scholarly journals The impact of chronic alcohol overuse on right ventricular myocardial strain

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
P Hamala ◽  
J D K Kasprzak ◽  
K W D Wierzbowska-Drabik
Keyword(s):  
Univariate Analysis ◽  
Myocardial Strain ◽  
Control Group ◽  
Apical Segment ◽  
Chronic Alcohol ◽  
Pure Ethanol ◽  
Funding Sources ◽  
Strain Data ◽  
The Impact ◽  
Rv Function

Abstract Background The mechanisms and detail effects of alcohol cardiac toxicity are not clear. Purpose We aimed, to evaluate the relationship between the consumed alcohol dose and severity of right ventricle (RV) myocardial injury in patients overusing alcohol. Methods We collected a group of patients chronically overusing alcohol (ALC- alcohol overusers) and matched to them control group of abstainers (CG-control group). Clinical and echocardiography data have been obtained and statistical analysis performed. RV strain data were obtained from free wall (RVGS). Strain data were presented as absolute values. Results Group with available and feasible data of RV function consisted of 53 ALC patients, 75% men, 50±12 years old, and 33 controls CG, 69% men. Alcohol unit (AU – 10 gram of pure ethanol) consumed per week (AUW) was 21 (12–44) in ALC and 0 (0–0) in CG, P<0.001. The mean time of alcoholism amounted 20 (10–26) years. RVGS was: 20±7% in ALC vs. 24±3% in CG, P=0.001. In ALC, RV middle segment strain (RVmid) was 22±8% vs. 24±3%, P=0.01 and RV apical segment strain (RVapx) was 17±7 vs. 22±3, P=0.0002, see Table. No significant differences were detected for RV diameter, TAPSE and RVS', see Table. Moreover, univariate analysis showed significant positive correlation between free time (FT- time between last alcohol ingestion and echocardiography examination) and RVGS (rho = 0.36, P=0.01) as well as between FT and global longitudinal left ventricle strain (LVGS) (rho = 0.33, P=0.01), whereas TAPSE and RVS' did not show this relationship (rho = 0.30, P=0.41 and rho = 0.21, P=0.14, respectively). See Figure for RVGS. Conclusions Chronic alcohol overuse was associated with significant worsening of RV function expressed by absolute values of RVGS and RV middle and apical segment strains, offering novel quantitative parameter for reflecting early, often subclinical, impairment of RV function. RVGS and LVGS (contrary to TAPSE and RVS') reflected also myocardial function recovery after alcohol intake cessation proportionally to the elapsed abstinence time. FUNDunding Acknowledgement Type of funding sources: None. Table 1 Figure 1

scholarly journals Effect of Flavor Enhancement on the Appreciation of Food in Breast Cancer Patients Undergoing Chemotherapy

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 320-320
Author(s):  
Kenza Drareni ◽  
Moustafa Bensafi ◽  
Helene Lusson ◽  
Damien Vansteene ◽  
Agnès Giboreau ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Hierarchical Cluster ◽  
Cross Sectional Study ◽  
Control Group ◽  
Breast Cancer Patients ◽  
Cross Sectional ◽  
Funding Sources ◽  
Significant Difference ◽  
The Impact

Abstract Objectives Given the influence of sensory signals on food intake regulation and the subsequent nutritional status, it is important to reduce the impact of commonly observed smell and taste alterations on the pleasure of eating during chemotherapy. This study aimed to examine the effect of various types of flavor enhancement on the appreciation of an appetizer by a group of patients undergoing chemotherapy. Methods Five eggplant appetizers with no seasoning (REF) or enhanced with either salt, lemon, garlic or cumin were developed. In this cross-sectional study, 36 healthy female subjects (age 58 ± 7 y) (control group) and 84 breast cancer patients (age 56 ± 11 y) treated with chemotherapy were recruited. A hierarchical cluster analysis based on patients' self-reported smell and taste abilities classified the patients in two groups: the ‘unaltered, (high sensory abilities) n = 49’ and the ‘altered, (poor sensory abilities), n = 35’ group. Participants tasted and assessed the appreciation of the reference appetizer on a visual analog scale and performed a randomized comparative liking task, by rating the appreciation for each flavor-enhanced appetizer relative to the REF (one-sample t-test). Results There was no significant difference in the appreciation of the REF appetizer between the three groups (P > 0.05). In the comparative liking task, the control group rated similarly the appreciation between the flavor-enhanced and the REF appetizers except for the cumin-enhanced appetizer, which was appreciated significantly more than the REF (P < 0.001). Patients in both ‘altered’ and ‘unaltered’ groups appreciated similarly the cumin appetizer (P > 0.05), more the salt and garlic-enhanced appetizers (P ≤ 0.001, P = 0.005, respectively) and significantly less the lemon-enhanced appetizer relative to the REF (P = 0.029), confirming a tendency for patients to reject acid-flavored foods. Conclusions The salt and garlic enhancements were appreciated by the patients independent of the stage of chemotherapy or the severity of smell and taste alterations. Flavor enhancement seems a good strategy to maintain the pleasure of eating in patients undergoing chemotherapy. Further research is still needed on the appreciation and intake of a complete meal (starter, main course, dessert). Funding Sources APICIL and ELIOR groups.

The utility of surgery in butterfly glioblastoma: A case-control study.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e13529-e13529
Author(s):  
Benjamin James Hall ◽  
Igor Maleyko ◽  
Andrew Brodbelt ◽  
Michael D Jenkinson ◽  
Emmanuel Chavredakis
Keyword(s):  
Survival Data ◽  
Postoperative Morbidity ◽  
Univariate Analysis ◽  
Tumour Volume ◽  
Control Group ◽  
Primary Brain Tumour ◽  
Significant Difference ◽  
Surgical Data ◽  
Multifocal Disease ◽  
The Impact

e13529 Background: Glioblastoma is the most common primary brain tumour and may rarely infiltrate the corpus callosum. Such ‘butterfly’ glioblastomas (BGBM) are believed to confer a poorer prognosis than their non-callosal counterparts. We aimed to determine the impact of surgery on overall survival (OS) and postoperative morbidity in butterfly glioblastomas. Methods: Retrospective analysis was performed on all case notes of patients histologically diagnosed with GBM from January 2011 to January 2017 at The Walton Centre NHS Foundation Trust, Liverpool. Data was collected under the following headings: demographics, tumour characteristics, surgical data, adjuvant therapy and survival data. A case-matched control group was produced according to age, sex and 1o resection. Univariate analysis was performed. Results: 632 glioblastoma patients were identified. 37 patients were diagnosed with butterfly BGBM, with a median age of 62.7 years and a gender split of 24 males (64.9%) to 13 females (35.1%). Median tumour volume was 31700mm3, with 24 (56%) tumours involving the genu and 13 (22%) the splenium of the callosum. Kaplan-Meier analysis with log-rank testing demonstrated a significant (p = 0.04) decrease in median OS in those with BGBM (100 days (95%CI 57-142)) vs controls (276 days (95%CI 224-327)). Resection of BGBMs resulted in longer median OS than biopsy alone (296 days (95%CI 229-363) vs 81 (66-96)), though this was a non-significant difference (p = 0.36). Multifocal disease occurred significantly more often in BGBM patients (p = 0.01), the exclusion of which from analysis demonstrated a significant survival benefit with resection (427 days (95%CI 207-647)) compared to biopsy (221 days (95%CI 151-291)) (p = 0.04). Postoperative complications did not occur significantly more often in BGBM resections than controls (7/36 (19.4%) vs 5/36 (13.9%) (p = 0.257)). Conclusions: Overall, butterfly glioblastomas confer a worse prognosis than those without callosal involvement. A greater prevalence of multifocal disease is seen in butterfly glioblastoma, warranting further investigation. Resection offers a significant improvement in OS in solitary butterfly glioblastomas without a significant increase in postoperative morbidity, and should therefore be considered an efficacious and safe treatment option.

scholarly journals THE INFLUENCE OF THE COORDINATION AND SPEED EXERCISE PROGRAM ON MORPHOLOGICAL CHARACTERISTICS OF CLASS TEACHING PUPILS

2020 ◽  
pp. 121
Author(s):  
Vladimir Momčilović ◽  
Zoran Momčilović ◽  
Srđan Nikolić
Keyword(s):  
Analysis Of Variance ◽  
Univariate Analysis ◽  
Exercise Program ◽  
Morphological Characteristics ◽  
Control Group ◽  
Speed Training ◽  
Primary School Pupils ◽  
And Control ◽  
The Impact ◽  
Experimental Group

In this paper, the authors presented a study aimed at determining the impact of coordination and speed training programs on morphological characteristics of classroom pupils. The sample of respondents included primary school pupils from Nis, aged 9 and 10 (± 6 months). The sample of 64 respondents was divided into two groups, an experimental and control group, 32 pupils in each group. The respondents of the experimental group were involved in the training process of exercising coordination and speed in additional PE classes, while the control group was involved only in regular PE classes. The results of the multivariate analysis of variance and the univariate analysis of variance showed that there are statistically significant differences in the morphological characteristics of the experimental group of respondents in the final measurement compared to the control group respondents  in the skin abdomen (ANTRB), the foreskin of the upper arm  (ANNAD), and the skin of the lower leg (ANPTK).

Effects of Transfusion on Free Flap Survival: Searching for an Optimal Hemoglobin Threshold for Transfusion

2018 ◽  
Vol 34 (08) ◽  
pp. 610-615 ◽  
Author(s):  
Min Ji Kim ◽  
Kyong-Je Woo ◽  
So Ra Kang ◽  
Bo Young Park
Keyword(s):  
Risk Factors ◽  
Blood Transfusion ◽  
Free Flap ◽  
Univariate Analysis ◽  
Multivariable Analysis ◽  
Free Tissue Transfer ◽  
Control Group ◽  
Flap Failure ◽  
Tissue Transfer ◽  
The Impact

Background Microsurgical free tissue transfer is a popular technique nowadays. Because of its considerably exquisite procedure, various risk factors can affect surgical outcome. However, current key practices, especially those in blood transfusion, are in contention due to the lack of enough evidence. Therefore, the objective of this study was to investigate the impact of perioperative blood transfusion on microsurgical complication. Methods Data of a total of 168 patients who underwent microvascular free tissue transfer from 2013 through 2016 were retrospectively reviewed. Age, comorbidity, anatomical surgical site, preoperative and postoperative lowest hemoglobin (Hb) level, estimated blood volume loss, and final clinical flap outcome were compared between patients with and without transfusion treatment. Factors with a significance of p < 0.05 in univariate analysis were included in the multivariate logistic regression model to identify independent risk factors. Results Of 168 patients, 72 (43%) were in the transfusion group. Cross analysis statistics showed that flap failure in the transfusion group was 3.6 times higher (p = 0.018) than that in the control group. Multivariable analysis revealed that age (p = 0.083) and perioperative lowest Hb level (p = 0.021) remained as significant predictors of flap failure. Receiver-operating characteristic curve analysis showed that the appropriate lower limit of transfusion commencement of Hb was 8.75 g/dL (area under the curve: 0.721). Conclusion A transfusion during perioperative period of free flap did not increase its failure rate. Rather than appropriate transfusion strategy, perioperative lowest Hb level, and age were significant predictors of flap failure. Therefore, transfusion can be confidently used in patients who undergo free flap without any hesitation. Results of this study provide practical evidence of performing perioperative transfusion for free tissue transfer patients.

Poor FEV1 or DLco on Pre-Transplant PFT Does Not Compromise Outcomes In Patients Undergoing a Reduced-Intensity Allogeneic Progenitor Cell Transplant.

Blood ◽  
2010 ◽  
Vol 116 (21) ◽  
pp. 1322-1322
Author(s):  
Manish Sharma ◽  
Rima M. Saliba ◽  
Muzaffar H. Qazilbash ◽  
Grace-Julia Okoroji ◽  
Uday Popat ◽  
...  
Keyword(s):  
Proportional Hazards ◽  
Conflicts Of Interest ◽  
Univariate Analysis ◽  
Patient Characteristics ◽  
Cancer Center ◽  
Control Group ◽  
Study Group ◽  
Cell Transplant ◽  
The Impact ◽  
Reduced Intensity

Abstract Abstract 1322 Background: Pre-transplant work-up prior to an allogeneic stem cell transplant (allo-SCT) generally includes pulmonary functions tests (PFT) with assessment of FEV1 and DLco. It has been previously published that patients with a DLco or FEV1 less than 60% of predicted have higher non-relapse mortality (NRM) when undergoing a myeloablative allo-SCT. However, the PFT criteria for selecting candidates for a reduced intensity (RI) allogeneic transplant allo-SCT remains poorly investigated. We performed a retrospective analysis to assess the impact of low FEV1 or DLco on NRM and overall survival (OS) in patients undergoing a RI allo-SCT. Methods: All patients who underwent a RI allo-SCT for hematological malignancies at MD Anderson Cancer Center from Jan 2000 to April 2009 were included. Using Cox's proportional hazards regression, we compared the rate of NRM and OS between patients who had a pre-transplant FEV1 or DLco > 50% (control group) prior to a RI allo-SCT and those with FEV1 and DLco < 50% (study group). The cumulative incidence of NRM was estimated considering disease progression as a competing risk. Actuarial OS was estimated by the Kaplan-Meier method. Results: Patient characteristics are presented in Table 1. There were no statistically significant differences between the study and control groups except for age and sex. A significantly higher proportion of patients were > 50 years in the control group (65%) compared with the low PFT group (45%, P=0.02) and there were more males in the control group (P=.001). The median FEV1 and DLco in the study group was 55% (28-111) and 47% (33-98) of predicted, respectively. On univariate analysis abnormal PFTs did not impact OS at 30 months (HR 1.1, 95% CI 0.7–1.8, P=0.7) or NRM at 1 year (HR 1.3, (95% CI 0.6–2.7, P=0.4). Active disease at SCT, and a diagnosis of CLL, NHL or HL were associated with significantly worse OS and NRM, whereas age >50 years was only associated with worse OS. Low PFT had no significant impact on OS and NRM when evaluated separately in patients older or younger than 50 years old. Conclusion: Our experience suggests that a low (<50% of predicted) FEV1 or a DLco on pre-transplant evaluation does not adversely impact NRM and OS after RI allo-SCT. These findings need to be validated in a multivariate analysis. Disclosures: No relevant conflicts of interest to declare.

scholarly journals Effectivenes of Mentoring Program to Improving Attitude of Pasien Safety

2020 ◽  
Vol 5 (9) ◽  
pp. 845-848
Author(s):  
Andaliaroza . ◽  
Putri Wulandini
Keyword(s):  
Patient Safety ◽  
Univariate Analysis ◽  
Control Group ◽  
P Value ◽  
Mentoring Program ◽  
Safety Incident ◽  
Post Test ◽  
Safety Knowledge ◽  
The Impact ◽  
Experimental Group

The occurrence of a patient safety incident in a hospital will have an adverse impact on the hospital, staff, and patients as service recipients. The impact caused is a decrease in the level of public trust in health services. . Efforts to implement a patient safety culture can be various and mentoring is a more appropriate way. This is because mentoring can provide support to individuals in the learning process with more powerful strength. This study uses a quasy experimental research type. This design consists of two groups, namely the experimental group and the control group. The research sample in this study were student nurses who would practice nursing clinics. The sampling technique used was random sampling. The research instrument used for this study was a pre-test and post-test questionnaire about patient safety knowledge along with a mentoring program to increase patient safety knowledge. data processing includes editing, coding, processing, cleaning, and tabulating. Data analysis includes: validity & reliability test, univariate analysis and bivariate analysis using SPSS assistance. The results of the study obtained there was a change in attitude in the experimental group with p-value 0.000; There was a change in attitude in the control group and the experimental group on the post test with a p value of 0.00. It is hoped that educational institutions will find out how prepared students are to enter the hospital regarding Patient Safety

scholarly journals Segmental evaluation of right ventricular systolic function in atrial septal defect (ASD) type II patients

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
P Rafouli-Stergiou ◽  
A Hiraoka ◽  
R Symons ◽  
J A Bogaert ◽  
P Morais ◽  
...  
Keyword(s):  
Right Ventricular ◽  
Atrial Septal Defect ◽  
Septal Defect ◽  
Myocardial Strain ◽  
Right Atrial ◽  
Cine Imaging ◽  
Control Group ◽  
Contrast Imaging ◽  
Study Objective ◽  
The Impact

Abstract Introduction A left to right (LR) shunt in atrial septal defect (ASD) may cause right heart and pulmonary overfilling, at the expense of the systemic circulation. Purpose The study objective was to evaluate the impact of LR shunt on left (LV) and right ventricular (RV) filling, function, and myocardial strain by using cardiovascular magnetic resonance imaging (CMR). Methods Thirty-five ASD type secundum patients (42±18 y.o.) were compared to a control group (n=40). Cine imaging was used to calculate ventricular volumes and ejection fraction (EF), global longitudinal (GLS) and circumferential (GCS), free wall (FW) and interventricular septal (IVS) longitudinal strain. Phase-contrast imaging was used to calculate pulmonary flow to systemic flow ratio (Qp/Qs). Results Qp/Qs was 2.2±0.60 (range 1.3–3.6), which resulted in higher RV end-diastolic volume/BSA (EDVi, 152±42 vs. 82±11 ml/m2), lower LV EDVi (72±17 vs. 83±10 ml/m2), and higher RV/LV EDVi ratio (2.1±0.5 vs. 1±0.1) compared to controls (all p&lt;0.001) [Figure 1]. Patients also presented with higher RV, but lower LV indexed stroke volumes (both p&lt;0.001), and a strong trend toward lower RVEF (p=0.08). They demonstrated significantly lower RV GLS (p=0.03) and longitudinal IVS strain (p&lt;0.001) [Figure 2]. RV FW strain or RV GCS did not differ among study groups. Shunt severity correlated with RV size and stroke volume, right atrial size and pulmonary trunk diameter (all p&lt;0.001). In contrast, no correlation was identified with functional nor strain parameters. Conclusion Cardiac remodeling in ASD patients with long-standing LR shunt negatively affects RV systolic performance, which is likely related to longitudinal septal dysfunction. FUNDunding Acknowledgement Type of funding sources: None. Figure 1 Figure 2

scholarly journals The effects of Flipped Classroom instructions on student’s motivation in Algebraic Component

2018 ◽  
Vol 8 (2) ◽  
pp. 10-26
Author(s):  
Mohd Zamri Abdullah ◽  
Mustafa Mamat
Keyword(s):  
Creative Thinking ◽  
Flipped Classroom ◽  
School Administrators ◽  
Univariate Analysis ◽  
Control Group ◽  
Good Communication ◽  
The Difference ◽  
Methods Of Learning ◽  
And Control ◽  
The Impact

The Ministry of Education Malaysia (MoE) has suggested usingFlipped Classroom (FC) teaching methodas an innovation inthe teaching of additional mathematics especially in algebra.The suggestion of using FC is very much related to the concept of 21th Century Classroom that emphasizes good communication, collaboration, critical as well as creative thinking. This quasi-experimentalresearchwas carried out to determine the effects of FC on the motivation of students taking additional mathematics.Treatment group (n = 36) was treated with FC methods, whereas control group (n = 34) received conventional methods of learning additional mathematics.To control the difference in dependent variables, a pre-test was given before the experiment started.After nine weeks of treatment, bothgroups were given a post-test.The motivational questionaire on additional mathematics was used as a tool to collect the data.In determining the differenceof databetweentreatment and control groups, thepre- andpost tests data were analyzed using multivariateanalysis ofvariance (MANOVA)followed by univariate analysis of variance(ANOVA).The findings from ANOVA analysis reveal that overall there was a difference between thetreatment and control groupsfor motivation.MANOVA analysis confirmsmore significant differences on motivational subscales namely on attention, relevance, level of confidence and satisfaction between these twogroups.In general, the impact was very substantial and gave a strong indication that the treatment was very meaningful.Therefore, this research has given a newandideal way of teaching additional mathematics to school administrators, subject teachers and students byengagingthe use ofalternativedynamic geometric softwares that are of the same quality as the ones supplied by MoE.

scholarly journals The impact of abnormal conduction zone on outcomes after catheter ablation for atrial fibrillation

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
T Mine ◽  
H Kishima ◽  
E Fukuhara ◽  
R Kitagaki ◽  
M Ishihara
Keyword(s):  
Atrial Fibrillation ◽  
Catheter Ablation ◽  
Univariate Analysis ◽  
Conduction Block ◽  
Right Atrial ◽  
Atrial Pacing ◽  
Funding Sources ◽  
Conduction Zone ◽  
A Site ◽  
The Impact

Abstract Background The abnormal conduction zone (ACZ) in the left atrium (LA) has attracted attention as an arrhythmia substrate in atrial fibrillation (AF). Purpose We investigated whether the ACZ affects outcomes after catheter ablation (CA) for AF. Methods We studied 78 patients (42 Non-paroxysmal AF, 49 males, and 68±10 years) who received CA for AF. High-density LA mapping during high right atrial pacing was constructed gaining than 2000 points (average 4377±846 points). Isochronal activation maps created at 5-ms interval setting. ACZ was identified by locating a site with isochronal crowding of ≥3 isochrones, and ≥8 isochrones were defined as the conduction block zone (CBZ) in a 4-mm diameter tag (conduction velocity were calculated as ≤27 cm/s and≤10 cm/s, respectively). Result Recurrent AF was detected in 25/78 patients (32%) during the follow-up period (9.2±3.0 month). ACZ and CBZ were distributed linearly, and ACZ was observed in 73 of 78 patients and 8 of these 73 patients had the CBZ. Univariate analysis revealed that elevated body mass index (26.2±3.8 vs. 24.3±3.3 kg/m2, P=0.0303), the higher prevalence of non-paroxysmal AF (72% vs. 45%, P=0.0272), larger LA diameter (47.6±6.6 vs. 42.1±6.9 mm, P=0.0014), and longer length of ACZ (79.7±45.1 vs. 52.9±35.7 mm, P=0.0058) were associated with recurrent AF after CA. On multivariate analysis, longer ACZ was independently associated with recurrent AF. Moreover, patients with longer ACZ (cutoff value: 84 mm) had a higher risk of recurrent AF than shorter ACZ (12/22; 55% vs 13/56; 23%, log-rank P=0.0024). Conclusion The length of ACZ was associated with recurrent AF after CA. FUNDunding Acknowledgement Type of funding sources: None.

scholarly journals Electrophysiology’s Identity Crisis: What our Clinical Trials Do and Do Not Say About Us

2020 ◽  
Vol 9 (1) ◽  
pp. 15-19
Author(s):  
David J Callans ◽  
Matthew Reynolds ◽  
Peter J Zimetbaum
Keyword(s):  
Clinical Trials ◽  
Scientific Basis ◽  
Observational Research ◽  
Small Scale ◽  
Control Group ◽  
Scientific Culture ◽  
Active Control Group ◽  
Funding Sources ◽  
Prospective Trials ◽  
The Impact

Although it has not always been this way, the impact of large, randomised clinical trials in electrophysiology is limited, at least compared with other disciplines in cardiology. This has been particularly true regarding procedural aspects of our field: successful randomised trials are rare and observational trials are small and typically without a proper active control group. In this article, the authors examine the reasons behind this circumstance, which include underinvestment from funding sources; lack of consensus on procedural endpoints; lack of consensus on techniques; and a therapeutic bias in favour of procedural intervention that stands in the way of investigator equipoise. Together, these factors have created a scientific culture dominated by small-scale, siloed, observational research and unwillingness to collaboratively advance the field with consensus and prospective trials. The authors feel that it is increasingly urgent to improve the scientific basis for clinical practice and explore strategies to accomplish this goal.

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