scholarly journals Prevalence of Dyslipidaemia and Pre-Diabetes Among Women with Polycystic Ovary Syndrome (PCOS): Do We Overestimate Cardiovascular Risk?

2019 ◽  
Vol 51 (08) ◽  
pp. 539-545
Author(s):  
Krzysztof C. Lewandowski ◽  
Justyna Płusajska ◽  
Wojciech Horzelski ◽  
Andrzej Lewiński
Keyword(s):  
Cardiovascular Risk ◽  
Total Cholesterol ◽  
Glucose Intolerance ◽  
Ldl Cholesterol ◽  
Polycystic Ovary ◽  
Hdl Cholesterol ◽  
Convincing Evidence ◽  
Common Belief ◽  
Low Hdl ◽  
Prevalence Of Obesity

AbstractPCOS is widely accepted as associated with an increased cardiovascular risk, however, without convincing evidence of an increased cardiovascular mortality. We assessed prevalence of obesity, glucose intolerance, and dyslipidaemia in 490 women with PCOS, aged 24.75±8.05 years, diagnosed according to the Rotterdam consensus criteria. Fifty-two percent of women had BMI<26 kg/m2, 81.8% had total cholesterol<200 mg/dl, 82.8% had LDL cholesterol<130 mg/dl (48.3%<100 mg/dl), 81.4% had triglycerides<150 mg/dl, 96.08% had fasting glucose<100 mg/dl, 90.3% had glucose<140 mg/dl at 120′ of OGTT. The most frequent abnormality was low HDL cholesterol, as only 33.9% had LDL>60 mg/dl. Combination of several risk factors related to dyslipidaemia was, however, relatively rare, for example, a combination of raised total cholesterol and LDL cholesterol was present only in 2.9% of subjects. An increase in BMI, total cholesterol, LDL-cholesterol, and glucose concentrations at 120′ of OGTT was more pronounced in women, who had raised concentrations of at least two androgens (n=172, 35.1%), yet there was no increase in insulin resistance parameters, that is, HOMA-IR, QUICKI, McAuley, or Belfiore index. Contrary to common belief, over 50% of women with PCOS have normal body weight, and with exception of lower HDL cholesterol, most have no significant dyslipidaemia or glucose intolerance. Women with normal or borderline abnormal androgens, who form the majority of PCOS subjects, seem to have more healthy metabolic profile. This might be one of the reasons for the absence of evidence of an increased CV mortality in women with PCOS.

scholarly journals GLYCEMIC AND LIPIDEIC STATUS IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION

2014 ◽  
Vol 04 (01) ◽  
pp. 009-014
Author(s):  
A. Harish Rao
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Fasting Glucose ◽  
Hdl Cholesterol ◽  
Serum Levels ◽  
Glucose Levels ◽  
Low Hdl ◽  
One Year

Abstract: Objective: to know the glycemic and lipidaemic status in patients with acute myocardial infarction, and with the secondary objective to know the effect of age, gender, diabetes, smoking, hypertension on fasting glucose and lipid levels. Methods and materials: The 74 patients admitted for acute myocardial infarction during the study period of one year were analysed for fasting glucose values and serum levels of total cholesterol, HDL cholesterol, LDL cholesterol and triglycerides. Results: The mean serum concentrations of total cholesterol, triglycerides, HDL cholesterol and LDL cholesterol were 233.28±45.34, 139.22±41.71, 171.43±36.53 and 27.07±36.53 respectively. Mean levels of total cholesterol, HDL cholesterol, triglycerides and fasting glucose values were not affected by age, gender, BMI, hypertension and smoking. BMI >30kg/m2 was associated with increased levels of total cholesterol(p=0.013) and LDL cholesterol(p=0.014). Also increase LDL cholesterol was seen in male gender(p=0.04). The prevalence of hypercholesterolemia, hypertriglyceridemia and low HDL cholesterol was 82.4%,77% and 78% respectively. Diabetes had no effect on lipid profile. Conclusion: our study highlighted the prevalence of dyslipidemias associated with myocardial infarction but not significant impact of fasting glucose levels.

scholarly journals Informativity of lipid metabolism indicators for diagnostics and estimation of the effectiveness of treatment of dogs with pancreatitis

2021 ◽  
pp. 26-32
Author(s):  
Andrii Zemlianskyi ◽  
Olga Tymoshenko ◽  
Andriy Zakhariev ◽  
Yevheniia Vashchyk ◽  
Nataliia Seliukova ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Treatment Effectiveness ◽  
Clinical Symptoms ◽  
Hdl Cholesterol ◽  
Laboratory Research ◽  
Morphological Studies ◽  
Lipid Metabolism Disorders ◽  
Low Hdl

The aim of the research: to substantiate the pathogenetic role of lipid metabolism disorders in the occurrence and course of pancreatitis in dogs and to establish the informativeness of its indicators for diagnosis and evaluation of treatment effectiveness based on clinical and laboratory research methods. Materials and methods. Used clinical, instrumental, laboratory methods, including morphological studies of blood, urine, biochemical studies of serum: determination of the lipid profile by the content of triacylglycerols, total cholesterol, lipoproteins cholesterol of very low – HDL, low – LDL and high density – VLDL, traditional tests and statistical methods. Results. It was found that the most significant changes are inherent in the metabolism of lipids and lipoproteins in the serum: significantly increased concentrations of cholesterol, triacylglycerols, LDL cholesterol and especially LDL cholesterol. The content of HDL cholesterol, on the contrary, in the acute course of pancreatitis is below normal. The content of triacylglycerols, LDL cholesterol and VLDL remains high. Total cholesterol is normalized, and the level of HDL is below normal. Conclusions. Serum lipidogram of dogs without clinical symptoms of pathology does not differ in composition from the results obtained by other researchers. For pancreatitis in dogs, the concentration of total cholesterol increases by 1.9 times, triacylglycerols – by 5.4 times, cholesterol VLDL – in 6.0 times and LDL cholesterol – 7.7 times. The content of HDL cholesterol, in contrast, in the acute course of pancreatitis is 1.5 times lower than in clinically healthy dogs. Treatment reduces the degree of hyperenzymemia by ALT and AST, but α-amylase activity is not normalized in dogs. Above normal levels of triacylglycerols, LDL cholesterol and VLDL, and HDL cholesterol remain low, despite treatment

scholarly journals Appropriate Total cholesterol cut-offs for detection of abnormal LDL cholesterol and non-HDL cholesterol among low cardiovascular risk population

2019 ◽  
Vol 18 (1) ◽  
Author(s):  
Nopakoon Nantsupawat ◽  
Apaputch Booncharoen ◽  
Anawat Wisetborisut ◽  
Wichuda Jiraporncharoen ◽  
Kanokporn Pinyopornpanish ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Risk Population ◽  
Low Cardiovascular Risk

scholarly journals ERICA: prevalence of dyslipidemia in Brazilian adolescents

2016 ◽  
Vol 50 (suppl 1) ◽  
Author(s):  
José Rocha Faria Neto ◽  
Vivian Freitas Rezende Bento ◽  
Cristina Pellegrino Baena ◽  
Marcia Olandoski ◽  
Luis Gonzaga de Oliveira Gonçalves ◽  
...  
Keyword(s):  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Plasma Lipids ◽  
Significant Proportion ◽  
Hdl Cholesterol ◽  
Cross Sectional Study ◽  
Cardiovascular Risks ◽  
Cross Sectional ◽  
High Prevalence ◽  
Low Hdl

ABSTRACT OBJECTIVE To determine the distribution of total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides in Brazilian adolescents, as well as the prevalence of altered levels of such parameters. METHODS Data from the Study of Cardiovascular Risks in Adolescents (ERICA) were used. This is a country-wide, school-based cross-sectional study that evaluated 12 to 17-year old adolescents living in cities with over 100,000 inhabitants. The average and distribution of plasma levels of total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides were evaluated. Dyslipidemia was determined by levels of total cholesterol ≥ 170 mg/dl, LDL cholesterol ≥ 130 mg/dl, HDL cholesterol < 45 mg/dL, or triglycerides ≥ 130 mg/dl. The data were analyzed by gender, age, and regions in Brazil. RESULTS We evaluated 38,069 adolescents – 59.9% of females, and 54.2% between 15 and 17 years. The average values found were: total cholesterol = 148.1 mg/dl (95%CI 147.1-149.1), HDL cholesterol = 47.3 mg/dl (95%CI 46.7-47.9), LDL cholesterol = 85.3 mg/dl (95%CI 84.5-86.1), and triglycerides = 77.8 mg/dl (95%CI 76.5-79.2). The female adolescents had higher average levels of total cholesterol, LDL cholesterol, and HDL cholesterol, without differences in the levels of triglycerides. We did not observe any significant differences between the average values among 12 to 14 and 15- to 17-year old adolescents. The most prevalent lipid alterations were low HDL cholesterol (46.8% [95%CI 44.8-48.9]), hypercholesterolemia (20.1% [95%CI 19.0-21.3]), and hypertriglyceridemia (7.8% [95%CI 7.1-8.6]). High LDL cholesterol was found in 3.5% (95%CI 3.2-4.0) of the adolescents. Prevalence of low HDL cholesterol was higher in Brazil’s North and Northeast regions. CONCLUSIONS A significant proportion of Brazilian adolescents has alterations in their plasma lipids. The high prevalence of low HDL cholesterol and hypertriglyceridemia, especially in Brazil’s North and Northeast regions, must be analyzed in future studies, to support the creation of strategies for efficient interventions.

scholarly journals Cardiovascular Risk in Reproductive-aged Women With Polycystic Ovary Syndrome According to Body Mass Index: a Systematic Review and Meta-analysis

2021 ◽  
Author(s):  
Chenchen Zhuang ◽  
Qiongying Wang ◽  
Wenjuan Wang ◽  
Runmin Sun ◽  
Xiaofang Zhang ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Cardiovascular Risk ◽  
Polycystic Ovary Syndrome ◽  
Ldl Cholesterol ◽  
Polycystic Ovary ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Ovary Syndrome ◽  
Hypertension Prevalence ◽  
Reproductive Aged Women

Abstract Background: To evaluate the association between cardiovascular risk and reproductive-aged women with polycystic ovary syndrome (PCOS) according to body mass index (BMI) categories.Methods: A literature search was conducted in MEDLINE, EMBASE, Cochrane Library and PubMed. Blood pressure (BP) [including systolic BP (SBP), diastolic BP (DBP) and hypertension prevalence] and plasma lipids [triglyceride, high-density lipoprotein (HDL)-cholesterol, nonHDL-cholesterol and low-density lipoprotein (LDL)-cholesterol] were calculated at different BMI levels.Results: SBP [MD (95% CI): 2.96 mmHg (1.62, 4.30), P < 0.001] and DBP [MD (95% CI): 1.64 mmHg (0.03, 3.24), P = 0.046] increased in reproductive-aged women with PCOS, however, hypertension prevalence had no difference [OR (95% CI): 1.56 (0.76, 3.06), P = 0.198]. HDL-cholesterol were [SMD (95% CI): -0.24 (-0.39, -0.09), P = 0.002] lower and triglyceride [SMD (95% CI): 0.37 (0.26, 0.48), P < 0.001] higher in reproductive PCOS women. Besides, LDL-cholesterol [SMD (95% CI): 0.25 (0.17, 0.34), P < 0.001] and nonHDL-cholesterol [SMD (95% CI): 0.38 (0.29, 0.47), P < 0.001] were higher in reproductive-aged PCOS. In the subgroup analysis, SBP and LDL-cholesterol were increased in BMI of < 25 kg/m2 and BMI of ≥ 30 kg/m2, but had no difference in BMI of 25-< 30 kg/m2. Triglyceride and nonHDL-cholesterol increased in all BMI categories. However, DBP and hypertension prevalence had no difference in all BMI categories.Conclusion: High baseline BP and dyslipidemia is represented in reproductive PCOS. Besides, reproductive PCOS women are significantly associated with increased cardiovascular risk independent of BMI categories.

scholarly journals Prevalence of Insulin Resistance, Dyslipidemia and Metabolic Syndrome in Infertile Women with Polycystic Ovary Syndrome

2021 ◽  
Vol 39 (4) ◽  
pp. 225-232
Author(s):  
Shakeela Ishrat ◽  
Marufa Hussain
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Polycystic Ovary Syndrome ◽  
Central Obesity ◽  
Polycystic Ovary ◽  
Hdl Cholesterol ◽  
Ovary Syndrome ◽  
Infertile Women ◽  
Low Hdl ◽  
Prevalence Of Obesity

Introduction: Polycystic ovary syndrome (PCOS) affects 5-10% of reproductive age women and it is a common cause of infertility in young women. Most of the infertile women with PCOS are overweight or obese with related risks of insulin resistance, dyslipidemia and metabolic syndrome. There is ethnic variation in the prevalence of obesity and its related metabolic abnormalities in women with polycystic ovary syndrome. This study was designed to explore the prevalence of insulin resistance, dyslipidemia and metabolic syndrome in infertile women with polycystic ovary syndrome in Bangladesh. Methods: This was a cross sectional study of 126 infertile women with polycystic ovary syndrome attending the Infertility unit of the Department of Obstertrics and Gynaecology at Bangabandhu Sheikh Mujib Medical University from January 2017 to December 2017. Results: The mean BMI was 26.58±3.18 and mean waist circumference was 91.07±9.5 cm. Regarding the prevalence of obesity, 47.6% of the women were overweight (BMI 23 - 27.5 kg/m2), 39.7% was obese (BMI>27.5 kg/m2) and central obesity (waist circumference ≥80 cm) was in 80.2%. In infertile women of PCOS, the prevalence of insulin resistance was 27.8% , dyslipidemia 93.7% metabolic syndrome 42.9% .Median fasting insulin was higher than the cut off for insulin resistance specific for south Asian population. Insulin resistance measured by hyperinsulinemia was much more frequent (65.9%) than that measured by HOMA-IR (27.8%).The most common lipid abnormality was low HDL cholesterol (90.5%) followed by elevated LDL-cholesterol (79.4%). Low HDL cholesterol (90.5%) and abdominal or central obesity (80.2%) were the most common criteria of metabolic syndrome. There is increasing trend in metabolic syndrome with age. Conclusion: Screening the infertile women with polycystic ovary syndrome for insulin resistance, dyslipidemia and metabolic syndrome is important because it allows for additional counseling about long term health consequences and emphasis on weight management. J Bangladesh Coll Phys Surg 2021; 39: 225-232

scholarly journals Cereal consumption and indicators of cardiovascular risk in adolescent girls

2010 ◽  
Vol 14 (4) ◽  
pp. 584-590 ◽  
Author(s):  
Debra L Franko ◽  
Ann M Albertson ◽  
Douglas R Thompson ◽  
Bruce A Barton
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Total Cholesterol ◽  
Adolescent Girls ◽  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Health Study ◽  
Activity Levels ◽  
Food Diary ◽  
Study Sites

AbstractObjectiveTo examine the association between cereal consumption and cardiovascular risk factors including waist, height, total cholesterol, LDL cholesterol and HDL cholesterol in a sample of adolescent girls.DesignLongitudinal study.SettingThe study was conducted from 1987 to 1997 and data were collected at three study sites (University of California at Berkeley, University of Cincinnati and Westat Inc., Rockville, MD, USA). Mixed models were used to estimate the association between the number of days of eating cereal and these four outcome variables.SubjectsGirls (n2371) who participated in the 10-year National Heart, Lung, and Blood Growth and Health Study (NGHS) and completed a 3 d food diary in years 1–5 and 7, 8 and 10.ResultsAdolescent girls who ate cereal more often had lower waist-to-height ratio (P< 0·005), lower total cholesterol (P< 0·05) and lower LDL cholesterol (P< 0·05), taking into account sociodemographic variables, physical activity levels and total energy intake.ConclusionsFindings suggest that cereal consumption is associated with markers of cardiovascular risk and that childhood patterns of consumption may influence the development of risk factors later in adolescence.

Effects of diacerein intake on cardiometabolic profiles in type 2 diabetics: a systematic review and meta-analysis of clinical trials.

2020 ◽  
Vol 27 ◽  
Author(s):  
Peyman Nowrouzi-Sohrabi ◽  
Reza Tabrizi ◽  
Mohammad Jalali ◽  
Navid Jamali ◽  
Shahla Rezaei ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Body Weight ◽  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Meta Analysis ◽  
Hdl Cholesterol ◽  
Cochrane Central Register ◽  
Statistical Heterogeneity

Introduction: A systematic review and meta-analysis of clinical trials was undertaken to evaluate the effect of diacerein intake on cardiometabolic profiles in patients with type 2 diabetes mellitus (T2DM). Methods: Electronic databases such as PubMed, EMBASE, Scopus, Web of Science, Google Scholar, and Cochrane Central Register of Controlled Trials were searched from inception to 31 July 2019. Statistical heterogeneity was evaluated using Cochran’s Q test and I-square (I2 ) statistic. Data were pooled using random-effect models and weighted mean difference (WMD). Results: From 1,733 citations, seven clinical trials were eligible for inclusion and meta-analysis. A significant reduction in hemoglobin A1c (HbA1c) (WMD -0.73; 95%CI -1.25 to -0.21; P= 0.006; I2 = 72.2%) and body mass index (BMI) (WMD -0.55; 95%CI -1.03 to -0.07; P= 0.026; I2 = 9.5%) were identified. However, no significant effect of diacerein intake was identified on fasting blood sugar (FBS) (WMD - 9.00; 95%CI -22.57 to 4.57; P= 0.194; I2 = 60.5%), homeostatic model assessment for insulin resistance (HOMA-IR) (WMD 0.39; 95%CI 0.95 to 1.73; P= 0.569; I2 = 2.2%), body weight (WMD -0.54; 95%CI -1.10 to 0.02; P= 0.059), triglycerides (WMD -0.56; 95%CI -24.16 to 23.03; P= 0.963; I2 = 0.0%), total-cholesterol (WMD -0.21; 95%CI -12.19 to 11.78; P= 0.973; I2 = 0.0%), HDL-cholesterol (WMD -0.96; 95%CI -2.85 to 0.93; P= 0.321; I2 = 0.0%), and LDL-cholesterol levels (WMD -0.09; 95%CI -8.43 to 8.25; P= 0.983; I2 = 37.8%). Conclusion: Diacerein intake may reduce HbA1c and BMI; however, no evidence of effect was observed for FBS, HOMA-IR, body weight, triglycerides, total-cholesterol, HDL-cholesterol or LDL-cholesterol.

scholarly journals Cardiovascular Disease Risk Factors: How Relevant in African Men With Prostate Cancer Receiving Androgen-Deprivation Therapy?

2017 ◽  
Vol 3 (1) ◽  
pp. 7-14
Author(s):  
Okon Ekwere Essien ◽  
Iya Eze Bassey ◽  
Rebecca Mtaku Gali ◽  
Alphonsus Ekpe Udoh ◽  
Uwem Okon Akpan ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Risk Factors ◽  
Cardiovascular Disease ◽  
Cardiovascular Risk ◽  
Waist Circumference ◽  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Treatment Naïve

Purpose Cardiovascular disease risk factors have been associated with androgen-deprivation therapy (ADT) in white and Hispanic populations. It is therefore relevant to determine if there exists a relationship between these parameters in the African population. Patients and Methods The design of the study was cross sectional. Prostate-specific antigen concentration, waist circumference, body mass index (BMI), lipid profile, glucose level, and insulin level were determined in 153 patients with prostate cancer and 80 controls. The patients with prostate cancer were divided into subgroups of treatment-naïve patients and those receiving ADT. Results Mean total cholesterol ( P = .010), LDL cholesterol ( P = .021), BMI ( P = .001), and waist circumference ( P = .029) values were significantly higher in patients treated with ADT when compared with treatment-naïve patients. In patients treated with ADT for up to 1 year, only mean BMI was significantly higher than in treatment-naïve patients, whereas those treated with ADT for more than 1 year had significantly higher mean BMI, waist circumference, total cholesterol, and LDL cholesterol values when compared with treatment-naïve patients. There were no significant differences in insulin or glucose levels. Those undergoing hormone manipulation after orchiectomy had fewer cardiovascular risk factors compared with those undergoing hormone manipulation alone. Conclusion This study shows that ADT results in elevated total cholesterol, LDL cholesterol, BMI, and waist circumference values, all of which are risk factors of cardiovascular disease. Screening for cardiovascular risk factors should be included in treatment plans for patients with prostate cancer.

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