scholarly journals EVALUATION OF ANTI-OBESITY ACTIVITY OF SOLASODINE IN HIGH FAT DIET-INDUCED OBESITY IN RAT

2017 ◽  
Vol 9 (3) ◽  
pp. 23 ◽  
Author(s):  
Satish Khaserao ◽  
Rahul Somani
Keyword(s):  
Body Weight ◽  
Total Cholesterol ◽  
Glucose Level ◽  
High Fat Diet ◽  
Total Cholesterol Level ◽  
Diet Group ◽  
Control Group ◽  
High Fat ◽  
Diet Control ◽  
Control Group Group

Objective: This study was planned to study the anti-obesity activities of solasodine on high fat (HF) diet-induced obese rats.Methods: Wistar rats were divided into six groups. Control group (Group 1) received normal diet and 0.5 % CMC (5 ml/kg). HF control group (Group 2) received HF diet. Group 3 received orlistat (25 mg/kg body weight per oral). Group 4, 5 and 6 received 25, 50 and 100 mg/kg body weight solasodine respectively. Treatment was given for 6 w to the respective group along with HF diet. Body weight, food intake and abdomen circumference was measured every week for 6 w. On day 42, the serum biochemical parameters like blood glucose and insulin, serum leptin, total cholesterol and triglyceride were evaluated. Animals were sacrificed with overdose of diethyl ether. The liver and retroperitoneal adipose tissues were removed and weighed immediately.Results: Treatment with solasodine at dose of 50 mg/kg and 100 mg/kg significantly (p<0.001) reduced body weight, abdomen circumference and retroperitoneal adipose tissue weight as compared to the HF diet control group. Solasodine also significantly reduced serum total cholesterol, triglyceride and glucose level as compared to HF diet control group (***p<0.001, **p<0.01, *p<0.05 when compared with normal control. ###p<0.001, #p<0.05 when compared with high fat control). In addition, it also inhibited the induction of fatty liver with accumulation of hepatic triglyceride.Conclusion: Solasodine exhibited anti-obesity effect by showing a reduction in body weight, abdomen circumference, total cholesterol level, triglyceride level and glucose level in high-fat diet fed rats.

scholarly journals Anti-hypercholesterolemic effect of Zingiber montanum extract

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 1798
Author(s):  
Swandari Paramita ◽  
Meiliati Aminyoto ◽  
Sjarif Ismail ◽  
Enos Tangke Arung
Keyword(s):  
Total Cholesterol ◽  
High Fat Diet ◽  
Diet Group ◽  
High Density Lipoproteins ◽  
Control Group ◽  
High Cholesterol ◽  
High Fat ◽  
Cholesterol Levels ◽  
White Rats ◽  
Diet Control

Background: Hypercholesterolemia, high cholesterol levels in the blood, can contribute to many forms of disease, most notably cardiovascular disease. Anti-hypercholesterolemic agents generally used for those conditions have several side effects for patients. Zingiber montanum, known locally as “bangle”, belongs to the family Zingiberaceae and is a potential plants for alternative anti-hypercholesterolemic agents. This plant, from East Kalimantan, is used in traditional medicine for health problems caused by high cholesterol levels. The aim of this research was to find alternatives to anti-hypercholesterolemic agents, especially from natural sources. Methods: This study was an experimental study using 30 Wistar male white rats. Subjects were randomly divided into 6 groups (n=5): (1) normal control group; (2) high fat diet control group; (3) high fat diet with simvastatin; (4-6) high fat diet with Zingiber montanum extracts 100, 200, and 400 mg/kg. After 4 weeks of treatment, blood was collected from all groups, and plasma concentrations of triglycerides, total cholesterol, high density lipoproteins (HDL), and low density lipoproteins (LDL) were measured. Results: The results showed significant differences in total cholesterol (p=0.000), LDL (p=0.000) and triglycerides (p=0.001) in the high-fat diet group with Z. montanum extract, as compared to the high-fat diet control. Meanwhile, there were no significant differences in HDL levels (p=0.830) between the high-fat diet group and other groups. The results also showed significant differences in total cholesterol and LDLs for rats treated with Z. montanum extract, 100 mg/kg (p=0.000), 200 mg/kg (p=0.000), and 400 mg/kg (p=0.000) compared to the high-fat diet group. The result of Z. montanum 400 mg/kg also showed a significant reduction, not only for total cholesterol and LDLs, but also for triglycerides (p=0.030). Conclusion: It could be concluded that Z. montanum extracts have the potency to be further developed as a new natural source of the anti-hypercholesterolemic agents.

scholarly journals Anti-dyslipidemia Effects of Tart Cherry Dietary Supplementation on Body Weight and Lipid Profiles of Serum in High Fat Diet-Fed Mice

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 1192-1192
Author(s):  
Songhee Ahn ◽  
Hyun-Sook !Kim
Keyword(s):  
Body Weight ◽  
Total Cholesterol ◽  
High Fat Diet ◽  
Serum Triglyceride ◽  
Dietary Supplementation ◽  
Control Group ◽  
Tart Cherry ◽  
High Fat ◽  
Cholesterol Levels ◽  
Diet Control

Abstract Objectives The objective of this study was to investigate the anti-dyslipidemia effects of tart cherry supplementation on body weight and lipid profiles of serum in High Fat Diet-Fed Mice. Methods After 2 weeks of adaptation period, forty 7-week-old male C57BL/6J mice were randomly divided into 4 groups (n = 10 per group): normal diet control group (ND), high fat diet control group (HF), HF group fed with 1% tart cherry powder (LC, low dose of cherry), HF group fed with 5% tart cherry powder (HC, high dose of cherry). After 12 weeks of tart cherry dietary supplementation, serum triglyceride (TG), total cholesterol (TC), and high-density lipoprotein cholesterol (HDL-C) were analyzed. Results Final body weight of LC (1%) and HC (5%) was significantly lower than that of HF control group (P &lt; 0.001). Also, body weight gained in LC (1%) and HC (5%) was significantly lower than HF control group (P &lt; 0.001). In serum, triglyceride (TG) and total cholesterol (TC) levels were significantly lower in HC (5%) group compared to HF control group (P &lt; 0.05, P &lt; 0.001, respectively). Serum HDL-cholesterol levels in LC (1%) and HC (5%) groups was significantly higher than HF control group (P &lt; 0.05). Conclusions Tart cherry dietary supplementation may have an anti-dyslipidemia effect in high fat diet-fed mice by lowering body weight gain and modulating serum cholesterol levels. Further analysis of AMPK-regulated fatty acid oxidation biomarkers are under investigation. Funding Sources This study received no external funding.

scholarly journals Effects of Cinnamon (Cinnamomum cassia) Consumption on Serum Lipid Profiles in Albino Rats

2020 ◽  
Vol 2020 ◽  
pp. 1-7 ◽  
Author(s):  
Fahadah Naeef Alsoodeeri ◽  
Hissah Mohammed Alqabbani ◽  
Norah Mubarak Aldossari
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Total Cholesterol ◽  
High Fat Diet ◽  
Serum Lipid ◽  
Diet Group ◽  
Lipid Profiles ◽  
Serum Total Cholesterol ◽  
Albino Rats ◽  
High Fat

Dyslipidemia is an important cause of cardiovascular diseases (CVDs), which are the most prevalent causes of morbidity and mortality. The purpose of this study was to assess the effects of cinnamon on body weight gain, food intake, and serum lipid profiles of albino rats. This study was conducted on 30 healthy male albino rats weighing approximately 130 ± 5 g. The study was divided into the following two experiments: experiment (1), wherein rats were fed a laboratory diet; and experiment (2), wherein rats were fed a high-fat diet. In experiment 1, a total of 15 rats were divided into three groups. Group A (n=5, untreated control) was fed laboratory diet, Group B n=5 was fed laboratory diet and cinnamon powder (2 g/kg body weight), and Group C n=5 was fed laboratory diet and cinnamon powder (4 g/kg body weight) for 30 days. In experiment (2), a total of 15 rats were similarly divided into three groups. Group D (n=5, treated control) was fed laboratory diet plus high-fat diet, Group E n=5 was fed cinnamon powder (2 g/kg body weight) mixed with laboratory diet plus high-fat diet, and Group F n=5 was fed cinnamon powder (4 g/kg body weight) mixed with laboratory diet plus high-fat diet daily for 30 days. An administration of 4 g/kg body weight of cinnamon extract powder decreased the final weight by 4.4%, body weight gains by 31.41%, food intake by 1.7%, and food efficiency ratio by 22.38% in hypercholesterolemic adult male rats as well as serum total cholesterol by 31.22%, triglyceride by 24.05%, and LDL-C by 43.49%, with an increase in the levels of HDL-C by 30.16%, furthermore, a significant decrease in serum total cholesterol, triglycerides, and LDL-C levels and increasing serum HDL-C on day 30 were observed P<0.001. This finding provides scientific evidence to substantiate the traditional use of cinnamon to treat hyperlipidemia.

Reductive effect of body weight in C57BL/6J mice fed a high-fat diet by Saesaengmyung Diet

2005 ◽  
Vol 83 (2) ◽  
pp. 161-165
Author(s):  
Hyo-Jin An ◽  
Na-Hyung Kim ◽  
Yun-Kyung Kim ◽  
Yeoung-Su Lyu ◽  
Taekyun Shin ◽  
...  
Keyword(s):  
Body Weight ◽  
Total Cholesterol ◽  
High Fat Diet ◽  
Ldl Cholesterol ◽  
Total Cholesterol Level ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Standard Diet ◽  
High Fat ◽  
Glucose Levels

The Saesaengmyung Diet (SD) is a newly developed dietary product to help control weight. The aim of this study was to evaluate whether SD combined with a high-fat (HF) diet could influence body weight, fat accumulation, and glucose levels in blood. C57BL/6J mice were fed for 8 weeks with a standard diet, an HF diet, and an HF + 10% or HF + 20% SD diet. Body weight was recorded weekly, and plasma levels of total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and glucose were analyzed at the end of the study. Weight increases in the 10% or 20% SD group were significantly less than in the HF diet group (p < 0.05). Plasma total cholesterol level significantly decreased by 33.5% in the 10% SD group and 38.8% in the 20% SD group, but the LDL cholesterol, HDL cholesterol, and glucose levels in the SD groups were not significantly changed. Our findings indicate that SD may be beneficial to overweight individuals in the reduction of weight gain induced by an HF diet.Key words: Saesaengmyung Diet, high-fat diet, obesity, body weight, cholesterol, glucose.

scholarly journals Role of resveratrol and chrysin on inflammation and liver function in obese mice

2021 ◽  
Author(s):  
Pipit Pitriani ◽  
◽  
Wang-Lok Lee ◽  
Hee-Geun Park ◽  
◽  
...  
Keyword(s):  
Body Weight ◽  
Liver Function ◽  
High Fat Diet ◽  
Diet Group ◽  
Normal Diet ◽  
Calorie Intake ◽  
Control Group ◽  
Obese Mice ◽  
High Fat ◽  
Impaired Liver Function

The incidence of obesity has been spreading throughout the world. Many of the complications caused by obesity, such as inflammation and impaired liver function. This study aimed to determine the effect of supplementation resveratrol and chrysin on inflammation and liver function of obese mice fed a high-fat diet. 40 mice (C57BL/6) were randomly divided into four groups: 10 in the normal diet (NC), 10 control group on a high-fat diet (HC), 10 in the high-fat diet with resveratrol (HRE), and 10 in the high-fat diet group with chrysin (HCH). Resveratrol 25 mg and 50mg of chrysin supplement per kg body weight were orally given with 0.1ml solution of Dimethyl Sulfoxide (DMSO) dissolved in for 15 weeks (4 times/week). The calorie intake of the group supplemented by resveratrol and chrysin significantly decreased. Group with high-fat diet, resveratrol, and chrysin increased body weight significantly compared to the normal diet group. The liver weight decreased in the resveratrol but not in the chrysin group. TNFα did not decrease in the resveratrol and chrysin group while IL1β significantly decreased. TLR 4 significantly decreased only in the chrysin group, while IL10 only increased in the resveratrol group. The collagen was decreased by resveratrol and chrysin supplementation while fibronectin was not affected by resveratrol or chrysin. The inflammatory process in the liver of obese mice fed a high-fat diet can be reduced by supplementing resveratrol and chrysin.

Pengaruh Pemberian Terapi Oksigen Hiperbarik Terhadap Kadar Kolesterol Total Pada Tikus Putih (Rattus novergicus) Jantan Galur Wistar Yang Di Induksi Diet Tinggi Lemak

2018 ◽  
Vol 16 (1) ◽  
pp. 1 ◽  
Author(s):  
AZRUL HILDAN SAFRIZAL
Keyword(s):  
Cardiovascular Disease ◽  
Total Cholesterol ◽  
Cholesterol Level ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
High Fat Diet ◽  
Oxygen Therapy ◽  
Total Cholesterol Level ◽  
High Fat ◽  
Cholesterol Levels

<p>The pattern and lifestyle of today's society with the presence of an interner facility makes people spend more time sitting out than on exercise and increased consumption of high-fat foods may increase the risk of cardiovascular disease. An effective therapy is needed in preventing the occurrence of cardiovascular disease. Hyperbaric oxygen now starts to develop for the treatment of several diseases, which in turn can increase the gene forming antioxidant enzymes and ROS. To determine effect of hyperbaric oxygen therapy on total cholesterol levels of wistar white rats (Rattusnovergicus) induced bye high fat. The study was carried out in an expeative post test only group control of three groups. One group is given standard feed. All groups induced high-fat diet and standard feed. Of the two groups induced, one group was given hyperbaric oxygen therapy with a dose of 3 x 30 minutes for six days on day 7 at a blood test to determine total cholesterol levels<strong>. </strong>One way Anova parametric statistic test showed that p = 0.007 &lt; α proved hypothesis that hyperbaric oxygen therapy giving effect to total cholesterol level of white mice of jantangalurist rings induced by high fat diet. Total cholesterol was significantly different between K (-) and K (+) and between K (-) and P. It was found that hyperbaric oxygen therapy had an effect on total cholesterol level dose of 3x30 minutes for six days.</p>

scholarly journals Protective Effects of Polyphenol Enriched Complex Plants Extract on Metabolic Dysfunctions Associated with Obesity and Related Nonalcoholic Fatty Liver Diseases in High Fat Diet-Induced C57BL/6 Mice

Molecules ◽  
2021 ◽  
Vol 26 (2) ◽  
pp. 302
Author(s):  
Ahtesham Hussain ◽  
Jin Sook Cho ◽  
Jong-Seok Kim ◽  
Young Ik Lee
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Mouse Model ◽  
High Fat Diet ◽  
Liver Diseases ◽  
Liver Weight ◽  
Control Group ◽  
High Fat ◽  
Herbal Formulation ◽  
Plants Extract

Background: Currently, obesity is a global health challenge due to its increasing prevalence and associated health risk. It is associated with various metabolic diseases, including diabetes, hypertension, cardiovascular disease, stroke, certain forms of cancer, and non-alcoholic liver diseases (NAFLD). Objective: The aim of this study to evaluate the effects of polyphenol enriched herbal complex (Rubus crataegifolius/ellagic acid, Crataegus pinnatifida Bunge/vitexin, chlorogenic acid, Cinnamomum cassiaa/cinnamic acid) on obesity and obesity induced NAFLD in the high-fat diet (HFD)-induced obese mouse model. Methods: Obesity was induced in male C57BL/6 mice using HFD. After 8 weeks, the mice were treated with HFD+ plants extract for 8 weeks. Body weight, food intake weekly, and blood sugar level were measured. After sacrifice, changes in the treated group’s liver weight, fat weight, serum biochemical parameters, hormone levels, and enzyme levels were measured. For histological analysis, tissues were stained with hematoxylin-eosin (H&E) and Oil Red-O. Results: Our results showed that the herbal complex ameliorated body weight and liver weight gain, and decreased total body fat in HFD-fed animals. Post prandial blood glucose (PBG) and fasting blood glucose (FBG) were lower in the herbal complex-treated group than in the HFD control group. Additionally, herbal formulation treatment significantly increased HDL levels in serum and decreased TC, TG, AST, ALT, deposition of fat droplets in the liver, and intima media thickness (IMT) in the aorta. Herbal complex increased serum adiponectin and decreased serum leptin. Herbal complex also increased carnitine palmityl transferase (CPT) activity and significantly decreased enzyme activity of beta-hydroxy beta methyl glutamyl-CoA (HMG-CoA) reductase, and fatty acid synthase (FAS). Conclusions: The results of this study demonstrated that the herbal complex is an effective herbal formulation in the attenuation of obesity and obesity-induced metabolic dysfunction including NAFLD in HFD-induced mouse model.

scholarly journals Antiobesity and Hypolipidemic Activity of Moringa oleifera Leaves against High Fat Diet-Induced Obesity in Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Souravh Bais ◽  
Guru Sewak Singh ◽  
Ramica Sharma
Keyword(s):  
Body Weight ◽  
Body Temperature ◽  
Total Cholesterol ◽  
High Fat Diet ◽  
Moringa Oleifera ◽  
Chronic Administration ◽  
The Body ◽  
Atherogenic Index ◽  
High Fat ◽  
Diet Induced Obesity

In the present study, the methanolic extract of Moringa oleifera leaves (MEMOL) was evaluated for antiobesity activity in rats. The antiobesity potential of MEMOL was studied against high fat diet-induced obesity (HFD) in rats. In this study, chronic administration of HFD in rats produced hypercholesterolemia (116.2 ± 0.27 mg/dL), which led to an increase in the body weight (225 gr), total cholesterol, triglycerides (263.0 ± 4.69 mg/dL), and attenuation in the levels of HDL (34.51 ± 2.20 mg/dL) as well as changes in body temperature of animals. Treatment of obese rats with MEMOL for 49 days resulted in a significant (P<0.001) change in body weight, total cholesterol, triglycerides, and LDL level along with a significant (P<0.001) increase in body temperature as compared to the HFD-induced obesity. MEMOL treated rats also showed a significant decrease in the level of liver biomarkers, organ weight, and blood glucose level. Further, rats treated with MEMOL (200 mg and 400 mg/kg) show reduced atherogenic index (1.7 ± 0.6 and 0.87 ± 0.76). The results indicate that the rats treated with Moringa oleifera (MO) have significantly attenuated the body weight without any change in the feed intake and also elicited significant thermogenic effect and to act as hypolipidemic and thermogenic property in obesity related disorders.

scholarly journals PO-043 The Effects of One-Time High Intensity Intermittent Training on Expression of LC3 Gene in Rats’ White Adipose Tissue

2018 ◽  
Vol 1 (3) ◽  
Author(s):  
Qishu Zhou ◽  
Chunyu Liang ◽  
Yafei Li ◽  
Yi Yan
Keyword(s):  
Adipose Tissue ◽  
White Adipose Tissue ◽  
High Intensity ◽  
High Fat Diet ◽  
Intermittent Exercise ◽  
Diet Group ◽  
Control Group ◽  
High Fat ◽  
Subcutaneous White Adipose Tissue ◽  
White Fat

Objective  To investigate the effect of one-time high-intensity intermittent exercise in white fat autophagy in obese rats and provide a theoretical basis of the molecular mechanism of exercise fat loss. Methods  Eighteen male 3-weeks-old rats were selected and divided into control group fed with normal diet (C), high-fat diet group fed with high fat diet (H). After 16 weeks, there were twelve obesity rats that divided into diet group (HS) and exercise group (HE). The other six control group rats of 19 weeks age were used as the standard (CS group). OE group did the high intensity intermittent exercise once. The CS group and the CS group were kept quietly. Three groups were taken subcutaneous white adipose tissue(S) and epididymal white adipose tissue (E) immediately after exercise. Mensurate the expression of LC3 gene in the tissue using the fluorescent quantitative PCR. Results 1. The expression of LC3 mRNA from white fat tissue was different to the tissues, which the expression of epididymal white adipose tissue of each group was higher than that in subcutaneous white adipose tissue (P <0.01). 2. Compared with CS group, the expression of epididymal white fat adipose tissue LC3 mRNA decreased (P<0.01) and the expression of the subcutaneous white adipose tissue increased from HS group (P <0.05). 3. Compared with OS group, the expression of epididymal white fat adipose tissue LC3 mRNA decreased (P<0.05) and the expression of subcutaneous white adipose tissue decreased from OS group. Conclusions The expression of LC3mRNA in epididymal white fat adipose tissue of rats was significantly higher than that of subcutaneous white fat. The changes of LC3mRNA expression of adipose tissue caused by high-fat diet have tissue differences. One-time high-intensity intermittent exercise can reduce the expression of LC3mRNA in fat tissue of obese rats. Its regulatory mechanism needs to be further studied.

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