A review on phytochemical and therapeutic potential of Iris germanica

2021 ◽  
Author(s):  
Bahareh Sadat Yousefsani ◽  
Motahareh Boozari ◽  
Kobra Shirani ◽  
Amirhossein Jamshidi ◽  
Majid Dadmehr
Keyword(s):  
Bioactive Compounds ◽  
Therapeutic Potential ◽  
Experimental Studies ◽  
Therapeutic Effects ◽  
Pharmacological Activities ◽  
Pharmacological Studies ◽  
Iris Germanica ◽  
Safety Studies ◽  
History Of ◽  
Therapeutic Activities

Abstract Objectives Iris germanica L. is a medicinal plant, which has a long history of uses, mainly in medieval Persia and many places worldwide for the management of a wide variety of diseases. In this study, we aimed to review ethnopharmacological applications in addition to phytochemical and pharmacological properties of I. germanica. Key findings Ethnomedical uses of I. germanica have been reported from many countries such as China, Pakistan, India, Iran and Turkey. The medicinal part of I. germanica is the rhizome and the roots. Based on phytochemical investigations, different bioactive compounds, including flavonoids, triterpenes, sterols, phenolics, ceramides and benzoquinones, have been identified in its medicinal parts. Current pharmacological studies represent that the plant possesses several biological and therapeutic effects, including neuroprotective, hypoglycaemic, hypolipidaemic, antimicrobial, antioxidant, antiproliferative, anti-inflammatory, antiplasmodial, antifungal, immunomodulatory, cytotoxic and antimutagenic effects. Summary Although the majority of preclinical studies reported various pharmacological activities of this plant, however, sufficient clinical trials are not currently available. Therefore, to draw a definitive conclusion about the efficacy and therapeutic activities of I. germanica and its bioactive compounds, further clinical and experimental studies are required. Moreover, it is necessary to focus on the pharmacokinetic and safety studies on the extracts of I. germanica.

Spices

2022 ◽  
pp. 760-777
Author(s):  
Nisha ◽  
Deepika
Keyword(s):  
Blood Glucose ◽  
Experimental Evidence ◽  
Bioactive Compounds ◽  
Underlying Mechanism ◽  
Pharmacological Activities ◽  
Glucose Lowering ◽  
Scientific Methods ◽  
Human Trials ◽  
History Of ◽  
Medicinal Properties

The term “spices” has been derived from the word “species,” which was connected to the group of exotic foods in medieval times. Spices and herbs have a long history of culinary use, medicinal properties, and as additives and thus have a distinct place in Ayurveda. Exhibiting the merits of spices by scientific methods still remains a challenge. This review investigates the anti-diabetic properties in preventing and managing diabetics and associated complications with commonly used spices. The bioactive compounds in these spices are additionally discussed. The major aim and object of the present work is to investigate the customary therapeutic usage of basic Indian spices and to corelate their observed pharmacological activities with the presence of explicit bioactive compounds present for the treatment or counteractive action of diabetes. This includes the basic underlying mechanism of their blood glucose lowering property including exploratory experimental evidence from proposed animal and human trials.

scholarly journals Cannabidiol for Pain Treatment: Focus on Pharmacology and Mechanism of Action

2020 ◽  
Vol 21 (22) ◽  
pp. 8870 ◽  
Author(s):  
Jakub Mlost ◽  
Marta Bryk ◽  
Katarzyna Starowicz
Keyword(s):  
Mechanism Of Action ◽  
Pain Treatment ◽  
Therapeutic Potential ◽  
Disease Model ◽  
Basic Research ◽  
Therapeutic Effects ◽  
Analgesic Effects ◽  
History Of ◽  
Research Findings ◽  
Anti Inflammatory

Cannabis has a long history of medical use. Although there are many cannabinoids present in cannabis, Δ9tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) are the two components found in the highest concentrations. CBD itself does not produce typical behavioral cannabimimetic effects and was thought not to be responsible for psychotropic effects of cannabis. Numerous anecdotal findings testify to the therapeutic effects of CBD, which in some cases were further supported by research findings. However, data regarding CBD’s mechanism of action and therapeutic potential are abundant and omnifarious. Therefore, we review the basic research regarding molecular mechanism of CBD’s action with particular focus on its analgesic potential. Moreover, this article describes the detailed analgesic and anti-inflammatory effects of CBD in various models, including neuropathic pain, inflammatory pain, osteoarthritis and others. The dose and route of the administration-dependent effect of CBD, on the reduction in pain, hyperalgesia or allodynia, as well as the production of pro and anti-inflammatory cytokines, were described depending on the disease model. The clinical applications of CBD-containing drugs are also mentioned. The data presented herein unravel what is known about CBD’s pharmacodynamics and analgesic effects to provide the reader with current state-of-art knowledge regarding CBD’s action and future perspectives for research.

scholarly journals Ficus deltoideaJack: A Review on Its Phytochemical and Pharmacological Importance

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Hamidun Bunawan ◽  
Noriha Mat Amin ◽  
Siti Noraini Bunawan ◽  
Syarul Nataqain Baharum ◽  
Normah Mohd Noor
Keyword(s):  
Scientific Literature ◽  
Therapeutic Potential ◽  
Future Research ◽  
Pharmacological Effects ◽  
Antidiabetic Drug ◽  
Medicinal Species ◽  
Ficus Deltoidea ◽  
Pharmacological Studies ◽  
History Of ◽  
History Of Use

Ficus deltoideaJack (Moraceae) has had a long history of use in traditional medicine among the Malays to alleviate and heal ailments such as sores, wounds, and rheumatism and as an after-birth tonic and an antidiabetic drug. Modern pharmacological studies demonstrated that this plant has a wide variety of beneficial attributes for human health. Despite its importance, a review of this species has not been published in the scientific literature to date. Here, we review and summarize the historic and current literature concerning the botany, traditional uses, phytochemistry, pharmacological effects, and toxicity of this wonder plant. This summary could be beneficial for future research aiming to exploit the therapeutic potential of this useful, medicinal species.

scholarly journals A Systematic Literature Review of the Potential Therapeutic Effects of Ayahuasca Tea Prepared From the Use of Banisteriopsis Caapi and Psychotria Viridis

2020 ◽  
Vol 9 (1) ◽  
pp. 112
Author(s):  
Adriane Cordeiro Trevisani ◽  
João Pedro Cordeiro Trevisani ◽  
Moacir Haverroth ◽  
Ailton Da Cruz Melo ◽  
Isabela Carvalho dos Santos ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Literature Review ◽  
Traditional Knowledge ◽  
Plant Species ◽  
Bioactive Compounds ◽  
Bacterial Infections ◽  
Therapeutic Potential ◽  
Alternative Therapy ◽  
Therapeutic Effects ◽  
Efficacy And Safety

Ayahuasca is a drink of indigenous origin made as a decoction obtained from medicinal plants found mainly in Acre, state of Brazil, which are the leaves of Psychtoria viridis, popularly known as “chacrona” in Brazil, and the stem of Banisteriopsis caapi, commonly known as mariri or jagube. The decoction is used in religious practices for the therapy of diseases that affect the human being, such as psychological disorders, neurological, parasitic and bacterial infections. Considering the existing bioactive compounds and the therapeutic potential of ayahuasca, this study aims to carry out a literature review of scientific articles (PubMed, Scielo and LILACS) in order to gather knowledge within 30 years of study about the therapeutic potentials of ayahuasca. In the current literature, the studies focus on the area of neuropsychology, dealing with ayahuasca as a form of therapy for neurological and neuromotor disorders. In addition, antimicrobial, antiparasitic, immunomodulatory, and antioxidant actions have already been reported. However, new studies are still needed in these areas in order to evaluate the efficacy and safety of ayahuasca and its component plant species, in order to use it as an alternative therapy, especially in the population from which the traditional knowledge about this beverage came from.

Bioactive Compounds Investigation From Methanol Bark Extract of Pterocarpus marsupium Using GC-MS Analysis

2017 ◽  
Vol 8 (03) ◽  
Author(s):  
Aruna L. Hugar ◽  
Amarvani P. Kanjikar ◽  
Ramesh L. Londonkar
Keyword(s):  
Methyl Ester ◽  
Bioactive Compounds ◽  
Acid Methyl Ester ◽  
Bark Extract ◽  
Therapeutic Effects ◽  
Octadecanoic Acid ◽  
New Novel ◽  
Ms Analysis ◽  
Novel Drug ◽  
Therapeutic Activities

Introduction: Medicinal plants still represent untapped sources of novel compounds with potential therapeutic effects for mitigating human maladies.Pterocarpus marsupium, commonly known as Bijasal, is a well-known drug in ayurvedic system of medicine. Materials and methods: The dried bark powder of P.marsupium was extracted by Soxhlet with methanol and analyzed by gas chromatography, while the mass spectra data of the compounds found in the extract was matched with the data available at National Institute of Standards and Technology (NIST) library. Results: The results of the GC-MS analysis provide different peaksdetermining the presence of 10 major phytocomponents, that are 1-Penten-3-one,1-(2,6,6-trimethyl-1-cyclohexen-1-yl)-; Geranyl isovalerate; 2-Pentadecanone,6, 10, 14-trimethyl;Cyclopropaneoctanal, 2-octyl-; Octadecanoic acid;10-Octadecanoic acid, methyl ester; Heptadecanoic acid, 16-methyl,-methyl ester; Phytol; 4,8,12,16-Tetramethyl heptadecan-4-olide; Dasycarpidan-1-methanol, acetate with different therapeutic activities. Conclusion: The presence of these bioactive compounds justifies that the Pterocarpus marsupiumcan offer a base for using this compound as herbal alternative for the synthesis and development of new drug to treat various infectious diseases. However, isolation of individual phytochemical constituents might be useful to formulate a new novel drug.

The Antihypertensive, Antimicrobial and Anticancer Peptides from Arthrospira with Therapeutic Potential: A Mini Review

2020 ◽  
Vol 20 (8) ◽  
pp. 593-606
Author(s):  
Grecia E. Barriga Montalvo ◽  
Luciana Porto de Souza Vandenberghe ◽  
Vanete Thomaz Soccol ◽  
Júlio Cesar de Carvalho ◽  
Carlos Ricardo Soccol
Keyword(s):  
Bioactive Peptides ◽  
Therapeutic Potential ◽  
Inhibition Mechanism ◽  
Therapeutic Effects ◽  
High Concentration ◽  
Tumour Control ◽  
Anticancer Peptides ◽  
Inhibition Of Angiogenesis ◽  
History Of ◽  
Purification Methods

: The interest in biological peptides from Arthrospira sp. (syn Spirulina) is increasing due to its Generally Recognised as Safe “GRAS” status, the high concentration of proteins and the history of its use as a supplement and nutraceutical agent. Arthrospira peptides can be generated by the controlled hydrolysis of proteins, using proteases, followed by fractionation. The peptides obtained have a range of therapeutic effects. Amongst these bioactive peptides, three classes are of major importance: the antihypertensive (AHP), antimicrobial (AMP) and anticancer (ACP) peptides. AHPs have the ability to work as inhibitors of angiotensin-converting enzyme (ACE), and help to control several diseases such as hypertension, obesity, and cardiovascular issues, AMPs play a crucial role in the immune response, inhibiting the development of pathogens such as bacteria, fungi, viruses and others, while ACPs can aid in tumour control by the induction of apoptosis or necrosis, or the inhibition of angiogenesis. Thus, bioactive peptides are of great significance to the pharmaceutical industry. However, they can show secondary effects. This paper reviews the inhibition mechanism of antimicrobial, hypertensive and anticancer peptides from Arthrospira sp., and the possible structures of the peptides according to the type of activity and its intensity. In addition, this paper describes the purification methods of absorption mechanisms, and reviews databases for designing peptides.

scholarly journals Imperata cylindrica: A Review of Phytochemistry, Pharmacology, and Industrial Applications

Molecules ◽  
2021 ◽  
Vol 26 (5) ◽  
pp. 1454
Author(s):  
Young-Kyung Jung ◽  
Dongyun Shin
Keyword(s):  
Medicinal Plant ◽  
Therapeutic Potential ◽  
Chemical Constituents ◽  
Industrial Applications ◽  
Imperata Cylindrica ◽  
Pharmacological Activities ◽  
Wide Range ◽  
Pharmacological Studies

Imperata cylindrica is a medicinal plant native to southwestern Asia and the tropical and subtropical zones. To date, 72 chemical constituents have been isolated and identified from I. cylindrica Among these compounds, saponins, flavonoids, phenols, and glycosides are the major constituents. Investigations of pharmacological activities of I. cylindrica revealed that this edible medicinal herb exhibits a wide range of therapeutic potential including immunomodulatory, antibacterial, antitumor, anti-inflammatory, and liver protection activities both in vivo and in vitro. The purpose of this review is to provide an overview of I. cylindrica studies until 2019. This article also intends to review advances in the botanical, phytochemical, and pharmacological studies and industrial applications of I. cylindrica, which will provide a useful bibliography for further investigations and applications of I. cylindrica in medicines and foods.

scholarly journals Review of the Traditional Uses, Phytochemistry, and Pharmacological Activities of Rhoicissus Species (Vitaceae)

Molecules ◽  
2021 ◽  
Vol 26 (8) ◽  
pp. 2306
Author(s):  
Nondumiso P. Dube ◽  
Xavier Siwe-Noundou ◽  
Rui W. M. Krause ◽  
Douglas Kemboi ◽  
Vuyelwa Jacqueline Tembu ◽  
...  
Keyword(s):  
South African ◽  
Therapeutic Strategy ◽  
Therapeutic Potential ◽  
Secondary Compounds ◽  
Pharmacological Activities ◽  
Sexually Transmitted ◽  
Traditional Uses ◽  
Pharmacological Studies ◽  
Gastrointestinal Complaints ◽  
Pharmacological Potential

Species within the genus Rhoicissus (Vitaceae) are commonly used in South African traditional medicine. The current review discusses the occurrence, distribution, traditional uses, phytochemistry, and pharmacological properties of Rhoicissus species covering the period 1981–2020. The data reported were systematically collected, read, and analysed from scientific electronic databases including Scopus, Scifinder, Pubmed, and Google Scholar. Reported evidence indicates that species in this genus are used for the treatment of gastrointestinal complaints, sexually transmitted infections (STIs), and infertility, as well as to tone the uterus during pregnancy and to facilitate delivery. Pharmacological studies have further shown that members of the Rhoicissus genus display antidiabetic, uterotonic, ascaricidal, hepatoprotective, antioxidant, antimicrobial, anticancer, and anti-inflammatory properties. They are linked to the presence of bioactive compounds isolated from the genus. Hence, Rhoicissus species can potentially be an alternative therapeutic strategy to treat diseases and develop safer and more potent drugs to combat diseases. Plant species of this genus have valuable medicinal benefits due to their significant pharmacological potential. However, scientific investigation and information of the therapeutic potential of Rhoicissus remain limited as most of the species in the genus have not been fully exploited. Therefore, there is a need for further investigations to exploit the therapeutic potential of the genus Rhoicissus. Future studies should evaluate the phytochemical, pharmacological, and toxicological activities, as well as the mode of action, of Rhoicissus crude extracts and secondary compounds isolated from the species.

scholarly journals Mini-Review on Phytochemistry and Pharmacological Studies of Piper regnellii (Miq.) C.DC.

2021 ◽  
Vol 12 (2) ◽  
pp. 1791-1802
Keyword(s):  
Web Of Science ◽  
Therapeutic Potential ◽  
Folk Medicine ◽  
Modern Medicine ◽  
Convincing Evidence ◽  
Herbaceous Plant ◽  
Pharmacological Activities ◽  
Pharmacological Studies ◽  
Treatment Of Wounds ◽  
Phytochemical Studies

Piper regnellii (Miq.) C.DC. is an herbaceous plant that can be found in tropical and subtropical regions of the world and commonly employed in folk medicine for the treatment of wounds, swellings, and skin irritations. In particular, phytochemical studies on P. regnellii have yielded essential oils, benzofuran neolignans, and phenylpropanoids, while the extracts and compounds demonstrated a broad spectrum of pharmacological activities. The present study aims to provide a review of previously published studies conducted on both the phytochemistry and pharmacological activities of P. regnellii. Accordingly, the scientific journals used for this brief literature review were obtained from various electronic sources, including Science Direct, PubMed, Google Scholar, Scopus, and Web of Science. In particular, the outcome of this review is expected to support the therapeutic potential of P. regnellii further as well as provide convincing evidence to its future clinical applications in modern medicine. Overall, this is aimed to increase the amount of data that supports the application and exploitation of new drug development.

scholarly journals The combination of two natural medicines, Chuanxiong and Asarum: A review of the chemical constituents and pharmacological activities

2021 ◽  
pp. 174751982110391
Author(s):  
Qingcheng Yang ◽  
Fangli Shen ◽  
Fengqin Zhang ◽  
Xue Bai ◽  
Yanru Zhang ◽  
...  
Keyword(s):  
Chemical Constituents ◽  
Experimental Studies ◽  
Chemical Components ◽  
Therapeutic Effects ◽  
Anticancer Activities ◽  
Volatile Oils ◽  
Pharmacological Activities ◽  
Single Drug ◽  
Traditional Natural ◽  
Natural Medicines

Traditional Chinese medicine has been clinically used in China for many years, with experimental studies and clinical trials having demonstrated that it is safe and valid. Among many traditional natural medicines, Chuanxiong and Asarum have been proven to be effective in the treatment of relieving pain. Actually, as well as analgesic, they have common attributes, such as anti-inflammatory, cardiovascular benefits, and anticancer activities, with volatile oils being their major components. Furthermore, Chuanxiong and Asarum have been combined as drug pairs in the same prescription for thousands of years, with examples being Chuanxiong Chatiao San and Chuanxiongxixintang. More interestingly, their combination has better therapeutic effects on diseases than a single drug. After the combination of Chuanxiong and Asarum forms a blend, a series of changes take place in their chemical components, such as the contents of the main active ingredients, ferulic acid and ligustilide, increased significantly after this progress. At the same time, the pharmacological effects of the combination appearing to be more powerful, such as synergistic analgesic. This review focuses on the chemical constituents and pharmacological activities of Chuanxiong, Asarum, and Chuanxiong Asarum compositions.

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