3D printing for enhanced drug delivery: current state-of-the-art and challenges

Clay–polymer composite materials is an exciting area of research and this Special Issue aims to address the current state-of-the-art of “Polymer Clay Nano-Composites” for several applications, among them antibacterial, environmental, water remediation, dental, drug delivery and others [...]

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Integrating real-time multi-resolution scanning and machine learning for Conformal Robotic 3D Printing in Architecture

International Journal of Architectural Computing ◽

10.1177/1478077120948203 ◽

2020 ◽

Vol 18 (4) ◽

pp. 371-384 ◽

Cited By ~ 1

Author(s):

Paul Nicholas ◽

Gabriella Rossi ◽

Ella Williams ◽

Michael Bennett ◽

Tim Schork

Keyword(s):

3D Printing ◽

State Of The Art ◽

Integrated Approach ◽

Design Experiment ◽

Material Behaviour ◽

New Materials ◽

Current State ◽

Neural Network Prediction ◽

Network Prediction ◽

Design Customization

Robotic 3D printing applications are rapidly growing in architecture, where they enable the introduction of new materials and bespoke geometries. However, current approaches remain limited to printing on top of a flat build bed. This limits robotic 3D printing’s impact as a sustainable technology: opportunities to customize or enhance existing elements, or to utilize complex material behaviour are missed. This paper addresses the potentials of conformal 3D printing and presents a novel and robust workflow for printing onto unknown and arbitrarily shaped 3D substrates. The workflow combines dual-resolution Robotic Scanning, Neural Network prediction and printing of PETG plastic. This integrated approach offers the advantage of responding directly to unknown geometries through automated performance design customization. This paper firstly contextualizes the work within the current state of the art of conformal printing. We then describe our methodology and the design experiment we have used to test it. We lastly describe the key findings, potentials and limitations of the work, as well as the next steps in this research.

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Nanoarchitectonics: Complexes and Conjugates of Platinum Drugs with Silicon Containing Nanocarriers. An Overview

International Journal of Molecular Sciences ◽

10.3390/ijms22179264 ◽

2021 ◽

Vol 22 (17) ◽

pp. 9264

Author(s):

Kinga Piorecka ◽

Jan Kurjata ◽

Wlodzimierz A. Stanczyk

Keyword(s):

Drug Delivery ◽

Driving Force ◽

State Of The Art ◽

Platinum Drugs ◽

Research Groups ◽

Current State ◽

Delivery Platform ◽

Silicon Based ◽

Intensive Search

The development in the area of novel anticancer prodrugs (conjugates and complexes) has attracted growing attention from many research groups. The dangerous side effects of currently used anticancer drugs, including cisplatin and other platinum based drugs, as well their systemic toxicity is a driving force for intensive search and presents a safer way in delivery platform of active molecules. Silicon based nanocarriers play an important role in achieving the goal of synthesis of the more effective prodrugs. It is worth to underline that silicon based platform including silica and silsesquioxane nanocarriers offers higher stability, biocompatibility of such the materials and pro-longed release of active platinum drugs. Silicon nanomaterials themselves are well-known for improving drug delivery, being themselves non-toxic, and versatile, and tailored surface chemistry. This review summarizes the current state-of-the-art within constructs of silicon-containing nano-carriers conjugated and complexed with platinum based drugs. Contrary to a number of other reviews, it stresses the role of nano-chemistry as a primary tool in the development of novel prodrugs.

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Delving Deeper into Dermal and Transdermal Drug Delivery: Factors and Mechanisms Associated with Nanocarrier-mediated Strategies

Current Pharmaceutical Design ◽

10.2174/1381612824666180924122640 ◽

2018 ◽

Vol 24 (27) ◽

pp. 3210-3222 ◽

Cited By ~ 6

Author(s):

Jyothsna Manikkath ◽

TK Sumathy ◽

Aparna Manikkath ◽

Srinivas Mutalik

Keyword(s):

Drug Delivery ◽

Transdermal Delivery ◽

Transdermal Drug Delivery ◽

Dispersion Medium ◽

State Of The Art ◽

Particle Engineering ◽

Key Factors ◽

Current State ◽

Routes Of Drug Administration ◽

Drug And Gene Delivery

Background: Advances in material science and particle engineering have led to the development of a rapidly growing number of nanoparticulate carriers for drug and gene delivery. These carriers are increasingly being investigated in dermal and transdermal routes of drug administration. Objective: To critically examine and summarize the primary factors and mechanisms involved in nanocarriermediated dermal and transdermal delivery of drugs. Method: Thorough literature search was undertaken, spanning the early development of nanocarrier-mediated dermal and transdermal drug delivery approaches, to the current state of the art, using online search tools. Results: Physicochemical, formulation, experimental and morphological factors, such as, material of construction or type of nanoparticle (NP), surface chemistry, particle size, particle shape, surface charge, dispersion medium, duration of exposure of skin to NPs, combination of NPs with physical agents, and aspects related to skin were identified and discussed. Conclusion: The key factors and mechanisms which influence NPs-skin interactions in dermal and transdermal drug delivery are discussed in this article in-line with the current advances in the field.

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Exosomes and Exosome-Inspired Vesicles for Targeted Drug Delivery

Pharmaceutics ◽

10.3390/pharmaceutics10040218 ◽

2018 ◽

Vol 10 (4) ◽

pp. 218 ◽

Cited By ~ 94

Author(s):

Sophia Antimisiaris ◽

Spyridon Mourtas ◽

Antonia Marazioti

Keyword(s):

Drug Delivery ◽

Targeted Drug Delivery ◽

State Of The Art ◽

Current State ◽

Targeted Drug

The similarities between exosomes and liposomes, together with the high organotropism of several types of exosomes, have recently prompted the development of engineered-exosomes or exosome-mimetics, which may be artificial (liposomal) or cell-derived vesicles, as advanced platforms for targeted drug delivery. Here, we provide the current state-of-the-art of using exosome or exosome-inspired systems for drug delivery. We review the various approaches investigated and the shortcomings of each approach. Finally the challenges which have been identified to date in this field are summarized.

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Bio-Inspired Polymer-Polymer Hybrids for Medical Applications

10.20944/preprints202106.0026.v1 ◽

2021 ◽

Author(s):

Gokhan Demirci ◽

Malwina Niedzwiedz ◽

Nina Kantor-Malujdy ◽

Miroslawa El Fray

Keyword(s):

Drug Delivery ◽

Hybrid Systems ◽

Drug Delivery Systems ◽

State Of The Art ◽

Antibacterial Properties ◽

Delivery Systems ◽

Medical Applications ◽

Polymer Hybrid ◽

Current State ◽

Advanced Biomaterials

Novel bio-inspired materials have gained recently great attention, especially in medical applications. Applying sophisticated design and engineering methods, various polymer-polymer hybrid systems with outstanding performance have been developed in last decades. Hybrid systems composed of bioelastomers and hydrogels are very attractive due to their high biocompatibility and elastic nature for advanced biomaterials used in various medical applications such as drug delivery systems and scaffolds for tissue engineering. Herein, we describe the advances in current state-of-the-art design, properties and applications of polymer-polymer hybrid systems in medical applications. Bio-inspired functionalities, including bioadhesiveness, injectability, antibacterial properties and degradability applicable to advanced drug delivery systems and medical devices will be discussed in a context of future efforts towards development of bioinspired materials.

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The changing face of additive manufacturing

Journal of Manufacturing Technology Management ◽

10.1108/jmtm-12-2016-0182 ◽

2017 ◽

Vol 28 (1) ◽

pp. 10-17 ◽

Cited By ~ 26

Author(s):

Ian Gibson

Keyword(s):

Additive Manufacturing ◽

3D Printing ◽

Design Methodology ◽

State Of The Art ◽

Personal Perspective ◽

Numerous Application ◽

Content Type ◽

The Past ◽

Current State ◽

The Future

Purpose The purpose of this paper is to discuss the current state-of-the-art in additive manufacturing, more commonly known as 3D printing, from the business perspectives. The primary drivers behind the development of the associated technologies are considered along with features that limit growth. Design/methodology/approach The approach is a personal perspective, based on approximately 25-years study of the development of the associated technologies and applications. Findings The discussion has found that the technology is still growing healthily, but with an understanding that there are numerous application areas that should be considered separately. Some areas are significantly more mature than others and success in some areas does not guarantee success in others. Originality/value This viewpoint has been prepared for the current state-of-the-art and can be compared with earlier viewpoints to see how things may have changed in the past. This should be of value to those interested to explore how the technology has developed in recent times and how it may move into the future.

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Nanostructured Lipid Carriers (NLCs): Nose-to-Brain Delivery and Theranostic Application

Current Drug Metabolism ◽

10.2174/1389200221666200719003304 ◽

2020 ◽

Vol 21 (14) ◽

pp. 1136-1143 ◽

Cited By ~ 2

Author(s):

Javed Ahmad ◽

Md. Rizwanullah ◽

Saima Amin ◽

Musarrat Husain Warsi ◽

Mohammad Zaki Ahmad ◽

...

Keyword(s):

Drug Delivery ◽

Drug Administration ◽

Neurological Disorders ◽

State Of The Art ◽

Scientific Data ◽

Nanostructured Lipid Carriers ◽

Brain Delivery ◽

Intranasal Route ◽

Current State ◽

The Brain

Background: Nanostructured lipid carriers (NLCs) are in high demand in the existing pharmaceutical domain due to its high versatility. It is the newer generation of lipid nanoparticulate systems having a solid matrix and greater stability at room temperature. Objective: To review the evidence related to the current state of the art of the NLCs system and its drug delivery perspectives to the brain. Methods: Scientific data search, review of the current state of the art and drug delivery perspectives to the brain for NLCs were undertaken to assess the applicability of NLCs in the management of neurological disorders through an intranasal route of drug administration Results: NLCs are designed to fulfill all the industrial needs like simple technology, low cost, scalability, and quantifications. Biodegradable and biocompatible lipids and surfactants used for NLCs have rendered them acceptable from regulatory perspectives as well. Apart from these, NLCs have unique properties of high drug payload, modulation of drug release profile, minimum drug expulsion during storage, and incorporation in various dosage forms like gel, creams, granules, pellets, powders for reconstitution and colloidal dispersion. Ease of surface- modification of NLCs enhances targeting efficiency and reduces systemic toxicity by providing site-specific delivery to the brain through the intranasal route of drug administration. Conclusion: The present review encompasses the in-depth discussion over the current state of the art of NLCs, nose-to-brain drug delivery perspectives, and its theranostic application as useful tools for better management of various neurological disorders. Further, pharmacokinetic consideration and toxicity concern is also discussed specifically for the NLCs system exploited in nose-to-brain delivery.

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Exosomes and Exosome-Inspired Vesicles for Targeted Drug Delivery

10.20944/preprints201810.0507.v1 ◽

2018 ◽

Cited By ~ 1

Author(s):

Sophia G. Antimisiaris ◽

Spyridon Mourtas ◽

Antonia Marazioti

Keyword(s):

Drug Delivery ◽

Targeted Drug Delivery ◽

State Of The Art ◽

Current State ◽

Targeted Drug

The similarities between exosomes and liposomes, together with the high organotropism of several types of exosomes, have recently prompted the development of engineered-exosomes or exosome-mimetics, which may be artificial (liposomal) or cell-derived vesicles, as advanced platforms for targeted drug delivery. Here we provide the current state-of-the-art of using exosome or exosome-inspired systems for drug delivery. We review the various approaches investigated and the shortcomings of each approach. Finally the challenges identified up-to-date in this field are summarized.

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Drug Delivery Nanosystems in Glioblastoma Multiforme Treatment: Current State of the Art

Current Neuropharmacology ◽

10.2174/1570159x18666200831160627 ◽

2020 ◽

Vol 18 ◽

Author(s):

Leonardo Delello Di Filippo ◽

Jonatas Lobato Duarte ◽

Marcela Tavares Luiz ◽

Jennifer Thayane Cavalcante de Araújo ◽

Marlus Chorilli

Keyword(s):

Drug Delivery ◽

Glioblastoma Multiforme ◽

State Of The Art ◽

Biological Effects ◽

Tumor Resection ◽

Inorganic Nanoparticles ◽

Future Perspectives ◽

Central Nervous System Cancer ◽

Current State ◽

Biopharmaceutical Properties

: Glioblastoma multiforme (GBM) is the most common primary malignant Central Nervous System cancer, responsible for about 4% of all deaths associated with neoplasia, characterized as one of the most fatal human cancers. Tumor resection does not possess curative character, thereby radio and/or chemotherapy are often necessary for the treatment of GBM. However, drugs used in GBM chemotherapy present some limitations, such as side effects associated with nonspecific drug biodistribution as well as limited bioavailability, which limits their clinical use. To attenuate the systemic toxicity and overcome the poor bioavailability, a very attractive approach is drug encapsulation in drug delivery nanosystems. The main focus of this review is to explore the actual cancer global problem, enunciate barriers to overcome in the pharmacological treatment of GBM, as well as the most updated drug delivery nanosystems for GBM treatment and how they influence biopharmaceutical properties of anti-GBM drugs. The discussion will approach lipid-based and polymeric nanosystems, as well as inorganic nanoparticles, regarding their technical aspects as well as biological effects in GBM treatment. Furthermore, the current state of the art, challenges to overcome and future perspectives in GBM treatment will be discussed.

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