scholarly journals The impact of the 30 most cited articles on hip arthroscopy: what is the subject matter?

2020 ◽  
Vol 7 (1) ◽  
pp. 14-21
Author(s):  
Alexander von Glinski ◽  
Emre Yilmaz ◽  
Ryan Goodmanson ◽  
Clifford Pierre ◽  
Sven Frieler ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Hip Arthroscopy ◽  
Randomized Clinical Trials ◽  
Technical Note ◽  
Small Sample ◽  
Level Of Evidence ◽  
Thomson Reuters ◽  
Treatment Indications ◽  
Small Sample Sizes ◽  
The Impact

Abstract The purpose of this study was to identify the 30 most cited articles on hip arthroscopy and discuss their influence on recent surgical treatment. Due to advancements in hip arthroscopy, there is a widening spectrum of diagnostic and treatment indications. The purpose of this study was to identify the 30 most cited articles on hip arthroscopy and discuss their influence on contemporary surgical treatment. The Thomson Reuters Web of Science was used to identify the 30 most cited studies on hip arthroscopy between 1900 and 2018. These 30 articles generated 6152 citations with an average of 205.07 citations per item. Number of citations ranged from 146 to 461. Twenty-five out of the 30 papers were clinical cohort studies with a level of evidence between III and IV, encompassing 4348 patients. Four studies were reviewed (one including a technical note) and one a case report. We were able to identify the 30 most cited articles in the field of hip arthroscopy. Most articles were reported in high-impact journals, but reported small sample sizes in a retrospective setting. Prospective multi-arm cohort trials or randomized clinical trials represent opportunities for future studies.

scholarly journals Viscoelastometric Testing to Assess Hemostasis of COVID-19: A Systematic Review

2021 ◽  
Vol 10 (8) ◽  
pp. 1740
Author(s):  
Marion Bareille ◽  
Michaël Hardy ◽  
Jonathan Douxfils ◽  
Stéphanie Roullet ◽  
Dominique Lasne ◽  
...  
Keyword(s):  
Systematic Review ◽  
Mechanical Strength ◽  
Small Sample ◽  
The Common ◽  
Small Sample Sizes ◽  
Definition Of ◽  
Reported Data ◽  
Prophylactic Anticoagulation ◽  
The Impact ◽  
Heparin Neutralization

Infection by SARS-CoV-2 is associated with a high risk of thrombosis. The laboratory documentation of hypercoagulability and impaired fibrinolysis remains a challenge. Our aim was to assess the potential usefulness of viscoelastometric testing (VET) to predict thrombotic events in COVID-19 patients according to the literature. We also (i) analyzed the impact of anticoagulation and the methods used to neutralize heparin, (ii) analyzed whether maximal clot mechanical strength brings more information than Clauss fibrinogen, and (iii) critically scrutinized the diagnosis of hypofibrinolysis. We performed a systematic search in PubMed and Scopus databases until December 31st, 2020. VET methods and parameters, and patients’ features and outcomes were extracted. VET was performed for 1063 patients (893 intensive care unit (ICU) and 170 non-ICU, 44 studies). There was extensive heterogeneity concerning study design, VET device used (ROTEM, TEG, Quantra and ClotPro) and reagents (with non-systematic use of heparin neutralization), timing of assay, and definition of hypercoagulable state. Notably, only 4 out of 25 studies using ROTEM reported data with heparinase (HEPTEM). The common findings were increased clot mechanical strength mainly due to excessive fibrinogen component and impaired to absent fibrinolysis, more conspicuous in the presence of an added plasminogen activator. Only 4 studies out of the 16 that addressed the point found an association of VETs with thrombotic events. So-called functional fibrinogen assessed by VETs showed a variable correlation with Clauss fibrinogen. Abnormal VET pattern, often evidenced despite standard prophylactic anticoagulation, tended to normalize after increased dosing. VET studies reported heterogeneity, and small sample sizes do not support an association between the poorly defined prothrombotic phenotype of COVID-19 and thrombotic events.

scholarly journals Cannabis and breastfeeding

2020 ◽  
Vol 25 (Supplement_1) ◽  
pp. S26-S28 ◽  
Author(s):  
Lisa Graves
Keyword(s):  
Health Care Providers ◽  
Small Sample ◽  
Adverse Outcomes ◽  
Care Providers ◽  
High Quality ◽  
High Quality Evidence ◽  
Small Sample Sizes ◽  
The Impact ◽  
Quality Evidence

Abstract Cannabis is one of the most commonly used substances in Canada with 15% of Canadians reporting use in 2019. There is emerging evidence that cannabis is linked to an impact on the developing brain in utero and adverse outcomes in infants, children, and adolescents. The impact of cannabis during breastfeeding has been limited by studies with small sample sizes, follow-up limited to 1 year and the challenge of separating prenatal exposure from that during breastfeeding. In the absence of high-quality evidence, health care providers need to continue to engage women in conversation about the potential concerns related to breastfeeding and cannabis use.

Real-world data evaluating immunotherapy markers and checkpoint inhibitor response among GI cancers in a large community-based oncology network.

2021 ◽  
Vol 39 (3_suppl) ◽  
pp. 113-113
Author(s):  
Carissa Jones ◽  
Rebecca Lachs ◽  
Emma Sturgill ◽  
Amanda Misch ◽  
Caressa Lietman ◽  
...  
Keyword(s):  
Checkpoint Inhibitor ◽  
Small Sample ◽  
Tumor Type ◽  
Real World Data ◽  
Loss To Follow Up ◽  
Kaplan Meier ◽  
Gi Cancers ◽  
Small Sample Sizes ◽  
Line Of Therapy ◽  
The Impact

113 Background: Checkpoint inhibitor (CPI) therapies have shown prolonged survival in patients (pts) with microsatellite instability (MSI). Tumor mutation burden (TMB) has also been associated with benefit from CPIs, with pembrolizumab recently approved for solid tumors with a TMB of ≥10 muts/mb. However, the validity of a tissue-agnostic approach has been debated given the high degree of TMB variation across tumor types. We sought to evaluate the impact of TMB and MSI on CPI response in pts with advanced gastrointestinal (GI) cancers who received NGS profiling. Methods: Patients within the Sarah Cannon network with GI cancer and comprehensive next generation sequencing (NGS) data were identified through Genospace, Sarah Cannon’s clinico-genomic analytics platform. Microsatellite (MS) status [high (MSI-H) vs. stable (MSS)] was defined by NGS. TMB-high (TMB-H) was defined as ≥10 muts/mb. Kaplan-Meier estimates were used to examine time to treatment failure (TTF), defined as the time from therapy start to start of next therapy, death, or loss to follow-up. Results: We identified 5,788 pts with GI cancers who received NGS, of which 48% (N=3,603) had colorectal cancer (CRC). MS status was evaluated on 4,219 (66%) NGS reports, TMB on 2,922 (46%) reports, and both on 2,863 (45%) reports. MSI-H and TMB-H co-occurred on 127 reports (4%), MSS/TMB-H occurred on 312 reports (11%), and MSS/TMB-Low (TMB-L) occurred on 2,424 reports (85%). No reports were MSI-H/TMB-L. Overall, 580 pts (14%) received CPI therapy (N=52 MSI-H/TMB-H, N=41 MSS/TMB-H, N=215 MSS/TMB-L). Independent of line of therapy or tumor type, TTF was significantly shorter for CPI vs. non-CPI therapies [median TTF (mTTF)=151 vs. 238 days, respectively, p=3.4x10-9]. As expected, MSI-H was also associated with longer CPI TTF compared to MSS (mTTF=727 vs. 124 days, p=3.1x10-11). Due to small sample sizes, further analyses were focused on pts with CRC (Table). TMB-H was independently associated with longer CPI TTF compared to TMB-L (Table, p=9.2x10-10). Similarly, the co-occurrence of MSI-H/TMB-H was also associated with longer CPI TTF (Table). However, there was no difference in CPI TTF for MSS/TMB-H and MSS/TMB-L (Table, p=0.45). All pts who received non-CPI therapies, regardless of MS/TMB group, had longer TTF than MSS/TMB-H and MSS/TMB-L pts who received CPI (Table). mTTF [days (N)] for pts with CRC by biomarker. Conclusions: Despite recent tissue-agnostic approvals, TMB does not appear to be a good biomarker of CPI response in pts with CRC. Rather, time to CPI failure is associated with the co-occurrence of TMB-H with MSI-H. Continued research is needed to identify better biomarkers of response to immunotherapy in GI cancers. [Table: see text]

A Review of Feeding Interventions for Infants with Cleft Palate

2004 ◽  
Vol 41 (3) ◽  
pp. 268-278 ◽  
Author(s):  
Julie Reid
Keyword(s):  
Cleft Palate ◽  
Nutrition Education ◽  
Small Sample ◽  
Data Driven ◽  
Quality Of Data ◽  
Level Of Evidence ◽  
Feeding Methods ◽  
Level I ◽  
Small Sample Sizes ◽  
Feeding Interventions

Objective A literature review was conducted to identify feeding interventions recommended for infants with cleft conditions. Selected articles were critically appraised using an evidence-based practice framework to determine the strength of the evidence underpinning each intervention. Design Electronic databases were searched for reports of cleft palate feeding interventions. The selected articles were coded as being data driven or not; those containing data were then critically appraised using a recognized evidence hierarchy. Finally, each report was ascribed a level of evidence (from I to IV), depending on the quality of data presented. Results Fifty-five articles published between 1955 and 2002 were reviewed. There are currently no completed systematic reviews relevant to this body of literature (level I evidence). Two well-designed randomized controlled trials (level II evidence) were found. These were considered to provide the strongest evidence for feeding intervention techniques. These articles described a combination of interventions, including early feeding and nutrition education, as well as assisted feeding methods for infants with isolated cleft conditions. Three examples of level III.3 evidence were also found. Fifty (91%) of 55 articles reviewed were non–data-driven reports of expert opinion (level IV). Conclusions A paucity of evidence rated as either moderate or strong prevailed, underscoring the need for ongoing scientific evaluation of feeding interventions used with infants who have cleft palate. A number of factors, including the heterogeneity of samples studied, lack of replication of trials, and small sample sizes, affected the type and strength of evidence underpinning specific feeding interventions.

Nutritional intervention for ADHD

2018 ◽  
Author(s):  
Jan K. Buitelaar ◽  
Nanda Rommelse ◽  
Verena Ly ◽  
Julia J. Rucklidge
Keyword(s):  
Fatty Acids ◽  
Clinical Relevance ◽  
Randomized Clinical Trials ◽  
Nutritional Intervention ◽  
Evidence Base ◽  
Small Sample ◽  
Omega 3 ◽  
Dietary Interventions ◽  
Small Sample Sizes ◽  
Sampling Procedures

This chapter discusses four dietary interventions (exclusion of artificial colours and preservatives; restrictive elimination diets/oligoantigenic diets; supplementation with omega-3 fatty acids; and supplementation with micronutrients) and their clinical relevance for ADHD. The evidence base for exclusion of artificial colours and preservatives has many gaps. Effectiveness of the elimination phase of elimination diets has been demonstrated in several randomized clinical trials and about one-third of the children with ADHD show an excellent response. Data on maintenance of effect in the longer term, however, are lacking. Supplementation of free fatty acids was associated with a small but reliable reduction of ADHD symptoms, but the clinical relevance is unclear. The trials using a broad spectrum of micronutrients show promise but suffered from small sample sizes, lack of controls, varied sampling procedures and inclusion criteria, and multiple assessment methods, and need confirmation.

The scale of it all: postcanine tooth size, the taxon-level effect, and the universality of Gould's scaling law

Paleobiology ◽  
2010 ◽  
Vol 36 (2) ◽  
pp. 188-203 ◽  
Author(s):  
Lynn E. Copes ◽  
Gary T. Schwartz
Keyword(s):  
Body Mass ◽  
Scaling Law ◽  
Small Sample ◽  
Tooth Size ◽  
Mathematical Methods ◽  
Scaling Relationship ◽  
Small Sample Sizes ◽  
Relationship Of ◽  
The Impact ◽  
Level Effect

In a seminal paper in 1975, Gould proposed that postcanine occlusal area (PCOA) should scale metabolically (0.75) with body mass across mammals. By regressing PCOA against skull length in a small sample of large-bodied herbivorous mammals, Gould provided some marginal support for this hypothesis, which he then extrapolated as a universal scaling law for Mammalia. Since then, many studies have sought to confirm this scaling relationship within a single order and have found equivocal support for Gould's assertion. In part, this may be related to the use of proxies for both PCOA and body mass, small sample sizes, or the influence of a “taxon-level effect,” rendering Gould's scaling “universal” problematic.Our goal was to test the universality of Gould's prediction and the impact of the taxon-level effect on regressions of tooth size on body mass in a large extant mammalian sample (683 species spanning 14 orders). We tested for the presence of two types of taxon-level effect that may influence the acceptance or rejection of hypothesized scaling coefficients. The hypotheses of both metabolic and isometric scaling can be rejected in Mammalia, but not in all sub-groups therein. The level of data aggregation also influences the interpretation of the scaling relationship. Because the scaling relationship of tooth size to body mass is highly dependent on both the taxonomic level of analysis and the mathematical methods used to organize the data, paleontologists attempting to retrodict body mass from fossilized dental remains must be aware of the effect that sample composition may have on their results.

scholarly journals Technical Note: The Normal Quantile Transformation and its application in a flood forecasting system

2011 ◽  
Vol 8 (5) ◽  
pp. 9275-9297 ◽  
Author(s):  
K. Bogner ◽  
F. Pappenberger ◽  
H. L. Cloke
Keyword(s):  
Gaussian Model ◽  
Flood Forecasting ◽  
Technical Note ◽  
Small Sample ◽  
Extreme Value Analysis ◽  
Practical Implementation ◽  
Value Analysis ◽  
Regression Methods ◽  
Forecasting System ◽  
Small Sample Sizes

Abstract. The Normal Quantile Transform (NQT) has been used in many hydrological and meteorological applications in order to make the Cumulated Density Function (CDF) of the observed, simulated and forecast river discharge, water level or precipitation data Gaussian. It is also the heart of the meta-Gaussian model for assessing the total predictive uncertainty of the Hydrological Uncertainty Processor (HUP) developed by Krzysztofowicz. In the field of geo-statistics this transformation is better known as Normal-Score Transform. In this paper some possible problems caused by small sample sizes for the applicability in flood forecasting systems will be discussed and illustrated by examples. For the practical implementation commands and examples from the freely available and widely used statistical computing language R (R Development Core Team, 2011) will be given (represented in Courier font) and possible solutions are suggested by combining extreme value analysis and non-parametric regression methods.

Ketamine Use and Opioid-Tolerant Cancer Patients

2018 ◽  
Author(s):  
Fardin Yousefshahi ◽  
Giuliano Michelagnoli ◽  
Juan Francisco Asenjo
Keyword(s):  
Cancer Pain ◽  
Cancer Patients ◽  
Randomized Clinical Trials ◽  
Pain Treatment ◽  
Small Sample ◽  
World Health ◽  
Chronic Cancer Pain ◽  
Small Sample Sizes ◽  
Health Organization ◽  
Intravenous Ketamine

Pain occurs in up to 70% of cancer patients and it can be challenging to manage. The standard for analgesic therapy is the World Health Organization ladder; however, up to 25% of patients don’t reach a level of comfort using this approach. Ketamine has been recognized as an excellent adjuvant for cancer pain treatment, especially when other analgesics have failed. Some randomized clinical trials have confirmed ketamine’s efficacy in refractory cancer pain, but most had small sample sizes and low power. Some publications have confirmed the beneficial effect of oral, intranasal, subcutaneous, or intravenous ketamine in treatment of refractory chronic cancer pain, while others are less conclusive. While ketamine is rapidly gaining ground as an adjuvant in treating pain in patients with cancers refractory to conventional therapy and/or patients with opioid tolerance, care should be taken to identify patients with ketamine contraindications in order to offer the greatest benefit with the lowest risk of side effects.

scholarly journals Surgical treatment of symptomatic post-slipped capital femoral epiphysis deformity: a comparative study between hip arthroscopy and surgical hip dislocation with or without intertrochanteric osteotomy

2020 ◽  
Vol 14 (2) ◽  
pp. 98-105 ◽  
Author(s):  
James D. Wylie ◽  
Michael P. McClincy ◽  
Nishant Uppal ◽  
Patricia E. Miller ◽  
Young-Jo Kim ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Hip Arthroscopy ◽  
Research Question ◽  
Slipped Capital Femoral Epiphysis ◽  
Hip Dislocation ◽  
Cartilage Defects ◽  
Surgical Hip Dislocation ◽  
Level Of Evidence ◽  
Articular Damage ◽  
Before And After

Purpose Our primary research question was to investigate the severity of deformity and articular damage as well as outcomes in patients undergoing hip arthroscopy compared with open surgery for the treatment of symptomatic slipped capital femoral epiphysis (SCFE) deformity. Methods Retrospective review of surgical treatment of symptomatic SCFE deformity with a minimum one-year follow-up. Patients were divided into three groups: the arthroscopic group, surgical hip dislocation(SHD) group and SHD with femoral osteotomy (SHD+ITO) group. Deformity severity was quantified. Hip outcome was assessed by the modified Merle d’Aubigné Postel (MDP) scores. Results There were more severe slips treated by SHD and SHD+ITO. There was more severe deformity in the SHD+ITO group than the arthroscopy group (p < 0.001). There were more full thickness acetabular cartilage defects in the SHD and the SHD+ITO groups (> 40%) compared with the arthroscopy group (11%; p = 0.03). The SHD+ITO and SHD group had lower MDP scores compared with the arthroscopy group both before and after surgery but no difference was detected in the amount of improvement from surgery across groups (p > 0.05). Moderate and severe SCFEs had worse preoperative scores but improvement was not different compared with mild SCFEs (p > 0.05). Conclusion Patients undergoing open treatment had more severe SCFE deformity with more extensive articular damage at reconstructive surgery compared with patients undergoing arthroscopy. All groups with SCFE deformity had improved pain and hip function postoperatively. Level of Evidence III

scholarly journals Genetic Mutations in Young Nonsmoking Patients With Oral Cavity Cancer: A Systematic Review

OTO Open ◽  
2020 ◽  
Vol 4 (4) ◽  
pp. 2473974X2097018
Author(s):  
Rohini R. Bahethi ◽  
Katelyn O. Stepan ◽  
Rachel Pinotti ◽  
Ryan Li ◽  
Nishant Agrawal ◽  
...  
Keyword(s):  
Risk Factors ◽  
Oral Cavity ◽  
Similar Rate ◽  
Genetic Alterations ◽  
Small Sample ◽  
Genetic Mutations ◽  
Case Control Studies ◽  
Level Of Evidence ◽  
Tp53 Mutations ◽  
Small Sample Sizes

Objective This investigation aims to review the known genetic mutations associated with oral cavity squamous cell carcinoma (OCSCC) in young adults with limited environmental risk factors (YLERs). Data Sources A comprehensive search strategy was designed to identify studies in MEDLINE (Ovid), Embase (Ovid), and Scopus from database inception to May 2017 that included adults ≤50 years of age with OCSCC and minimal tobacco use history (≤10 pack-years) who had their tumors genetically sequenced or mutational profiles analyzed. Review Methods Identified articles were screened by 2 reviewers. Quality of evidence was graded by the MINORS criteria for case-control studies; other studies were graded by assigning a level of evidence for gene mutation literature. Results Thirteen studies met our inclusion criteria, and 130 patients met our criteria for age and tobacco history. TP53 was the most commonly evaluated gene (10 of 13 studies) and the most frequently observed mutation. One study reported that nonsmokers had significantly fewer TP53 mutations, while 9 studies found no difference in the prevalence of TP53 mutations. No other mutations were found specific to this cohort. Conclusions TP53 mutations may occur at a similar rate in YLERs with OCSCC as compared with older patients or those with risk factors. However, few studies have aimed to characterize the genetic landscape of oral cavity tumors in this population, often with small sample sizes. Future studies are needed to explore unidentified genetic alterations leading to tumor susceptibility or alternative mechanisms of carcinogenesis.

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