Autoimmunkrankheiten und Allergien – ganzheitliche Diagnostik und Therapie

2021 ◽  
Vol 70 (02) ◽  
pp. 76-81
Author(s):  
Volker Schmiedel
Keyword(s):  
Vitamin D ◽  
Omega 3 ◽  
Chronische Entzündung ◽  
Diagnostik Und Therapie ◽  
Omega 6

ZusammenfassungDie Grundlage für eine erfolgreiche Therapie von Autoimmunkrankheiten ist die Messung einiger Laborwerte und deren anschließende Optimierung. Die Basis stellen Vitamin D, Fettsäuren (Omega-6, Omega-3 etc.), Selen, Zink, Eisen (Serumeisen, Ferritin) sowie Entzündungsmarker (z. B. BSG, CRP) dar. Die Therapie einer komplexen Erkrankung, wie sie eine chronische Entzündung darstellt, sollte auch komplex erfolgen – ein „Wundermittel“ gibt es leider nicht. Die Basis besteht dabei – wie bei vielen anderen Krankheiten auch – aus Ernährung, Bewegung und Entspannung. Praktisch immer liegen aber trotz ausgewogener Ernährung bei Entzündungen Mangelzustände vor, die es mit den richtigen Nährstoffen in einer adäquaten Dosis zu behandeln gilt. Weitere optionale Verfahren werden ebenfalls kurz dargestellt.

scholarly journals The Roles of Inflammation, Oxidative Stress and the Gut-Brain Axis in Treatment Refractory Depression in Youth: Complementary and Integrative Medicine Interventions

2020 ◽  
Vol 5 (4) ◽  
Author(s):  
Deborah R. Simkin ◽  
L. Eugene Arnold ◽  
Keyword(s):  
Oxidative Stress ◽  
Vitamin D ◽  
Inflammatory Cytokines ◽  
B Vitamins ◽  
Fermented Foods ◽  
Omega 3 ◽  
Methyl Donors ◽  
Refractory Depression ◽  
Omega 6 ◽  
Pro Inflammatory Cytokines

Teen depression and suicide rates have risen despite conventional treatments. This article reviews adjunctive interventions that may improve outcomes. A search of the National Library of Medicine database used tailored searches with combinations of specific terms. Modern lifestyle is associated with increased inflammation and pro-inflammatory cytokines leading to, for instance, hyperactivation of the hypothalamic-pituitary-adrenal axis, which promotes depression. Inflammation also increases oxidative stress, leading to mitochondrial dysfunction, also associated with depression. Diets with less probiotic-containing fermented foods change the microbiome and decrease the bio-availability of mood-regulating B vitamins crucial to neurotransmitter production. Vitamin D deficiency allows increased pro-inflammatory cytokines and disrupts mitochondrial function and monoamine production. Deficiencies/insufficiencies of magnesium, Vitamin D, and B vitamins correlate with depression severity. Deficiencies of the folate and methylation cycles may lead to treatment-resistant depression. Imbalance of omega-6 and omega-3 fatty acid intake allows more pro-inflammatory eicosanoids (prostaglandins, thromboxanes, leukotrienes) from omega-6 than anti-inflammatory eicosanoids from omega-3. Refractory youth depression may be linked to abnormalities in functional biological systems, with excessive inflammation, oxidative stress, and gut-brain issues. Mediterranean diet, vitamins/minerals, omega-3 fatty acids, methyl donors, meditation, and exercise are worth considering as adjunctive treatments. More research is needed.

scholarly journals Associations between Vitamin D, Omega 6:Omega 3 Ratio, and Biomarkers of Aging in Individuals Living with and without Chronic Pain

Nutrients ◽  
2022 ◽  
Vol 14 (2) ◽  
pp. 266
Author(s):  
Akemi T. Wijayabahu ◽  
Angela M. Mickle ◽  
Volker Mai ◽  
Cynthia Garvan ◽  
Toni L. Glover ◽  
...  
Keyword(s):  
Vitamin D ◽  
Chronic Pain ◽  
Cellular Aging ◽  
Omega 3 ◽  
Serum Samples ◽  
Cross Sectional ◽  
Biomarkers Of Aging ◽  
Pain Status ◽  
Omega 6 ◽  
Anti Inflammatory

Elevated inflammatory cytokines and chronic pain are associated with shorter leukocyte telomere length (LTL), a measure of cellular aging. Micronutrients, such as 25-hydroxyvitamin D (vitamin D) and omega 3, have anti-inflammatory properties. Little is known regarding the relationships between vitamin D, omega 6:3 ratio, LTL, inflammation, and chronic pain. We investigate associations between vitamin D, omega 6:3 ratio, LTL, and C-reactive protein (CRP) in people living with/without chronic pain overall and stratified by chronic pain status. A cross-sectional analysis of 402 individuals (63% women, 79.5% with chronic pain) was completed. Demographic and health information was collected. Chronic pain was assessed as pain experienced for at least three months. LTL was measured in genomic DNA isolated from blood leukocytes, and micronutrients and CRP were measured in serum samples. Data were analyzed with general linear regression. Although an association between the continuous micronutrients and LTL was not observed, a positive association between omega 6:3 ratio and CRP was detected. In individuals with chronic pain, based on clinical categories, significant associations between vitamin D, omega 6:3 ratio, and CRP were observed. Findings highlight the complex relationships between anti-inflammatory micronutrients, inflammation, cellular aging, and chronic pain.

scholarly journals The Effect of Omega-3 Fatty Acids on Thromboxane, Brain-Derived Neurotrophic Factor, Homocysteine, and Vitamin D in Depressive Children and Adolescents: Randomized Controlled Trial

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1095
Author(s):  
Zuzana Paduchová ◽  
Barbora Katrenčíková ◽  
Magdaléna Vaváková ◽  
Lucia Laubertová ◽  
Zuzana Nagyová ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Vitamin D ◽  
Depressive Symptoms ◽  
Children And Adolescents ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Oil Emulsion ◽  
Omega 6

In the DEPOXIN project, we have found that a high ratio of omega-6/omega-3 fatty acids (FA) is associated with worsening of depressive symptoms in children and adolescents with depressive disorder (DD) and that the 12-week omega-3 FA supplementation modulates DD symptoms. Here we present our results of the secondary outcomes: the levels of thromboxane (TXB), brain-derived neurotrophic factor (BDNF), homocysteine (HCy) and vitamin D. Fifty-eight patients were randomized into two arms. One group received a fish oil emulsion enriched with omega-3 FA, and the other received a sunflower oil emulsion containing omega-6 FA, for 12 weeks. Depressive symptoms were evaluated, using the Child’s Depressive Inventory (CDI). The patients with DD had elevated TXB levels and decreased vitamin D levels, as compared to healthy controls. Both CDI and omega-6/omega-3 ratio correlated positively with TXB and negatively with BDNF at baseline. Compared to the omega-6 FA group, the supplementation with omega-3 FA for 12 weeks significantly reduced plasma TXB (p = 0.024) and increased BDNF (p = 0.011) levels. No changes in HCy and vitamin D were observed. Our results demonstrate the possible role of TXB and BDNF in the pathophysiology of DD and the benefits of omega-3 FA supplementation. The study was registered with the ISRCTN registry (ISRCTN81655012).

scholarly journals Maternal Vitamin D, Folate, and Polyunsaturated Fatty Acid Status and Bacterial Vaginosis during Pregnancy

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Anne L. Dunlop ◽  
Robert N. Taylor ◽  
Vin Tangpricha ◽  
Stephen Fortunato ◽  
Ramkumar Menon
Keyword(s):  
Vitamin D ◽  
Fatty Acid ◽  
Bacterial Vaginosis ◽  
Nutrient Concentrations ◽  
Omega 3 ◽  
Nugent Score ◽  
Omega 3 Fatty Acid ◽  
Acid Ratio ◽  
Omega 6 ◽  
25 Hydroxy Vitamin D

Objective. To investigate associations among serum 25-hydroxy-vitamin D (25-OH-D), folate, omega-6/omega-3 fatty acid ratio and bacterial vaginosis (BV) during pregnancy.Methods. Biospecimens and data were derived from a random sample (N=160) of women from the Nashville Birth Cohort. We compared mean plasma nutrient concentrations for women with and without BV during pregnancy (based on Nugent score ≥7) and assessed the odds of BV for those with 25-OH-D <12 ng/mL, folate <5 ug/L, and omega-6/omega-3 ratio >15.Results. The mean plasma 25-OH-D was significantly lower among women with BV during pregnancy (18.00±8.14 ng/mL versus24.34±11.97 ng/mL,P=0.044). The adjusted odds of BV were significantly increased among pregnant women with 25-OH-D <12 ng/mL (aOR 5.11, 95% CI: 1.19–21.97) and folate <5 ug/L (aOR 7.06, 95% CI: 1.07–54.05).Conclusion. Vitamin D and folate deficiencies were strongly associated with BV (Nugent score ≥7) during pregnancy.

Nutrition and Cancer

2021 ◽  
pp. 570-586
Author(s):  
Shazia Ali ◽  
Asiya Batool ◽  
Asma Tariq ◽  
Aashiq Hussain Bhat ◽  
Abid Qureshi ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Vitamin D ◽  
Cancer Prevention ◽  
Dietary Factors ◽  
Omega 3 ◽  
Food Contaminants ◽  
Cancer Risks ◽  
Omega 6 ◽  
Vitamin B 12

Cancer is the second biggest killer worldwide. It has been estimated that specific lifestyle and dietary measures can prevent 30–40% of all cancers. Consumption of nutrient sparse foods, such as refined flour products and concentrated sugars, consumption of red meat, low fibre intake, and disproportion of omega 3 and omega 6 fatty acids, contributes to cancer risks. Microbiological and chemical food contaminants as well as conventional and industrial food processing methods may further increase the carcinogenicity of diets while protective agents in a cancer prevention diet include folic acid, selenium, vitamin D, vitamin B-12, chlorophyll, and antioxidants such as the carotenoids, kryptoxanthin, lycopene, and lutein. Diet can also influence the gut microbes that may have positive or adverse effects on cancer risk. The authors summarize cancer prevention by functional foods and discuss the role of different dietary factors such as promoter or inhibitor in pathogenesis of different subtypes of cancer worldwide.

Assessment of the Dietary Intakes of 6- and 12-Month-Old Infants in Saudi Arabia

2017 ◽  
Vol 87 (1-2) ◽  
pp. 37-48
Author(s):  
Riyadh A. Alzaheb ◽  
Norah Alatawi ◽  
Khawla A. Daoud ◽  
Naema Altawil
Keyword(s):  
Vitamin D ◽  
Saudi Arabia ◽  
Age Groups ◽  
Dietary Intakes ◽  
Dietary Survey ◽  
Daily Energy ◽  
Omega 6 ◽  
24 Hour Recall ◽  
Adequate Nutrient ◽  
Selection Of

Abstract.Background: Establishing understanding of infants’ dietary intakes can support interventions to improve their diets and overall health. Because information on the dietary intakes of infants aged ≤12 months in Saudi Arabia is scarce, this study examined the diets of infants aged 6 and 12 months in Saudi Arabia and determined their main dietary sources of total energy and macronutrients. Methods: A crosssectional dietary survey employing a single 24-hour recall was performed between May and December 2015 with a sample of mothers of 278 healthy 6-month-old and 259 12-month-old infants. An analysis of the dietary intake data determined the nutrient intake adequacy and the percentage contributions of foods to energy and macronutrient intakes. Results: The respective mean daily energy intakes of the 6-month-old and 12-month-old infants in the study were 703 kcal and 929 kcal. Both age groups recorded adequate nutrient intakes, with the exception that the 6-month-olds’ mean vitamin D intake fell below the recommended Adequate Intake (AI), and the 12-month-olds’ intakes of omega-6 fatty acids and vitamin D were also below the AI, along with their iron intake which fell short of the Recommended Dietary Allowance (RDA). Conclusion: The data generated here will assist health professionals in planning interventions which aim to improve infants’ diets and to offer guidance to parents on the appropriate selection of food for their infants.

Ernährung bei rheumatischen Erkrankungen

2018 ◽  
Vol 38 (04) ◽  
pp. 258-264 ◽  
Author(s):  
G. Keyßer
Keyword(s):  
Vitamin D ◽  
Rheumatoide Arthritis ◽  
Omega 3 ◽  
Per Se

ZusammenfassungEinflüsse der Ernährung auf das Risiko, eine rheumatische Erkrankung zu entwickeln, sind in erster Linie für die rheumatoide Arthritis (RA), in geringerem Maße auch für Spondyloarthritiden (SpA) und entzündliche Bindegewebserkrankungen gesichert. Die Inzidenz der RA ist mit kindlicher Unterernährung und niedrigem Geburtsgewicht assoziiert, die der SpA mit der Dauer des Stillens im Säuglings-alter. Einzelne Nahrungskomponenten wie Seefisch mit hohem Fettgehalt, Zitrusfrüchte oder geringe Alkoholmengen können protektiv auf das RA-Risiko wirken. Raucher haben ein per se deutlich erhöhtes Risiko für eine RA, welches durch vermehrte Kochsalzzufuhr und Übergewicht potenziert wird. Zahlreiche Interventionsstudien haben versucht, den Nutzen einzelner Kostformen bei etablierter RA nachzuweisen. Dazu gehören neben verschiedenen Fastenformen auch Elementardiäten, Eliminationsdiäten und andere hypoaller-gene Kostformen sowie Studien zu veganer und glutenfreier Ernährung. Die Mehrzahl dieser Untersuchungen ist in Qualität und Aussagekraft unbefriedigend geblieben. Allerdings ist eine an den Prinzipien der Mittelmeerkost ausgerichtete Ernährung wahrscheinlich von Nutzen für RA-Patienten, auch wenn die positiven Effekte in erster Linie die Reduktion des kardiovaskulären Risikos betreffen. Nahrungsergänzungsmittel werden häufig für die Anwendung bei etablierter RA beworben, allerdings lassen sich positive Effekte nur für Fischölkapseln in ausreichend hoher Dosierung von Omega-3-Fettsäuren nachweisen. Die Zufuhr von Eisenpräparaten und Vitamin D sollte nicht unkritisch erfolgen, sondern an objektiven Kriterien ausgerichtet werden. Probiotika sind aufgrund neuer Erkenntnisse zu Pathogenese rheumatischer Erkrankungen in kleineren Studien bei RA und SpA zum Einsatz gekommen, haben jedoch bisher keinen überzeugenden Wirksamkeitsnachweis gezeigt.

Teor e composição de lipídeos como ferramenta de gestão na nutrição de bovinos

2020 ◽  
Vol 9 (7) ◽  
pp. e334974037
Author(s):  
Graciele Araújo de Oliveira Caetano ◽  
Angela Aparecida da Fonseca ◽  
Cibelle Borges Figueiredo
Keyword(s):  
Omega 3 ◽  
Ácido Linoleico Conjugado ◽  
Omega 6 ◽  
3 Omega

Um fator diferencial na produção de bovinos é a compreensão da contribuição individual dos ácidos graxos e do papel dos lipídeos nos ruminantes, tanto na forma de análise (ácido graxo ou extrato etéreo), conceitos relacionados às características de ômega 3, ômega 6 e ácido linoleico conjugado na bio-hidrogenação, no metabolismo pós-absorção, bem como no conteúdo e composição dos ácidos graxos em relação à matéria seca dos alimentos. Sabe-se que diversos fatores podem afetar o teor, digestibilidade e degradabilidade das fibras presente na forragem, e o mesmo ocorre com os lipídeos. As diferenças entre os valores dos compostos presentes nos lipídeos podem ocorrer dependendo do ambiente, região do país ou fase de colheita e por isso, torna-se importante obter a análise da composição de ácidos graxos dos alimentos lipídicos, para que dessa maneira seja possível otimizar a utilização deste nutriente na dieta de animais ruminantes. Sendo assim, a proposta dessa revisão será trazer a discussão sobre o tema e abordar um entendimento sobre o conteúdo e composição de ácidos graxos dos ingredientes que compõem a dieta dos animais ruminantes, com ênfase na influência exercida no desempenho produtivo, imunonutrição, e no produto final (carne ou leite).

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