Green synthesis of AgNPs, characterization as an effective wound healing agent in the wound care after anorectal surgery

The wound care market is rapidly expanding due to the development of innumerable dressings that exhibit specific healing requirements for different wound types. The use of biomaterials as suitable wound dressing material is highly advantageous due to their biocompatibility, biodegradability, and non-toxicity. Cyanobacteria have been widely explored for their potential applications in wound healing, as they are the rich source of bioactive compounds with antibacterial, antitumor, antiviral, antioxidant, and antifungal activities. In recent years this group of organisms has been widely studied due to their immense potential in biomedical applications. Although their different bioactivities can support wound healing in different ways, very few forms have proven utility as a wound-healing agent. This chapter gives an insight into the potential of cyanobacteria in wound healing. Different bioactive compounds present in variable forms of cyanobacteria and their associated activities were reported to support tissue regeneration and wound healing acceleration. As the demand for cost-effective, bioactive wound care products is ever increasing, these organisms have immense potential to be utilized for the development of bioactive wound dressings. Hence, various bioactive compounds of cyanobacteria, their associated activities, and roles in wound healing have been briefly reviewed in this chapter.

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Review Paper: Considerations for Determining if a Natural Product Is an Effective Wound-Healing Agent

The International Journal of Lower Extremity Wounds ◽

10.1177/1534734608316028 ◽

2008 ◽

Vol 7 (2) ◽

pp. 75-81 ◽

Cited By ~ 11

Author(s):

William J. Lindblad

Keyword(s):

Wound Healing ◽

Natural Products ◽

Animal Models ◽

Animal Species ◽

Review Paper ◽

Wound Care ◽

Research Groups ◽

Clinical Observations ◽

Healing Agent ◽

Enhance Wound Healing

Many research groups are examining natural products for their vulnerary activity. On the basis of the countless years of folklore and clinical observations, these preparations are being fractionated and applied to wounds in a variety of animal species. Despite this work, the number of agents that have documented ability to enhance wound healing is minimal. This article provides a brief review of some of the major historical milestones in wound care and provides a framework for studying plant products so as to achieve statistically significant results in biologically important models of healing. Only with the use of reference standards, data from appropriate animal models, and human trials can we begin to mine the great potential of these natural products.

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Experience of negative pressure wound therapy over sternal wound healing: A retrospective review

WCET Journal ◽

10.33235/wcet.39.2.9-18 ◽

2019 ◽

Vol 39 (2) ◽

pp. 9-18

Author(s):

Wai Sze Ho ◽

Wai Kuen Lee ◽

Ka Kay Chan ◽

Choi Ching Fong

Keyword(s):

Wound Healing ◽

Negative Pressure ◽

Negative Pressure Wound Therapy ◽

Assessment Tool ◽

Wound Care ◽

Wound Therapy ◽

Treatment Pathways ◽

Wound Assessment ◽

One Year

Objectives The aim of this study was to retrospectively review the effectiveness of negative pressure wound therapy (NPWT) in sternal wound healing with the use of the validated Bates-Jensen Wound Assessment Tool (BWAT), and explore the role of NPWT over sternal wounds and future treatment pathways. Methods Data was gathered from patients' medical records and the institution's database clinical management system. Seventeen subjects, who had undergone cardiothoracic surgeries and subsequently consulted the wound care team in one year were reviewed. Fourteen of them were included in the analysis. Healing improvement of each sternal wound under continuous NPWT and continuous conventional dressings was studied. In total, 23 continuous NPWT and 13 conventional dressing episodes were analysed with the BWAT. Results Among conventional dressing episodes, sternal wound improvement was 2.5–3% over 10 days to 3.5 weeks, whereas 4–5% sternal healing was achieved in 5 days to 2 weeks with sternal wire presence. Better healing at 11% in 1 week by conventional dressing was attained after sternal wire removal. In NPWT episodes, 8–29%, 13–24%, and 15–46% of healing was observed in 2 weeks, 3.5 to 5 weeks and 6 to 7 weeks, respectively. Only 39% wound healing was acquired at the 13th week of NPWT in one subject. With sternal wire present, 6%–29% wound healing progress was achieved by NPWT in 1–4 weeks, and 16–23% wound improvement in 2 to 4.5 weeks by NWPT after further surgical debridement. After sternal wire removal, 6–34% sternal wound healing occurred by continuous NPWT for 1–2 weeks, and maximum healing at 46% after 2.5 weeks of NPWT were observed. Conclusions Better wound healing was achieved in the NPWT group in comparison to conventional dressings alone. However, suboptimal sternal wound healing by NPWT alone was observed. Removal of sternal wire may improve the effectiveness of NPWT. Successful tertiary closure after NPWT among subjects supports the important bridging role of NPWT in sternal wound healing. Factors causing stagnant sternal wound healing by NPWT alone are discussed.

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Short Report: The Moisture Balance with Aloe Vera Gel in Diabetic Wound Healing

International Journal of Nursing and Health Services (IJNHS) ◽

10.35654/ijnhs.v1i1.9 ◽

2018 ◽

Vol 1 (1) ◽

pp. 21-23

Author(s):

Fahrianto Selamet ◽

Andi Mayasari Usman ◽

Rian Adi Pamungkas

Keyword(s):

Diabetes Mellitus ◽

Wound Healing ◽

Wound Care ◽

Aloe Vera ◽

Foot Ulcer ◽

Diabetic Foot Ulcer ◽

Short Report ◽

Bacterial Reduction ◽

Moisture Balance ◽

Patients With Diabetes

Diabetic foot ulcer (DF) is a chronic complication of diabetes mellitus (DM), which impact on the morbidity, mortality and quality of patients’ lives.Of those patients with diabetes mellitus, approximately 15% to 25% developed to the foot ulcer. Beside has the infection and debridement of devitalized tissue downloading; the moisture imbalance becomes the factors of recalcitrant to healing. Moist wound healing is often contraindicated to the non-healable wounds. While wound care involves the debridement, bacterial reduction, and moisture balance in order to achieve the good granulation of the tissue development and adequate blood supply.

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Neonatal Intravenous Extravasation Injuries: Evaluation of a Wound Care Protocol

Neonatal Network The Journal of Neonatal Nursing ◽

10.1891/0730-0832.25.1.13 ◽

2006 ◽

Vol 25 (1) ◽

pp. 13-19 ◽

Cited By ~ 23

Author(s):

Doris Sawatzky-Dickson ◽

Karen Bodnaryk

Keyword(s):

Wound Healing ◽

Birth Weight ◽

Wound Infection ◽

Gestational Age ◽

Wound Care ◽

Systemic Infection ◽

Coagulase Negative Staphylococcus ◽

Evidence Based ◽

Infection Rates ◽

Care Protocol

Purpose:To evaluate an evidence-based wound protocol for intravenous extravasation injuries in neonates.Sample:Nine newborns with intravenous extravasation injuries. Birth weight: 582–4,404 gm, gestational age: 24–40 weeks.Results:Five wounds were colonized with coagulase-negative Staphylococcus species, two with diphtheroids, three with Enterococcus. There was no evidence of wound infection or systemic infection. Rates of wound healing ranged from one to six weeks.

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Evaluation of Potential Application of Wharton’s Jelly-Derived Human Mesenchymal Stromal Cells and its Conditioned Media for Dermal Regeneration using Rat Wound Healing Model

Cells Tissues Organs ◽

10.1159/000513895 ◽

2021 ◽

pp. 1-14

Author(s):

Caroline Mathen ◽

Mrunal Ghag Sawant ◽

Raghubansh Gupta ◽

Wilfrid Dsouza ◽

Shilpa G. Krishna

Keyword(s):

Wound Healing ◽

Mesenchymal Stromal Cells ◽

Stromal Cells ◽

Therapeutic Potential ◽

Wound Care ◽

Free Cell ◽

Conditioned Media ◽

Human Umbilical Cord ◽

Human Mscs ◽

Wound Model

Mesenchymal stromal cells and the derived conditioned media represent an area of tremendous medical interest and, among other clinical applications, are currently being extensively explored for wound healing. The aim of this study was to comparatively evaluate the wound healing potential of xeno-free human umbilical cord-derived mesenchymal stromal cells (MSCs) and the conditioned media (CM) in a full-thickness excision wound model in rats. The evaluation parameters included rate of wound healing, serum cytokine analyses, collagen content, histopathology, and hyperspectral imaging as an independent qualitative and quantitative tool. Both the cell-based and cell-free approaches scored better in lower inflammation, as evidenced in lower IL-10 and stable IL-6 levels, and improved rate of wound healing (<i>p</i> < 0.0001). More importantly, no adverse reaction or rejection was observed although human MSCs and CM were used in a xenogeneic model. The presence of hFGF, hHGF, hGCSF, hIL-1Ra, hVEGF, and hIL-6 in the secretome may elucidate the regenerative potential of the xeno-free cell-based and cell-free approaches which have translational value for advanced wound care. The results revealed the therapeutic potential of both the cell-based and cell-free approaches for wound healing.

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Effectiveness of biofilm‐based wound care system on wound healing in chronic wounds

Wound Repair and Regeneration ◽

10.1111/wrr.12738 ◽

2019 ◽

Vol 27 (5) ◽

pp. 540-547 ◽

Cited By ~ 8

Author(s):

Yukie Mori ◽

Gojiro Nakagami ◽

Aya Kitamura ◽

Takeo Minematsu ◽

Mikio Kinoshita ◽

...

Keyword(s):

Wound Healing ◽

Chronic Wounds ◽

Wound Care ◽

Care System

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Identifying New Pathways and Targets for Wound Healing and Therapeutics from Natural Sources

Current Drug Delivery ◽

10.2174/1567201818666210111101257 ◽

2021 ◽

Vol 18 ◽

Author(s):

Xinchi Feng ◽

Jinsong Hao

Keyword(s):

Wound Healing ◽

Molecular Mechanisms ◽

Chronic Wounds ◽

Wound Care ◽

Healing Process ◽

Unmet Need ◽

Wound Dressings ◽

Wound Healing Process ◽

Natural Sources ◽

Viable Approach

: Chronic wounds remain a significant public problem and the development of wound treatments has been a research focus for the past few decades. Despite advances in the products derived from endogenous substances involved in a wound healing process (e.g. growth factors, stem cells, and extracellular matrix), effective and safe wound therapeutics are still limited. There is an unmet need to develop new therapeutics. Various new pathways and targets have been identified and could become a molecular target in designing novel wound agents. Importantly, many existing drugs that target these newly identified pathways could be repositioned for wound therapy, which will facilitate fast translation of research findings to clinical applications. This review discusses the newly identified pathways/targets and their potential uses in the development of wound therapeutics. Some herbs and amphibian skins have been traditionally used for wound repairs and their active ingredients have been found to act in these new pathways. Hence, screening these natural products for novel wound therapeutics remains a viable approach. The outcomes of wound care using natural wound therapeutics could be improved if we can better understand their cellular and molecular mechanisms and fabricate them in appropriate formulations, such as using novel wound dressings and nano-engineered materials. Therefore, we also provide an update on the advances in the wound therapeutics from natural sources. Overall, this review offers new insights into novel wound therapeutics.

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