P–137 Male embryos take longer to develop to the blastocysts stage

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
J Fraire-Zamora ◽  
M Martínez ◽  
D García ◽  
R Vassena ◽  
A Rodríguez
Keyword(s):  
Statistical Difference ◽  
Small Sample Size ◽  
Time Lapse ◽  
Study Groups ◽  
Blastocyst Stage ◽  
Small Sample ◽  
Preimplantation Embryos ◽  
Specific Difference ◽  
Male And Female ◽  
Morphokinetic Parameters

Abstract Study question Are there any differences in developmental timings between male and female preimplantation embryos? Summary answer There is a tendency for statistical difference in the time to reach blastocyst stage for male embryos compared to female embryos What is known already Differences in gene expression and metabolic uptake between male and female preimplantation embryos have been found in animal models and humans. These differences could affect the developmental timings of embryos resulting in differences in either sex. Morphokinetic parameters can precisely assess developmental timings. Only a few studies have analyzed morphokinetic parameters between male and female preimplantation embryos and no consensus has been reached on whether there is any sex-specific difference. The objective of this study is to compare morphokinetic parameters between male and female preimplantation embryos to determine any sex-specific developmental differences. Study design, size, duration This is a retrospective study including 102 preimplantation embryos from February 2018 to February 2020. The morphokinetic parameters obtained from time-lapse records of each embryo were: time to pronuclear fading (tPNf), times to 2–8 cells (t2, t3, t4, t5, t6, t7, t8), time to start of blastulation (tSB) and time to full blastocyst stage (tB). A two-tailed Student’s t-test was used to compare morphokinetic parameters between embryo sexes. A p < 0.05 was considered statistically significant. Participants/materials, setting, methods The study included retrospective time-lapse data from preimplantation embryos giving rise to 51 baby boys and 51 baby girls, as seen at birth. This is a single-center study with standardized culture conditions. Embryos in both study groups issued from cycles with donated oocytes. Only elective blastocyst stage single-embryo transfers (SET) on day 5 were assessed. Main results and the role of chance A tendency to statistical difference (p = [0.1–0.05]) was observed for blastocyst-related morphokinetic parameters: tSB (mean time was 89.6±6.3 hours in male embryos vs. 86.9±8.1 hours in female embryos, p = 0.06) and tB (100.2±5.9 hours versus 97.9±6.5 hours, p = 0.07). Male embryos showed an increased average time of 2.7 hours to tSB and 2.3 hours to tB, while no differences were found in the mean times of all the other morphokinetic paraments measured (p > 0.50): tPNf (∼21.8±3.0 hours) t2 (∼24.4±3.2 hours); t3 (∼35.6±3.9 hours); t4 (∼36.6±4.6 hours); t5 (∼46.9±6.0 hours); t6 (∼53.5±7.0 hours); t7 (∼54.1±7.3 hours) and t8 (∼54.1±7.3 hours). This finding suggests a sex-specific difference in reaching blastocyst stages. Limitations, reasons for caution The main limitation of the study is its retrospective nature and the small sample size. We analyzed the data of embryos leading to a live birth (high-quality embryos), therefore, caution should be made when generalizing results to non-implanting embryos (of potentially lower quality). Wider implications of the findings: Sex-specific differences in developmental timings of preimplantation embryos at blastocyst stage, as evidenced by time-lapse data, should be considered to avoid selection biases during embryo transfers in ART clinic. Trial registration number Not applicable

scholarly journals Analysis of Morphokinetic Parameters of Feline Embryos Using a Time-Lapse System

Animals ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 748
Author(s):  
Joanna Kochan ◽  
Agnieszka Nowak ◽  
Barbara Kij ◽  
Sylwia Prochowska ◽  
Wojciech Niżański
Keyword(s):  
Embryo Development ◽  
Embryo Quality ◽  
Time Lapse ◽  
Blastocyst Stage ◽  
Cavity Formation ◽  
Non Invasive ◽  
Morphokinetic Parameters ◽  
Morphological Defects ◽  
Development In Vitro

The aim of this study was to analyze the morphokinetic parameters of feline embryos using a time lapse system. Oocytes matured in vitro were fertilized (IVF) and in vitro cultured in a time lapse-system (Primo Vision®, Gothenburg, Sweden). The first cell division of embryos occurred between 17 h post insemination (hpi) and 38 hpi, with the highest proportion of embryos (46%) cleaving between 21 and 24 hpi. The timing of the first cleavage significantly affected further embryo development, with the highest development occurring in embryos that cleaved at 21–22 hpi. Embryos that cleaved very early (17–18 hpi) developed poorly to the blastocyst stage (2%) and none of the embryos that cleaved later than 27 hpi were able to reach the blastocyst stage. Morphological defects were observed in 48% of the embryos. There were no statistically significant differences between the timing intervals of the first cleavage division and the frequency of morphological defects in embryos. Multiple (MUL) morphological defects were detected in more than half (56%) of the abnormal embryos. The most frequent single morphological defects were cytoplasmic fragmentation (FR) (8%) and blastomere asymmetry (AS) (6%). Direct cleavage (DC) from 1–3 or 3–5 blastomeres, reverse cleavage (RC) and vacuoles were rarely observed (2–3%). The timing of blastocyst cavity formation is a very good indicator of embryo quality. In our study, blastocyst cavity formation occurred between 127–167 hpi, with the highest frequency of hatching observed in blastocysts that cavitated between 142–150 hpi. Blastocysts in which cavitation began after 161 h did not hatch. In conclusion, the timing of the first and second cleavage divisions, the timing of blastocyst cavity formation and morphological anomalies can all be used as early and non-invasive indicators of cat embryo development in vitro.

scholarly journals Prevalence of Blood Groups in Eastern UP Population

2020 ◽  
Author(s):  
Pradeep Kumar ◽  
Vandana Rai
Keyword(s):  
Small Sample Size ◽  
Uttar Pradesh ◽  
Allelic Frequency ◽  
Blood Groups ◽  
Small Sample ◽  
Blood Type ◽  
Allele Frequency Distribution ◽  
Abo Blood Groups ◽  
Male And Female ◽  
Different Types

Approximately 300 different types of blood groups are identified so far, the ABO and Rh antigens are still the clinically most significant and genetically most polymorphic of all human blood group systems to date. A total of 200 unrelated individuals from Uttar Pradesh were studied for the phenotype and allele frequency distribution of ABO and Rh (D) blood groups. In total 200 samples analyzed, phenotype B blood type has the highest frequency 36.5% (n=73), followed by O (34.5%; n=69), A (20.5%; n=41) and AB (8.5%; n=17). The O, A and B frequencies were 0.5849, 0.1571 and 0.2580 respectively. The overall phenotypic frequencies of ABO blood groups were B>O>A>AB. The variation in phenotypic frequencies between male and female might be due to small sample size of male sample. The allelic frequency of Rh-negative was 0.2.

P–561 Male and female blastocyst: any difference other than the sex?

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
B Carrasc. Canal ◽  
M C Pons ◽  
M Parriego ◽  
M Boada ◽  
S García ◽  
...  
Keyword(s):  
Embryo Transfer ◽  
Sperm Quality ◽  
Time Lapse ◽  
Blastocyst Stage ◽  
Study Data ◽  
Single Step ◽  
Chromosomal Anomalies ◽  
Low Oxygen ◽  
Male And Female ◽  
Normal Copy Number

Abstract Study question Is there any imbalance in the sex ratio (SR) and in the aneuploidy rate of male and female human blastocysts from a PGT-A programme? Summary answer Although SR in human blastocysts is significantly male-biased, more aneuploidies are observed among male blastocysts, resulting in comparable euploid male and female embryos available. What is known already More boys than girls are born worldwide, meaning that the SR at birth is biased towards males. Differences in the SR of children born after ART have been also reported. Factors such as the insemination technique or the day of embryo transfer have been shown to be related to the SR at birth, but whether the SR is shifted during the preimplantation and/or postimplantation development remains unknown. Study design, size, duration: Embryos from patients undergoing 921 PGT-A cycles from September 2017 to February 2020 were included in the study. Data from the chromosomal constitution of 2637 biopsied blastocysts was retrospectively analysed. Participants/materials, setting, methods Embryos were cultured in time-lapse incubators with low oxygen tension (5%) (Embryoscope®; Geri®) using single-step medium (Global®, LifeGlobal®; GTL™, Vitrolife). Blastocyst biopsy was performed between D5-D7 followed by immediate vitrification (Cryotop®, Kitazato). Trophectoderm samples were analysed by NGS. Embryos were categorized as euploid, aneuploid or mosaic. Embryos were called as mosaic when the deviation from the normal copy number was ≥30% and <70%. Main results and the role of chance Overall biopsies from 2637 blastocysts were analysed, 1320 on day 5 (50.1%), 1169 on day 6 (44.3%) and 148 on day 7 (5.6%). Sex distribution among the embryos analysed was skewed in favor of male sex with 1401 diagnosed as male (53.1%) and 1236 were female (46.9%), [OR (95%CI):1.13(1.05–1.22)]. As a consequence of this biased SR, more male embryos reached the blastocyst stage and were biopsied both on day 5/6 (708/1320, 53.6% on day 5 and 619/1169, 53% on day 6). Embryos biopsied on day 7 were balanced between sexes with 50% being male and 50% being female. Following biopsy and PGT-A, 1086 (41.2%) of the embryos were classified as euploid, 1349 (51.16%) as aneuploid, and 202 (7.7%) as mosaic embryos. More chromosomal anomalies were observed among male blastocysts when compared to the female ones, 738 (52.7%) vs 611 (49.4%). Similarly, mosaicism was more frequents in male as compared with female blastocysts, 123 (8.8%) vs 79 (6.4%). (P = 0.000). As more aneuploidies are observed among male blastocysts, the final number of available euploid blastocysts for embryo transfer was comparable between sexes (540 male/546 female), [OR (95%CI): 0.99 (0.87–1.11)]. Limitations, reasons for caution This is a retrospective study. Only embryos at the blastocyst stage have been analyzed. Potential confounding factors such as sperm quality or the female age have not been analyzed. No data regarding the SR at birth have been analyzed in these study. Wider implications of the findings: In our study, more male embryos develop to the blastocyst when compared to female ones. It can be hypothesized that female embryos can be more affected by an early arrest at cleavage stages. SR at birth would be expected to be similar as more aneuploidy is observed in male embryos. Trial registration number Not applicable

Breast cancer frequency and survival by molecular subtype in central Illinois.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e13631-e13631
Author(s):  
Hamsa Sahib ◽  
Sabree Abedrabo ◽  
Zurain Niaz ◽  
Cameron Koester ◽  
Ruby Maini ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Statistical Difference ◽  
Triple Negative ◽  
Molecular Subtype ◽  
Small Sample Size ◽  
Cox Proportional Hazards ◽  
Small Sample ◽  
Future Research ◽  
Luminal A ◽  
Central Illinois

e13631 Background: Breast cancer is the most common female malignancy. In 2019, it is estimated that there were 268,000 new cases of female breast cancer. The most common subtype was HR+/HER2 based on 2012-2016 cases, a much higher rate than triple negative breast cancer. Best survival rates are found among women with HR+/HER2- subtype followed by HR+/HER2+ and HR-/HER+ subtypes. Triple negative subtype comparatively had a poorer survival.Our objective was to determine breast cancer rate and survival by molecular subtype in the central Illinois population. Methods: A cohort of 478 patients diagnosed with breast cancer between January 2014 and December 2017 was identified by using ICD codes. Eligibility criteria included pathology confirmed breast cancer.Categorical variables were summarized as frequencies and percentages. Predictors of survival were assessed with Cox proportional hazards regression analyses.All significance was assumed at the p < 0.05 level. Results: Luminal A breast cancer was the most common type in our population. In the cohort of 478 patients, 208 patients (74%) were found to have Luminal A. whereas, 37 patients (13.21%) had Basal subtype, 20 patients (7.14%) had Luminal B and 13 patients (5.36%) had Her2 enriched subtype. However, there was no statistical difference in survival between the subtypes. Conclusions: Although the frequency of cancer subtypes in our population is comparable to the national epidemiology data,we observed that there is no statistical difference in survival as compared to NCI SEERS data. This could be due to optimum care and patient’s adherence to chemo-radiation or due to small sample size. This could be an important area of future research to investigate if we can increase survival of poor prognosis subtypes (as triple negative) by following the same measures. Long term follow up for the patients in the study might also be necessary.

scholarly journals Impact of Spirituality on Depression, Anxiety and Stress of Students Preparing for Competitive Exams

2016 ◽  
Vol 3 (3) ◽  
Author(s):  
Manpreet Ola
Keyword(s):  
Small Sample Size ◽  
Inverse Correlation ◽  
Small Sample ◽  
Female Students ◽  
Significant Inverse Correlation ◽  
Male And Female ◽  
College Ranking ◽  
Self Worth ◽  
History Of ◽  
Age Range

Background: Gradually over the years trend towards education system in our country has changed, it has become highly competitive. On the basis of one’s grades admissions to various “top colleges” is provided, which further leads to “high packaged placements”. On the basis of one’s job status and college ranking their self worth is measured and all this puts lot of burden on students who have to continuously strive to achieve better than their batch mates, their siblings, relatives, neighbors etc. Aim: The aim of the study was to see whether spirituality would have any impact on depression, anxiety and stress in male and female students preparing for competitive exams. Methods: Participants were 60 students (30 males and 30 females) from areas of Rajasthan and Delhi, India, in the age range of 16-25 years, with no history of any psychiatric illness. They gave their consent to participate in the study. Spirituality was assessed using the daily spiritual experience scale by Underwood & Teresi, (2002), depression, anxiety, and stress levels through Depression, Anxiety, Stress Scales (DASS by Lovibond & Lovibond, 1995). Sample was purposive and the data were collected in individual situations. Results: There was difference between male and female students with regard to spirituality, depression, anxiety and stress, however only on the dimension of anxiety the results were significant, where female students had significantly more anxiety than that of male students (t = 2.87, p = .01). With regard to correlation between spirituality, depression, anxiety and stress there was significant inverse correlation for male and female students. However only for anxiety scores in females, there was a significant inverse correlation (r=-.417, p= .01). Conclusion: It can be concluded that spirituality to some extent helps in reducing anxiety. At the same time it is essential for us to realize that spirituality is not the only way to help the young stressed students to cope with this life challenge, the family simultaneously needs to be supportive and not over pressurize the students and should stop comparing them to one or the other. However due to the small sample size the result findings cannot be generalized.

scholarly journals Harnessing cytoplasmic particles movement of the human early embryo analysed by advanced imaging and artificial intelligence to predict development to blastocyst stage

2020 ◽  
Author(s):  
Giovanni Coticchio ◽  
Giulia Fiorentino ◽  
Giovanna Nicora ◽  
Raffaella Sciajno ◽  
Federica Cavalera ◽  
...  
Keyword(s):  
Neural Network ◽  
Artificial Intelligence ◽  
Performance Metrics ◽  
Short Term Memory ◽  
Research Question ◽  
Time Lapse ◽  
Blastocyst Stage ◽  
Preimplantation Embryos ◽  
Embryo Viability ◽  
Movement Velocity

AbstractResearch QuestionProgress in artificial intelligence (AI) and advanced image analysis offers unique opportunities to develop novel embryo assessment approaches. In this study, we tested the hypothesis that such technologies can extract and harness novel information derived from cytoplasmic movements of the early human embryo to predict development to blastocyst.DesignIn a proof-of principle study, an artificial neural network (ANN) approach was undertaken to assess retrospectively 230 human preimplantation embryos. After ICSI, embryos were subjected to time-lapse monitoring for 44 hours. For comparison as a standard embryo assessment methodology, a single senior embryologist assessed each embryo to predict development to blastocyst stage (BL) based on a single picture frame taken at 42 hours of development. In the experimental approach, in embryos that developed to blastocyst or destined to arrest (NoBL), cytoplasm movement velocity (CMV) was recorded by time-lapse monitoring during the first 44 hours of culture and analysed with a Particle Image Velocimetry (PIV) algorithm to extract quantitative information. Three main AI approaches, the k-Nearest Neighbor (k-NN), the Long-Short Term Memory Neural Network (LSTM-NN) and the hybrid ensemble classifier (HyEC) were employed to classify the two embryo classes.ResultsBlind operator assessment classified each embryo in terms of ability of development to blastocyst, reaching a 75.4% accuracy, 76.5% sensitivity, 74.3% specificity, 74.3% precision and 75.4% F1 score. After integration of results from AI models together with the blind operator classification, the performance metrics improved significantly, with a 82.6% accuracy, 79.4% sensitivity, 85.7% specificity, 84.4% precision and 81.8% F1 score.ConclusionsThe present study suggests the possibility to predict human blastocyst development at early cleavage stages by detection of CMV and AI analysis. This indicates the importance of the dynamics of the cytoplasm as a novel and valuable source of data to assess embryo viability.

scholarly journals Rates of Ischemia Amongst Asymptomatic Patients with High Coronary Artery Calcium Scores

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Aaron Jones ◽  
Dustin Thomas
Keyword(s):  
Heart Disease ◽  
Statistical Difference ◽  
Stress Testing ◽  
Small Sample Size ◽  
Demographic Data ◽  
Cost Effective ◽  
Small Sample ◽  
Lifestyle Changes ◽  
Coronary Angiogram ◽  
Asymptomatic Patients

CACS may be used to recommend lifestyle changes or other treatment recommendations to reduce the risk of heart disease. The incidence of asymptomatic ischemia in patients with elevated CACS is poorly defined.  Furthermore, the CACS cut-off above which it is clinically important and cost effective to look for and diagnose ischemia is also not well defined. The purpose of this study is to better define the incidence of asymptomatic ischemia in Parkview Heart Institute (PHI) patients with elevated CACS, including an examination of demographic data that may also influence the rate of ischemia. 118 Patients who were screened for CAD, received CACS ≥ 400, and subsequently had stress testing or invasive coronary angiogram within 6 months were admitted into the study. Through statistical analysis it was determined there was no statistical difference in rates of ischemia between patients with CACS of 400-999 and those >1000. However, due to a small sample size this study will be continued to strengthen its results and investigate if demographics play a role in rates of ischemia.

scholarly journals Comparison of two different doses of citicoline in patients with traumatic brain injury

2020 ◽  
pp. 8-15
Keyword(s):  
Muscle Strength ◽  
Small Sample Size ◽  
Head Injuries ◽  
Study Groups ◽  
Small Sample ◽  
Positive Effects ◽  
Number Of Patients ◽  
Significant Difference ◽  
Traumatic Head ◽  
The Mean

Introduction: The ever-increasing and common occurrence of head traumas highlight the importance of adopting therapeutic measures for the reduction of the associated morbidity and mortality. Citicoline, as a safe medicine with positive effects on improving traumatic injuries, has been proven to be useful in various studies. However, there are still no data on the specific standard method and dosage of citicoline for the treatment of patients with traumatic head injuries. Regarding this, the present study was performed to determine the effective therapeutic dosage of citicoline and its impact on patients with traumatic head injuries. Methods: This double-blind clinical trial was performed on 30 patients with traumatic concussion (a Glasgow coma scale [GCS] of ≤8) admitted to the intensive care unit and neurosurgery department. The patients were randomly divided into three groups of A (control), B (citicoline with a dosage of 0.5 g/twice a day), and C (citicoline with a dosage of 1.5 g/twice a day). The GCS, degree of muscle strength, Glasgow outcome score (GOS), contusion volume, and cerebral edema (based on brain CT scans) were calculated at specific times and intervals. In addition, the patients' dependency on a ventilator and their length of ICU stay were registered. Results: Mean GCS on the first day of stay, GCS changes on the third and fourth days of stay, first and seventh days of stay, seventh and fourteenth days of stay, and first and fourteenth days of stay in the three study groups showed the significant statistical difference (P<0.05). Significant statistical differences were seen between the GOS of the 30th day of stay in the three study groups (P<0.05). The contusion volume difference was only significant between the first and seventh days of stay in groups A and C (P<0.05). No significant difference was observed in the mean length of stay in ICU and duration of dependency on a ventilator in the three study groups (P<0.05). The mean degree of muscle strength was only significantly different on the first day of stay between groups B and C (P=0.008). Conclusions: In contrary to similar studies, the results of the current study revealed that citicoline had no positive effect on patient healing. This result may be due to the small sample size and the inconsistent first-day GCSs of the patients in all three groups. Therefore, given the confirmation of the effectiveness of citicoline even at higher dosages in other studies in future studies, it is recommended to use populations with a larger number of patients.

scholarly journals Development of a robust automated tool for the annotation of embryo morphokinetic parameters

2018 ◽  
Author(s):  
M Feyeux ◽  
A Reignier ◽  
M Mocaer ◽  
J Lammers ◽  
D Meistermann ◽  
...  
Keyword(s):  
Human Embryo ◽  
Large Scale ◽  
Embryo Quality ◽  
Time Lapse ◽  
Preimplantation Embryos ◽  
Manual Annotation ◽  
Annotation Tool ◽  
Automated Annotation ◽  
Morphokinetic Parameters ◽  
Automated Tool

AbstractStudy QuestionIs it possible to automatically annotate human embryo development in time-lapse devices, with results comparable to manual annotation?Summary AnswerWe developed an automated tool for the annotation of embryo morphokinetic parameters having a high concordance with expert manual annotation in a large scale-study.What is Known AlreadyMorphokinetic parameters obtained with time-lapse devices are increasingly used for human embryo quality assessment. However, their annotation is timeconsuming and can be operator-dependent, highlighting the need of developing automated approaches.Study Design, Size, DurationThis monocentric pilot study was conducted using 701 blastocysts originating from 584 couples undergoing IVF with embryo culture in a time-lapse device and on 4 mouse embryos.Participants/Materials, Setting, MethodsAn automated annotation tool was developed based on grey level coefficient of variation and detection of the thickness of the zona pellucida. The timings of cellular events obtained with the automated tool were compared with those obtained manually by 2 expert embryologists. The same procedure was applied on 4 mouse preimplantation embryos obtained with a different device in a different setting.Main Results and the Role of ChanceAlthough some differences were found when embryos were considered individually, we found an overall excellent concordance between automated and manual annotation of human embryo morphokinetics from fertilization to expanded blastocyst stage (r2=0.94). Moreover, the automated annotation tool gave promising results across species (human, mice).Limitations, Reasons for CautionThese results should undergo multi-centric external evaluation in order to test the overall performance of the annotation tool.Wider Implications of the FindingsOur system performs significantly better than the ones reported in the literature and on a bigger cohort, paving the way for high-throughput analysis of multicentric morphokinetic databases, providing new insights into the clinical value of morphokinetics as predictor of embryo quality and implantation.Study Funding/Competing Interest(s)This study was partly funded by Finox Forward Grant 2016.Trial Registration NumberNA

scholarly journals 213. Assessment of Compliance with Order Set and Bundle for Management of Staphylococcus aureus Bacteremia

2021 ◽  
Vol 8 (Supplement_1) ◽  
pp. S214-S215
Author(s):  
Ryan R Flynn ◽  
Marilee Obritsch ◽  
Veronica Lesselyoung ◽  
Joe Strain ◽  
John Kappes
Keyword(s):  
Staphylococcus Aureus ◽  
Statistical Difference ◽  
Small Sample Size ◽  
Small Sample ◽  
Single Center ◽  
Recurrence Rates ◽  
Adequate Treatment ◽  
Single Center Study ◽  
Center Study ◽  
Order Set

Abstract Background Staphylococcus aureus (S. aureus) is an aerobic gram-positive coccus that causes a variety of infections. S. aureus bloodstream infections, also known as bacteremias, have significant morbidity and mortality and are difficult to eradicate. A single-center study showed a 9.4% recurrence rate for S. aureus bacteremia, despite adequate treatment. The Infectious Disease Society of America (IDSA) recognizes the seriousness of S. aureus infections, particularly methicillin-resistant S. aureus (MRSA), and has released guidance for treatment of these infections. Guidance for S. aureus bacteremias include identification and removal of the source and early optimization of antibiotics. Serial imaging and laboratory monitoring, including repeat blood cultures, are also necessary to establish the duration of therapy, ensure microbiologic eradication, and reduce the risk of long-term complications. Due to the complexity of S. aureus bacteremia, early involvement of infectious diseases (ID) specialists is strongly recommended. Methods This retrospective, single-center study was designed to evaluate the current management of S. aureus bacteremias, including compliance to the elements of the S. aureus order set and bundle. Patients 18 years and older who had a positive blood culture for S. aureus were included in this study. Recurrence of S. aureus infection was assessed at 6 months. Data was analyzed to compare patients with and without ID consults. Results Eighty-four patients met inclusion criteria. ID consultation resulted in a higher percentage of patients achieving 100% compliance with the bundle elements compared to patients without ID consults (73% vs 25%, respectively; p=0.009). For further breakdown of compliance see Table 1. No statistical difference was detected in recurrence rates (11% vs 33%, respectively; p=0.18) or mortality (8% vs 25%, respectively; p= 0.17) possibly due to the small sample size. Table 1. Outcomes Conclusion ID specialist involvement for the treatment of S. aureus bacteremia resulted in greater compliance with the S. aureus bacteremia bundle. No statistical difference in recurrence or mortality rates was detected. Disclosures All Authors: No reported disclosures

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