scholarly journals GARLIC: IT'S ROLE IN ORAL AND SYSTEMIC HEALTH

2013 ◽  
Vol 03 (04) ◽  
pp. 017-022
Author(s):  
Harini K. ◽  
Subash Babu ◽  
Vidya Ajila ◽  
Shruthi Hegde
Keyword(s):  
Allium Sativum ◽  
Therapeutic Agents ◽  
Treatment Modalities ◽  
Traditional Treatment ◽  
Traditional System ◽  
Frequent Use ◽  
Anti Oxidant ◽  
Resistant Strains ◽  
Therapeutic Properties ◽  
Systemic Health

AbstractA range of treatment modalities are available for the treatment of different oral diseases.The frequent use and misuse of currently available therapeutic agents has led to the evolution of increased incidence of adverse effects and development of resistant strains. Hence the search for an alternative option continues. Medicinal plants have been used as traditional treatment agents since ages. Garlic (Allium sativum) has been recognized for a number of therapeutic properties in the traditional system of medicine. Allium sativum is traditionally employed to treat infection, colds, diabetes, heart disease, and a host of other disorders. Clinically, it has been evaluated for lowering blood pressure, cholesterol, and glucose concentration, as well as for the prevention of arteriosclerosis and cancer. It is well known for its potent anti- inflammatory, anti- oxidant, anti-bacterial and antimutagenic properties. This article aims to review the efficacy of garlic in maintaining oral health in particular and overall health in general.

Traditional knowledge to clinical trials: a review on nutritional and therapeutic potential of Pithecellobium dulce

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Suresh Sulekha Dhanisha ◽  
Sudarsanan Drishya ◽  
Chandrasekharan Guruvayoorappan
Keyword(s):  
Combinatorial Chemistry ◽  
Therapeutic Potential ◽  
New Drugs ◽  
Pharmacological Properties ◽  
Traditional System ◽  
The Past ◽  
Drug Of Choice ◽  
Anti Oxidant ◽  
Therapeutic Properties ◽  
Different Parts

Abstract The review describes botanical aspects, bioactive phytocompounds and pharmacological properties of different parts of Pithecellobium dulce, with special emphasis on the nutritional status of its fruits. The different parts of plant extract have been reported to possess anti-oxidant, anti-inflammatory, anti-microbial, anti-diabetic, cardio protective, anti-diarrhoeal, anti-ulcerogenic, larvicidal and ovicidal activities. Different parts of plant extracts were reported to contain several bioactive phytocompounds such as flavonoids, saponins, tannins, alkaloids etc. Natural products discovered so far served as a viable source for new drugs. Over the past few years, continued and perpetual attention of people has been paid to medicinal plants in connection with its remarkable importance in drug discovery. Plant products always remains a drug of choice for the identification of novel leads despite facing a tough competition from existing synthetic alternatives derived from combinatorial chemistry, owing to their efficacy, side effects, and safety. P. dulce is a highly acclaimed genus in traditional system of medicine because of its versatile nutraceutical and pharmacological properties. In this review we discuss in detail about nutritional and various therapeutic properties of P. dulce.

scholarly journals Punica granatum L. (Dadim) Punica granatum L. (Dadim), Therapeutic Importance of World’s Most Ancient Fruit Plant

2021 ◽  
Vol 11 (3) ◽  
pp. 113-121
Author(s):  
Isha Kumari ◽  
Hemlata Kaurav ◽  
Gitika Chaudhary
Keyword(s):  
Punica Granatum ◽  
Punicic Acid ◽  
Dietary Practices ◽  
Traditional System ◽  
Anti Cancer ◽  
Ethnic History ◽  
History Of ◽  
Anti Oxidant ◽  
Therapeutic Properties ◽  
Punica Granatum L

The custom of using plants for the therapeutic and dietary practices is as old as origin of humanity on the earth. One of the most ancient fruit plant is Punica granatum L., pomegranate belongs to Lythraceae family. The plant has a very rich ethnic history of its utilization around the world. The plant was used to symbolize prosperity, life, happiness, fertility etc. Apart from the ethnic beliefs associated with the plant, it is a well-considered plant based remedy used in treatment of many diseases in traditional system like Ayurveda and folk system of medicine. In Ayurveda it is esteemed as a Rasayana. It is used in many Ayurvedic polyherbal formulations which are used against many diseases. The plant consists of numerous phytochemical constituents in it such as polysaccharides, minerals, polyphenols, tannins, saponins, quinones, alkaloids, glycosides, coumarins, terpenoids, steroids etc. Each of the phytochemical constituent is associated with important therapeutic properties. This supper food is globally known for its high anti-oxidant potential. Other associated properties of this medicinal fruit plant are anti-microbial, hepatoprotective, cardioprotective, anti-diabetic, anti-cancer, immunomodulatory, anti-inflammatory, anti-hypertensive, anti-anemic etc. The aim of present review is to provide information related to phytochemistry, traditional uses in Ayurveda and folk medicinal system and therapeutic properties of Punica granatum L. Keywords: Dadim, Rasapanchak, Punicalagin, Punicic acid, Anti-oxidant.

Phytoceuticals in aniseeds: a practical approach for isolation and identification

2016 ◽  
Vol 5 (01) ◽  
pp. 4701
Author(s):  
Shobha R. I. ◽  
Andallu B.
Keyword(s):  
Chronic Diseases ◽  
Column Chromatography ◽  
High Performance ◽  
Methanolic Extract ◽  
Analytical Techniques ◽  
Therapeutic Agents ◽  
Systematic Research ◽  
Isolation And Identification ◽  
Traditional System ◽  
Pharmacologically Active

Nature has provided mankind with a broad and structurally diverse array of pharmacologically active chemical compounds, phytoceuticals, which have proved to be indispensable for the cure of chronic diseases or as lead structures for novel therapeutic agents. Almost, 70% of modern medicines in India have been developed from plants used in the traditional system of medicine. With the technological advances and the development of more sophisticated isolation and analytical techniques, there is great scope for further systematic research to screen and isolate many more phytoceuticals which might be more effective/as effective as synthetic drugs and thereby assess their potential in protecting against chronic diseases. The present investigation is aimed at isolation and identification of phytoceuticals in a spice, aniseed (Pimpinella anisum L), therapeutically less-exploited and widely used only for culinary purpose, using analytical techniques viz. column chromatography, high performance thin layer chromatography (HPTLC.) and nuclear magnetic resonance spectrometry. Among all the solvent fractions of methanolic extract tested, methanolic extract and ethyl acetate fraction possessed highest amounts of bioactive compounds viz. phenolics, flavonoids, flavonols which was confirmed by qualitative, quantitative and HPTLC. analyses. Spectral analysis using NMR. of one of the sub-fractions of aniseeds obtained by column chromatography, revealed the presence of a glycosylated flavone, luteolin-6C-glucoside in aniseeds.  The present study revealed aniseeds to be a great source of bioactive phytoceuticals which can be novel candidates for development of new therapeutic agents.

Specialized, pro-resolving mediators as potential therapeutic agents for alleviating fibromyalgia symptomatology

Pain Medicine ◽  
2021 ◽  
Author(s):  
Gregory Livshits ◽  
Alexander Kalinkovich
Keyword(s):  
Animal Experiments ◽  
Therapeutic Agents ◽  
Treatment Modalities ◽  
Inflammatory Factors ◽  
Gut Dysbiosis ◽  
Unsuccessful Treatment ◽  
Pain Sensitization ◽  
Novel Strategy ◽  
Inflammation Resolution

Abstract Objective To present a hypothesis on a novel strategy in the treatment of fibromyalgia (FM). Design A narrative review. Setting FM as a disease remains a challenging concept for numerous reasons, including undefined etiopathogenesis, unclear triggers and unsuccessful treatment modalities. We hypothesize that the inflammatome, the entire set of molecules involved in inflammation, acting as a common pathophysiological instrument of gut dysbiosis, sarcopenia, and neuroinflammation, is one of the major mechanisms underlying FM pathogenesis. In this setup, dysbiosis is proposed as the primary trigger of the inflammatome, sarcopenia as the peripheral nociceptive source, and neuroinflammation as the central mechanism of pain sensitization, transmission and symptomatology of FM. Whereas neuroinflammation is highly-considered as a critical deleterious element in FM pathogenesis, the presumed pathogenic roles of sarcopenia and systemic inflammation remain controversial. Nevertheless, sarcopenia-associated processes and dysbiosis have been recently detected in FM individuals. The prevalence of pro-inflammatory factors in the cerebrospinal fluid and blood has been repeatedly observed in FM individuals, supporting an idea on the role of inflammatome in FM pathogenesis. As such, failed inflammation resolution might be one of the underlying pathogenic mechanisms. In accordance, the application of specialized, inflammation pro-resolving mediators (SPMs) seems most suitable for this goal. Conclusions The capability of various SPMs to prevent and attenuate pain has been repeatedly demonstrated in laboratory animal experiments. Since SPMs suppress inflammation in a manner that does not compromise host defense, they could be attractive and safe candidates for the alleviation of FM symptomatology, probably in combination with anti-dysbiotic medicine.

Assessment of sickling inhibitory activity of Ficus carpensis, Newbouldia laevis, Carpolobia lutea and Carpolobia caudata on human erythrocytes HbSS

2021 ◽  
Vol 10 (1) ◽  
pp. 15-18
Author(s):  
Jean François Sibri ◽  
◽  
Joël Akakpo-Akue ◽  
Jacques Auguste Alfred Bognan Ackah ◽  
M'Bèféhê Soro ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Aqueous Extract ◽  
Inhibitory Activity ◽  
Chemical Study ◽  
Cell Disease ◽  
Traditional Treatment ◽  
Anti Oxidant ◽  
The Subject ◽  
Increased Susceptibility

Sickle cell disease is a hemoglobinopathy. In hypoxia situation, homozygous individuals might suffer from vaso-occlusive seizures, hemolytic anemia and increased susceptibility to infections. A recipe of the leaves of Ficus carpensis, Newbouldia laevis, Carpolobia lutea and Carpolobia caudate, four plants used in the traditional treatment of sickle cell disease in the Daloa region, was the subject of this study. This investigation was initiated in order to assess sickle cell inhibitory activity of the recipe, by using Emmel’s method. The decocted (DS) and the aqueous extract (EA) of the recipe brought the residual sickle cell rate at 10 and 11% respectively. Which correspond to sickle cell inhibitory activity of 90% for the decocted (DS) and 89% for the aqueous extract (EA). These activities were higher than that of phenylalanine (83%) which is used as an antisickling amino acid reference. The chemical study of the both extracts of the recipe revealed the presence of compounds known for their anti-oxidant and anti-sickle cell activities. Those flavonoids, polyphenols and alkaloids could be partly responsible for the sickle cell inhibitory activity of the recipe. These results showed that both the extracts of the recipe had antisickling activity. The use of this recipe of four plants in the traditional treatment of sickle cell disease in the Daloa region might be justified.

scholarly journals Antibiotic Therapy Associated Cardiotoxicity

2021 ◽  
Vol 4 (10) ◽  
pp. RV18-RV21
Author(s):  
Manisha Jha ◽  
Akram Khan
Keyword(s):  
Antibiotic Therapy ◽  
Health Risks ◽  
Adverse Reactions ◽  
Therapeutic Agents ◽  
Qt Prolongation ◽  
Aortic Aneurysms ◽  
Drug Reactions ◽  
Frequent Use ◽  
High Concern

The improper and frequent use of antibiotics has been on a rise. Empirical use for unapproved indications leads to development of resistant pathogens. Many other adverse drug reactions are associated with the use of antibiotics. These may be due to the direct effect of these drugs or due to their interactions with other therapeutic agents. Cardiac toxicities like QT prolongation, aortic aneurysms and dissections are of high concern and may result in long-term health risks. To prevent these adverse reactions, antibiotics should be used as per the manufacturer’s and physician’s instructions. The use of interacting drugs should be avoided wherever possible. Polypharmacy practice should be done after considering all the patient’s health aspects. This review summarizes the cardiac toxicities of commonly prescribed antibiotics and their interactions with other drugs.

scholarly journals Mutravirechaniya mahakashaya as a solution towards urinary disorders – A compilation on research-based evaluation

2020 ◽  
Vol 6 (3) ◽  
pp. 194-201
Author(s):  
Darshana Deka ◽  
Keyword(s):  
Biological Activities ◽  
Fluid Collection ◽  
Medical Science ◽  
Urinary Calculi ◽  
Renal Calculi ◽  
Treatment Modalities ◽  
Renal Diseases ◽  
Individual Plant ◽  
Urinary Flow ◽  
Traditional System

Renal disorders are growing very rapidly among people all over the world nowadays and the treatment modalities available in modern medicine have undesirable side effects on human health. Plants of mutravirechaniya mahakashaya, described as, 35th mahakashaya in the 4th chapter of Charaka Samhita, Purvardha are mostly recognised for their urine inducing or urinary flow increasing capacity along with urinary system defending property in the ancient ayurvedic medical science. Formulations containing these plants as main ingredients have been regularly prescribed for the cases of abdominal fluid collection, renal problems, renal calculi, fluid collection in the lower extremities or any other cases of fluid overload in traditional system of Indian medicine. Studies approving urinary flow enhancing capacity along with the urinary calculi destroying property for the active ingredient of the individual plant, explain these plants’ utilization for renal diseases. Induction of adequate urine output is the basic concept of treatment for these disorders as majority of these conditions hamper normal filtration mechanism of the excretory system. Current article tries to specify the research works done scientifically upon the herbs having diuretic properties grouped together under the roof of mutravirechaniya mahakashaya in ayurvedic classics. It is composed of the knowledge gained from various scholarly articles, scientific papers, books and research topics gathered through the medium of documentation and internet. The presented compilation work helps towards proving its biological activities and pharmacology of its extracts which will contribute towards further exploration of this group of great clinical potential. However, further studies should be carried out to identify the mechanism of the pharmacological actions of these drugs classically mentioned in a group of diuretics.

scholarly journals REVIEW: Organosulphure compound of garlic (Allium sativum L.) and its biological activities

2003 ◽  
Vol 1 (2) ◽  
pp. 65-76 ◽  
Author(s):  
UDHI EKO HERNAWAN ◽  
AHMAD DWI SETYAWAN
Keyword(s):  
Platelet Aggregation ◽  
Side Effects ◽  
Allium Sativum ◽  
Urinary Infection ◽  
Biological Activities ◽  
Bioactive Compound ◽  
Traditional Medicines ◽  
Anti Cancer ◽  
Long Time ◽  
Anti Oxidant

Garlic has been used a long time ago as traditional medicines. The valuable bulb is used to treat hypertension, respiratory infection, headache, hemorrhoids, constipation, bruised injury or slice, insomnia, cholesterol, influenza, urinary infection, etc. Garlic bulbs can be used as anti-diabetic, anti-hypertension, anti-cholesterol, anti-atheroschlerosis, anti-oxidant, anti-cell platelet aggregation, fibrinolyse spur, anti-viral, anti-microbial, and anti-cancer. The ultimate bioactive compound of garlic is organo-sulphure components, i.e. alliin, allicin, ajoene, allyl sulphide groups, and allyl cystein. There was not any report of any side effects or toxicity of garlic.

Three Dynamic Healing Modalities for the Treatment of Substance Use and Co-Occurring Disorders: Aromatherapy, Equine Therapy, and Creative Arts Therapies

2018 ◽  
Author(s):  
E. Hitchcock Scott
Keyword(s):  
Large Scale ◽  
Addiction Treatment ◽  
Treatment Modalities ◽  
Treatment Programs ◽  
Creative Arts ◽  
Traditional Treatment ◽  
Equine Therapy ◽  
Creative Arts Therapies ◽  
The Right ◽  
Healing Modalities

This chapter comprises three subchapters, and each subchapter offers a brief introduction to 1 of 3 healing modalities: (1) aromatherapy, (2) equine therapy, and (3) creative arts therapies. All 3 healing processes are considered to be well regarded in the field of addiction treatment. Yet the credibility of each one could benefit from more well-designed, large-scale, randomized controlled trials. Even so, there is significant research supporting the efficacy of each of the 3 treatment modalities. Safety is especially important with impulsive patient populations, such as those with dual diagnoses, addiction and trauma. All three modalities are able to be powerful, and at times transformative, when practiced by qualified health practitioners. For patients who struggle with substance abuse, co-occurring disorders and adverse childhood experiences, especially those who have felt as if they were failed by traditional treatment programs, a non-traditional treatment modality may provide just the right intervention.

scholarly journals New legume sources as therapeutic agents

2002 ◽  
Vol 88 (S3) ◽  
pp. 287-292 ◽  
Author(s):  
Zecharia Madar ◽  
Aliza H. Stark
Keyword(s):  
Functional Foods ◽  
Health Benefits ◽  
Glycaemic Index ◽  
Therapeutic Agents ◽  
Lipid Lowering ◽  
Potential Health ◽  
Saponin Content ◽  
Daily Diet ◽  
Faba Beans ◽  
Therapeutic Properties

This review evaluates the potential health benefits of three legume sources that rarely appear in Western diets and are often overlooked as functional foods. Fenugreek (Trigonella foenum graecum) and isolated fenugreek fractions have been shown to act as hypoglycaemic and hypocholesterolaemic agents in both animal and human studies. The unique dietary fibre composition and high saponin content in fenugreek appears to be responsible for these therapeutic properties. Faba beans (Vicia faba) have lipid-lowering effects and may also be a good source of antioxidants and chemopreventive factors. Mung beans (Phaseolus aureus, Vigna radiatus) are thought to be beneficial as an antidiabetic, low glycaemic index food, rich in antioxidants. Evidence suggests that these three novel sources of legumes may provide health benefits when included in the daily diet.

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