ASSOCIATION OF PHYSICAL ACTIVITY AND OTHER LIFESTYLE FACTORS WITH FIBRINOGEN AND FACTOR VII IN ELDERLY MEN 863

SummaryThe association between plasma fibrinogen, factor VII, factor X, activated partial thromboplastin time, antithrombin III and the lifestyle factors cigarette smoking, alcohol use, fat intake and physical activity was assessed in 802 men aged 70-90 years in Zutphen (The Netherlands), Montegiorgio and Crevalcore (Italy).Smoking was positively associated with fibrinogen, also after adjustment for other lifestyle factors, age, use of anticoagulants and aspirin like drugs, body mass index, and history of myocardial infarction. Alcohol use was associated with increased levels of factor X and decreased levels of antithrombin III. Fat intake was positively associated with antithrombin III. Between cohorts, considerable differences were observed in levels of haemostatic parameters and the lifestyle factors. Compared to the mediterranean cohorts the Zutphen cohort showed the highest levels of fibrinogen and factor VII. Differences in lifestyle factors could, however, not explain differences between cohorts in levels of any of the haemostatic parameters, despite the observed associations between lifestyle factors and haemostatic parameters.

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Effects of a 1-Year Physical Activity Intervention on Markers of Hemostasis among Breast Cancer Survivors: A Randomized Controlled Trial

TH Open ◽

10.1055/s-0040-1721782 ◽

2021 ◽

Vol 05 (01) ◽

pp. e14-e23

Author(s):

Siv Kjølsrud Bøhn ◽

Inger Thune ◽

Vidar Gordon Flote ◽

Hanne Frydenberg ◽

Gro Falkenér Bertheussen ◽

...

Keyword(s):

Breast Cancer ◽

Physical Activity ◽

Postmenopausal Women ◽

Cancer Patients ◽

Physical Activity Intervention ◽

Intervention Group ◽

Factor Vii ◽

Breast Cancer Patients ◽

Hemostatic Factors

Abstract Introduction Physical activity may reduce the development of breast cancer. Whereas hypercoagulability has been linked to adverse outcomes in breast cancer patients, the effects of physical activity on their hemostatic factors are unknown. The study aimed to assess whether long-term (1 year) physical activity can affect hemostatic factors in breast cancer patients. Methods Fifty-five women (35–75 years) with invasive breast cancer stage I/II were randomized to a physical activity intervention (n = 29) lasting 1 year or to a control group (n = 26), and analyzed as intention to treat. Fibrinogen, factor VII antigen, tissue factor pathway inhibitor, and von Willebrand factor (VWF) antigen as well as prothrombin fragment 1 + 2, the endogenous thrombin potential and D-dimer, were measured in plasma before intervention (baseline), and then after 6 and 12 months. Results Maximal oxygen uptake (measure of cardiorespiratory fitness) decreased the first 6 months among the controls, but remained stable in the intervention group. We found no significant differences between the two study groups regarding any of the hemostatic factors, except a significantly higher increase in factor VII antigen in the intervention group. The effect of the intervention on VWF was, however, significantly affected by menopausal stage, and a significant effect of the intervention was found on VWF among postmenopausal women, even after adjustment for dietary intake. Conclusion Long-term physical activity had no effect on the majority of the hemostatic factors measured, but led to increased plasma concentrations of factor VII antigen and prevented an increase in VWF concentration after breast cancer treatment in postmenopausal women. The clinical impact of these findings for risk of vascular thrombosis warrants further studies.

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Health and nutrition literacy in adults: Links with lifestyle factors and obesity

Mediterranean Journal of Nutrition and Metabolism ◽

10.3233/mnm-200471 ◽

2020 ◽

Vol 13 (4) ◽

pp. 361-370

Author(s):

Maria Michou ◽

Demosthenes B. Panagiotakos ◽

Christos Lionis ◽

Vassiliki Costarelli

Keyword(s):

Physical Activity ◽

Alcohol Consumption ◽

Linear Regression ◽

Smoking Status ◽

Linear Regression Analysis ◽

Cross Sectional Study ◽

Lifestyle Factors ◽

Linear Regression Models ◽

Chi Square ◽

Cross Sectional

BACKGROUND: Low Health Literacy (HL) and Nutrition Literacy (NL) are associated with serious negative health outcomes. OBJECTIVES: The aim of this study was to investigate certain lifestyle factors and obesity, in relation to HL and NL. METHODS: This cross-sectional study was conducted in the urban area of the Attica region, in Greece. The sample consisted of 1281 individuals, aged ≥18 years. HL, NL sociodemographic characteristics and lifestyle factors (physical activity, smoking status, alcohol consumption,) were assessed. Mann-Whitney U, the Kruskall Wallis, Pearson chi-square tests and multiple linear regression models were used. RESULTS: Linear regression analysis has shown that smoking, alcohol consumption and physical activity, were associated with HL levels (–1.573 points for ex-smokers in comparison to smokers, p = 0.035, –1.349 points for alcohol consumers in comparison to non-consumers, p = 0.006 and 1.544 points for physically active individuals to non-active, p = 0.001). With respect to NL levels, it was also not associated with any of these factors. Obesity was not associated with HL and NL levels. CONCLUSIONS: Certain lifestyle factors, including physical activity, are predicting factors of HL levels, in Greek adults. The results contribute to the understanding of the relationship between lifestyle factors and HL and should be taken into account when HL policies are designed.

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Association Between Changes in Habitual Physical Activity and Changes in Bone Density, Muscle Strength, and Functional Performance in Elderly Men and Women

Journal of the American Geriatrics Society ◽

10.1111/j.1532-5415.2008.02039.x ◽

2008 ◽

Vol 56 (12) ◽

pp. 2252-2260 ◽

Cited By ~ 39

Author(s):

Robin M. Daly ◽

Henrik G. Ahlborg ◽

Karin Ringsberg ◽

Per Gardsell ◽

Ingemar Sernbo ◽

...

Keyword(s):

Physical Activity ◽

Bone Density ◽

Muscle Strength ◽

Functional Performance ◽

Habitual Physical Activity ◽

Elderly Men ◽

Men And Women

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A Scoping Review of Modifiable Risk Factors in Pediatric Onset Multiple Sclerosis: Building for the Future

Children ◽

10.3390/children5110146 ◽

2018 ◽

Vol 5 (11) ◽

pp. 146 ◽

Cited By ~ 2

Author(s):

Julie Pétrin ◽

Max Fiander ◽

Prenitha Doss ◽

E. Yeh

Keyword(s):

Physical Activity ◽

Multiple Sclerosis ◽

Vitamin D ◽

Relapse Rate ◽

Scoping Review ◽

Full Text ◽

Lifestyle Factors ◽

Increased Risk ◽

Modifiable Lifestyle Factors ◽

Pediatric Onset

Knowledge of the effect of modifiable lifestyle factors in the pediatric multiple sclerosis (MS) population is limited. We therefore conducted a scoping review, following the framework provided by Arksey and O’Malley. Four databases were searched for pediatric MS and modifiable lifestyle factors using index terms and keywords, from inception to May 2018. All quantitative and qualitative primary articles were included and limited to English and full text. Of the 7202 articles identified and screened, 25 full-text articles were relevant to our objective and were included. These articles focused on diet obesity, physical activity, and sleep. In cross-sectional analyses, these lifestyle factors were associated with increased risk of pediatric onset MS (POMS), and increased disease activity. Diet, particularly vitamin D and vegetable intake, was associated with reduced relapse rate. Obesity was linked to increased risk of POMS, and physical activity was associated with reduced relapse rate and sleep/rest fatigue. Thus, available studies of lifestyle related outcomes in pediatric MS suggest specific lifestyle related factors, including obesity, higher vitamin D levels, and higher physical activity may associate with lower disease burden in POMS. Studies reviewed are limited by their observational designs. Future studies with longitudinal and experimental designs may further clarify the role of modifiable lifestyle factors in this population.

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Differing Contributions of Classical Risk Factors to Type 2 Diabetes in Multi-Ethnic Malaysian Populations

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph15122813 ◽

2018 ◽

Vol 15 (12) ◽

pp. 2813

Author(s):

Noraidatulakma Abdullah ◽

Nor Abdul Murad ◽

John Attia ◽

Christopher Oldmeadow ◽

Mohd Kamaruddin ◽

...

Keyword(s):

Physical Activity ◽

Risk Factors ◽

Type 2 Diabetes ◽

Family History ◽

Characteristic Curve ◽

Lifestyle Factors ◽

Predictive Utility ◽

Family History Of Diabetes ◽

History Of

The prevalence of type 2 diabetes is escalating rapidly in Asian countries, with the rapid increase likely attributable to a combination of genetic and lifestyle factors. Recent research suggests that common genetic risk variants contribute minimally to the rapidly rising prevalence. Rather, recent changes in dietary patterns and physical activity may be more important. This nested case-control study assessed the association and predictive utility of type 2 diabetes lifestyle risk factors in participants from Malaysia, an understudied Asian population with comparatively high disease prevalence. The study sample comprised 4077 participants from The Malaysian Cohort project and included sub-samples from the three major ancestral groups: Malay (n = 1323), Chinese (n = 1344) and Indian (n = 1410). Association of lifestyle factors with type 2 diabetes was assessed within and across ancestral groups using logistic regression. Predictive utility was quantified and compared between groups using the Area Under the Receiver-Operating Characteristic Curve (AUC). In predictive models including age, gender, waist-to-hip ratio, physical activity, location, family history of diabetes and average sleep duration, the AUC ranged from 0.76 to 0.85 across groups and was significantly higher in Chinese than Malays or Indians, likely reflecting anthropometric differences. This study suggests that obesity, advancing age, a family history of diabetes and living in a rural area are important drivers of the escalating prevalence of type 2 diabetes in Malaysia.

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Physical Activity and Cardiovascular Risk Factors among Elderly Men in Finland, Italy, and The Netherlands

American Journal of Epidemiology ◽

10.1093/oxfordjournals.aje.a008785 ◽

1996 ◽

Vol 143 (6) ◽

pp. 553-561 ◽

Cited By ~ 58

Author(s):

F. C. H. Bijnen ◽

E. J. M. Feskens ◽

C. J. Caspersen ◽

S. Giampaoli ◽

A. M. Nissinen ◽

...

Keyword(s):

Physical Activity ◽

Risk Factors ◽

Cardiovascular Risk ◽

The Netherlands ◽

Cardiovascular Risk Factors ◽

Elderly Men

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Changes in Objectively Measured Lifestyle Factors During the COVID-19 Pandemic in Community-Dwelling Older Adults

10.21203/rs.3.rs-847301/v1 ◽

2021 ◽

Author(s):

Takuya Ataka ◽

Noriyuki Kimura ◽

Atsuko Eguchi ◽

Etsuro Matsubara

Keyword(s):

Physical Activity ◽

Older Adults ◽

Sedentary Time ◽

Vigorous Physical Activity ◽

Wearable Sensors ◽

Lifestyle Factors ◽

Community Dwelling ◽

Activity Level ◽

Objectively Measured ◽

Community Dwelling Older Adults

Abstract Background: In this manuscript, we aimed at investigating whether objectively measured lifestyle factors, including walking steps, sedentary time, amount of unforced physical activity, level of slight and energetic physical activity, conversation time, and sleep parameters altered before and during the COVID-19 pandemic among community-dwelling older adults.Methods: Data were obtained from a prospective cohort study conducted from 2015 to 2019 and a subsequent dementia prevention study undertaken in September 2020. Community-dwelling adults aged ≥65 years wore wearable sensors before and during the pandemic.Results: A total of 56 adults were enrolled in this study. The mean age was 74.2±3.9 years, and 58.9% (n=33) of the participants were female. The moderate and vigorous physical activity time significantly decreased and sedentary time significantly increased during the pandemic. Conclusions: This is the first study to demonstrate differences in objectively assessed lifestyle factors before and during the COVID-19 pandemic among community-dwelling older adults. The findings show that the pandemic has adversely affected physical activity among older adults living on their own in Japan.

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App Technology to Support Physical Activity and Intake of Vitamins and Minerals After Bariatric Surgery (the PromMera Study): Protocol of a Randomized Controlled Clinical Trial (Preprint)

10.2196/preprints.19624 ◽

2020 ◽

Author(s):

Stephanie Erika Bonn ◽

Mari Hult ◽

Kristina Spetz ◽

Marie Löf ◽

Ellen Andersson ◽

...

Keyword(s):

Physical Activity ◽

Bariatric Surgery ◽

Controlled Trial ◽

Intervention Group ◽

Study Participant ◽

Lifestyle Factors ◽

Lifestyle Changes ◽

Control Group ◽

Controlled Clinical Trial ◽

Randomized Controlled

BACKGROUND To optimize postoperative outcomes after bariatric surgery, lifestyle changes including increased physical activity are needed. Micronutrient deficiency after surgery is also common and daily supplementation is recommended. OBJECTIVE The aim of the PromMera study is to evaluate the effects of a 12-week smartphone app intervention on promotion of physical activity (primary outcome) and adherence to postsurgery vitamin and mineral supplementation, as well as on other lifestyle factors and overall health in patients undergoing bariatric surgery. METHODS The PromMera study is a two-arm, randomized controlled trial comprising patients undergoing bariatric surgery. Participants are randomized postsurgery 1:1 to either the intervention group (ie, use of the PromMera app for 12 weeks) or the control group receiving only standard care. Clinical and lifestyle variables are assessed pre- and postsurgery after 18 weeks (postintervention assessment), 6 months, 1 year, and 2 years. Assessments include body composition using Tanita or BOD POD analyzers, muscle function using handgrip, biomarkers in blood, and an extensive questionnaire on lifestyle factors. Physical activity is objectively measured using the ActiGraph wGT3X-BT triaxial accelerometer. RESULTS A total of 154 participants have been enrolled in the study. The last study participant was recruited in May 2019. Data collection will be complete in May 2021. CONCLUSIONS Implementing lifestyle changes are crucial after bariatric surgery and new ways to reach patients and support such changes are needed. An app-based intervention is easily delivered at any time and can be a key factor in the adoption of healthier behavioral patterns in this rapidly growing group of patients. CLINICALTRIAL ClinicalTrials.gov NCT03480464; https://clinicaltrials.gov/ct2/show/NCT03480464 INTERNATIONAL REGISTERED REPORT DERR1-10.2196/19624

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607Longitudinal weight gain and lifestyle factors in women with and without polycystic ovary syndrome

International Journal of Epidemiology ◽

10.1093/ije/dyab168.046 ◽

2021 ◽

Vol 50 (Supplement_1) ◽

Author(s):

Mamaru Ayenew Awoke ◽

Arul Earnest ◽

Anju Joham ◽

Allison Hodge ◽

Wendy Brown ◽

...

Keyword(s):

Physical Activity ◽

Weight Gain ◽

Polycystic Ovary Syndrome ◽

Energy Intake ◽

Glycemic Index ◽

Weight Change ◽

Polycystic Ovary ◽

Lifestyle Factors ◽

Sitting Time ◽

Ovary Syndrome

Abstract Background Women with polycystic ovary syndrome (PCOS) have a higher prevalence of overweight/obesity and greater weight gain than women without PCOS. The association of lifestyle factors with weight change in PCOS is not known. Methods We used data from the 1973-78 birth cohort of the Australian Longitudinal Study on Women’s Health collected from seven surveys over 19 years (N = 14127 survey 1). Linear mixed-effects models were used to examine associations between diet, physical activity, and sitting time with weight change, after adjustment for socio-demographics, psychological factors, and health care utilisation. Results Women with PCOS gained more weight annually (0·26 kg/year, 95% CI 0·13, 0·39; P < 0·0001) and over 19 years (4·75 kg; 95% CI 3·17, 6·34; P < 0·0001) than women without PCOS (adjusted analyses). For all women, there were positive associations between weight gain and energy intake, sitting time, and stress; inverse associations with fibre intake and physical activity; and no associations with diet quality, glycemic index, healthcare utilization, depression, or anxiety. There were interactions between lifestyle factors (energy intake P = 0·006, glycemic index P = 0·007, sitting time P = 0·029, and physical activity P = 0·022), PCOS status and time (age) such that weight gain varied between women with and without PCOS according to these factors. Conclusions Women with PCOS had a higher rate of weight gain than women without PCOS. This was most marked in those with indicators of unhealthy lifestyles. Increased stress, energy intake and sitting time and lower physical activity contributed to weight gain in women with and without PCOS. Key messages The findings reinforce the importance of early and ongoing lifestyle intervention and the potential use of specific lifestyle factors for weight gain prevention and management in PCOS.

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