scholarly journals The combination of two natural medicines, Chuanxiong and Asarum: A review of the chemical constituents and pharmacological activities

2021 ◽  
pp. 174751982110391
Author(s):  
Qingcheng Yang ◽  
Fangli Shen ◽  
Fengqin Zhang ◽  
Xue Bai ◽  
Yanru Zhang ◽  
...  
Keyword(s):  
Chemical Constituents ◽  
Experimental Studies ◽  
Chemical Components ◽  
Therapeutic Effects ◽  
Anticancer Activities ◽  
Volatile Oils ◽  
Pharmacological Activities ◽  
Single Drug ◽  
Traditional Natural ◽  
Natural Medicines

Traditional Chinese medicine has been clinically used in China for many years, with experimental studies and clinical trials having demonstrated that it is safe and valid. Among many traditional natural medicines, Chuanxiong and Asarum have been proven to be effective in the treatment of relieving pain. Actually, as well as analgesic, they have common attributes, such as anti-inflammatory, cardiovascular benefits, and anticancer activities, with volatile oils being their major components. Furthermore, Chuanxiong and Asarum have been combined as drug pairs in the same prescription for thousands of years, with examples being Chuanxiong Chatiao San and Chuanxiongxixintang. More interestingly, their combination has better therapeutic effects on diseases than a single drug. After the combination of Chuanxiong and Asarum forms a blend, a series of changes take place in their chemical components, such as the contents of the main active ingredients, ferulic acid and ligustilide, increased significantly after this progress. At the same time, the pharmacological effects of the combination appearing to be more powerful, such as synergistic analgesic. This review focuses on the chemical constituents and pharmacological activities of Chuanxiong, Asarum, and Chuanxiong Asarum compositions.

scholarly journals Seeing the Unseen of the Combination of Two Natural Resins, Frankincense and Myrrh: Changes in Chemical Constituents and Pharmacological Activities

Molecules ◽  
2019 ◽  
Vol 24 (17) ◽  
pp. 3076 ◽  
Author(s):  
Bo Cao ◽  
Xi-Chuan Wei ◽  
Xiao-Rong Xu ◽  
Hai-Zhu Zhang ◽  
Chuan-Hong Luo ◽  
...  
Keyword(s):  
Chronic Diseases ◽  
Chemical Constituents ◽  
Chemical Components ◽  
Pharmacological Effects ◽  
Pharmacological Activities ◽  
Channel Characteristics ◽  
Natural Resins ◽  
Ancient Times ◽  
Traditional Natural ◽  
Natural Drugs

For the treatment of diseases, especially chronic diseases, traditional natural drugs have more effective therapeutic advantages because of their multi-target and multi-channel characteristics. Among many traditional natural medicines, resins frankincense and myrrh have been proven to be effective in the treatment of inflammation and cancer. In the West, frankincense and myrrh have been used as incense in religious and cultural ceremonies since ancient times; in traditional Chinese and Ayurvedic medicine, they are used mainly for the treatment of chronic diseases. The main chemical constituents of frankincense and myrrh are terpenoids and essential oils. Their common pharmacological effects are anti-inflammatory and anticancer. More interestingly, in traditional Chinese medicine, frankincense and myrrh have been combined as drug pairs in the same prescription for thousands of years, and their combination has a better therapeutic effect on diseases than a single drug. After the combination of frankincense and myrrh forms a blend, a series of changes take place in their chemical composition, such as the increase or decrease of the main active ingredients, the disappearance of native chemical components, and the emergence of new chemical components. At the same time, the pharmacological effects of the combination seem magically powerful, such as synergistic anti-inflammation, synergistic anticancer, synergistic analgesic, synergistic antibacterial, synergistic blood-activation, and so on. In this review, we summarize the latest research on the main chemical constituents and pharmacological activities of these two natural resins, along with chemical and pharmacological studies on the combination of the two.

A review on phytochemical and therapeutic potential of Iris germanica

2021 ◽  
Author(s):  
Bahareh Sadat Yousefsani ◽  
Motahareh Boozari ◽  
Kobra Shirani ◽  
Amirhossein Jamshidi ◽  
Majid Dadmehr
Keyword(s):  
Bioactive Compounds ◽  
Therapeutic Potential ◽  
Experimental Studies ◽  
Therapeutic Effects ◽  
Pharmacological Activities ◽  
Pharmacological Studies ◽  
Iris Germanica ◽  
Safety Studies ◽  
History Of ◽  
Therapeutic Activities

Abstract Objectives Iris germanica L. is a medicinal plant, which has a long history of uses, mainly in medieval Persia and many places worldwide for the management of a wide variety of diseases. In this study, we aimed to review ethnopharmacological applications in addition to phytochemical and pharmacological properties of I. germanica. Key findings Ethnomedical uses of I. germanica have been reported from many countries such as China, Pakistan, India, Iran and Turkey. The medicinal part of I. germanica is the rhizome and the roots. Based on phytochemical investigations, different bioactive compounds, including flavonoids, triterpenes, sterols, phenolics, ceramides and benzoquinones, have been identified in its medicinal parts. Current pharmacological studies represent that the plant possesses several biological and therapeutic effects, including neuroprotective, hypoglycaemic, hypolipidaemic, antimicrobial, antioxidant, antiproliferative, anti-inflammatory, antiplasmodial, antifungal, immunomodulatory, cytotoxic and antimutagenic effects. Summary Although the majority of preclinical studies reported various pharmacological activities of this plant, however, sufficient clinical trials are not currently available. Therefore, to draw a definitive conclusion about the efficacy and therapeutic activities of I. germanica and its bioactive compounds, further clinical and experimental studies are required. Moreover, it is necessary to focus on the pharmacokinetic and safety studies on the extracts of I. germanica.

scholarly journals Scutellaria barbata: A Review on Chemical Constituents, Pharmacological Activities and Clinical Applications

2020 ◽  
Vol 26 (1) ◽  
pp. 160-175 ◽  
Author(s):  
Qiong Chen ◽  
Khalid Rahman ◽  
Su-Juan Wang ◽  
Shuang Zhou ◽  
Hong Zhang
Keyword(s):  
Blood Circulation ◽  
Chemical Constituents ◽  
Blood Stasis ◽  
Clinical Applications ◽  
In Vivo Studies ◽  
Chemical Components ◽  
Pharmacological Activities ◽  
Scutellaria Barbata ◽  
Pharmacologically Active

Scutellaria barbata has a long history of medical use in Traditional Chinese Medicine for removing heat and toxic material, promoting blood circulation and removing blood stasis, and inducing diuresis to reduce edema. Recent pharmacology investigations have provided evidence for its anti-cancer, bacteriostasis, anti-virus, anti-inflammation, anti-oxidation and immunity enhancement properties. The efficacy of activating blood circulation and removing blood stasis has unique advantages in the treatment of cardiovascular and cerebrovascular diseases. A total of 84 compounds have been isolated from S. barbata and are characterized mainly as flavonoids, diterpenoids, followed by polysaccharide, volatile oil and steroids. Peer-reviewed articles published over the last few years were gathered by consulting the databases PubMed, Elsevier, Springer, and Chinese Herbal Classics. This review mainly focuses on the pharmacologically active constituents isolated from S. barbata，which have been subjected to in vitro and/or in vivo studies. Although, the chemical components, pharmacological activities, toxicology, clinical applications and mechanisms of action of S. barbata have been investigated, many constituents remain unknown. Further investigations are required to investigate the medicinal properties of S. barbata.

scholarly journals Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review

Nutrients ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 872 ◽  
Author(s):  
Gaber El-Saber Batiha ◽  
Amany Magdy Beshbishy ◽  
Lamiaa G. Wasef ◽  
Yaser H. A. Elewa ◽  
Ahmed A. Al-Sagan ◽  
...  
Keyword(s):  
Allium Sativum ◽  
Biological Activities ◽  
Chemical Constituents ◽  
Biological Properties ◽  
Herbaceous Plant ◽  
Anticancer Activities ◽  
Active Constituent ◽  
Pharmacological Activities ◽  
Traditional Medicines ◽  
Traditional Remedy

Medicinal plants have been used from ancient times for human healthcare as in the form of traditional medicines, spices, and other food components. Garlic (Allium sativum L.) is an aromatic herbaceous plant that is consumed worldwide as food and traditional remedy for various diseases. It has been reported to possess several biological properties including anticarcinogenic, antioxidant, antidiabetic, renoprotective, anti-atherosclerotic, antibacterial, antifungal, and antihypertensive activities in traditional medicines. A. sativum is rich in several sulfur-containing phytoconstituents such as alliin, allicin, ajoenes, vinyldithiins, and flavonoids such as quercetin. Extracts and isolated compounds of A. sativum have been evaluated for various biological activities including antibacterial, antiviral, antifungal, antiprotozoal, antioxidant, anti-inflammatory, and anticancer activities among others. This review examines the phytochemical composition, pharmacokinetics, and pharmacological activities of A. sativum extracts as well as its main active constituent, allicin.

scholarly journals Chemical Composition and Enzymatic Screening of Micromeria fruticosa serpyllifolia Volatile Oils Collected from Three Different Regions of West Bank, Palestine

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Nihaya Salameh ◽  
Naser Shraim ◽  
Nidal Jaradat
Keyword(s):  
Plant Extracts ◽  
Biological Activities ◽  
West Bank ◽  
Chemical Components ◽  
Chemical Compositions ◽  
Therapeutic Effects ◽  
Volatile Oils ◽  
Ic50 Values ◽  
Micromeria Fruticosa

Introduction. Volatile oils (VOs) have been commonly used in cosmetics and food as fragrances, flavoring, and preservative agents or in alternative medicine for their therapeutic effects. This necessitates investigating those plants and their VOs. This study was conducted to investigate the chemical compositions of the VOs of Micromeria fruticosa serpyllifolia growing widely in three regions in Palestine (i.e., Hebron, Ramallah, and Nablus districts representing south, middle, and north of West Bank). Afterwards, VOs were subjected to in vitro screening and their enzymatic properties were compared. Methods. The analysis of chemical components of VOs was performed by gas chromatography coupled with mass spectrometry (GC-MS). The antilipase activity was evaluated using porcine pancreatic lipase and p-nitrophenyl butyrate. The antiamylase activity was assessed using porcine pancreatic α-amylase, starch, and 3,5-dinitrosalicylic. Results. Plant extracts yield range was 0.67 to 0.99 w/w%. GC-MS analysis showed the high percentages of oxygenated components in the range of 86.1-89.88% and nonoxygenated components in the range of 4.38-4.71%. Seven components were observed, pulegone was the most abundant component in the three samples in the range of 74.43-86.04%, and isomenthone was the second most abundant component with the range of 3.16-14.41%. The sample collected from Nablus showed the most potent antilipase and antiamylase activity with IC50 values of 39.81 μg/mL and 3.31 μg/mL, respectively. Conclusions. The study showed that Micromeria fruticosa serpyllifolia volatile oils samples from different regions in Palestine contained different proportions of phytochemicals which provided different potential biological activities such as antiobesity and antidiabetes activities that were in line with traditional uses of the plant extracts. The plant extracts showed higher antilipase and antiamylase potency than that of the relative references and there were significant differences in these activities compared to each other.

scholarly journals Metabolic Profile, Bioactivities, and Variations in the Chemical Constituents of Essential Oils of the Ferula Genus (Apiaceae)

2021 ◽  
Vol 11 ◽  
Author(s):  
Priyankaraj Sonigra ◽  
Mukesh Meena
Keyword(s):  
Essential Oils ◽  
Biological Activities ◽  
Chemical Constituents ◽  
Sesquiterpene Lactones ◽  
Far East ◽  
North India ◽  
Chemical Components ◽  
Volatile Oils ◽  
Factors Affecting ◽  
Sulfur Containing

The genus Ferula is the third largest and a well-known genus of the Apiaceae family. It is categorized in the Peucedaneae tribe and Ferulinae subtribe of the Apiaceae family. At present, about 180 Ferula species have been reported. The genus is mainly distributed throughout central and South-West Asia (especially Iran and Afghanistan), the far-East, North India, and the Mediterranean. The genus Ferula is characterized by the presence of oleo-gum-resins (asafoetida, sagapenum, galbanum, and ammoniacum) and their use in natural and conventional pharmaceuticals. The main phytochemicals present in the genus Ferula are as follows: coumarin, coumarin esters, sesquiterpenes, sesquiterpene lactones, monoterpene, monoterpene coumarins, prenylated coumarins, sulfur-containing compounds, phytoestrogen, flavonoids and carbohydrates. This genus is considered to be a valuable group of medicinal plants due to its many different biological and pharmacological uses as volatile oils (essential oils). Numerous biological activities are shown by the chemical components of the essential oils obtained from different Ferula species. Because this genus includes many bioactivities such as antimicrobial, insecticidal, antioxidant, cytotoxic, etc., researchers are now focusing on this genus. Several reviews are already available on this particular genus, including information about the importance and the uses of all the phytochemicals found in the species of Ferula. Despite this, no review that specifically provides information about the biological activities of Ferula-derived essential oils, has been published yet. Therefore, the present review has been conducted to provide important information about the chemical profile, factors affecting the chemical composition, and biological activities of essential oils of the Ferula species.

Geographical variation in Chemo profile, Genetic profile and In-vitro Anticancer activity of Chitraka (Plumbago zeylanica Linn.) collected from Himalayas and Western Ghats

2019 ◽  
Vol 4 (04) ◽  
Author(s):  
Rajesh Sharma ◽  
Shraddha Naik ◽  
Vikas Saroch
Keyword(s):  
Medicinal Plants ◽  
Anticancer Activity ◽  
Western Ghats ◽  
Chemical Constituents ◽  
Himalayan Region ◽  
Chemical Components ◽  
Genetic Profile ◽  
Anticancer Activities ◽  
Plumbago Zeylanica

Therapeutic actions of medicinal plants are due to the chemical components present in them. These chemical constituents often vary with change in geographical and climatic conditions. Climate, altitude, and temperature play an important role to make a herb therapeutically potent. Ancient Ayurvedic physicians mentioned that medicinal plants which grow in Himalayan region are more potent as compared to the plants growing in other regions. A modest study was therefore undertaken to compare the in vitro anticancer activity of Plumbago zeylanica Linn. collected from Himalayan region and Western Ghats with respect to their chemo profile and genetic patterns. Variation in physio-chemical, phyto-chemical, the genetic profiles were observed in plants collected from these two regions and corresponding variation was also seen in their anticancer activities.

scholarly journals Biomedical Properties of a Natural Dietary Plant Metabolite, Zerumbone, in Cancer Therapy and Chemoprevention Trials

2014 ◽  
Vol 2014 ◽  
pp. 1-20 ◽  
Author(s):  
Heshu Sulaiman Rahman ◽  
Abdullah Rasedee ◽  
Swee Keong Yeap ◽  
Hemn Hassan Othman ◽  
Max Stanley Chartrand ◽  
...  
Keyword(s):  
Scientific Evidence ◽  
Future Research ◽  
Therapeutic Effects ◽  
Anticancer Activities ◽  
Pharmacological Activities ◽  
Naturally Occurring ◽  
Plant Metabolite ◽  
Natural Foods

Zerumbone (ZER) is a naturally occurring dietary compound, present in many natural foods consumed today. The compound derived from several plant species of the Zingiberaceae family that has been found to possess multiple biomedical properties, such as antiproliferative, antioxidant, anti-inflammatory, and anticancer activities. However, evidence of efficacy is sparse, pointing to the need for a more systematic review for assessing scientific evidence to support therapeutic claims made for ZER and to identify future research needs. This review provides an updated overview of in vitro and in vivo investigations of ZER, its cancer chemopreventive properties, and mechanisms of action. Therapeutic effects of ZER were found to be scientifically plausible and could be explained partially by in vivo and in vitro pharmacological activities. Much of the research outlined in this paper will serve as a foundation to explain ZER anticancer bioactivity, which will open the door for the development of strategies in the treatment of malignancies using ZER.

scholarly journals Pharmacognostic Study on Elsholtzia ciliata (Thumb.) Hyl: Anatomy, Phytochemistry and Pharmacological Activities

2021 ◽  
Vol 14 (11) ◽  
pp. 1152
Author(s):  
Qian Zhang ◽  
Niara Moura Porto ◽  
Carolina Carvalho Guilhon ◽  
Thais Biondino Sardella Giorno ◽  
Daniela Sales Alviano ◽  
...  
Keyword(s):  
Quality Control ◽  
Chemical Constituents ◽  
Chemical Compounds ◽  
Anticancer Activities ◽  
Pharmacological Activities ◽  
Elsholtzia Ciliata ◽  
Nmr Techniques ◽  
Phytochemical Profile ◽  
Anti Inflammatory ◽  
Mtt Assays

Elsholtzia ciliata (Thunb.) Hyl, family Lamiaceae, is an important and popular anti-bacterial and anti-inflammatory Traditional Chinese Medicine (TCM). However, there are limited scientific studies on its anatomy and pharmacological activities. Moreover, the information of chemical constituents in relation to its non-volatile constituents are still missing. The current study aimed to evaluate the anatomic, pharmacological and phytochemical profile of Elsholtzia ciliata, providing means for the quality control of this herbal drug. The methodology designed for this study included the preparation of anatomic sections and their description, extraction, chromatography, structural elucidation of isolated compounds by NMR techniques and their quantification by HPLC using pharmacological assays (Formalin, hot plate, DPPH, antimicrobial-Gram positive, Gram Negative and fungus, and MTT assays) to confirm the activities described for this species. Results of the anatomic study are aligned with the pattern expected for plants belonging to the Lamiaceae family; Ursolic acid and Oroxylin were isolated from this plant species. The findings observed in this study indicate that Elsholtzia ciliata possess anti-inflammatory, antinociceptive, antioxidant, antimicrobial and anticancer activities. The chemical compounds isolated from its leaves and the anatomy profile of its parts provide the basis for further quality control for this plant.

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