scholarly journals Novel epigenetic determinants of type 2 diabetes in Mexican-American families

2015 ◽  
Vol 24 (18) ◽  
pp. 5330-5344 ◽  
Author(s):  
Hemant Kulkarni ◽  
Mark Z. Kos ◽  
Jennifer Neary ◽  
Thomas D. Dyer ◽  
Jack W. Kent ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Dna Methylation ◽  
Mexican Americans ◽  
Mexican American ◽  
Fasting Blood Glucose ◽  
Phenotypic Traits ◽  
High Risk Population ◽  
Cpg Sites ◽  
Increased Risk

Abstract Although DNA methylation is now recognized as an important mediator of complex diseases, the extent to which the genetic basis of such diseases is accounted for by DNA methylation is unknown. In the setting of large, extended families representing a minority, high-risk population of the USA, we aimed to characterize the role of epigenome-wide DNA methylation in type 2 diabetes (T2D). Using Illumina HumanMethylation450 BeadChip arrays, we tested for association of DNA methylation at 446 356 sites with age, sex and phenotypic traits related to T2D in 850 pedigreed Mexican-American individuals. Robust statistical analyses showed that (i) 15% of the methylome is significantly heritable, with a median heritability of 0.14; (ii) DNA methylation at 14% of CpG sites is associated with nearby sequence variants; (iii) 22% and 3% of the autosomal CpG sites are associated with age and sex, respectively; (iv) 53 CpG sites were significantly associated with liability to T2D, fasting blood glucose and insulin resistance; (v) DNA methylation levels at five CpG sites, mapping to three well-characterized genes (TXNIP, ABCG1 and SAMD12) independently explained 7.8% of the heritability of T2D (vi) methylation at these five sites was unlikely to be influenced by neighboring DNA sequence variation. Our study has identified novel epigenetic indicators of T2D risk in Mexican Americans who have increased risk for this disease. These results provide new insights into potential treatment targets of T2D.

scholarly journals DNA Methylation and Type 2 Diabetes: the Use of Mendelian Randomization to Assess Causality

2019 ◽  
Vol 7 (4) ◽  
pp. 191-207 ◽  
Author(s):  
Diana L. Juvinao-Quintero ◽  
Marie-France Hivert ◽  
Gemma C. Sharp ◽  
Caroline L. Relton ◽  
Hannah R. Elliott
Keyword(s):  
Type 2 Diabetes ◽  
Dna Methylation ◽  
Mendelian Randomization ◽  
Epidemiological Studies ◽  
Mendelian Randomisation ◽  
Cross Sectional ◽  
Epigenetic Markers ◽  
Cpg Sites ◽  
Disease Understanding

Abstract Purpose of Review This review summarises recent advances in the field of epigenetics in order to understand the aetiology of type 2 diabetes (T2D). Recent Findings DNA methylation at a number of loci has been shown to be robustly associated with T2D, including TXNIP, ABCG1, CPT1A, and SREBF1. However, due to the cross-sectional nature of many epidemiological studies and predominant analysis in samples derived from blood rather than disease relevant tissues, inferring causality is difficult. We therefore outline the use of Mendelian randomisation (MR) as one method able to assess causality in epigenetic studies of T2D. Summary Epidemiological studies have been fruitful in identifying epigenetic markers of T2D. Triangulation of evidence including utilisation of MR is essential to delineate causal from non-causal biomarkers of disease. Understanding the causality of epigenetic markers in T2D more fully will aid prioritisation of CpG sites as early biomarkers to detect disease or in drug development to target epigenetic mechanisms in order to treat patients.

scholarly journals The Expression Level of mRNA, Protein, and DNA Methylation Status of FOSL2 of Uyghur in XinJiang in Type 2 Diabetes

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Jun Li ◽  
Siyuan Li ◽  
Ying Hu ◽  
Guolei Cao ◽  
Siyao Wang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Type 2 Diabetes ◽  
Dna Methylation ◽  
Methylation Status ◽  
Methylation Data ◽  
Biochemical Indicators ◽  
Expression Levels ◽  
Protein Levels ◽  
Cpg Sites

Objective. We investigated the expression levels of both FOSL2 mRNA and protein as well as evaluating DNA methylation in the blood of type 2 diabetes mellitus (T2DM) Uyghur patients from Xinjiang. This study also evaluated whether FOSL2 gene expression had demonstrated any associations with clinical and biochemical indicators of T2DM. Methods. One hundred Uyghur subjects where divided into two groups, T2DM and nonimpaired glucose tolerance (NGT) groups. DNA methylation of FOSL2 was also analyzed by MassARRAY Spectrometry and methylation data of individual units were generated by the EpiTyper v1.0.5 software. The expression levels of FOS-like antigen 2 (FOSL2) and the protein expression levels were analyzed. Results. Significant differences were observed in mRNA and protein levels when compared with the NGT group, while methylation rates of eight CpG units within the FOSL2 gene were higher in the T2DM group. Methylation of CpG sites was found to inversely correlate with expression of other markers. Conclusions. Results show that a correlation between mRNA, protein, and DNA methylation of FOSL2 gene exists among T2DM patients from Uyghur. FOSL2 protein and mRNA were downregulated and the DNA became hypermethylated, all of which may be involved in T2DM pathogenesis in this population.

scholarly journals En Balance: The Contribution of Physical Activity to the Efficacy of Spanish Diabetes Education of Hispanic Americans with Type 2 Diabetes

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Dequina A. Nicholas ◽  
Lorena M. Salto ◽  
Kristen Lavelle ◽  
Joy Wilson ◽  
W. Lawrence Beeson ◽  
...  
Keyword(s):  
Physical Activity ◽  
Type 2 Diabetes ◽  
Weight Loss ◽  
Glycemic Control ◽  
Education Program ◽  
Mexican Americans ◽  
Diabetes Education ◽  
Fasting Blood Glucose ◽  
Active Group

Purpose. En Balance, a culturally sensitive diabetes education program, improves glycemic control in Hispanics with type 2 diabetes. The program emphasized diet, physical activity, and other factors important for glycemic control. However, the individual contributions of these education factors are unclear. The purpose of this study is to assess the contribution of physical activity to the success of En Balance in improving the health of Mexican Americans with type 2 diabetes. Methods. A retrospective study was conducted with plasma samples collected pre- and post-3-month study. Samples from 58 (18 males and 40 females) Hispanic subjects with type 2 diabetes were analyzed for the concentration of kynurenines, known to decrease in response to exercise. After three months, health outcomes for the active group (decreased kynurenines) and the rest of the cohort were evaluated by paired Wilcoxon signed-rank test. Results. Half of the subjects had increased kynurenine levels at the end of the educational program. We found that the subjects in the active group with decreased kynurenine concentrations displayed statistically greater improvements in fasting blood glucose, A1C, cholesterol, and triglycerides despite weight loss being higher in the group with increased kynurenine concentrations. Conclusions. En Balance participants with decreased kynurenine levels had significantly improved glycemic control. These data suggest that physical activity significantly contributes to the success of the En Balance education program. This analysis indicates that diabetes public health educators should emphasize the benefit of physical activity on glycemic control even in the absence of major weight loss.

scholarly journals PREVALENCE OF HYPOTHYROIDISM IN TYPE 2 DIABETES MELLITUS

2019 ◽  
Vol 3 (9) ◽  
Author(s):  
Dr. Harish Basera ◽  
Dr. K.C. Pant
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Fasting Blood Glucose ◽  
Family History Of Diabetes ◽  
Increased Risk

Introduction: Thyroid hormone deficiency can lead to adverse health effects even death, if left untreated. It is a pathological condition known as hypothyroidism. Most common symptoms of hypothyroidism in adults are weight gain, fatigue, lethargy, cold intolerance, constipation, and dry skin. These clinical presentations can differ with age and sex, among other factors. Thyroid Stimulating Hormone (TSH), is associated with an increased risk of developing a number of clinical conditions, like cardiovascular diseases, diabetes, lung disease, malignant condition, and psychiatric disorders, both before and after the diagnosis of thyroid dysfunction. Type 2 Diabetes Mellitus (T2DM) is the chronic endocrine disease which is characterized by hyperglycemia resulting in impaired insulin secretion insulin resistance. Material and Methods: This prospective observational study was carried out at OPD of Dept. of Medicine at Govt. Doon Medical College and Hospital. The study period was between jan2019 to August 2019. The anthropometric measurements and demographic characteristics of patients included in the study were recorded. The clinical details and medications are entered into Excel sheet of Microsoft Excel 2013. Biochemical tests were done and reports were entered. Results: Prevalence of hypothyroidism in T2DM is found to be 10.94% in our study. Average BMI was observed to be 28.01 kg/m2 with SD of 3.39 kg/m2. Level of T3 and T4 were observed to be 0.98(0.23) ng/ml and 1.24(0.29) ng/ml respectively. Fasting blood glucose level was 133.05(17.81) mg/dl and post prandial blood glucose level was 201.54(27.33) mg/dl. Among all 112 patients, 71(63.39%) of cases had a family history of diabetes. Conclusion: It is noted that one-tenth of patients with type 2 diabetes mellitus has hypothyroidism. BMI was noted to be more than 28 kg/m2 among all patients. Hypothyroidism may be prevalent in T2DM patients due to duration of diabetes, obesity. To confirm the findings, more studies in this area are required. Keywords: T2DM, Hypothyroidism, TSH, T3, T4.

Abstract 054: Diet Beverage Intake is Positively Associated With Incident Coronary Heart Disease in People With Type 2 Diabetes

Circulation ◽  
2018 ◽  
Vol 137 (suppl_1) ◽  
Author(s):  
Andrew O Odegaard ◽  
Lyn M Steffen ◽  
David R Jacobs ◽  
Katherine L Tucker ◽  
Kenneth J Mukamal ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Meta Analysis ◽  
Health Concern ◽  
Cardiovascular Health Study ◽  
High Risk Population ◽  
Incident Coronary Heart Disease ◽  
Increased Risk

Introduction: Diet beverages are calorie free beverages sweetened with non-nutritive sweeteners. People with diabetes are the highest per-capita consumers of diet beverages, tending to consume them as a replacement for dietary sources of sugar, especially in place of sugar sweetened beverages. This behavior is endorsed by dietetic and scientific organizations and diet beverages are marketed synonymously with better health, weight loss, and thus, are considered advantageous for diabetes control. The underlying public health concern is the lack of data to support or refute this concept. Hypothesis: Higher diet beverage intake is positively associated with incident Coronary Heart Disease (CHD) Methods: We pooled the data sets of the Atherosclerosis Risk in Communities (ARIC) study (1987-2014), Cardiovascular Health Study (CHS) (1989-2014), Framingham Offspring Study (FOS) (1995-2014), Jackson Heart Study (JHS) (2000-2012), and Multi-Ethnic Study of Atherosclerosis (MESA (2000-2013) to conduct a prospective examination of the association of diet beverage intake with the incidence of CHD among participants with clinically ascertained type 2 diabetes (T2D) without prevalent CHD and with valid dietary data (N=3,947). We carried out a 2-step meta-analysis using individual level, cohort-specific Cox regression analyses with identical adjustment for demographic, lifestyle, overall diet quality and clinical risk factors to generate effect estimates that were pooled together using fixed and random effects meta-analysis. Results: 1,046 participants developed adjudicated CHD during follow-up. There was a positive, graded association between diet beverage intake and risk of incident CHD (Table). Results were consistent by sex, race and age. Conclusions: Diet beverage intake is associated with increased risk of developing CHD in a population with T2D. These results suggest the need to further evaluate dietary recommendations related to diet beverages and consider their role in this high risk population.

scholarly journals An evaluation of lipid profile and pro-inflammatory cytokines as determinants of cardiovascular disease in those with diabetes: a study on a Mexican American cohort

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Amna Tahir ◽  
Perla J. Martinez ◽  
Fayyaz Ahmad ◽  
Susan P. Fisher-Hoch ◽  
Jennifer L. Gay ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Early Diagnosis ◽  
Lipid Profile ◽  
Heart Attack ◽  
Mexican Americans ◽  
Inflammatory Markers ◽  
Fasting Blood Glucose ◽  
Low Grade

AbstractSedentary life styles coupled with high-calorie diets and unhealthy social habits such as smoking, have put an ever-increasing number of people at risk of cardiovascular disorders (CVD), worldwide. A concomitant increase in the prevalence of type 2-diabetes (hyperglycemia), a risk factor for CVD, has further contributed towards escalating CVD-related mortalities. The increase in number of cases of type 2-diabetes underscores the importance of early diagnosis of cardiovascular disease in those with diabetes. In this work, we have evaluated the sensitivity and specificity of dyslipidemia and proinflammatory cytokines to be used as biomarkers for predicting the risk of CVD in those with diabetes. We hypothesize that interplay between dyslipidemia and diabetes-induced low-grade inflammation in those with type 2-diabetes increases the risk of CVD. A total of 215 participants were randomly recruited from the Cameron County Hispanic Cohort (CCHC). Of these, 99% were Mexican Americans living on Texas-Mexico border. Levels of cytokines, adipokines and lipid profile were measured. Cardiovascular disease (CVD) for this study was defined as prior diagnosis of heart attack, angina and stroke, while diabetes was defined by fasting blood glucose (FBG) of > 100 mg/dL and HbA1c of > 6.5, in accordance with American Diabetes Association (ADA) guidelines. Depending on type and distribution of data, various statistical tests were performed. Our results demonstrated higher rates of heart attack (14% vs 11.8%) and stroke (19.8% vs 10%) in those with diabetes as compared to non-diabetes. The odds of having a heart attack were eight times higher in the presence of elevated triglycerides and pro-inflammatory markers (TNFα and IL6) as compared to presence of pro-inflammatory markers only. The odds for heart attack among those with diabetes, increased by 20 fold in presence of high levels of triglycerides, TNFα, and IL6 when coupled with low levels of high-density lipid cholesterol (HDL-C). Lastly, our analysis showed that poorly controlled diabetes, characterized by HbA1c values of > 6.5 increases the odds of stroke by more than three fold. The study quantifies the role of lipid profile and pro-inflammatory markers in combination with standard risk factors towards predicting the risk of CVD in those with type 2-diabetes. The findings from the study can be directly translated for use in early diagnosis of heart disease and guiding interventions leading to a reduction in CVD-associated mortality in those with type 2-diabetes.

scholarly journals Obstructive Sleep Apnea, a Risk Factor for Cardiovascular and Microvascular Disease in Patients With Type 2 Diabetes: Findings From a Population-Based Cohort Study

2020 ◽  
Author(s):  
Nicola J Adderley ◽  
Anuradhaa Subramanian ◽  
Konstantinos Toulis ◽  
Krishna Gokhale ◽  
Thomas Taverner ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cohort Study ◽  
Microvascular Complications ◽  
High Risk Population ◽  
Diabetes Diagnosis ◽  
Obstructive Sleep ◽  
Increased Risk ◽  
Ckd Stage ◽  
All Cause Mortality

<div><b>Objective</b>: To determine risk of cardiovascular diseases (CVD), microvascular complications and mortality in patients with type 2 diabetes who subsequently develop obstructive sleep apnoea(OSA) compared to patients with type 2 diabetes without a diagnosis of OSA.</div><div><b>Research Design and Methods</b>: An age-, sex-, body mass index- and diabetes duration-matched cohort study using data from a UK primary care database from 01/01/2005 to 17/01/2018. Participants aged ≥16 years with type 2 diabetes were included. Exposed participants were those who developed OSA after their diabetes diagnosis; unexposed participants were those without diagnosed OSA. Outcomes were composite CVD (ischaemic heart disease(IHD), stroke/transient ischaemic attack(TIA), heart failure(HF)); peripheral vascular disease(PVD); atrial fibrillation(AF); peripheral neuropathy(PN); diabetes-related foot disease(DFD); referable retinopathy; chronic kidney disease(CKD); all-cause mortality. The same outcomes were explored in patients with pre-existing OSA before a diagnosis of type 2 diabetes versus diabetes without diagnosed OSA.</div><div><b>Results</b>: 3,667 exposed participants and 10,450 matched controls were included. Adjusted hazard ratios for the outcomes were: composite CVD 1.54(95%CI 1.32,1.79); IHD 1.55(1.26,1.90); HF 1.67(1.35,2.06); stroke/TIA 1.57(1.27,1.94); PVD 1.10(0.91,1.32); AF 1.53(1.28,1.83); PN 1.32(1.14,1.51); DFD 1.42(1.16,1.74); retinopathy 0.99(0.82,1.21); CKD (stage 3-5) 1.18(1.02,1.36); albuminuria 1.11(1.01,1.22); all-cause mortality 1.24(1.10,1.40). In the prevalent OSA cohort the results were similar but some associations not observed.<br></div><div><b>Conclusions</b>: Patients with type 2 diabetes who develop OSA are at increased risk of CVD, AF, PN, DFD, CKD, and all-cause mortality compared to patients without diagnosed OSA. Patients with type 2 diabetes who develop OSA are a high-risk population and strategies to detect OSA and prevent cardiovascular and microvascular complications should be implemented.</div>

scholarly journals Epigenome-wide association study of lung function in Latino children and youth with asthma

2022 ◽  
Vol 14 (1) ◽  
Author(s):  
Esther Herrera-Luis ◽  
Annie Li ◽  
Angel C. Y. Mak ◽  
Javier Perez-Garcia ◽  
Jennifer R. Elhawary ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Lung Function ◽  
Association Study ◽  
Whole Blood ◽  
Mexican Americans ◽  
Mexican American ◽  
Puerto Ricans ◽  
Cpg Sites ◽  
Significance Threshold ◽  
American Children

Abstract Introduction DNA methylation studies have associated methylation levels at different CpG sites or genomic regions with lung function. Moreover, genetic ancestry has been associated with lung function in Latinos. However, no epigenome-wide association study (EWAS) of lung function has been performed in this population. Here, we aimed to identify DNA methylation patterns associated with lung function in pediatric asthma among Latinos. Results We conducted an EWAS in whole blood from 250 Puerto Rican and 148 Mexican American children and young adults with asthma. A total of five CpGs exceeded the genome-wide significance threshold of p = 1.17 × 10−7 in the combined analyses from Puerto Ricans and Mexican Americans: cg06035600 (MAP3K6, p = 6.13 × 10−8) showed significant association with pre-bronchodilator Tiffeneau–Pinelli index, the probes cg00914963 (TBC1D16, p = 1.04 × 10−7), cg16405908 (MRGPRE, p = 2.05 × 10−8), and cg07428101 (MUC2, p = 5.02 × 10−9) were associated with post-bronchodilator forced vital capacity (FVC), and cg20515679 (KCNJ6) with post-bronchodilator Tiffeneau–Pinelli index (p = 1.13 × 10−8). However, these markers did not show significant associations in publicly available data from Europeans (p > 0.05). A methylation quantitative trait loci analysis revealed that methylation levels at these CpG sites were regulated by genetic variation in Latinos and the Biobank-based Integrative Omics Studies (BIOS) consortium. Additionally, two differentially methylated regions in REXOC and AURKC were associated with pre-bronchodilator Tiffeneau–Pinelli index (adjusted p < 0.05) in Puerto Ricans and Mexican Americans. Moreover, we replicated some of the previous differentially methylated signals associated with lung function in non-Latino populations. Conclusions We replicated previous associations of epigenetic markers with lung function in whole blood and identified novel population-specific associations shared among Latino subgroups.

scholarly journals Polymorphic variant in gpx2 gene (rs4902346) and predisposition to type 2 diabetes mellitus

2020 ◽  
pp. 17-27
Author(s):  
Ю.Э. Азарова ◽  
Е.Ю. Клёсова ◽  
О.Ю. Бушуева ◽  
Т.А. Самгина ◽  
В.А. Азарова ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Hydrogen Peroxide ◽  
Type 2 Diabetes Mellitus ◽  
Redox Homeostasis ◽  
Fasting Blood Glucose ◽  
Recessive Model ◽  
Increased Risk ◽  
Antioxidant Defense Enzymes

Окислительный стресс служит важной составляющей патогенеза сахарного диабета 2 типа (СД2). Одним из ферментов антиоксидантной защиты является глутатионпероксидаза 2 (GPX2), использующая глутатион в качестве ко-субстрата для восстановления перекиси водорода H2O2 и обладающая наибольшей экспрессией в поджелудочной железе, - органе, имеющем непосредственное отношение к развитию диабета. Тем не менее, данные о связи GPX2 с предрасположенностью к СД2 в литературе отсутствуют. Целью исследования стало изучение ассоциации полиморфного варианта rs4602346 (А>G) в интроне гена GPX2 с риском развития СД2, а также его влияния на показатели редокс-гомеостаза плазмы крови. В исследование включено 3197 неродственных индивидов славянского происхождения, в том числе 1570 пациентов с СД2 и 1609 сопоставимых по полу и возрасту здоровых добровольцев. Генотипирование полиморфизма гена GPX2 проводили методом полимеразной цепной реакции в режиме реального времени с дискриминацией аллелей с помощью TaqMan зондов на термоциклере CFX96 Touch Bio-Rad. Генотип G/G ассоциировался с повышенным риском развития заболевания (OR 1,41, 95%CI 1,02-1,96, р=0,039, рецессивная модель). Выявленная ассоциация сохранила значимость и после введения поправки на пол, возраст и индекс массы тела (ORadj 1,50, 95%CI 1,04-2,16, рadj=0,03). При раздельном сравнении больных СД2 мужчин и женщин с контролем оказалось, что установленная ассоциация rs4902346 была характерна только для мужчин (ORadj 2,09, 95%CIadj 1,22-3,59, рadj=0,0065), в то время как частоты генотипов и аллелей GPX2 больных женщин не отличались от соответствующих показателей здоровых (р>0,05). Оценка редокс-статуса показала увеличение содержания перекиси водорода и снижение уровня общего глутатиона в плазме больных по сравнению с контролем (р<0,05). Корреляционный анализ обнаружил, что уровень перекиси водорода пациентов прямо пропорционален концентрации глюкозы крови натощак. Анализ взаимосвязей между генетическими и биохимическими данными выявил, что генотип G/G rs4902346 ассоциирован со снижением содержания восстановленного глутатиона в плазме больных СД2 женщин (р=0,0086). Таким образом, нами впервые выявлена ассоциация rs4902346 гена GPX2 с развитием СД2 и показаны значительные половые различия в ассоциациях с исследованными фенотипами. Oxidative stress is an important component of the pathogenesis of type 2 diabetes mellitus (T2D). Glutathione peroxidase 2 is one of the antioxidant defense enzymes which uses glutathione as a co-substrate to reduce hydrogen peroxide and has the highest expression in the pancreas, an organ that is directly related to the development of diabetes. However, there is no data on the association of GPX2 with a predisposition to T2D. The aim of the study was to investigate the association of rs4602346 (A>G) in the intron of the GPX2 gene with a risk of T2D, as well as the effect of this SNP on blood plasma redox homeostasis. The study included 3197 unrelated individuals of Slavic origin, including 1570 patients with T2D and 1609 age- and sex-matching healthy volunteers. GPX2 gene polymorphism was genotyped using real-time PCR on a CFX96 Touch Bio-Rad thermal cycler. The G/G genotype was associated with an increased risk of the disease (OR 1,41, 95% CI 1,02-1,96, P=0,039, recessive model). The identified association retained its significance even after correction for gender, age, and body mass index (ORadj 1,50, 95% CI 1,04-2,16, Padj=0,03). Gender-stratified analysis revealed that the established association of rs4902346 was characteristic only for diabetic males (ORadj 2,09, 95% CIadj 1,22-3,59, Padj=0,0065), and was not observed in diabetic females (P>0,05). Assessment of redox status showed an increase in the content of hydrogen peroxide and a decrease in the level of total glutathione in the plasma of patients compared with the control (P <0.05). A correlation analysis found that patients’ hydrogen peroxide levels are directly proportional to their fasting blood glucose concentrations. An analysis of the relationships between genetic and biochemical data showed that the G/G genotype rs4902346 is associated with a decrease in the content of reduced glutathione in the plasma of female patients with T2D (P=0,0086). Thus, we identified for the first time the association of rs4902346 with an increased risk of T2D and showed significant gender differences in the associations of the GPX2 gene with the studied phenotypes.

Sign in / Sign up

Export Citation Format

Share Document