Administration of a Nutraceutical Mixture Composed by Aloe arborescens, Annona muricata, Morinda citrifolia, Beta rubra, Scutellaria baicalensis, and Vaccinium myrtillus Reduces Doxorubicin-Induced Side Effects

Tanaman obat merupakan jenis tumbuhan yang dapat memberikan manfaat medis bagi manusia, jenis tanaman ini banayak ditemukan dilingkungan sekitar maupun dihutan. Penelitian tentang tanaman obat di Taman Hutan Raya Prof.Ir Herman Yohanes Desa Kotabes berlangsung selama satu bulan yaitu bulan Februari-Maret 2019. Tujuan dari penelitian ini adalah untuk mengetahui jenis-jenis tanaman obat yang berpotensi sebagai obat trdisional bagi masyarakat Desa Kotabes. Manfaat dari penelitian ini yaitu seabagai informasi bagi masyarakat Nusa Tenggra Timur secara khususnya dan bagi masyarakat Indonesia pada umumnya. Manfaat lain yaitu sebagai data keanekaragaman tanaman obat Nusantara khususnya di TAHURA Kupang. Metode yang digunakan dalam penelitian ini berupa metode belt transek (transek sabuk) dengan transek kuadran. Hasil penelitian dianalisis berdasarkan pada buku Tanaman obat Andriani & Arisandi 2008, buku Flora Van Stenis 2008 dan jurnal. Analisis keanekaragaman jenis tanaman obat menggunakan rumus Shannon-Wiener. Adapun spesies tanaman obat yang ditemukan yakni: Arange pinnate, Plectocomiopsis mira, Strobilantes crispus, Annona muricata, Chromolaena odorata, Alstonia scholaris, Garnicia cf.bancana, Ceiba pentandra, Swietenia macrophylla, Piper caducibra cteum, Morinda citrifolia, dan sterculia quadrifa. Ke-sebelasan spesies tergolong dalam famili : Araceae, Acantahceae, Annonaceae, Asteraceae, Apocynaceae, Gutiferae, Malvaceae, Meliaceae, Piperaceae, Rubiaceae, dan Sterculiaceae. Indeks keanekaragaman tanaman obat pada setiap stasiun yaitu pada stasiun 1dengan H’= 0,87, stasiun 2 dengan H’= 0,71, dan pada stasiun 3 dengan H’= 0,78 yang diperoleh di Taman Hutan Raya Prof.Ir Herman Yohanes dan tergolong dalam indeks keanekaragaman rendah. Dari penelitian ini diharapkan adanya penelitian lanjutan untuk mengetahui kandungan kimia dan pemakaian dosis agar terjamin keamanan kesehatan pengguna.

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Anti-leech activity of Scutellaria baicalensis and Morinda citrifolia extracts against Piscicola geometra

IOP Conference Series Earth and Environmental Science ◽

10.1088/1755-1315/137/1/012031 ◽

2018 ◽

Vol 137 ◽

pp. 012031 ◽

Cited By ~ 2

Author(s):

P N Rizky ◽

T C Cheng ◽

H Nursyam

Keyword(s):

Scutellaria Baicalensis ◽

Morinda Citrifolia

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Análise in vitro da atividade antifúngica de extratos vegetais frente a leveduras pertencentes à espécie Candida albicans

Research Society and Development ◽

10.33448/rsd-v10i10.19075 ◽

2021 ◽

Vol 10 (10) ◽

pp. e440101019075

Author(s):

Lara Vitória de Araújo Costa Pereira ◽

Luciane Costa Silva ◽

Marcela Coelho de Sá ◽

Mariana de Carvalho Moreira ◽

Gabriel Lima Maia Soares do Nascimento ◽

...

Keyword(s):

Candida Albicans ◽

Apis Mellifera ◽

Morus Alba ◽

Morinda Citrifolia ◽

Annona Muricata ◽

Caryocar Brasiliense

A candidíase é uma das afecções mais comuns, estimando-se que a grande parte das mulheres apresentará, ao longo da vida, pelo menos um episódio da infecção. E com isso a importância de estudos sobre outros métodos alternativos para tratamento baseados em extratos vegetais, os quais apresentam potencial ecológico para substituir o emprego de produtos sintéticos. Assim, a pesquisa teve como objetivo analisar a atividade antifúngica de extratos brutos dos vegetais Morinda citrifolia (None), Caryocar brasiliense (Pequi), Annona muricata (Graviola), Morus alba L. (Amora) e Apis mellífera L. (Própolis) frente a levedura Candida albicans. Os vegetais foram coletados no município de Teresina-PI e secos a temperatura ambiente sob a sombra, com exposição diária de 4 h; moídos em moinho de facas; os extratos foram obtidos em metanol e os testes de suscetibilidade foram realizados em triplicata nos meios de cultura ágar-ágar e ágar Muller-Hinton, pela técnica da difusão em ágar. Utilizou-se a cepa de Candida albicans ATCC-76485 nos testes. Dos cinco vegetais utilizados, os extratos de Pequi e de Própolis, apresentaram atividade antifúngica sobre a cepa de C. albicans, com o segundo extrato apresentando maior poder de ação sobre a levedura. Portanto, os extratos do Apis melífera L. e do Caryocar brasiliense apresentaram atividade anti C. albicans, enquanto os de Morus alba L., Morinda citifolia L. e Annona muricata L. não apresentaram.

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Effect of Morinda citrifolia and Annona muricata on Erhlich Tumor Cells in Swiss Albino Mice and In Vitro Fibroblast Cells

Journal of Medicinal Food ◽

10.1089/jmf.2018.0061 ◽

2019 ◽

Vol 22 (1) ◽

pp. 46-51

Author(s):

Cleber da Silveira Torres ◽

Francisnaira da Silva Santos ◽

Elen Landgraf Guiguer ◽

Adriano Cressoni de Araújo ◽

Sandra Maria Barbalho ◽

...

Keyword(s):

Tumor Cells ◽

Morinda Citrifolia ◽

Fibroblast Cells ◽

Annona Muricata ◽

Swiss Albino Mice ◽

Albino Mice

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KOMBINASI EKSTRAK BUAH MENGKUDU (Morinda citrifolia L.) DAN DAUN SIRSAK (Annona muricata L.) DALAM MENGHAMBAT BAKTERI Escherichia coli DAN Staphylococcus aureus

Kartika Jurnal Ilmiah Farmasi ◽

10.26874/kjif.v4i2.65 ◽

2016 ◽

Vol 4 (2) ◽

Author(s):

Sri Sudewi ◽

Widya Astuty Lolo

Keyword(s):

Escherichia Coli ◽

Staphylococcus Aureus ◽

Morinda Citrifolia ◽

Annona Muricata

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Increasing antioxidant activity of soursop (Annona muricata L.) and noni (Morinda citrifolia L.) leaves fermented by Lactobacillus plantarum BP102

Journal of Biological Researches ◽

10.23869/bphjbr.27.2.20223 ◽

2022 ◽

Vol 27 (2) ◽

pp. 73-77

Author(s):

Dayu Nirwana Putri ◽

Sri Widyarti ◽

Yoga Dwi Jatmiko

Keyword(s):

Antioxidant Activity ◽

Lactobacillus Plantarum ◽

Methanol Extract ◽

Cell Metabolism ◽

Morinda Citrifolia ◽

Activity Levels ◽

Annona Muricata ◽

High Concentration ◽

Dpph Method ◽

External Sources

Free radicals are constantly produced by either cell metabolism or from external sources. At high concentration, they induced a tissue damage called oxidative stress. Soursop leaf (Annona muricata L.) and noni leaf (Morinda citrifolia L.) are medicinal plants with potency as antioxidants. This study aimed to evaluate the capacity of Lactobacillus plantarum BP102 in elevating the antioxidant activity of soursop and noni leaves. Dried-powder and methanol extract of soursop and noni leaves were diluted with sterile distilled water 3 g/30 mL and 0.3 g/30 mL, respectively, inoculated with 1% (v/v) of L. plantarum BP102 inoculum. The antioxidant activity was carried out using the 2.2-diphenyl-1-picrylhydrazyl (DPPH) method. The antioxidant activity increased in dried-powder and methanol extract of soursop and noni leaves with different activity levels after being fermented using L. plantarum BP102 based on IC50. The increasing antioxidant activity in dried-powder of soursop leaves IC50 6.41±0.06 to 0.034±0.01 mg/mL (99.5%) was higher than of the methanol extract IC50 2.78±0.00 to 0.11±0.01 mg/mL (96%). Unfortunately, the effect of fermentation towards noni leaves could only be observed in the form of methanol extract IC50 12.8±0.01 to 0.33±0.02 mg/mL (increased by 97.4%), the dried-powder of noni leaves was suspended and produced a dark color. The probiotic L. plantarum BP102 was used as a fermented agent in increasing the bioactive compounds especially related to antioxidant activity.

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Gastric Ulcers Produced by Cisplatin

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100099337 ◽

1981 ◽

Vol 39 ◽

pp. 582-583

Author(s):

S.K. Aggarwal ◽

J. San Antonio

Keyword(s):

Electron Microscopy ◽

Single Dose ◽

Side Effects ◽

Antitumor Agent ◽

Gastric Ulcers ◽

Enzyme Cytochemistry ◽

Intestinal Toxicity ◽

Ovarian Cancers ◽

Inner Surface

Cisplatin (cis-dichlorodiammineplatinum(II)) a potent antitumor agent is now available for the treatment of testicular and ovarian cancers. It is however, not free from its serious side effects including nephrotoxicity, gastro intestinal toxicity, myelosuppression, and ototoxicity. Here we now report that the drug produces peculiar bloating of the stomach in rats and induces acute ulceration.Wistar-derived rats weighing 200-250 g were administered cisplatin(9 mg/kg) ip as a single dose in 0.15 M NaCl. After 3 days the animals were sacrificed by decapitation. The stomachs were removed, the contents analyzed for pepsin and acidity. The inner surface was examined with a dissecting microscope after a moderate stretching for ulcers. Affected areas were fixed and processed for routine electron microscopy and enzyme cytochemistry.The drug treated animals kept on food and water consistently showed bloating and lesions (Fig. 1) with a frequency of 6-70 ulcers in the rumen section of the stomachs.

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Effects of cisplatin treatment on the rat neurohypophysis

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100142256 ◽

1986 ◽

Vol 44 ◽

pp. 122-123

Author(s):

J.M. Fadool ◽

P.J. Boyer ◽

S.K. Aggarwal

Keyword(s):

Side Effects ◽

Urine Output ◽

Morphological Changes ◽

Limiting Factor ◽

Antineoplastic Drugs

Cisplatin (CDDP) is currently one of the most valuable antineoplastic drugs available. However, it has severe toxic side effects of which nephrotoxicity is the major dose limiting factor in its use. It induces morphological changes in the kidney with hampered urine output. The present study is an effort to determine the influence of the drug on the neurohypophysis for any antidiuretic effects on the kidney.

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Severe Drooling and Treatment With Botulinum Toxin

Perspectives on Swallowing and Swallowing Disorders (Dysphagia) ◽

10.1044/sasd21.1.15 ◽

2012 ◽

Vol 21 (1) ◽

pp. 15-21

Author(s):

Merete Bakke ◽

Allan Bardow ◽

Eigild Møller

Keyword(s):

Botulinum Toxin ◽

Side Effects ◽

Health Risk ◽

Flow Rate ◽

Clinical Evidence ◽

Acetylcholine Release ◽

Psychosocial Problems ◽

Rate Reduction ◽

Local Inhibition ◽

Surgical Treatments

Severe drooling is associated with discomfort and psychosocial problems and may constitute a health risk. A variety of different surgical and non-surgical treatments have been used to diminish drooling, some of them with little or uncertain effect and others more effective but irreversible or with side effects. Based on clinical evidence, injection with botulinum toxin (BTX) into the parotid and submandibular glands is a useful treatment option, because it is local, reversible, and with few side effects, although it has to be repeated. The mechanism of BTX is a local inhibition of acetylcholine release, which diminishes receptor-coupled secretion and results in a flow rate reduction of 25–50% for 2–7 months.

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