scholarly journals Anti-inflammatory Diet for Interstitial Cystitis (AID-IC): Study Protocol for a Randomized Controlled Cross-Over Trial

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 1276-1276
Author(s):  
Barbara Gordon ◽  
Cynthia !Blanton
Keyword(s):  
Dietary Intake ◽  
Symptom Severity ◽  
Animal Studies ◽  
Inflammatory Responses ◽  
Control Diet ◽  
Saturated Fat ◽  
Dietary Recommendations ◽  
Saturated Fats ◽  
Dietary Components ◽  
Anti Inflammatory

Abstract Objectives IC/BPS is characterized by pelvic pain, pressure, or discomfort in the bladder and pelvic area coupled with urinary frequency and urgency. The cause is unknown. Dietary intake appears to exacerbate IC/BPS symptoms for many patients; however, the association is not well understood. The potential role of saturated fat and other inflammatory dietary components in provoking IC/BPS symptoms will be explored. Animal studies associate high dietary intake of saturated fats with activation of toll-like receptor (TLR4) cell signaling and pro-inflammatory responses. Saturated free fatty acids were linked to changes in the bladder on a cellular level. The goal of the AID-IC study is to investigate the efficacy of an anti-inflammatory diet (limits lipid intake and increases antioxidant intake) on symptom severity. Methods In a 22-week, crossover study, women with IC/BPS will be randomized into two groups. Group one will receive 10 weeks of a therapeutic anti-inflammatory diet that eliminates foods commonly bothersome for those with this condition; 5 days/week prepared, home-delivered meals were provided. Group 2 will receive counseling from a dietitian on standard IC/BPS dietary recommendations (control diet). After a two-week washout period, dietary interventions for the two groups will be switched. Primary outcomes include changes in inflammatory biomarkers (TNF-alpha and IL-1) and scores on three validated symptom severity surveys. Results We hypothesize that an anti-inflammatory diet that excludes foods commonly bothersome for individuals with IC/BPS will help manage symptomology for these patients. Furthermore, we hypothesize that the severity of symptoms will be mediated by the reduction of pro-inflammatory responses associated with the influence of a diet low in saturated fats and high in anti-inflammatory dietary components. Conclusions The feasibility of managing IC/BPS symptoms by influencing inflammatory activity via restricting lipid intake and increasing antioxidant-rich foods has not previously been investigated. The findings may offer preliminary data on a cost-effective, noninvasive therapy. Funding Sources Mountain West Clinical & Translational Research Infrastructure Network (National Institute of General Medical Sciences, NIH).

scholarly journals Inflammatory Disease Processes and Interactions with Nutrition

2009 ◽  
Vol 101 (S1) ◽  
pp. 1-45 ◽  
Author(s):  
P. C. Calder ◽  
R. Albers ◽  
J.-M. Antoine ◽  
S. Blum ◽  
R. Bourdet-Sicard ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Vitamin E ◽  
Barrier Function ◽  
Inflammatory Responses ◽  
Clinical Symptoms ◽  
Tissue Injury ◽  
Inflammatory Reactions ◽  
Gut Barrier Function ◽  
Dietary Components ◽  
Anti Inflammatory

Inflammation is a stereotypical physiological response to infections and tissue injury; it initiates pathogen killing as well as tissue repair processes and helps to restore homeostasis at infected or damaged sites. Acute inflammatory reactions are usually self-limiting and resolve rapidly, due to the involvement of negative feedback mechanisms. Thus, regulated inflammatory responses are essential to remain healthy and maintain homeostasis. However, inflammatory responses that fail to regulate themselves can become chronic and contribute to the perpetuation and progression of disease. Characteristics typical of chronic inflammatory responses underlying the pathophysiology of several disorders include loss of barrier function, responsiveness to a normally benign stimulus, infiltration of inflammatory cells into compartments where they are not normally found in such high numbers, and overproduction of oxidants, cytokines, chemokines, eicosanoids and matrix metalloproteinases. The levels of these mediators amplify the inflammatory response, are destructive and contribute to the clinical symptoms. Various dietary components including long chain ω-3 fatty acids, antioxidant vitamins, plant flavonoids, prebiotics and probiotics have the potential to modulate predisposition to chronic inflammatory conditions and may have a role in their therapy. These components act through a variety of mechanisms including decreasing inflammatory mediator production through effects on cell signaling and gene expression (ω-3 fatty acids, vitamin E, plant flavonoids), reducing the production of damaging oxidants (vitamin E and other antioxidants), and promoting gut barrier function and anti-inflammatory responses (prebiotics and probiotics). However, in general really strong evidence of benefit to human health through anti-inflammatory actions is lacking for most of these dietary components. Thus, further studies addressing efficacy in humans linked to studies providing greater understanding of the mechanisms of action involved are required.

scholarly journals Does personalised nutrition advice based on apolipoprotein E and methylenetetrahydrofolate reductase genotype affect dietary behaviour?

2021 ◽  
pp. 026010602110328
Author(s):  
Alexandra King ◽  
Shaghayegh Saifi ◽  
Jenna Smith ◽  
Leta Pilic ◽  
Catherine A-M Graham ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Cardiovascular Risk ◽  
Dietary Intake ◽  
Apolipoprotein E ◽  
Methylenetetrahydrofolate Reductase ◽  
Saturated Fat ◽  
Dietary Behaviour ◽  
Dietary Recommendations ◽  
Personalised Nutrition ◽  
Risk Genotype

Background: Dietary intake is linked to numerous modifiable risk factors of cardiovascular disease. Current dietary recommendations in the UK to reduce the risk of cardiovascular disease are not being met. A genotype-based personalised approach to dietary recommendations may motivate individuals to make positive changes in their dietary behaviour. Aim: To determine the effect of a personalised nutrition intervention, based on apolipoprotein E ( ApoE, rs7412; rs429358) and methylenetetrahydrofolate reductase ( MTHFR, rs1801133) genotype, on reported dietary intake of saturated fat and folate in participants informed of a risk genotype compared to those informed of non-risk genotype. Methods: Baseline data ( n = 99) were collected to determine genotype (non-risk vs risk), dietary intake and cardiovascular risk (Q-Risk®2 cardiovascular risk calculator). Participants were provided with personalised nutrition advice via email based on their ApoE and MTHFR genotype and reported intake of folate and saturated fat. After 10 days, dietary intake data were reported for a second time. Results: Personalised nutrition advice led to favourable dietary changes, irrespective of genotype, in participants who were not meeting dietary recommendations at baseline for saturated fat ( p < 0.001) and folate ( p = 0.002). Only participants who were informed of a risk ApoE genotype met saturated fat recommendations following personalised nutrition advice. Conclusion: Incorporation of genotype-based personalised nutrition advice in a diet behaviour intervention may elicit favourable changes in dietary behaviour in participants informed of a risk genotype. Participants informed of a non-risk genotype also respond to personalised nutrition advice favourably but to a lesser extent.

scholarly journals OP29 Long-term dietary patterns are associated with pro-inflammatory and anti-inflammatory features of the gut microbiome

2021 ◽  
Vol 15 (Supplement_1) ◽  
pp. S028-S029
Author(s):  
L Bolte ◽  
A Vich Vila ◽  
F Imhann ◽  
V Collij ◽  
V Peters ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Dietary Intake ◽  
Dietary Patterns ◽  
Gut Microbiome ◽  
Inflammatory Responses ◽  
Meta Analysis ◽  
Dietary Factors ◽  
Metagenomic Sequencing ◽  
Anti Inflammatory

Abstract Background The gut microbiome directly affects the balance of pro-inflammatory and anti-inflammatory responses in the gut. As microbes thrive on dietary substrates, the question arises whether we can nourish an anti-inflammatory gut ecosystem. In this study, we investigated the relation between 173 dietary factors and the microbiome of 1425 individuals spanning four cohorts: Crohn’s disease, ulcerative colitis, irritable bowel syndrome and the general population. Methods Shotgun metagenomic sequencing was performed to profile gut microbial composition and function. Dietary intake was assessed through food frequency questionnaires. We performed unsupervised clustering to identify dietary patterns and microbial clusters. Next, linear models were conducted between dietary intake and microbial species and pathways, adding age, sex, caloric intake and sequencing read depth as covariates. Analyses were conducted per cohort, followed by a meta-analysis and heterogeneity estimation. Multiple testing correction was performed on the obtained p-values and a FDR &lt;0.05 was defined as significance cut-off. Results We identified 38 associations between dietary patterns and microbial clusters. Moreover, 61 individual foods and nutrients were associated with 61 species and 249 metabolic pathways in the meta-analysis across healthy individuals and patients with IBS, Crohn’s disease and UC (FDR&lt;0.05, heterogeneity p-value&gt;0.05). Processed foods and animal-derived foods were consistently associated with higher abundances of Firmicutes, Ruminococcus species of the Blautia genus and endotoxin synthesis pathways. The opposite associations were found for clusters comprising fish, nuts, bread and legumes. Moreover, while total plant protein intake was associated with a higher Bifidobacterium abundance (FDR=0.048, coef=4.98), animal-derived protein showed a negative association (FDR=1.30x10-05, coef= -4.1). Lastly, we observed positive associations of fecal calprotectin with a fast food cluster (FDR=4.14x10-4, coef=0.24) and a cluster comprised of high-fat meat, potatoes and gravy (FDR=0.003, coef =0.22), while the opposite was seen for clusters of fish and nuts (FDR=0.038, coef= -0.1) and bread and legumes (FDR=0.005, coef= -2.48). Conclusion We identified dietary patterns that consistently correlate with groups of bacteria with shared functional roles in both, health and disease. Moreover, specific foods and nutrients were associated with species known to infer mucosal protection and anti-inflammatory effects. A decrease in these bacteria has already been associated with both IBS and IBD. We propose microbial mechanisms through which the diet affects inflammatory responses in the gut as a rationale for future intervention studies.

scholarly journals USE OF SPICES AND SPICES AS NATURAL ANTIOXIDANTS AND ANTI-CARCINOGENIC FACTORS

2021 ◽  
pp. 80-85
Author(s):  
O. P. Maidebura ◽  
N. I. Korylchuk ◽  
A. V. Kravetska
Keyword(s):  
Inflammatory Responses ◽  
Natural Antioxidants ◽  
Negative Effects ◽  
Daily Consumption ◽  
Human Diet ◽  
Treatment Groups ◽  
Anticancer Effects ◽  
Saturated Fats ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Spices and condiments are natural biotechnological agents that exhibit therapeutic activity in the collection of free radicals formed due to oxidative stress, thereby exhibiting both antioxidant and anticancer effects. The aim of the article is a scientific-theoretical and experimental review of the use of spices and condiments as natural antioxidants and anticancer factors, their therapeutic effect on metabolic disorders and overweight.Materials and methods. During the work, an experimental study of the anti-inflammatory effect of a mixture of spices on metabolism in humans (men) with overweight, cardiovascular disease and metabolic disorders.Results and discussion. The study revealed a change in triglyceride levels between treatment groups, and an estimated 13 subjects gave a TG difference of (15 ± 32) mg / dL (mean ± SD) with 80 % potency (α = 0.05). Quantitative assessment of inflammatory responses was performed in 22 subjects because it was not possible to collect enough blood to perform the tests needed to assess inflammatory cytokine secretion and triglyceride levels.Study participants ate foods such as foods high in saturated fats and carbohydrates 1000 kcal, containing 33 % kcal saturated fats and 36% kcal carbohydrates without additional spices; food containing 2 g of a mixture of spices; food containing 6 g of spice mixture, with a washout period ≥ 3 days between days of intervention. The study shows that the percentage of monocytes increased significantly in circulation 240 minutes after eating food containing spices.The study found that the consumption of spices can reduce the negative effects of foods that contain significant levels of carbohydrates and fats in food. Conclusions. A diet containing a mixture of spices was developed to investigate the anti-inflammatory effect of spices in the context of food consumption, and for this purpose spices were chosen that are widely used for daily consumption in the human diet.

scholarly journals Novel Gut Microbiota Patterns Involved in the Attenuation of Dextran Sodium Sulfate-Induced Mouse Colitis Mediated by Glycerol Monolaurate via Inducing Anti-inflammatory Responses

mBio ◽  
2021 ◽  
Author(s):  
Qiufen Mo ◽  
Tao Liu ◽  
Aikun Fu ◽  
Shengyue Ruan ◽  
Hao Zhong ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Sodium Sulfate ◽  
Inflammatory Responses ◽  
Dextran Sodium Sulfate ◽  
Food Grade ◽  
Glycerol Monolaurate ◽  
Dietary Components ◽  
Anti Inflammatory

The gut microbiota, which can be highly and dynamically affected by dietary components, is closely related to IBD pathogenesis. Here, we demonstrated that food-grade glycerol monolaurate (GML)-mediated enhancement of Bifidobacterium and fecal SCFAs could be responsible for the anticolitis effect.

scholarly journals Microalgal Lipid Extracts Have Potential to Modulate the Inflammatory Response: A Critical Review

2021 ◽  
Vol 22 (18) ◽  
pp. 9825
Author(s):  
Tiago Alexandre Conde ◽  
Ioannis Zabetakis ◽  
Alexandros Tsoupras ◽  
Isabel Medina ◽  
Margarida Costa ◽  
...  
Keyword(s):  
Chronic Inflammation ◽  
Dietary Habits ◽  
Inflammatory Responses ◽  
Positive Impact ◽  
Noncommunicable Diseases ◽  
Low Grade ◽  
Bioactive Lipids ◽  
Inflammatory Status ◽  
Dietary Components ◽  
Anti Inflammatory

Noncommunicable diseases (NCD) and age-associated diseases (AAD) are some of the gravest health concerns worldwide, accounting for up to 70% of total deaths globally. NCD and AAD, such as diabetes, obesity, cardiovascular disease, and cancer, are associated with low-grade chronic inflammation and poor dietary habits. Modulation of the inflammatory status through dietary components is a very appellative approach to fight these diseases and is supported by increasing evidence of natural and dietary components with strong anti-inflammatory activities. The consumption of bioactive lipids has a positive impact on preventing chronic inflammation and consequently NCD and AAD. Thus, new sources of bioactive lipids have been sought out. Microalgae are rich sources of bioactive lipids such as omega-6 and -3 polyunsaturated fatty acids (PUFA) and polar lipids with associated anti-inflammatory activity. PUFAs are enzymatically and non-enzymatically catalyzed to oxylipins and have a significant role in anti and pro-resolving inflammatory responses. Therefore, a large and rapidly growing body of research has been conducted in vivo and in vitro, investigating the potential anti-inflammatory activities of microalgae lipids. This review sought to summarize and critically analyze recent evidence of the anti-inflammatory potential of microalgae lipids and their possible use to prevent or mitigate chronic inflammation.

scholarly journals Flavonoids: Nutraceuticals for Rheumatic Diseases via Targeting of Inflammasome Activation

2021 ◽  
Vol 22 (2) ◽  
pp. 488
Author(s):  
Young-Su Yi
Keyword(s):  
Rheumatic Diseases ◽  
Fruits And Vegetables ◽  
Inflammatory Responses ◽  
Protein Complexes ◽  
Cellular Damage ◽  
Inflammatory Rheumatic Diseases ◽  
Inflammasome Activation ◽  
Central Feature ◽  
Inflammatory Protein ◽  
Anti Inflammatory

Inflammation, an innate immune response that prevents cellular damage caused by pathogens, consists of two successive mechanisms, namely priming and triggering. While priming is an inflammation-preparation step, triggering is an inflammation-activation step, and the central feature of triggering is the activation of inflammasomes and intracellular inflammatory protein complexes. Flavonoids are natural phenolic compounds predominantly present in plants, fruits, and vegetables and are known to possess strong anti-inflammatory activities. The anti-inflammatory activity of flavonoids has long been demonstrated, with the main focus on the priming mechanisms, while increasing numbers of recent studies have redirected the research focus on the triggering step, and studies have reported that flavonoids inhibit inflammatory responses and diseases by targeting inflammasome activation. Rheumatic diseases are systemic inflammatory and autoimmune diseases that primarily affect joints and connective tissues, and they are associated with numerous deleterious effects. Here, we discuss the emerging literature on the ameliorative role of flavonoids targeting inflammasome activation in inflammatory rheumatic diseases.

scholarly journals Administration route governs the therapeutic efficacy, biodistribution and macrophage targeting of anti-inflammatory nanoparticles in the lung

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Lu Wang ◽  
Yafei Rao ◽  
Xiali Liu ◽  
Liya Sun ◽  
Jiameng Gong ◽  
...  
Keyword(s):  
Therapeutic Efficacy ◽  
Lung Inflammation ◽  
Respiratory Diseases ◽  
Inflammatory Responses ◽  
The Other ◽  
Target Cells ◽  
Administration Route ◽  
Toll Like Receptor ◽  
Administration Routes ◽  
Anti Inflammatory

Abstract Background Uncontrolled inflammation is a central problem for many respiratory diseases. The development of potent, targeted anti-inflammatory therapies to reduce lung inflammation and re-establish the homeostasis in the respiratory tract is still a challenge. Previously, we developed a unique anti-inflammatory nanodrug, P12 (made of hexapeptides and gold nanoparticles), which can attenuate Toll-like receptor-mediated inflammatory responses in macrophages. However, the effect of the administration route on its therapeutic efficacy and tissue distribution remained to be defined. Results In this study, we systematically compared the effects of three different administration routes [the intratracheal (i.t.), intravenous (i.v.) and intraperitoneal (i.p.)] on the therapeutic activity, biodistribution and pulmonary cell targeting features of P12. Using the LPS-induced ALI mouse model, we found that the local administration route via i.t. instillation was superior in reducing lung inflammation than the other two routes even treated with a lower concentration of P12. Further studies on nanoparticle biodistribution showed that the i.t. administration led to more accumulation of P12 in the lungs but less in the liver and other organs; however, the i.v. and i.p. administration resulted in more nanoparticle accumulation in the liver and lymph nodes, respectively, but less in the lungs. Such a lung favorable distribution was also determined by the unique surface chemistry of P12. Furthermore, the inflammatory condition in the lung could decrease the accumulation of nanoparticles in the lung and liver, while increasing their distribution in the spleen and heart. Interestingly, the i.t. administration route helped the nanoparticles specifically target the lung macrophages, whereas the other two administration routes did not. Conclusion The i.t. administration is better for treating ALI using nanodevices as it enhances the bioavailability and efficacy of the nanodrugs in the target cells of the lung and reduces the potential systematic side effects.

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