Fasting and Postprandial Triglycerides Across Older Adulthood: A Cross-sectional Study

Abstract Objectives Elevated postprandial triglycerides (TG) are a risk factor for cardiovascular disease (CVD). Although some evidence suggests that older adults exhibit greater postprandial TG than younger adults, it is unknown how postprandial lipid tolerance changes across the spectrum of older adulthood. This cross-sectional study examines postprandial TG responses across the spectrum of aging, as well as factors that may modify this response. Methods We are recruiting individuals into four age categories (age 50–59, 60–69, 70–79, 80–89 years), with an equal number of participants and sex distribution in each group. Participants undergo body composition testing via bioelectrical impedance analysis and complete a 130-item food frequency questionnaire. Participants return to the lab after a 10-hour fast and blood is drawn both before and 4 hours after consumption of a high-fat meal (9 kcal/kg body mass; 73% fat, 26% CHO) to determine fasting and postprandial TG. Results Thirty participants (50’s: n = 12; 60’s: n = 11; 70’s: n = 4; 80’s: n = 3) have completed the study (total N = 60). There was no difference (P = 0.52) in BMI across age groups (50’s: 29.5 ± 5.4 kg/m2; 60’s: 29.1 ± 5.5 kg/m2; 70’s: 25.9 ± 3.8 kg/m2; 80’s: 26.1 ± 1.6 kg/m2). There was also no difference (P = 0.68) in body fat (BF%) across age groups (50’s: 37.5 ± 7.2%; 60’s: 39.53 ± 7.0%; 70’s: 43.6 ± 8.2%; 80’s: 39.5 ± 18.1%). Similarly, there was no difference (P = 0.76) in fasting TG across age groups (50’s: 98.8 ± 40.6 mg/dL; 60’s: 117.9 ± 83.3 mg/dL; 70’s: 105.3 ± 39.7 mg/dL; 80’s: 79.7 ± 31.7 mg/dL), nor was there a difference (P = 0.74) in 4-hr TG (50’s: 162.3 ± 70.8 mg/dL; 60’s: 187.5 ± 105.5 mg/dL; 70’s: 181.8 ± 89.6 mg/dL; 80’s: 130.7 ± 55.1 mg/dL). Lastly, there was no difference (P = 0.16) in fruit and vegetable (FV) intake (50’s: 4.4 ± 1.9 servings/day (s/d); 60’s: 8.2 ± 5.5 s/d; 70’s: 6.2 ± 4.6 s/d; 80’s: 7.9 ± 2.4 s/d). Conclusions At this point in the study, it cannot be concluded that there is a significant difference in fasting or postprandial TG across aging strata, possibly due to no differences in BMI, BF%, or FV intake. When complete, this study will provide valuable insight with regard to the impact of aging and other lifestyle factors on postprandial lipemia and subsequent CVD risk. Funding Sources This project is funded by the Donna Cadwalader Research and Development Grant.

Download Full-text

THE IMPACT OF ASTHMAAND ITS MEDICATIONS ON DENTAL CARIES STATUS AND STREPTOCOCCUS MUTANS COUNT IN CHILDREN: A CROSS-SECTIONAL STUDY

10.36106/ijsr/7515919 ◽

2020 ◽

pp. 20-23

Author(s):

Sneha Upadhyay ◽

Jyoti Bhavthankar ◽

Mandakini Mandale ◽

Nivedita Kaorey

Keyword(s):

Dental Caries ◽

Streptococcus Mutans ◽

Cross Sectional Study ◽

Control Group ◽

Healthy Children ◽

Sectional Study ◽

Cross Sectional ◽

Asthmatic Children ◽

Significant Difference ◽

The Impact

Background: Asthma and its medications have been linked to oral diseases in asthmatic children. Aim: Assessment of the dental caries status, salivary Streptococcus mutans count and S. mutans colony score in children receiving inhaled anti asthmatic medications and their comparison in healthy children Material and Method: A cross-sectional study was performed on 40 asthmatic children and 40 healthy children in the age group of 6-14 years. DMFT/deft indices were calculated and saliva samples were collected. Diluted saliva was inoculated on MSB agar plates. S. mutans count and colony score were analysed after 24-48 hours of inoculation. Results: Statistically significant difference was observed in the mean DMFT/deft index, salivary S. mutans load and S. mutans colony score in children of the asthmatic group and control group. Conclusion: Prevalence of dental caries and cariogenic bacteria is higher in asthmatic children.

Download Full-text

Breast density in women with premature ovarian failure or postmenopausal women using hormone therapy: analytical cross-sectional study

Sao Paulo Medical Journal ◽

10.1590/s1516-31802010000400007 ◽

2010 ◽

Vol 128 (4) ◽

pp. 211-214 ◽

Cited By ~ 9

Author(s):

Patrícia Magda Soares ◽

César Cabello ◽

Luis Alberto Magna ◽

Eduardo Tinois ◽

Cristina Laguna Benetti-Pinto

Keyword(s):

Hormone Therapy ◽

Postmenopausal Women ◽

Breast Density ◽

Premature Ovarian Failure ◽

Cross Sectional Study ◽

Ovarian Failure ◽

Sectional Study ◽

Cross Sectional ◽

Significant Difference ◽

The Impact

CONTEXT AND OBJECTIVE: Studies on postmenopausal women have reported increased risk of breast cancer relating to the type and duration of hormone therapy (HT) used. Women with premature ovarian failure (POF) represent a challenge, since they require prolonged HT. Little is known about the impact of prolonged HT use on these women's breasts. This study aimed to evaluate the effects of one type of HT on the breast density of women with POF, compared with postmenopausal women. DESIGN AND SETTING: Cross-sectional study at the Department of Obstetrics and Gynecology, Universidade Estadual de Campinas (Unicamp). METHODS: 31 women with POF and 31 postmenopausal women, all using HT consisting of conjugated equine estrogen combined with medroxyprogesterone acetate, and matched according to HT duration, were studied. Mammography was performed on all subjects and was analyzed by means of digitization or Wolfe's classification, stratified into two categories: non-dense (N1 and P1 patterns) and dense (P2 and Dy). RESULTS: No significant difference in breast density was found between the two groups through digitization or Wolfe's classification. From digitization, the mean breast density was 24.1% ± 14.6 and 18.1% ± 17.2 in the POF and postmenopausal groups, respectively (P = 0.15). Wolfe's classification identified dense breasts in 51.6% and 29.0%, respectively (P = 0.171). CONCLUSION: There was no difference in breast density between the women with POF and postmenopausal women, who had used HT for the same length of time. These results may help towards compliance with HT use among women with POF.

Download Full-text

B Part of It School Leaver protocol: an observational repeat cross-sectional study to assess the impact of a meningococcal serogroup B (4CMenB) vaccine programme on carriage ofNeisseria meningitidis

BMJ Open ◽

10.1136/bmjopen-2018-027233 ◽

2019 ◽

Vol 9 (5) ◽

pp. e027233 ◽

Cited By ~ 3

Author(s):

Helen S Marshall ◽

Mark McMillan ◽

Ann Koehler ◽

Andrew Lawrence ◽

Jenny MacLennan ◽

...

Keyword(s):

Controlled Trial ◽

Age Groups ◽

Case Fatality ◽

Cluster Randomised Controlled Trial ◽

Cross Sectional Study ◽

Sectional Study ◽

School Students ◽

Cross Sectional ◽

The Impact ◽

Carriage Prevalence

IntroductionInvasive meningococcal disease is uncommon but associated with a high-case fatality rate. Carriage prevalence of the causative bacteria,Neisseria meningitidis, is high in adolescents. A large (n=34 500) cluster randomised controlled trial (RCT) to assess the impact of a meningococcal B (MenB) vaccine on meningococcal carriage was implemented in the state of South Australia (SA) for year 10, 11 and 12 senior school students in 2017–2018. This study will assess the impact of MenB vaccine (4CMenB) on carriage prevalence in school leavers in SA, 1 and 2 years after implementation of the cluster RCT in adolescents. Measuring the impact of population programmes on carriage can assist in informing future meningococcal immunisation programmes such as targeted age groups and use of catch-up campaigns.Methods and analysisThis repeat cross-sectional study will assess carriage prevalence in 2018 and 2019. All school leavers who attended year 12 in any school in SA in 2018 or 2019 will be invited to participate in this study. An oropharyngeal swab will be taken from each participating student and a risk factor questionnaire completed by the student following informed consent. Students will attend clinics at SA universities, technical colleges, and metropolitan, rural and remote government council clinics. Confirmed vaccination history will allow a comparison in carriage prevalence between vaccinated and unvaccinated school leavers. A sample size of 4096 students per year will provide 80% power to detect a 20% difference in carriage prevalence of disease-causing meningococci (defined as genogroup A, B, C, W, X or Y) between years.Ethics and disseminationThe study was approved by the Women’s and Children’s Health Network Human Research Ethics Committee. Results will be published in international peer review journals and presented at national and international conferences.Trial registration numberNCT03419533; Pre-results

Download Full-text

Understanding Driving as an Everyday Activity: International Perspectives

Innovation in Aging ◽

10.1093/geroni/igaa057.2592 ◽

2020 ◽

Vol 4 (Supplement_1) ◽

pp. 730-730

Author(s):

Anne Dickerson ◽

Isabelle Gelinas ◽

Moon Choi

Keyword(s):

Older Adults ◽

Cross Sectional Study ◽

Crash Risk ◽

Sectional Study ◽

Fitness To Drive ◽

Cross Sectional ◽

Everyday Activity ◽

Older Adulthood ◽

International Perspectives ◽

The Impact

Abstract This international symposium brings together leading occupational therapy researchers from around the world with a shared focus is on evaluating and improving the driving performance of older adults to decrease their crash risk and facilitate their community participation. In this session, five groups of international scholars will share their collective and individual research outcomes for driving as a means of community mobility. The first presentation will outline their collective international, cross-sectional study of 247 older adults from seven countries where the impact of driving on out-of-home mobility was compared. Each presentation that follows will then present results from innovative studies of ways in which to assess and address fitness to drive in older adulthood. Our discussant will summarize the potential expansion of the current work and engage the audience through interactive questions. Transportation and Aging Interest Group Sponsored Symposium.

Download Full-text

The Impact of the COVID-19 Pandemic Outbreak on Eating and Lifestyle Habits of Adolescents in Bosnia and Herzegovina: a Cross-sectional Study

10.21203/rs.3.rs-529005/v1 ◽

2021 ◽

Author(s):

Nevena Ćorić ◽

Anita Jurić ◽

Andrea Karlovic

Keyword(s):

Physical Activity ◽

Weight Change ◽

Cross Sectional Study ◽

Social Characteristics ◽

Dietary Vitamin ◽

Sectional Study ◽

Lifestyle Habits ◽

Cross Sectional ◽

Significant Difference ◽

The Impact

Abstract Background: Pandemic caused by the COVID-19 virus brought tremendous changes in the lifestyle of adolescents, about which numerous studies have been published. Due to extended restrictions, long term impact should be investigated.Methods: This cross-sectional study enrolled 953 voluntary participants aged 14 to 21, from different regions of B&H. Participants were asked to complete an online 37-item survey, regarding socio-demographics, geographic, social characteristics, dietary and lifestyle habits, physical activity, including their consumption of dietary, vitamin and mineral supplements. They also needed to provide information about their weight, height and weight change during the entire period of the COVID-19 pandemic from March 2020 until the end of November when the study was completed. For data entry and analysis, SPSS (version 25) and Microsoft Excel were used.Results: At the time of completing the survey, a slightly lower BMI of participants was noticed compared to the time before the pandemic. A statistically significant difference was determined between males and females BMI, boys BMI was slightly higher. Females gained and men lost BW. Increased intake of unhealthy types of food was associated with weight change. Increased mental stress during the pandemic was associated with dietary changes, respectively with decreased as also increased food amount. High percent of participants (40.4%) who increased their physical activity did not alter their eating in the form of the food amount. This study reported use of some dietary supplements which have not been used before the pandemic by 63.5% participants.Conclusions: This paper presents a unique insight into the changing lifestyle and eating habits of adolescents in B&H during lockdown and post-lockdown period of research. Considering that pandemic is still ongoing, data from study like this may be useful to create further steps in battling the pandemic.

Download Full-text

Evaluation of the Knowledge and Perceptions about Pharmacovigilance Activities among Pharmacy Students in Nigeria: A Cross-Sectional Study

Bangladesh Pharmaceutical Journal ◽

10.3329/bpj.v20i1.32082 ◽

2017 ◽

Vol 20 (1) ◽

pp. 1-13

Author(s):

Osemene Kanayo Patrick ◽

Afolabi Margaret Olubunmi

Keyword(s):

Age Groups ◽

Knowledge Score ◽

Cross Sectional Study ◽

Pharmacy Students ◽

Sectional Study ◽

Knowledge Domain ◽

Cross Sectional ◽

Mean Values ◽

Significant Difference ◽

The Mean

Studies on pharmacovigilance (PV) activities in Nigeria focused on perceptions of PV among professional healthcare workers are described here. There is paucity of information on pharmacy students knowledge about PV activities. Hence, this study, evaluated the knowledge and perceptions of final year pharmacy students about PV activities using descriptive and inferential statistics. A cross sectional study was undertaken in three Nigerian universities with a pretested questionnaire during the period of January and February, 2016. The questionnaire included closed-ended questions on demographic variables and questions designed to achieve the objectives of the study. Data was analyzed with IBM SPSS Statistics 20 and presented in percentages, means, standard deviations and median at 50% percentile. The mean knowledge score of pharmacovigilance and adverse drug reporting for the final year students was 4.25±0.18. There were significant differences in the mean scores of knowledge domain by age groups 21-24 years 4.8±0.70, 25-30 years 6.2 ± 0.84 and >30 years 4.6±0.72 at p=0.001; gender: male 4.1±1.20 and female 4.4±0.98 at (p=0.0001) as well as the current universities attended as follows University 1 with a scrore of 5.1±1.03, University 2 had a mean score of 6.3±0.99 at p=0.0120 and University 3 with a mean score of 4.3±1.01 at p=0.012. Furthermore, significant difference exist in the mean values of pharmacovigilance knowledge between those who had taking some courses in pharmacovigilance (7.3± 0.22) and those who did not (4.7 ± 0.13) at p=0.0001. Generally, the students had inadequate knowledge of PV activities. Therefore, emphasis on relevant PV courses in their curriculum is necessary.Bangladesh Pharmaceutical Journal 20(1): 1-13, 2017

Download Full-text

Built form and depression among the Chinese rural elderly: a cross-sectional study

BMJ Open ◽

10.1136/bmjopen-2020-038572 ◽

2020 ◽

Vol 10 (12) ◽

pp. e038572

Author(s):

Qin-wei Qiu ◽

Jing Li ◽

Jia-yu Li ◽

Yong Xu

Keyword(s):

Cross Sectional Study ◽

Rural Elderly ◽

Sectional Study ◽

Cross Sectional ◽

Built Form ◽

Housing Area ◽

Significant Difference ◽

Few Data ◽

The Impact ◽

Rural Elders

ObjectivesFew data on the association between housing structure and depression among rural elders in China are available. We examined the impact of built forms on depression.DesignThis is a cross-sectional study.SettingA representative sample of rural residents aged 60 years or older in China.ParticipantsA total of 5090 older adults in 2019 in rural Suzhou, China.Outcome measuresAssociations of built form with odds of probable and possible depression.ResultsThere was significant difference among elders living in varied sizes of house. Older age (vs 60–64 years: 75–79 years AdjOR, 1.737; 95% CI, 1.309 to 2.305; ≥80 years AdjOR, 2.072; 95% CI, 1.439 to 2.981), male sex (AdjOR, 0.719; 95% CI, 0.593 to 0.871), single (AdjOR, 1.303; 95% CI, 1.032 to 1.646), self-care disability (AdjOR, 4.761; 95% CI, 3.960 to 5.724), three or more chronic diseases (AdjOR, 2.200; 95% CI, 1.657 to 2.920), living alone (AdjOR, 1.443; 95% CI, 1.059 to 1.966), living in cottage (AdjOR, 1.426; 95% CI, 1.033 to 1.967), living space (vs <50 m2: 201–250 m2 AdjOR, 0.566; 95% CI, 0.359 to 0.893; >250 m2 AdjOR, 0.337; 95% CI, 0.223 to 0.511) and space per person (vs <30 m2: 30- m2 AdjOR, 0.502; 95% CI, 0.362 to 0.697; 40- m2 AdjOR, 0.473; 95% CI, 0.347 to 0.646; 50- m2 AdjOR, 0.418; 95% CI, 0.339 to 0.515) were associated with risk of depression among Chinese rural elders.ConclusionThe built form was significantly and meaningfully associated with depression among Chinese rural elders. More attention should be paid to preventing mental illness among the rural elderly living in the small housing area and cottages in China.

Download Full-text

Effect of clinical rotation on attitude of medical students towards psychiatry and mental patients: a cross-sectional study from Western Rajasthan

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20213919 ◽

2021 ◽

Vol 9 (10) ◽

pp. 2981

Author(s):

Aditi Agrawal ◽

Sanjay Gehlot ◽

Ashok Singhal ◽

Amandeep .

Keyword(s):

Mental Illness ◽

Medical Students ◽

Cross Sectional Study ◽

Mental Illnesses ◽

Urban Setting ◽

Sectional Study ◽

Undergraduate Medical Students ◽

Cross Sectional ◽

Significant Difference ◽

The Impact

Background: People with mental illnesses experience extreme stigmatization and discrimination despite their ubiquitous presentation. Studies have reported that these negative stereotypes are shared by health care professionals too. Attitude of undergraduate medical students towards psychiatry is vital as it reflects their willingness to deal with psychiatric and behavioral disorders in general practice.Methods: A descriptive cross-sectional study was conducted in a government medical college in Rajasthan to explore the impact of sociodemographic variables and undergraduate psychiatry training on the attitude of medical students towards mental illness and psychiatry. 105 first year MBBS students and 75 interns participated in the study. Attitude towards mental illness (AMI) scale and attitude towards psychiatry-30 (ATP-30) scale were used to document AMI and ATP respectively. Data collected were analyzed using SPSS statistical software and appropriate tests were used to compare mean scores of both groups.Results: There was no statistically significant difference on AMI and ATP scores between the undergraduate medical students and interns. Females, students belonging to urban setting and more educated families had a favorable attitude towards psychiatric patients. A notable shift in scores on ATP scale towards positive side was reflected between male MBBS students and interns and among students coming from rural background with exposure to medical curriculum.Conclusions: No attitude change was observed in majority of participants indicating need for greater emphasis on mental health and psychiatry.

Download Full-text

Dental caries and its association with present day dietary patterns: a cross-sectional study

International Journal of Community Medicine and Public Health ◽

10.18203/2394-6040.ijcmph20181737 ◽

2018 ◽

Vol 5 (5) ◽

pp. 2138

Author(s):

Vaibhav Munjal ◽

Puneet Singh Talwar ◽

Jagjit Singh ◽

Mandeep Kumar ◽

Ramandeep Gambhir

Keyword(s):

Dental Caries ◽

Age Groups ◽

Simple Random Sampling ◽

Vegetarian Diet ◽

Cross Sectional Study ◽

Age Group ◽

Sectional Study ◽

Contributing Factors ◽

Cross Sectional ◽

Significant Difference

Background: Dental caries is a multifactorial disease with diet being one of the contributing factors. The influence of vegetarianism on the development of caries has scarcely been investigated in the past. Therefore, this study was done to evaluate the association of dental caries with frequency of sugar exposures and vegetarian / mixed diet.Methods: The present cross-sectional study was conducted among 2500 school children of 12 and 15 years age groups selected on the basis of simple random sampling from different schools of the city. Dental caries was recorded using Decayed, Missing and Filled teeth index (WHO modification, 1997) and correlated with the different dietary variables. Subjects were also segregated on the basis of diet: vegetarian and mixed. Statistical analysis was done using Student t-test and Pearson’s Correlation Coefficient.Results: The prevalence of dental caries in the 12 and 15 year age group of subjects consuming mixed diet was 83.36% and 86.47% respectively. It was lower in case of subjects on vegetarian diet. The correlation between DMFS and TSE, FSE and AMSE was found to be statistically significant (p<0.05) in the 12 year age-group. In the 15 year age-group the correlation of DMFS with TSE and LSE was also found to be statistically significant (p<0.05).Conclusions: There was no statistically significant difference in dental caries status among subjects in both the groups (vegetarian and mixed). However, there was significant association between sugar exposures and dental caries among subjects of both the age-groups.

Download Full-text

Serological surveys to inform SARS-CoV-2 epidemic curve: a cross-sectional study from Odisha, India

Scientific Reports ◽

10.1038/s41598-021-89877-y ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Jaya Singh Kshatri ◽

◽

Debdutta Bhattacharya ◽

Srikanta Kanungo ◽

Sidhartha Giri ◽

...

Keyword(s):

Age Groups ◽

Population Based ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Epidemic Curve ◽

Significant Difference ◽

Asymptomatic Infections ◽

Demographic Risk ◽

Demographic Risk Factors

AbstractThis was a population based cross-sectional study carried out to estimate and compare the seroprevalence, hidden prevalence and determine the demographic risk factors associated with SARS-CoV-2 infection among adults in the three largest cities of Odisha, India, and ascertain the association with the progression of the epidemic. The survey carried out in August 2020 in the three largest cities of the state of Odisha, India. Blood samples were collected from the residents using random sampling methods and tested for anti- SARS CoV-2 antibodies using an automated CLIA platform. A total of 4146 participants from the 3 cities of Bhubaneswar (BBS), Berhampur (BAM) and Rourkela (RKL) participated. The female to male participation ratio was 5.9:10 across the three cities. The gender weighted seroprevalence across the three cities was 20.78% (95% CI 19.56–22.05%). While females reported a higher seroprevalence (22.8%) as compared to males (18.8%), there was no significant difference in seroprevalence across age groups. A majority of the seropositive participants were asymptomatic (90.49%). The case to infection ratio on the date of serosurvey was 1:6.6 in BBS, 1:61 in BAM and 1:29.8 in RKL. The study found a high seroprevalence against COVID-19 in urban Odisha as well as high numbers of asymptomatic infections. The epidemic curves had a correlation with the seroprevalence.

Download Full-text