

The Body ◽

Ability To Work ◽

Blood Flows

Blood pressure is the force of blood pushing against blood vessel walls as the heart pumps out blood, and high blood pressure, also called hypertension, is an increase in the amount of force that blood places on blood vessels as it moves through the body. Factors that can increase this force include higher blood volume due to extra fluid in the blood and blood vessels that are narrow, stiff, or clogged(1). High blood pressure can damage blood vessels in the kidneys, reducing their ability to work properly. When the force of blood flow is high, blood vessels stretch so blood flows more easily. Eventually, this stretching scars and weakens blood vessels throughout the body, including those in the kidneys.

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Assessment of the Biochemical Status of Workers Manufacturing Ethylbenzene and Styrene

ЗДОРОВЬЕ НАСЕЛЕНИЯ И СРЕДА ОБИТАНИЯ - ЗНиСО / PUBLIC HEALTH AND LIFE ENVIRONMENT ◽

10.35627/2219-5238/2020-327-6-40-43 ◽

2020 ◽

pp. 40-43

Author(s):

RR Galimova ◽

ET Valeeva ◽

GV Timasheva ◽

AB Bakirov

Keyword(s):

Catalase Activity ◽

Free Radical Oxidation ◽

The Body ◽

Atherogenic Index ◽

Radical Oxidation ◽

Professional Groups ◽

Biochemical Status ◽

The Central Nervous System ◽

Hepatic Protein Synthesis ◽

Increased Activity

Introduction: Production of ethylbenzene and styrene (EBS) is one of the most important stages in organic synthesis. The products have general toxic, hepatotoxic, irritating and narcotic effects on the human body. Severe exposures to EВS can induce pronounced disorders of the central nervous system such as styrene sickness and encephalopathy and of peripheral blood such as leukopenia and lymphocytosis. Materials and methods: We studied homeostasis indices in 376 workers of the main professional groups engaged in the production of EBS including equipment operators, repairmen, and instrumentation and automation fitters. Results: We established an increase in lipid peroxidation by the level of malondialdehyde amid an increase in catalase activity and a decrease in blood retinol and α-tocopherol levels. We also noted an increased activity of indicator enzymes including ALT, AST, GGT, and alkaline phosphatase. Significant changes in lipid metabolism in the form of cholesterolemia, triglyceridemia, a higher atherogenic index, and lower cholesterol of non-atherogenic blood serum lipids demonstrating atherogenic changes in the body were revealed. Conclusions: The earliest prenosological disorders in the body of the examined workers included an impaired hepatic protein synthesis, the development of cytolysis processes and a change in the integrity and functional activity of the liver cell in individuals, an imbalance in the oxidant-antioxidant system, one of the reasons of which was the adverse occupational exposure to hazardous chemicals. An increase in catalase activity is a protective compensatory reaction during the activation of free radical oxidation processes.

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Melatonin Modulates Lactation by Regulating Prolactin Secretion Via Tuberoinfundibular Dopaminergic Neurons in the Hypothalamus- Pituitary System

Current Protein and Peptide Science ◽

10.2174/1389203721666200511093733 ◽

2020 ◽

Vol 21 (8) ◽

pp. 744-750 ◽

Cited By ~ 1

Author(s):

Hongyang Li ◽

JingyaWei ◽

Fengtao Ma ◽

Qiang Shan ◽

Duo Gao ◽

...

Keyword(s):

Pineal Gland ◽

Pituitary Gland ◽

Antioxidant Capacity ◽

Dopaminergic Neurons ◽

Growth And Development ◽

Endocrine System ◽

Mammary Glands ◽

Prolactin Secretion ◽

The Body ◽

Stimulation Of

In-depth studies have identified many hormones important for controlling mammary growth and maintaining lactation. One of these is melatonin, which is synthesized and secreted by the pineal gland to regulate circadian rhythms, improve antioxidant capacity, and enhance immunity. Prolactin is secreted by the pituitary gland and is associated with the growth and development of mammary glands as well as initiation and maintenance of lactation. The hypothalamus-pituitary system, the most important endocrine system in the body, regulates prolactin secretion mainly through dopamine released from tuberoinfundibular dopaminergic neurons. This review provides a reference for further study and describes the regulation of lactation and prolactin secretion by melatonin, primarily via the protection and stimulation of tuberoinfundibular dopaminergic neurons.

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Review of Curd, Paneer and Cheese as Nitya Asevaniya Ahara Dravya w.s.r. to Dadhi, Kilat and Kurchika

Journal of Ayurveda and Integrated Medical Sciences (JAIMS) ◽

10.21760/jaims.v2i1.7514 ◽

2017 ◽

Vol 2 (1) ◽

Author(s):

Saylee Deshmukh ◽

Vyas M. K.

Keyword(s):

Vitamin A ◽

Growth And Development ◽

Milk Protein ◽

The Body ◽

Rich Source ◽

Food Items ◽

Common Food ◽

Daily Diet ◽

Healthy Growth

Curd, Paneer and Cheese are rich source of milk protein, calcium, Vitamin A, Phosphorous, vitamins, minerals and protein which are required by the body in high proportions for healthy growth and development. It is common food in India. Cheese is also a rich source of fat. Curd, Paneer and Cheese can be correlated with Dadhi, Paneer and Cheese in Ayurveda classics which are listed in Nitya Asevaniya Ahara Dravya (food items not to be taken in daily diet). Present study aims to explain rationale behind description of these food items as Nitya Asevaniya Ahara Dravya.

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EFFECT OF DDAVP ON PRIMARY HEMOSTASIS WITH CONGENITAL AFIBRINOGENEMIA

10.1055/s-0038-1644129 ◽

1987 ◽

Author(s):

M Taki ◽

M Inagaki ◽

T Miura ◽

N Saito ◽

T Meguro ◽

...

Keyword(s):

Platelet Aggregation ◽

Retention Rate ◽

Platelet Membrane ◽

Bleeding Tendency ◽

Primary Hemostasis ◽

Prolonged Bleeding Time ◽

Before And After ◽

Congenital Afibrinogenemia ◽

Von Willebrand ◽

Platelet Functions

It has been reported recently that DDAVP might be an useful tool in the therapy and prevention of bleeding in patients with congenital afibrinogenemia (CA).To study the mechanism of its efficacy, changes in the platelet functions of a patient with CA were examined prior to, and one hour after, the infusion of DDAVP (0.4 μg/Kg). A patient with Glanzmann's thrombasthenia (GT) was also examined, to allow a study of the role of platelet membrane glycoprotein IIb/IIIa (GP IIb/IIIa), a deficient platelet in GT, in the resulting effects of the drug. When both patients were infused with DDAVP, the level of plasma von Willebrand factor (vWF) increased two- to fourfold, accompanied by an enhancement of ristocetin-induced platelet agglutination. The level of plasma fibrinogen was never changed.The prolonged bleeding time observed was markedly improved only in the CA patient, remaining unchanged in the GT patient, after the infusion of DDAVP. This indicates that DDAVP is effective in diminishing the bleeding tendency in CA, but not in GT. Among the platelet functions tested, only the platelet retention rate on glass beads, ADP-induced platelet aggregation and collagen-induced platelet aggregation improved in CA, each remaining unchanged in GT. In particular, collagen-induced platelet aggregation was markedly improved in the CA patient. However, the platelet adhesion to collagen (50 μg/ml)-Sepharose remained normal, both before and after the infusion of DDAVP in CA.These results suggest that an increase in the plasma vWF level and the existence of platelet membrane GPIIb/IIIa may be necessary for the improvement of primary hemostasis, after the infusion of DDAVP. The vWF-mediated platelet aggregation by collagen or ADP may produce this effect in the CA patient.

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Growth and development of children under 5 years of age with tetralogy of Fallot in a Chinese population

Scientific Reports ◽

10.1038/s41598-021-93726-3 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Xin Li ◽

Jin Zhu ◽

Jun An ◽

Yuqing Wang ◽

Yili Wu ◽

...

Keyword(s):

Body Weight ◽

Tetralogy Of Fallot ◽

Growth Retardation ◽

Growth And Development ◽

Heart Defects ◽

Body Height ◽

Child Growth ◽

The Body ◽

Early Age ◽

Local Conditions

AbstractCongenital Heart Defects (CHDs) are associated with different patterns of malnutrition and growth retardation, which may vary worldwide and need to be evaluated according to local conditions. Although tetralogy of Fallot (TOF) is one of the first described CHDs, the etiology outcomes in growth and development of TOF in early age child is still unclear in most cases. This study was designed to investigate the growth retardation status of Chinese pediatric TOF patients under 5 years old. The body height, body weight and body mass index (BMI) of 262 pediatric patients (138 boys and 124 girls) who underwent corrective surgery for TOF between 2014 and 2018 were measured using conventional methods. The average body height, body weight and BMI of the patients were significantly lower than WHO Child Growth Standards, while the most affected was body height. Meanwhile, higher stunting frequency and greater deterioration of both the body height and weight happened in elder age (aged 13–60 months) rather than in infant stage (aged 0–12 months) among these patients. Our results confirmed that intervention should be given at early age to prevent the growth retardation of TOF patients getting severer.

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