Juvenile Ceroid Lipofuscinosis CLN3: A Fatal Disease with Primary Ocular Manifestation

SARS-COV2 virus causes Coronavirus disease (COVID-19) and represents the causative agent of a potentially fatal disease that is of great global public health concern. The novel coronavirus (2019) was discovered in 2019 in Wuhan, the market of the wet animal, China with viral pneumonia cases and is life-threatening. Today, WHO announces COVID-19 outbreak as a pandemic. COVID-19 is likely to be zoonotic. It is transmitted from bats as intermediary animals to human. Also, the virus is transmitted from human to human who is in close contact with others. The computerized tomographic chest scan is usually abnormal even in those with no symptoms or mild disease. Treatment is nearly supportive; the role of antiviral agents is yet to be established. The SARS-COV2 virus spreads faster than its two ancestors, the SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV), but has lower fatality. In this article, we aimed to summarize the transmission, symptoms, pathogenesis, diagnosis, treatment, and vaccine to control the spread of this fatal disease.

Download Full-text

A Never-Ending Story of Anogenital Warts: Review Article

Journal of the Medical Association of Thailand ◽

10.35755/jmedassocthai.2020.06.11530 ◽

2020 ◽

Vol 103 (6) ◽

pp. 614-619

Keyword(s):

Hpv Vaccine ◽

Social Issues ◽

Anogenital Warts ◽

Negative Effects ◽

Fatal Disease ◽

Anogenital Wart ◽

Sexually Transmitted ◽

Dormant Stage ◽

Ideal Method ◽

Basic Medical

Anogenital wart (AGW) has long been one of the most common sexually transmitted infections, which has negative effects on psychological and social issues. Its slowly progressive nature and long dormant stage prevent AGW from elimination. Although diagnosis is as simple as inspection using the naked eyes or a magnifying glass and basic medical treatment is the main treatment modality, the long period of clinical response appears to be the biggest challenge. Many patients suffer from this non-fatal disease for over half a year. Onward transmission obviously continues during the occurrence of lesions. Primary prevention, particularly vaccination against human papillomavirus (HPV vaccine), is an ideal method. HPV vaccine is a promising method; however, its high cost limits wide accessibility. In addition, despite being vaccinated, some women present with AGW. Therefore, a never-ending story of AGW remains to be explored. The Siriraj Female STI Clinic, which has over 20 years of experience in treating women with AGW, would like to share some experience so that these patients will be treated with more understanding. Keywords: Anogenital wart, Prevention, Surveillance, Siriraj experience

Download Full-text

Eye in COVID-19: A Brief Review

Pakistan Journal of Ophthalmology ◽

10.36351/pjo.v36i3.1040 ◽

2020 ◽

Vol 36 (3) ◽

Author(s):

Muhammad Mohsin Ali ◽

Qudsia Anwar Dar ◽

Zahid Kamal ◽

Alishba Khan

Keyword(s):

Infection Control ◽

Respiratory Symptoms ◽

Literature Search ◽

Control Measures ◽

Transmission Route ◽

Ocular Manifestation ◽

Personal Protection ◽

Personal Protection Equipment ◽

Ocular Manifestations ◽

Infection Control Measures

This is a brief review covering the currently available literature on ocular manifestations of COVID-19, andprevention strategies for ophthalmologists. A literature search was carried out of Pubmed, Google Scholar andWHO database of publications on COVID. Keywords used in the search were eye, ocular manifestations,ophthalmology, COVID-19, nCoV-2019, and coronavirus disease. All available articles were reviewed and thosepertinent to the study topic were included. Considering the dearth of information available, ophthalmology journals were also searched separately for relevant articles. Major ocular manifestation of COVID reported in literature is red eye, which usually presents before the onset of respiratory symptoms. Since the eye can be a possible transmission route for SARS-CoV-2, infection control measures should be undertaken by ophthalmologists, including use of personal protection equipment and eye/face covering. A framework for structuring ophthalmological services during the COVID pandemic is also presented in this review.

Download Full-text

Neuronal Ceroid Lipofuscinosis: The Increasing Spectrum of an Old Disease

Current Molecular Medicine ◽

10.2174/1566524014666141010154913 ◽

2014 ◽

Vol 14 (8) ◽

pp. 1043-1051 ◽

Cited By ~ 12

Author(s):

A. Simonati ◽

F. Pezzini ◽

F. Moro ◽

F.M. Santorelli

Keyword(s):

Neuronal Ceroid Lipofuscinosis ◽

Ceroid Lipofuscinosis

Download Full-text

New Insight for the Prognosis of CCHF: Clinical, Laboratory and Sonography Findings

Current Medical Imaging Formerly Current Medical Imaging Reviews ◽

10.2174/1573405615666191111115354 ◽

2020 ◽

Vol 16 (9) ◽

pp. 1125-1130

Author(s):

Hamid Owaysee Osquee ◽

Sepehr Taghizadeh ◽

Mehdi Haghdoost ◽

Hadi Pourjafar ◽

Fereshteh Ansari

Keyword(s):

Odds Ratio ◽

Clinical Laboratory ◽

Fatal Outcome ◽

Hemorrhagic Fever ◽

Demographic Characteristics ◽

Pelvic Cavity ◽

Fatal Disease ◽

Laboratory Findings ◽

Report Data ◽

Sistan And Baluchestan

Introduction: In this article, we report data on confirmed CCHF cases from Iran and describe the association between studying factors and outcomes of the disease. Objective: Crimean Congo Hemorrhagic Fever (CCHF) is an acute and fatal disease with various clinical and paraclinical characteristics. Methods: In the Study design, we evaluated demographic characteristics, clinical, laboratory and sonographic findings of 160 CCHF confirmed cases during 2003 and 2012 in Zabol (A city in Sistan and Baluchestan province of Iran). The association between these factors and the fatal outcome was evaluated by regression analysis. Results: The disease had a fatal outcome in 7 (4.4%) of patients. Females had more severe symptoms and higher odds for death (odds ratio11.57, p=0.005). Leukocytosis (p<0.001), PT (p<0.001) and PTT (p=0.008) elongation, AST (p=0.010) and ALT (p<0.001) elevation were significantly associated with fatal outcome. CNS related symptoms (odds ratio 5.9, p=0.027) in clinical examination and ascites (odds ratio 38.4, p=0.012) and liquid in the pelvic cavity (odds ratio 24.2, p=0.004) were also identified as risk factors of death in this study. Conclusions: Our data suggest that in addition to clinical and laboratory findings practitioners consider sonography for CCHF prognosis.

Download Full-text

Chemotherapy-sparing treatment of haemophagocytic lymphohistiocytosis with intravenous immunoglobulins and corticosteroids

BMJ Case Reports ◽

10.1136/bcr-2020-234490 ◽

2020 ◽

Vol 13 (5) ◽

pp. e234490

Author(s):

Evan C Chen ◽

Jonathan A Stefely ◽

Bimalangshu R Dey ◽

Walter H Dzik

Keyword(s):

Effective Treatment ◽

Disease Severity ◽

Critically Ill ◽

Intravenous Immunoglobulins ◽

Current Treatment ◽

Haemophagocytic Lymphohistiocytosis ◽

Tailored Therapy ◽

Fatal Disease ◽

Therapeutic Challenge

Haemophagocytic lymphohistiocytosis (HLH) can be a rapidly fatal disease. Current treatment in adults is extrapolated from the HLH-2004 protocol that specifies a regimen of etoposide, dexamethasone and cyclosporine. However, HLH presents as a spectrum of disease severity. A therapeutic challenge arises for milder cases where the harms of potent chemotherapy such as etoposide may outweigh its benefit. We present a case of an adult with HLH who developed significant pancytopenia but was otherwise not critically ill and who responded to treatment with a chemotherapy-sparing approach consisting of intravenous immunoglobulins and corticosteroids alone. The case illustrates that tailored therapy may allow effective treatment of the disorder while minimising therapy-related toxicities.

Download Full-text