Sven Otto Hörstadius. 18 February 1898 — 16 June 1996

2000 ◽  
Vol 46 ◽  
pp. 243-256 ◽  
Author(s):  
C.-O. Jacobson

During the past few decades, developmental biology has become one of the most exciting areas of science. This is largely a result of the rapidly growing knowledge of molecular biology, partly resulting from the achievements of earlier generations of embryologists. One of the men of special importance among the embryologists of the twentieth century was Sven Hörstadius. Most of the content in today's biology textbooks describes results from the post – Watson–Crick era. However, few texts exclude figures and facts from Sven Hörstadius's dissertation of exactly seventy years ago. His experiments on sea urchin larvae shed light on a couple of the most central findings in developmental biology, namely that the uneven distribution of the egg–cell contents gives rise to early embryo cells with shifting qualities, and that communication between these cells has an essential role in the differentiation process. In the same way, his achievements on the neural crest and its impact on head development in vertebrates have been of lasting importance.

2019 ◽  
Author(s):  
Di Fu ◽  
Cornelius Weber ◽  
Guochun Yang ◽  
Matthias Kerzel ◽  
Weizhi Nan ◽  
...  

Selective attention plays an essential role in information acquisition and utilizationfrom the environment. In the past 50 years, research on selective attention has beena central topic in cognitive science. Compared with unimodal studies, crossmodalstudies are more complex but necessary to solve real-world challenges in both humanexperiments and computational modeling. Although an increasing number of findingson crossmodal selective attention have shed light on humans’ behavioral patterns andneural underpinnings, a much better understanding is still necessary to yield the samebenefit for intelligent computational agents. This article reviews studies of selectiveattention in unimodal visual and auditory and crossmodal audiovisual setups from themultidisciplinary perspectives of psychology and cognitive neuroscience, and evaluatesdifferent ways to simulate analogous mechanisms in computational models and robotics.We discuss the gaps between these fields in this interdisciplinary review and provideinsights about how to use psychological findings and theories in artificial intelligence fromdifferent perspectives.


Author(s):  
Charles Roddie

When interacting with others, it is often important for you to know what they have done in similar situations in the past: to know their reputation. One reason is that their past behavior may be a guide to their future behavior. A second reason is that their past behavior may have qualified them for reward and cooperation, or for punishment and revenge. The fact that you respond positively or negatively to the reputation of others then generates incentives for them to maintain good reputations. This article surveys the game theory literature which analyses the mechanisms and incentives involved in reputation. It also discusses how experiments have shed light on strategic behavior involved in maintaining reputations, and the adequacy of unreliable and third party information (gossip) for maintaining incentives for cooperation.


Vaccines ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 535
Author(s):  
Ban Qi Tay ◽  
Quentin Wright ◽  
Rahul Ladwa ◽  
Christopher Perry ◽  
Graham Leggatt ◽  
...  

The development of cancer vaccines has been intensively pursued over the past 50 years with modest success. However, recent advancements in the fields of genetics, molecular biology, biochemistry, and immunology have renewed interest in these immunotherapies and allowed the development of promising cancer vaccine candidates. Numerous clinical trials testing the response evoked by tumour antigens, differing in origin and nature, have shed light on the desirable target characteristics capable of inducing strong tumour-specific non-toxic responses with increased potential to bring clinical benefit to patients. Novel delivery methods, ranging from a patient’s autologous dendritic cells to liposome nanoparticles, have exponentially increased the abundance and exposure of the antigenic payloads. Furthermore, growing knowledge of the mechanisms by which tumours evade the immune response has led to new approaches to reverse these roadblocks and to re-invigorate previously suppressed anti-tumour surveillance. The use of new drugs in combination with antigen-based therapies is highly targeted and may represent the future of cancer vaccines. In this review, we address the main antigens and delivery methods used to develop cancer vaccines, their clinical outcomes, and the new directions that the vaccine immunotherapy field is taking.


2017 ◽  
Vol 4 (4) ◽  
pp. 205316801773975 ◽  
Author(s):  
Meagan Smith ◽  
Sean M. Zeigler

Was 9/11 the opening salvo in a new age of terrorism? Some argue that this act ushered in a more chaotic world. Others contend an increased focus on terrorism in the past 15 years is the result of conflating terrorist activity with insurgency. We shed light on these claims by analyzing data on domestic and transnational terrorist incidence from 1989 to 2014. The evidence suggests that the years since 9/11 have been different from those preceding them. Once the prevalence of conflicts is accounted for, the post-9/11 era is a significantly less terror prone period than the years before it. A country not suffering civil conflict was upwards of 60 percent more likely to experience terrorism prior to or during the year 2001 than since. However, the opposite trend holds for those countries with a higher proportion of Muslims. Prior to 2001, countries with higher Muslim populations experienced less domestic terrorism. Since 9/11, these countries have experienced significantly more terrorism – both domestic and international – than they had previously.


2017 ◽  
Vol 24 (5) ◽  
pp. 323-337 ◽  
Author(s):  
Carolyn Ellis ◽  
Jerry Rawicki

This article extends the research of Jerry Rawicki and Carolyn Ellis who have collaborated for more than eight years on memories and consequences of the Holocaust. Focusing on Jerry’s memories of his experience during the Holocaust, they present dialogues that took place during five recorded interviews and follow-up conversations that reflect on the similarity of Hitler’s seizing of power in the 1930s to the meteoric rise of Donald Trump. Noting how issues of class and race were taking an increasingly prominent role in their conversations and collaborative writing, they also begin to examine discontent in the rural, White working class and Carolyn’s socialization within that community. These dialogues and reflections seek to shed light on the current political climate in America as Carolyn and Jerry struggle to cope with their fears and envision a hopeful path forward for their country.


KronoScope ◽  
2021 ◽  
Vol 21 (1) ◽  
pp. 7-27
Author(s):  
Carl Humphries

Abstract “Being is said in many ways,” claimed Aristotle, initiating a discussion about existential commitment that continues today. Might there not be reasons to say something similar about “having been,” or “having happened,” where these expressions denote something’s being located in the past? Moreover, if history – construed not only as an object of inquiry (actual events, etc.) but also as a way of casting light on certain matters – is primarily concerned with “things past,” then the question just posed also seems relevant to the question of what historical understanding amounts to. While the idea that ‘being’ may mean different things in different contexts has indisputable importance, the implications of other, past-temporal expressions are elusive. In what might any differences of substantive meaning encountered there consist? One starting point for responding – the one that provides the subject matter explored here – is furnished by the question of whether or not a certain way of addressing matters relating to the past permits or precludes forms of intelligibility that could be said to be ‘radically historical.’ After arguing that the existing options for addressing this issue remain unsatisfactory, I set out an alternative view of what it could mean to endorse or reject such an idea. This involves drawing distinctions and analogies connected with notions of temporal situatedness, human practicality and historicality, which are then linked to a further contrast between two ways of understanding the referential significance of what is involved when we self-ascribe a relation to a current situation in a manner construable as implying that we take ourselves to occupy a unique, yet circumstantially defined, perspective on that situation. As regards the latter, on one reading, the specific kind of indexically referring language we use – commonly labelled “de se” – is something whose rationale is exhausted by its practical utility as a communicative tool. On the other, it is viewed as capturing something of substantive importance about how we can be thought of as standing in relation to reality. I claim that this second reading, together with the line of thinking about self-identification and self-reference it helps foreground, can shed light on what it would mean to affirm or deny the possibility of radically historical forms of intelligibility – and thus also on what it could mean to ascribe a plurality of meanings to talk concerning things being ‘in the past.’


2015 ◽  
Vol 51 ◽  
pp. 302-321
Author(s):  
Marion Bowman

This essay focuses upon a significant place, Glastonbury, at an important time during the early twentieth century, in order to shed light on a particular aspect of Christianity which is frequently overlooked: its internal plurality. This is not simply denominational diversity, but the considerable heterogeneity which exists at both institutional and individual level within denominations, and which often escapes articulation, awareness or comment. This is significant because failure to apprehend a more detailed, granular picture of religion can lead to an incomplete view of events in the past and, by extension, a partial understanding of later phenomena. This essay argues that by using the concept of vernacular religion a more nuanced picture of religion as it is – or has been – lived can be achieved.


2016 ◽  
Vol 6 (1) ◽  
pp. 37
Author(s):  
Jamal Subhi Ismail Nafi’

<p>This article is an attempt to explore the inclusion and the use of superstitious elements in Mark Twain’s novel <em>The Adventures of Huckleberry Finn</em> (1884) and Shakespeare’s play <em>Macbeth</em> (1611). Superstition involves a deep belief in the magic and the occult, to almost to an extent of obsession, which is contrary to realism. Through the analytical and psychological approaches, this paper tries to shed light on Twain’s and Shakespeare’s use of supernaturalism in their respective stories, and the extent the main characters are influenced by it. A glance at both stories reveals that characters are highly affected by superstitions, more than they are influenced by their religious beliefs, or other social factors and values. The researcher also tries to explore the role played by superstition, represented by fate and the supernatural in determining the course of actions characters undertake in both dramas. The paper concluded that the people who lived in the past were superstitious to an extent of letting magic, omens; signs, etc. affect and determine their lives; actions and future decisions. They determine their destiny and make it very difficult for them to avoid it, alter it or think rationally and independently. And that, man’s actions are not isolated, but closely connected to the various forces operating in the universe.</p>


2020 ◽  
Vol 3 (1) ◽  
pp. 64
Author(s):  
Alket Aliu

It is of special importance to differentiate between the original Albanian language used orally by the Albanian highlanders reciting by heart the articles of the Codex “Kanun” and the Albanian language used by the staff who recorded the highlanders’ reciting, as well as the language used by the editors, who edited the book before it was forwarded for printing. Our study pays special attention to the abilities and capabilities of the recorder of “Kanun”, who was a renowned intellectual. He possessed all round knowledge of jurisprudence in general and the traditional law “Kanun” in particular because he was not only ordained a catholic priest but he was a law graduated as well. At the same time father Gjeçovi was a well known ethnographer, historian and archeologist. Our study aims at analyzing the material (stuff) recorded by father Gjeçovi focusing on some “artificial” out of place elements cropping up in such a material. Such elements are due to the double functioning of him as the recorder of the oral traditional law “Kanun”, but also as an editor of the recorded material. These recorded material of the traditional law is studied by us not simply as something frozen in that moment of time when Gjeçovi recorded them, but also as they evolved up to nowadays trying to shed light upon their “roots” in the framework of the linguistic usage.


2012 ◽  
Vol 6 (2) ◽  
pp. 129
Author(s):  
Yi Ying

Chinese time adverbs describe status of behavior, modal frequency, or that the behavior has occurred, occurred in the past, present or future. When describe a time, it usually emphasizes the meaning. Indonesian time adverbs describe an event or action occurred at a time. It indicates the status of behavior, modal or indicates whether the conduct has occurred, has not happened, will happen, repeat and describe the act or thing is not yet completed. This study attempts to shed light on why students incline to make mistake in using Chinese time adverbs. Furthermore, students face difficulty in differentiating between Chinese and Indonesian time adverbs. Chinese Indonesia have the similar meaning of time adverb, such as: gang, yijing, cengjing, zhengzai, jiang, hai, mashang but function in a sentence not exactly same.


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