Permanent magnetic field, direct electric field, and infrared to reduce blood glucose level and hepatic function in mus musculus with diabetic mellitus

Diabetes mellitus is a metabolic disease which indicated with increasing blood glucose level. Carbohidrate, protein, mineral and secondary metabolite (alkaloid, tannin and saponin) can be benefical to treat diabetes mellitus. Rats were randomly divided into three groups. First, control group. Second, STZ group, untreated diabetic. Third, STZ+GA 15% group, diabetic treated with GA 15%. Result showed that blood glucose level before STZ induction on control and STZ group within normal range 78,57±11,90 mg/dL and 74,85±6,86 mg/dL. Blood glucose level significantly increase after STZ induction on STZ and STZ+GA 15% group become 375±6,53 mg/dL and 346,42±50,23 mg/dL. Diabetic rat treated with GA 15% revealed decrease in blood glucose level compared to untreated diabetic rat. Blood glucose level on STZ+GA 15% group continuously decrease become 96,42±13,45 mg/dL and 82,14±9,19 mg/dL. In conclusion, GA 15% could reduce blood glucose level on diabetic rat.

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High antioxidant level in cajanus sajan reduces blood glucose level and improves blood lipid profile of rats as diabetes mellitus models

International Journal of Health Sciences ◽

10.29332/ijhs.v5n1.725 ◽

2021 ◽

Vol 5 (1) ◽

Author(s):

Yuli Laraeni ◽

I Gusti Ayu Nyoman Danuyanti ◽

Ersandhi Resnhaleksmana ◽

Iswari Pauzi ◽

I Komang Agusjaya Mataram ◽

...

Keyword(s):

Blood Glucose ◽

Blood Glucose Level ◽

Lipid Profile ◽

Glucose Level ◽

Blood Lipid ◽

Polyol Pathway ◽

Protein Glycation ◽

Blood Lipid Profile ◽

Reduce Blood Glucose ◽

Reduce Blood Glucose Level

Hyperglycemia in DM was able to increase glucose auto-oxidation, protein glycation, and polyol pathway activation. As a result, it can accelerate the formation of reactive oxygen compounds acting as the main factor causing DM complication. Prior to our evaluation of pigeon bean Tempe with formulations of 25%, 50% and 75%, we tested the number and activity of its antioxidant. Then we substituted it on standard feed for 14 days to find the effects on glucose level and lipid profile. The effects was then compared to that before the intervention. The result showed that the total and activity of antioxidant in pigeon bean Tempe (Cajanus sajan) was 15% and 41.30% respectively. On the other side, pigeon bean Tempe with a formulation of 75% was more able to reduce blood glucose level, total cholesterol, triglycerides, and LDL-cholesterol by 44.08%, 34.38%,35.80%, and 43.22% respectively (p<0.05) if compared to pigeon bean Tempe with formulations of 25% and 50%. Meanwhile pigeon bean Tempe with formulation of 75% provided better effects for an increase of HDL level 56.20% (p<0.05). All test results on Tempe formulation used were compared to that before intervention.

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Study of blood glucose and SGPT lowering effects of Daphne Mucronata Royle in induced diabetic rabbits

JOURNAL OF BOTANY ◽

10.33195/uochjb-v1i1392017 ◽

2017 ◽

pp. 132-143

Author(s):

AZIZ ULLAH

Keyword(s):

Blood Glucose ◽

Glucose Level ◽

Methanol Extract ◽

Enzyme Level ◽

Diabetic Control ◽

Reduce Blood Glucose ◽

Reduce Blood Glucose Level ◽

Reduction Effect ◽

Daphne Mucronata ◽

Diabetic Rabbits

This study was carried out to study Anti-diabetic effect of the plant Daphne mucronataextract in alloxan induced diabetic rabbits. To the first fifteen healthy rabbits taken and divided them into five groups as each group contains three numbers of rabbits. Group one kept in normal condition means no induction or treatment observed. Group second was given the diabetic control dose in quantity (12mg/kg). Group three also treated with the dose rate (125mg/kg) the D. Mucronata(methanol) extract. Similarly group no four was treat with the subject extract in the concentration of (225mg/kg). And the last fifth group of rabbits had the dosage of extract (325mg/kg). This mechanism of entrance was orally ingestion and the treatment duration was eight hours, after each of the next two hours from the start the blood samples were collected, serum separated and the glucose level determined by the method known by Kit method. After all the observations we reached to an impressive conclusion that the D. Mucronata(methanol) extract has significant potential to reduce blood glucose level and also recognized to be effective to reduce the blood SGPT enzyme level, so it can be suggested that this plant has such antidiabetic and SGPT reduction effect.

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PENGARUH EKSTRAK BAWANG HITAM TERHADAP PENURUNAN KADAR GLUKOSA DARAH PADA MENCIT

THE JOURNAL OF MUHAMMADIYAH MEDICAL LABORATORY TECHNOLOGIST ◽

10.30651/jmlt.v4i1.7269 ◽

2021 ◽

Vol 4 (1) ◽

pp. 49

Author(s):

Pipit Festi W

Keyword(s):

Diabetes Mellitus ◽

Blood Glucose ◽

Mus Musculus ◽

T Test ◽

Control Group ◽

Control Group Design ◽

Significance Level ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Reduce Blood Glucose

Administration of oral hypoglycemic drugs and insulin is one of the most common pharmacological treatments given to people with diabetes mellitus. This treatment is carried out in the long term so that it causes side effects and is carried out continuously so that it will affect the financial condition of the diabetes mellitus patient. The purpose of this study was to determine the effect of black garlic extract on decreasing blood glucose levels in mice (mus musculus). This study uses the design of True Experimental design (pretest-posttest with control group design). The population is mice in Pusvetma Surabaya. Sampling method uses Non Probability Sampling Purposive Sampling type. Samples taken were 30 mice consisting of 15 intervention groups and 15 control groups. Data was collected using observation sheets, then analyzed using Independent sample t test and Dependent sample t test with a significance level of 5 0.05. The results showed: Using the test Independent sample T test obtained a significance value ρ = 0,000 It can be concluded that there is an effect of black onion extract to reduce blood glucose levels in mice. In the paired t-test test in the treatment group showed ρ = 0,000 that there were differences in blood glucose levels before being given extracts of garlic and after being given intervention. It is expected that black garlic can be used as an alternative medicine to reduce blood glucose levels.Keyword : Ekstrak of black garlic, Blood sugar levels, mus musculus

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The effect of electric field, magnetic field, and infrared ray combination to reduce HOMA-IR index and GLUT 4 in diabetic model of Mus musculus

Lasers in Medical Science ◽

10.1007/s10103-019-02916-z ◽

2019 ◽

Vol 35 (6) ◽

pp. 1315-1321 ◽

Cited By ~ 5

Author(s):

Suhariningsih ◽

Dwi Winarni ◽

Saikhu A. Husen ◽

Firas Khaleyla ◽

Alfian Pramudita Putra ◽

...

Keyword(s):

Magnetic Field ◽

Electric Field ◽

Mus Musculus ◽

Glut 4 ◽

Diabetic Model

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Study on Hypoglycaemic Effect of Spirulina platensis on Long-Evans Rats

Bangladesh Journal of Scientific and Industrial Research ◽

10.3329/bjsir.v45i2.5715 ◽

1970 ◽

Vol 45 (2) ◽

pp. 163-168 ◽

Cited By ~ 2

Author(s):

MOF Mridha ◽

MAA Jahan ◽

N Akhtar ◽

JL Munshi ◽

Z Nessa

Keyword(s):

Blood Glucose ◽

Blood Glucose Level ◽

Glucose Level ◽

Spirulina Platensis ◽

Hypoglycaemic Effect ◽

High Fat ◽

High Concentration ◽

Reference Drug ◽

Reduce Blood Glucose ◽

Long Evans

Spirulina containing high concentration of functional nutrients is emerging as an important therapeutic food. So the present study was designed to evaluate the hypoglycaemic properties of Spirulina platensis on long-evans rats. Two sets of experiment were conducted, the 1st set was compared with the effect of Spirulina platensis, glibenclamide, glucose and water after feeding 60 minutes. Glibenclamide was used as a standard reference drug. The findings clearly indicated that the oral administration of Spirulina platensis (150mg/kg b.w) significantly tended to reduce blood glucose level of rat than that of glibenclamide. In the 2nd experiment long-term hypoglycaemic effect of Spirulina platensis 0.5% and 2.5% fed with high fat high sugar containing diet and 150mg/kg b.w with normal laboratory diet was also observed. The 2nd findings also indicated that the blood glucose level was significantly decreased in both the diet when supplemented with Spirulina platensis. Key words: Diabetic mellitus; High fat diet; Hypoglycaemic; Spirulina platensis; Body weight DOI: 10.3329/bjsir.v45i2.5715Bangladesh J. Sci. Ind. Res. 45(2), 163-168, 2010

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Uji Efek Antidiabetik Ekstrak Daun Trembesi (Albizia saman (Jacq.) Merr) Terhadap Mencit (Mus musculus L)

WARTA FARMASI ◽

10.46356/wfarmasi.v8i2.94 ◽

2019 ◽

Vol 8 (2) ◽

pp. 43-52

Author(s):

Muhammad Azdar Setiawan ◽

Muhammad Syaiful Saehu ◽

Kartini Kartini

Keyword(s):

Body Weight ◽

Blood Glucose ◽

Mus Musculus ◽

Leaf Extract ◽

Positive Control ◽

Negative Control ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Reduce Blood Glucose ◽

Albizia Saman

ABSTRAK Daun trembesi (Albizia saman (Jacq.) Merr) adalah salah satu tanaman berkhasiat menurunkan kadar glukosa darah dimana kandungan kimianya berpotensi menurunkan kadar glukosa darah antara lain flavonoid yang bekerja dengan cara menstimulasi sel- sel beta dari pulau langerhans, sehingga sekresi insulin ditingkatkan.Penelitian ini bertujuan untuk mengetahui efek antidiabetes ekstrak daun trembesi (Albizia saman (Jacq.) Merr) pada mencit (Mus musculus). Metode Penelitian ini merupakan penelitian Eksperimen dimana sebanyak 20 ekor mencit dibuat diabetes dengan menggunakan Streptozotosin 150 mg/kgBB secara Intraperitonial. Kemudian dibagi menjadi 5 kelompok perlakuan, yaitu: Ekstrak dosis 25 mg/kgBB, 50 mg/kgBB, 100 mg/kgBB, sebagai kontrol positif Glibenclamid 5 mg dan kontrol negatif suspensi Na.CMC 0,5%. Data yang diperoleh dianalisis dengan uji ANOVA. Hasil analisa statistik menunjukan pada konsentrasi ekstrak 100 mg/kgBB memberikan efek yang optimum dengan perlakuan kontrol positif Glibenklamid. Kata Kunci : Ekstrak Daun Trembesi, Antidiabetik. ABSTRACT Trembesi leaf (Albizia saman (Jacq.) Merr) is one of the efficacious plants to reduce blood glucose levels where the chemical content has the potential to reduce blood glucose levels, among others, flavonoids that work by stimulating beta cells of the island langerhans, so that insulin secretion is increased. It aims to determine the antidiabetic effect of trembesi leaf extract (Albizia saman (Jacq.) Merr) in mice (Mus musculus). This research method is an experimental study in which as many as 20 mice were made diabetic using Streptozotosin 150 mg / kgBW intraperitonially. Then divided into 5 treatment groups, namely: Extract dose 25 mg / kg body weight, 50 mg / kg body weight, 100 mg / kg body weight, as positive control Glibenclamid 5 mg and negative control suspension Na.CMC 0.5%. The data obtained were analyzed by ANOVA test. The results of statistical analysis showed that the extract concentration of 100 mg / kgBB gave the optimum effect with the positive control of Glibenclamide. Keywords: Trembesi Leaf Extract, Antidiabetic.

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