scholarly journals Analysis of the effect of ionizing radiation on the properties of bulk nonwoven material

2021 ◽  
Vol 2124 (1) ◽  
pp. 012024
Author(s):  
M S Lisanevich ◽  
R Yu Galimzyanova ◽  
V V Ivanov
Keyword(s):  
Ionizing Radiation ◽  
Medical Devices ◽  
Dose Range ◽  
Nonwoven Material ◽  
Breaking Load ◽  
Static Field ◽  
Wound Dressings ◽  
Radiation Sterilization ◽  
Nonwoven Materials ◽  
Wide Range

Abstract At the moment, there is a wide range of bulky nonwovens for various purposes on the market. One of the important areas of using such materials is healthcare. In particular, bulky nonwoven materials are intended for the manufacture of wound dressings, evacuation kits for newborns. Disposable medical devices of this kind are usually subjected to radiation sterilization. As is known from earlier studies, radiation sterilization significantly affects the performance of nonwovens. In this regard, for nonwoven materials for medical use, an important characteristic is the stability of indicators after exposure to radiation sterilization. As a result of the study of bulk nonwovens Holofiber ® after radiation radiation in the dose range from 20-60 kGy, there were no significant changes in operational performance. The stiffness increased by an average of 3-10%. The stiffness indicators after ionizing radiation according to GOST 24684 also meet the requirements. The value of electrification increased due to an increase in the static field under the action of ionizing radiation. It is worth noting that the values of electrification are within the norm established by GOST 32995. The breaking load varies from 1-5%. Thus, non-woven materials Holofiber ® PROFI, article P 35191, Holofiber ® SOFT, article P 5197, Holofiber ® SOFT, article P 5200 are recommended for the production of medical devices.

scholarly journals Effects of radiation sterilization on the properties of nonwoven medical devices

2020 ◽  
Vol 64 (11) ◽  
pp. 127-134
Author(s):  
Maria S. Lisanevich ◽  
◽  
Reseda Yu. Galimzyanova ◽  
Ildar N. Musin ◽  
◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Medical Devices ◽  
Human Life ◽  
Low Cost ◽  
Absorbed Dose ◽  
Nonwoven Material ◽  
Radiation Sterilization ◽  
Nonwoven Materials ◽  
Wide Range ◽  
Materials Used

Currently, there is a tendency for a significant increase in production and expansion of areas of application of nonwoven materials (NM), which are used in almost all areas of human life. Such properties of NMs as hydrophilicity or hydrophobicity, air permeability, good barrier and strength indicators at a relative low cost allow them to be effectively used for medical purposes. Nonwovens for medical use (NMMN) are considered. The most important stage in the final processing of medical devices made of NM is radiation sterilization. The influence of the absorbed dose and the type of ionizing radiation on the properties of NMMN of various designs: obtained by spunlace technology, by spunbond-meltblown-spunbond technology, and laminated nonwoven material has been studied. As a result of the conducted research, it was recommended: to sterilize NM with an electron beam, to control the consumer properties of medical devices from NM to check the quality of products after sterilization by assessing the change in the strength index with elongation, additionally to assess for laminated NM – water resistance, spunlace – absorption. In the production of nonwoven materials, various polymers are used, which have correspondingly different resistance to radiation sterilization. Some materials, for example, based on polypropylene, degrade when exposed to radiation, and the level of technical characteristics of the material is significantly reduced. It is also possible for autooxidative reactions initiated by radiation to occur in polymers, which can continue for a long time after irradiation of articles. To use these materials in radiation sterilized medical devices, it is necessary to have an understanding of the effect of ionizing radiation in a wide range of sterilizing doses on the materials used in these devices.

The Effect of Radiation Sterilization on the Stress-Strain Properties of Non-Woven Materials -Based on Polypropylene

2020 ◽  
Vol 992 ◽  
pp. 403-408
Author(s):  
Elvina R. Rakhmatullina ◽  
M.S. Lisanevich ◽  
Rezeda Yu. Galimzyanova ◽  
Yu.N. Khakimullin
Keyword(s):  
Ionizing Radiation ◽  
Absorbed Dose ◽  
Breaking Load ◽  
Radiation Sterilization ◽  
Stress Strain ◽  
Cross Direction ◽  
Absorbed Doses ◽  
Single Use ◽  
The Cross ◽  
The Web

Non-woven materials are widely used for the manufacture of disposable medical clothing and underwear. Radiation is widely used to sterilize single-use medical devices. The paper analyzes the effect of ionizing radiation at absorbed doses of 0-60 kGy on the stress-strain properties of medical non-woven spanmelt material based on polypropylene obtained by blow-molding technology. It has been established that ionizing radiation significantly reduces the breaking load and elongation in the machine and cross directions of the web. For this type of material, the most critical is the decrease in strength in the cross direction of the web, primarily because the level of strength in the cross direction of spanmelt materials is generally low. Sterilization by ionizing radiation further reduces strength and leads to the fact that non-woven materials irradiated with an absorbed dose of 50-60 kGy are close to unacceptable values in accordance with the requirements of EN 13975-2011.

Influence of Gamma and Electron Radiation on the Strength Characteristics of Nonwoven SMS Materials Based on Polypropylene

2021 ◽  
Vol 899 ◽  
pp. 172-178
Author(s):  
Rezeda Yu. Galimzyanova ◽  
Maria S. Lisanevich ◽  
Yuri N. Khakimullin
Keyword(s):  
Tensile Strength ◽  
Ionizing Radiation ◽  
Barrier Properties ◽  
Strength Characteristics ◽  
Radiation Sterilization ◽  
Electron Radiation ◽  
Medical Products ◽  
Absorbed Doses ◽  
Nonwoven Materials ◽  
Important Health

Radiation sterilization is widely used to sterilize nonwoven SMS medical products. SMS materials have improved filtering and barrier properties, low bacteriopermeability and, due to these properties, are indispensable for medicine. They are used to make such important health care products as disposable surgical clothing and underwear. As a result of the research carried out, the effect of gamma and electron radiation, in the range of absorbed doses from 15 to 25 kGy, on the strength characteristics of nonwoven SMS materials based on polypropylene with a surface density of 35, 40, 50 g/cm2 was studied. It has been established that the strength characteristics (tensile strength, tensile strength, and tear strength) of nonwoven materials decrease after exposure to ionizing radiation. The higher the density of the material, the more its characteristics decrease after radiation sterilization. It was also found that gamma radiation, due to its nature, has a stronger effect on nonwoven materials based on polypropylene, and leads to a stronger decrease in strength characteristics. In general, for products sterilized by ionizing radiation and made from SMS materials, it is important to control the strength characteristics, primarily, the tensile strength in the transverse direction of the web stuff.

The Effect of Polyquinone and Phenol-Phosphite Stabilizer on the Resistance of Polypropylene to Ionizing Radiation

2019 ◽  
Vol 816 ◽  
pp. 328-332 ◽  
Author(s):  
M.S. Lisanevich ◽  
Elvina R. Rakhmatullina ◽  
Yu.N. Khakimullin ◽  
Rezeda Yu. Galimzyanova ◽  
R.M. Akhmadullin ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Medical Devices ◽  
Polymeric Materials ◽  
Melt Flow Index ◽  
Flow Index ◽  
Radiation Sterilization ◽  
Melt Flow ◽  
Medical Products ◽  
Degradation Temperature

For polymeric materials intended for the manufacture of disposable sterile medical devices, resistance to sterilization methods is important. For the manufacture of disposable medical products is widely used polypropylene, destructive during radiation sterilization. It is established that the addition of polyquinone leads to a decrease in the destruction of polypropylene, which is manifested in a decrease in the values of the melt flow index and an increase in the degradation temperature of polypropylene of the irradiated compositions.

scholarly journals Influence of electron radiation on the physical and mechanical properties of a nonwoven fabric made using Spunlace technology

2021 ◽  
Vol 2124 (1) ◽  
pp. 012015
Author(s):  
R Yu Galimzyanova ◽  
M S Lisanevich ◽  
Yu N Khakimullin
Keyword(s):  
Mechanical Properties ◽  
Ionizing Radiation ◽  
Relative Elongation ◽  
Physical And Mechanical Properties ◽  
Nonwoven Fabric ◽  
Breaking Load ◽  
Raw Material ◽  
Radiation Sterilization ◽  
Electron Radiation ◽  
Surgical Gowns

Abstract The effect of electron radiation on the physical and mechanical properties of Sontara nonwoven fabric produced using spunlace technology has been studied. The initial raw material for the manufacture of materials using this technology, as a rule, are viscose, polyester, polypropylene and cellulose fibers. Such nonwovens are highly breathable and are therefore used in disposable surgical gowns and suits. Since radiation can be used to sterilize disposable surgical gowns, it is important to assess the resistance to ionizing radiation. It was found that the Sontara brand material is resistant to the effects of ionizing radiation - the physical and mechanical characteristics of the material (breaking load and relative elongation) in the longitudinal and transverse directions of the web do not significantly change when irradiated with absorbed doses up to 60 kGy. It should also be noted that a cloth with a basis weight of 68 g/m2 has a significant smell of strength after radiation sterilization.

scholarly journals EPR-Investigation of Irradiated Imported Foodstuffs and Parameters of EPR Signals

2012 ◽  
Vol 14 (4) ◽  
pp. 343 ◽  
Author(s):  
T. Seredavina ◽  
O. Stakhov ◽  
N. Sushkova ◽  
A. Nurkasymova
Keyword(s):  
Dose Range ◽  
Radiation Sterilization ◽  
Paramagnetic Resonance ◽  
Wide Range ◽  
Radiation Induced ◽  
Electron Paramagnetic Resonance Technique ◽  
Probable Impact ◽  
Gamma Irradiated ◽  
Electron Paramagnetic ◽  
Selection Of

Study by EPR (electron paramagnetic resonance) technique of a wide range of food products imported to Kazakhstan and of analogous domestic foodstuffs has been carried out in order to develop a methodic that would make it possible to control the fact of radiation sterilization of food. Elaborated method of sample preparing for EPR-study included dividing into components, removing moisture by drying or lyophilizing then grinding till dimensional work fraction. Selection of optimal conditions for spectra recording and algorithm of spectra treatment enabled authors to allocate correctly initial EPR-signals and to obtain information on shape, intensities and parameters. Model gamma-irradiations of the initial whole products with subsequent study of prepared EPR-specimen have been carried out. Influence of irradiation on the intensities of EPR-signals and possible changes of EPR-characteristics have been studied in dose range (0.1-25) kGy. EPR-signals of free radicals (FR) of radiation origin were obtained from the EPR-spectra of gamma-irradiated delicious fruits, citrus, vegetables and others. Nonmonotonous dependences of FR concentration on a dose, along with linear ones were observed. Intensities of initial signals and of radiation-induced ones are much higher in solid components, than in pulp, dependences on dose are more close to linearity, which can be used in some cases for retrospective EPR-dosimetry. The obtained results can be explained taking into account specificities of the studied objects, and probable impact of radiochemical reactions of the irradiated water products with radicals formed in substances of foodstuff at irradiation.

scholarly journals One-step preparation of antimicrobial silicone materials based on PDMS and salicylic acid: insights from spatially and temporally resolved techniques

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Luca Barbieri ◽  
Ioritz Sorzabal Bellido ◽  
Alison J. Beckett ◽  
Ian A. Prior ◽  
Jo Fothergill ◽  
...  
Keyword(s):  
Salicylic Acid ◽  
Laser Scanning ◽  
Pathogenic Bacteria ◽  
Pharmaceutical Products ◽  
Laser Scanning Microscopy ◽  
Wound Dressings ◽  
Confocal Laser ◽  
Vis Spectroscopy ◽  
Wide Range ◽  
One Step

AbstractIn this work, we introduce a one-step strategy that is suitable for continuous flow manufacturing of antimicrobial PDMS materials. The process is based on the intrinsic capacity of PDMS to react to certain organic solvents, which enables the incorporation of antimicrobial actives such as salicylic acid (SA), which has been approved for use in humans within pharmaceutical products. By combining different spectroscopic and imaging techniques, we show that the surface properties of PDMS remain unaffected while high doses of the SA are loaded inside the PDMS matrix. The SA can be subsequently released under physiological conditions, delivering a strong antibacterial activity. Furthermore, encapsulation of SA inside the PDMS matrix ensured a diffusion-controlled release that was tracked by spatially resolved Raman spectroscopy, Attenuated Total Reflectance IR (ATR-IR), and UV-Vis spectroscopy. The biological activity of the new material was evaluated directly at the surface and in the planktonic state against model pathogenic bacteria, combining confocal laser scanning microscopy, electron microscopy, and cell viability assays. The results showed complete planktonic inhibition for clinically relevant strains of Staphylococcus aureus and Escherichia coli, and a reduction of up to 4 orders of magnitude for viable sessile cells, demonstrating the efficacy of these surfaces in preventing the initial stages of biofilm formation. Our approach adds a new option to existing strategies for the antimicrobial functionalisation of a wide range of products such as catheters, wound dressings and in-dwelling medical devices based on PDMS.

The Application of Multicriteria Decision Analysis Methods in Health Care: A Literature Review

2021 ◽  
pp. 0272989X2110190
Author(s):  
Ilyas Khan ◽  
Liliane Pintelon ◽  
Harry Martin
Keyword(s):  
Health Care ◽  
Decision Making ◽  
Decision Analysis ◽  
Medical Devices ◽  
Hybrid Methods ◽  
Multicriteria Decision Analysis ◽  
Multicriteria Decision ◽  
Health Care Decision ◽  
Wide Range ◽  
Care Decision

Objectives The main objectives of this article are 2-fold. First, we explore the application of multicriteria decision analysis (MCDA) methods in different areas of health care, particularly the adoption of various MCDA methods across health care decision making problems. Second, we report on the publication trends on the application of MCDA methods in health care. Method PubMed was searched for literature from 1960 to 2019 in the English language. A wide range of keywords was used to retrieve relevant studies. The literature search was performed in September 2019. Articles were included only if they have reported an MCDA case in health care. Results and Conclusion The search yielded 8,318 abstracts, of which 158 fulfilled the inclusion criteria and were considered for further analysis. Hybrid methods are the most widely used methods in health care decision making problems. When it comes to single methods, analytic hierarchy process (AHP) is the most widely used method followed by TOPSIS (technique for order preference by similarity to ideal solution), multiattribute utility theory, goal programming, EVIDEM (evidence and value: impact on decision making), evidential reasoning, discrete choice experiment, and so on. Interestingly, the usage of hybrid methods has been high in recent years. AHP is most widely applied in screening and diagnosing and followed by treatment, medical devices, resource allocation, and so on. Furthermore, treatment, screening and diagnosing, medical devices, and drug development and assessment got more attention in the MCDA context. It is indicated that the application of MCDA methods to health care decision making problem is determined by the nature and complexity of the health care problem. However, guidelines and tools exist that assist in the selection of an MCDA method.

scholarly journals Marine Polysaccharides as a Versatile Biomass for the Construction of Nano Drug Delivery Systems

Marine Drugs ◽  
2021 ◽  
Vol 19 (6) ◽  
pp. 345
Author(s):  
Ying Sun ◽  
Xiaoli Ma ◽  
Hao Hu
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Pharmaceutical Preparations ◽  
Utilization Efficiency ◽  
Wound Dressings ◽  
Marine Biomass ◽  
Nano Drug Delivery ◽  
Wide Range ◽  
Marine Polysaccharide

Marine biomass is a treasure trove of materials. Marine polysaccharides have the characteristics of biocompatibility, biodegradability, non-toxicity, low cost, and abundance. An enormous variety of polysaccharides can be extracted from marine organisms such as algae, crustaceans, and microorganisms. The most studied marine polysaccharides include chitin, chitosan, alginates, hyaluronic acid, fucoidan, carrageenan, agarose, and Ulva. Marine polysaccharides have a wide range of applications in the field of biomedical materials, such as drug delivery, tissue engineering, wound dressings, and sensors. The drug delivery system (DDS) can comprehensively control the distribution of drugs in the organism in space, time, and dosage, thereby increasing the utilization efficiency of drugs, reducing costs, and reducing toxic side effects. The nano-drug delivery system (NDDS), due to its small size, can function at the subcellular level in vivo. The marine polysaccharide-based DDS combines the advantages of polysaccharide materials and nanotechnology, and is suitable as a carrier for different pharmaceutical preparations. This review summarizes the advantages and drawbacks of using marine polysaccharides to construct the NDDS and describes the preparation methods and modification strategies of marine polysaccharide-based nanocarriers.

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