Recent Advances in Reactions of Propargylamines

Synthesis ◽  
2019 ◽  
Vol 52 (01) ◽  
pp. 1-20 ◽  
Author(s):  
Xia Sheng ◽  
Kaijun Chen ◽  
Chengjin Shi ◽  
Dayun Huang
Keyword(s):  
Building Blocks ◽  
Future Research ◽  
Recent Advances ◽  
Leaving Groups ◽  
Trigger Mechanisms ◽  
Made In

Propargylamines are extremely versatile and common building blocks in the field of chemistry. This review highlights the recent advances made in the reactions of propargylamines between 2009 and 2019. The reaction types are classified into six categories based on the trigger mechanisms: (1) amino moieties as leaving groups, (2) hydrogenation, (3) rearrangement, (4) nucleophilic amines, (5) nucleophilic carbons, and (6) electrophilic alkynes. We hope that this review will promote future research in this area.1 Introduction2 Amino Moieties as Leaving Groups3 Hydrogenation4 Rearrangement5 Nucleophilic Amines6 Nucleophilic Carbons 7 Electrophilic Alkynes8 Conclusions

scholarly journals Recent Advances in Palladium-Catalyzed Isocyanide Insertions

Molecules ◽  
2020 ◽  
Vol 25 (21) ◽  
pp. 4906
Author(s):  
Jurriën W. Collet ◽  
Thomas R. Roose ◽  
Bram Weijers ◽  
Bert U. W. Maes ◽  
Eelco Ruijter ◽  
...  
Keyword(s):  
Organic Synthesis ◽  
Building Blocks ◽  
Insertion Reactions ◽  
Chemical Reagents ◽  
The Past ◽  
Recent Advances ◽  
Recent Developments ◽  
Palladium Catalyzed ◽  
Made In ◽  
Rapid Incorporation

Isocyanides have long been known as versatile chemical reagents in organic synthesis. Their ambivalent nature also allows them to function as a CO-substitute in palladium-catalyzed cross couplings. Over the past decades, isocyanides have emerged as practical and versatile C1 building blocks, whose inherent N-substitution allows for the rapid incorporation of nitrogeneous fragments in a wide variety of products. Recent developments in palladium catalyzed isocyanide insertion reactions have significantly expanded the scope and applicability of these imidoylative cross-couplings. This review highlights the advances made in this field over the past eight years.

Perspective on Devolpment of Nanotechnology in Textiles

2010 ◽  
Vol 113-116 ◽  
pp. 670-673
Author(s):  
Jun Chen ◽  
Juan Hong Gu ◽  
Yan Liu
Keyword(s):  
Textile Industry ◽  
Melt Spinning ◽  
Performance Enhancement ◽  
Future Research ◽  
Textile Manufacturing ◽  
Recent Advances ◽  
The Future ◽  
Textile Industries ◽  
Almost All ◽  
Made In

Nanotechnology has proven its importance in almost all areas, and textile industry is not an expectation. Several applications of nanotechnology can be extended to attain the performance enhancement of textile manufacturing machines and processes. Using different methods like electro spraying and electro spinning, various materials have been used to increase additional functions in textiles. This treatment is applied to give textiles the desired handle, to make further processing easier and to improve the thermal and antistatic properties. In this manuscript, we have summarized the recent advances made in nanotechnology and the methods of fabricating functional fibers by electrospinning and melt spinning preparation. Applications of the nanotechnology in textile industries are also summarized in this paper with some novel ideas that can be utilized for the future research in this area.

Tertiary Enamides: Versatile and Available Substrates in Synthetic Chemistry

2019 ◽  
Vol 16 (1) ◽  
pp. 70-97 ◽  
Author(s):  
Xiaohua Cai ◽  
Mengzhi Yang ◽  
Hui Guo
Keyword(s):  
Chemical Reaction ◽  
Coupling Reaction ◽  
Building Blocks ◽  
Synthetic Chemistry ◽  
The Past ◽  
Recent Advances ◽  
Complex Building ◽  
Group A ◽  
Unique Stability ◽  
Made In

Background: Enamines and their variant enamides as powerful and versatile synthons have attracted great attention in synthetic chemistry. Enamides display unique stability and reduce enaminic reactivity in view of the electron-withdrawing effect of N-acyl group. A great deal of satisfactory achievements in the synthesis and application of enamides has been made in recent years. Especially, tertiary enamides without N-H bond regarded as low reactivity of compounds in the past can act as excellent nucleophiles to react with electrophiles for the construction of various nitrous molecules. </P><P> Objective: This review focuses on recent advances on tertiary enamides in the synthetic strategies and applications including addition, coupling reaction, functionalization and electro- or photo-chemical reaction. Conclusion: Tertiary enamides as electron-deficient nucleophiles display a satisfactory balance between stability and reactivity to offer multiple opportunities for the construction of various functionalized nitrogencontaining compounds. Further exploration of the reactive mechanisms involved tertiary enamides and the development of novel and efficient transformations to generate ever more complex building blocks starting from tertiary enamides are particularly worth pursuing.

Reuse of Sludge from Pulp and Paper Industry Pilot and Full Scale Applications

1993 ◽  
Vol 28 (2) ◽  
pp. 17-26 ◽  
Author(s):  
V. Eroǧlu ◽  
A. M. Saatçi
Keyword(s):  
Economic Analysis ◽  
Paper Industry ◽  
Pulp And Paper Industry ◽  
Pulp And Paper ◽  
Full Scale ◽  
Primary Sludge ◽  
Recent Advances ◽  
Made In

Recent advances made in the reuse of pulp and paper industry sludges in hardboard production are explained. Data obtained from pilot and full-scale plants using primary sludge of a pulp and paper industry as an additive in the production of hardboard is presented. An economic analysis of the reuse of pulp and paper primary sludge in hardboard manufacturing is given. The quality of the hardboard produced is tested and compared with the qualities of the hardboard produced by the same plant before the addition of primary sludge. The hardboard with primary sludge additive has been used in Turkey for about a year in the manufacturing of office and home furniture. The results are very satisfactory when the primary sludge is used at 1/4 ratio.

Recent advances on the synthesis of the antidepressant Paroxetine

2020 ◽  
Vol 27 ◽  
Author(s):  
Joana Santos ◽  
M. Fernanda Proença ◽  
Ana Joao Rodrigues ◽  
Patricia Patrício ◽  
H. Sofia Domingues
Keyword(s):  
Total Synthesis ◽  
Neurological Disorders ◽  
Serotonin Reuptake ◽  
Potent Inhibitor ◽  
Starting Material ◽  
Substitution Pattern ◽  
Biological Probes ◽  
Recent Advances ◽  
Treatment Of Depression ◽  
Made In

: Paroxetine is a potent inhibitor of serotonin reuptake and is widely prescribed for the treatment of depression and other neurological disorders. The synthesis of paroxetine and the possibility to prepare derivatives with a specific substitution pattern that may allow their use as biological probes, is an attractive topic especially for medicinal chemists engaged in neurosciences research. Considering the extensive work that was developed in the last decade on the total synthesis of paroxetine, this review summarizes the most important contributions in this field, organized according to the reagent that was used as starting material. Most of the methods allowed to prepare paroxetine in 4-9 steps with an overall yield of 9-66%. Despite the progress made in this area, there is still room for improvement, searching for new eco-friendly and sustainable synthetic alternatives.

scholarly journals Rational design of photocatalysts for ammonia production from water and nitrogen gas

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Seokwoo Choe ◽  
Sung Min Kim ◽  
Yeji Lee ◽  
Jin Seok ◽  
Jiyong Jung ◽  
...  
Keyword(s):  
Energy Source ◽  
Rational Design ◽  
Future Research ◽  
Ammonia Production ◽  
Significant Progress ◽  
Nitrogen Gas ◽  
Research Directions ◽  
Effective Strategies ◽  
Future Research Directions ◽  
Made In

AbstractPhotocatalytic N2 reduction has emerged as one of the most attractive routes to produce NH3 as a useful commodity for chemicals used in industries and as a carbon-free energy source. Recently, significant progress has been made in understanding, exploring, and designing efficient photocatalyst. In this review, we outline the important mechanistic and experimental procedures for photocatalytic NH3 production. In addition, we review effective strategies on development of photocatalysts. Finally, our analyses on the characteristics and modifications of photocatalysts have been summarized, based on which we discuss the possible future research directions, particularly on preparing more efficient catalysts. Overall, this review provides insights on improving photocatalytic NH3 production and designing solar-driven chemical conversions.

scholarly journals Implantable Thin Film Devices as Brain-Computer Interfaces: Recent Advances in Design and Fabrication Approaches

Coatings ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 204
Author(s):  
Yuhao Zhou ◽  
Bowen Ji ◽  
Minghao Wang ◽  
Kai Zhang ◽  
Shuaiqi Huangfu ◽  
...  
Keyword(s):  
Thin Film ◽  
High Resolution ◽  
Future Research ◽  
Nano Fabrication ◽  
Computer Interfaces ◽  
Continuous Progress ◽  
Open Mesh ◽  
Remarkable Progress ◽  
Thin Film Devices ◽  
Made In

Remarkable progress has been made in the high resolution, biocompatibility, durability and stretchability for the implantable brain-computer interface (BCI) in the last decades. Due to the inevitable damage of brain tissue caused by traditional rigid devices, the thin film devices are developing rapidly and attracting considerable attention, with continuous progress in flexible materials and non-silicon micro/nano fabrication methods. Therefore, it is necessary to systematically summarize the recent development of implantable thin film devices for acquiring brain information. This brief review subdivides the flexible thin film devices into the following four categories: planar, open-mesh, probe, and micro-wire layouts. In addition, an overview of the fabrication approaches is also presented. Traditional lithography and state-of-the-art processing methods are discussed for the key issue of high-resolution. Special substrates and interconnects are also highlighted with varied materials and fabrication routines. In conclusion, a discussion of the remaining obstacles and directions for future research is provided.

Smooth Muscle Contraction: Recent Advances

1994 ◽  
Vol 72 (11) ◽  
pp. 1317-1319
Author(s):  
Newman L. Stephens
Keyword(s):  
Smooth Muscle ◽  
Muscle Contraction ◽  
Myosin Light Chain ◽  
Kinase Activity ◽  
Smooth Muscle Contraction ◽  
Recent Advances ◽  
Regulation Of Contraction ◽  
Muscle Biochemistry ◽  
Remarkable Progress ◽  
Made In

Research in smooth muscle contraction has shown remarkable progress over the last 5 years. Striking advances have been made in the areas of biochemical regulation of contraction, centering on myosin light chain kinase activity, and of biophysical delineation of the contractile process at the actomyosin level by use of the newly developed motility assay. The purpose of the symposium held at Minaki, Ont., was to obtain a comprehensive reporting of the recent advances made in the area of smooth muscle contraction. Specifically, advances in the areas of biophysics of contraction, energetics, and contractile and regulator proteins (including the interesting newcomers caldesmon and calponin) and the changes that occur in pathophysiological entities such as asthma, hypertension, anaphylactic shock, high-altitude hypoxia, and persistent pulmonary hypertension of the newborn were presented.Key words: smooth muscle biophysics, smooth muscle biochemistry, energetics of smooth muscle, pathophysiology of smooth muscle.

scholarly journals Molecular biology of potexviruses: recent advances

2007 ◽  
Vol 88 (6) ◽  
pp. 1643-1655 ◽  
Author(s):  
Jeanmarie Verchot-Lubicz ◽  
Chang-Ming Ye ◽  
Devinka Bamunusinghe
Keyword(s):  
Gene Silencing ◽  
Rna Synthesis ◽  
Triple Gene Block ◽  
Potato Virus X ◽  
Future Research ◽  
Virus Movement ◽  
Suppressor Activity ◽  
Gene Block ◽  
Recent Advances

Recent advances in potexvirus research have produced new models describing virus replication, cell-to-cell movement, encapsidation, R gene-mediated resistance and gene silencing. Interactions between distant RNA elements are a central theme in potexvirus replication. The 5′ non-translated region (NTR) regulates genomic and subgenomic RNA synthesis and encapsidation, as well as virus plasmodesmal transport. The 3′ NTR regulates both plus- and minus-strand RNA synthesis. How the triple gene-block proteins interact for virus movement is still elusive. As the potato virus X (PVX) TGBp1 protein gates plasmodesmata, regulates virus translation and is a suppressor of RNA silencing, further research is needed to determine how these properties contribute to propelling virus through the plasmodesmata. Specifically, TGBp1 suppressor activity is required for virus movement, but how the silencing machinery relates to plasmodesmata is not known. The TGBp2 and TGBp3 proteins are endoplasmic reticulum (ER)-associated proteins required for virus movement. TGBp2 associates with ER-derived vesicles that traffic along the actin network. Future research will determine whether the virus-induced vesicles are cytopathic structures regulating events along the ER or are vehicles carrying virus to the plasmodesmata for transfer into neighbouring cells. Efforts to assemble virions in vitro identified a single-tailed particle (STP) comprising RNA, coat protein (CP) and TGBp1. It has been proposed that TGBp1 aids in transport of virions or STP between cells and ensures translation of RNA in the receiving cells. PVX is also a tool for studying Avr–R gene interactions and gene silencing in plants. The PVX CP is the elicitor for the Rx gene. Recent reports of the PVX CP reveal how CP interacts with the Rx gene product.

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