Anti-dyslipidemia Effects of Tart Cherry Dietary Supplementation on Body Weight and Lipid Profiles of Serum in High Fat Diet-Fed Mice
Abstract Objectives The objective of this study was to investigate the anti-dyslipidemia effects of tart cherry supplementation on body weight and lipid profiles of serum in High Fat Diet-Fed Mice. Methods After 2 weeks of adaptation period, forty 7-week-old male C57BL/6J mice were randomly divided into 4 groups (n = 10 per group): normal diet control group (ND), high fat diet control group (HF), HF group fed with 1% tart cherry powder (LC, low dose of cherry), HF group fed with 5% tart cherry powder (HC, high dose of cherry). After 12 weeks of tart cherry dietary supplementation, serum triglyceride (TG), total cholesterol (TC), and high-density lipoprotein cholesterol (HDL-C) were analyzed. Results Final body weight of LC (1%) and HC (5%) was significantly lower than that of HF control group (P < 0.001). Also, body weight gained in LC (1%) and HC (5%) was significantly lower than HF control group (P < 0.001). In serum, triglyceride (TG) and total cholesterol (TC) levels were significantly lower in HC (5%) group compared to HF control group (P < 0.05, P < 0.001, respectively). Serum HDL-cholesterol levels in LC (1%) and HC (5%) groups was significantly higher than HF control group (P < 0.05). Conclusions Tart cherry dietary supplementation may have an anti-dyslipidemia effect in high fat diet-fed mice by lowering body weight gain and modulating serum cholesterol levels. Further analysis of AMPK-regulated fatty acid oxidation biomarkers are under investigation. Funding Sources This study received no external funding.