Neurotoxicity of General Anaesthetics
2019 ◽
pp. 93-110
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This chapter covers the neurotoxicity of general anaesthetics. It discusses how a large body of preclinical evidence shows an association of anaesthetic exposure with neural cell injury and death in the developing brain. Several putative mechanisms have been demonstrated in vitro and in in vivo animal models. Furthermore, these exposures have been associated with impaired behavioural and cognitive development in young animals. Several retrospective human studies of neurocognitive and behavioural disorders following childhood exposure to anaesthesia suggest a similar association, and prospective studies in humans are currently ongoing. The implication of this information on anaesthetic practise remains to be seen.
2005 ◽
Vol 289
(4)
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pp. E562-E569
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2019 ◽
Vol 14
(6)
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pp. 504-518
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2021 ◽
Vol 22
(4)
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pp. 1514
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Keyword(s):
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