scholarly journals Epidemiological profiles and associated risk factors of SARS-CoV-2 positive patients based on a high-throughput testing facility in India

Open Biology ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 200288
Author(s):  
Sumit Malhotra ◽  
Manju Rahi ◽  
Payal Das ◽  
Rini Chaturvedi ◽  
Jyoti Chhibber-Goel ◽  
...  
Keyword(s):  
Risk Factors ◽  
High Throughput ◽  
National Level ◽  
International Travel ◽  
Disease Spread ◽  
Multivariable Logistic Regression Analysis ◽  
Risk Behaviours ◽  
Co Morbidity ◽  
Associated Risk Factors ◽  
Epidemiological Characteristics

We describe the epidemiological characteristics and associated risk factors of those presenting at a large testing centre for SARS-CoV-2 infection. This is a retrospective record review of individuals who underwent SARS-CoV-2 testing by reverse transcription–polymerase chain reaction (RT-PCR) at a high-throughput national-level government facility located in the north of India. Samples collected from 6 April to 31 December 2020 are included in this work and represent four highly populous regions. Additionally, there was a prospective follow-up of 1729 cases through telephone interviews from 25 May 2020 to 20 June 2020. Descriptive analysis has been performed for profiling clinic-epidemiological aspects of suspect cases. Multivariable logistic regression analysis was undertaken to determine risk factors that are associated with SARS-CoV-2 test positivity and symptom status. A total of 125 600 participants' details have been included in this report. The mean (s.d.) age of the participants was 33.1 (±15.3) years and 66% were male. Among these tested, 9515 (7.6%) were positive for COVID-19. A large proportion of positive cases were asymptomatic. In symptomatic positive cases, the commonest symptoms were cough and fever. Increasing age (groups 20–59 and ≥60 years compared to age group less than 5 years), male sex, history of international travel, symptoms for SARS-CoV-2, and participants from Delhi and Madhya Pradesh were positively associated with SARS-CoV-2 test positivity. Having co-morbidity, risk behaviours and intra-familial positivity were associated with a positive odds ratio for exhibiting SARS-CoV-2 symptoms. Intensified testing and isolation of cases, identification of both asymptomatic and symptomatic individuals and additional care of those with co-morbidities and risk behaviours will all be collectively important for disease containment in India. Reasons for differentials in testing between men and women remain an important area for in-depth study. The increased deployment of vaccines is likely to impact the trajectory of COVID-19 in the coming time, and therefore our data will serve as a comparative resource as India experiences the second wave of infection in light of newer variants that are likely to accelerate disease spread.

scholarly journals PREVALENCE OF BOVINE FACIOLOSIS IN HALABA MUNICIPAL ABATTOR SOUTHERN ETHIOPIA

2016 ◽  
Vol 4 (11) ◽  
pp. 82-91
Author(s):  
Muna Abdella ◽  
WubitTafese Mhatebu
Keyword(s):  
Risk Factors ◽  
Body Condition ◽  
Cross Sectional Study ◽  
Control Measures ◽  
Southern Ethiopia ◽  
Multivariable Logistic Regression Analysis ◽  
Cross Sectional ◽  
Significant Difference ◽  
Prevention And Control Measures ◽  
Associated Risk Factors

A cross-sectional study was carried out from November 2015 to march 2016 on bovine fasciolosis, to assess the abattoir based prevalence, predominant species of bovine fasciolosis and associated risk factors of the disease in cattle slaughtered in Halaba municipal abattoir. A total of 384 cattle were examined using post mortem examination. Infection rates were (3.64%), 2.34%, 2.08%, and 1.82 % F. gigantic, F. hepatica, mixed and immature respectively with the overall prevalence of 9.88 % (38). F. gigantic was found to be the most prevalent species in cattle of the study area. Multivariable logistic regression analysis showed that the risk of fasciola infection was significantly higher in poor body condition animals than in medium and good body condition animals (p < 0.05). However, in terms of age, sex and breed, no statistically significant difference was found between infected animals (p > 0.05).The present study showed that bovine fasciolosis is one of the important pathogens in cattle in the study area and warrants appropriate disease prevention and control measures and further epidemiological investigations to determine the different agro ecological risk factors on the occurrence of the disease.

scholarly journals Seroprevalence and Risk Factors Associated with Contagious Caprine Pleuropneumonia in Western Amhara, Northwest Ethiopia

2019 ◽  
Vol 2019 ◽  
pp. 1-7
Author(s):  
Askale Abrhaley ◽  
Mebrat Ejo ◽  
Tsegaw Fentie
Keyword(s):  
Risk Factors ◽  
Cross Sectional Study ◽  
Northwest Ethiopia ◽  
Control Measures ◽  
Enzyme Linked Immunosorbent Assay ◽  
Multivariable Logistic Regression Analysis ◽  
High Seroprevalence ◽  
Cross Sectional ◽  
Contagious Caprine Pleuropneumonia ◽  
Associated Risk Factors

Contagious caprine pleuropneumonia (CCPP) has been identified as a significant problem in goat production, especially in the arid and semiarid lowland areas of Ethiopia. Even though CCPP was reported in most of the goat rearing areas of the country, there is no adequate information on the disease in the Amhara Region. Cross-sectional study was conducted from November 2016 to April 2017 in the districts of Western Amhara to estimate the seroprevalence and identify the associated risk factors for occurrence of the CCPP. The risk factors considered included age, sex, agroclimate, and districts. A competitive enzyme-linked immunosorbent assay (cELISA) was carried out on a total of 400 goat sera samples, out of which 34 samples were found seropositive for specific antibodies against CCPP, with the overall seroprevalence of 8.5% (95% confidence interval (CI) =5.8, 11.2). Among the epidemiological factors considered, age and sex of the goats were not significantly associated with CCPP seroprevalence (p>0.05). However, the seropositivity was slightly higher in adults (9.9%) and female goats (9.0%) compared to young (6.3%) and male (7.5%) goats, respectively. The analysis of seroprevalence by district shows that the seroprevalence of CCPP in Metema (OR=14.34; 95%CI= 1.80, 114.09; p=0.012) and Fogera (OR=9.99; 95%CI= 1.10, 91.16; p= 0.041) was significantly higher compared to other study districts. Multivariable logistic regression analysis also identified the district as a risk factor for the occurrence of a high seroprevalence of CCPP. The present study revealed the seroprevalence and the distribution of CCPP in Western Amhara districts, and hence appropriate control measures including regular investigation and vaccination should be implemented to alleviate the problem.

scholarly journals Epidemiological study of osteonecrosis of the femoral head using the national registry of designated intractable diseases in Japan

2021 ◽  
Author(s):  
Ryuichi Sato ◽  
Wataru Ando ◽  
Wakaba Fukushima ◽  
Takashi Sakai ◽  
Hidetoshi Hamada ◽  
...  
Keyword(s):  
Risk Factors ◽  
Femoral Head ◽  
Sampling Bias ◽  
National Registry ◽  
Similar Distribution ◽  
Public Subsidies ◽  
Gender And Age ◽  
Associated Risk Factors ◽  
Epidemiological Characteristics ◽  
Incident Cases

ABSTRACT Objectives We aimed to investigate the epidemiological characteristics of osteonecrosis of the femoral head (ONFH) using the designated intractable diseases (DID) database in Japan. Methods Data on patients who had received public subsidies for medical costs due to ONFH from 2012 to 2013 were extracted from the DID database. The incidence and prevalence of ONFH, distribution of gender, age, and the prevalence of associated risk factors were assessed. These epidemiological characteristics were compared with those of another nationwide ONFH survey conducted during a similar period. Results Data on 3264 newly diagnosed patients (incident cases) and 20,042 patients registered until 2013 (prevalent cases) were evaluated. The corrected annual incidence and prevalence of ONFH per 100,000 were 3.0 and 18.2–19.2, respectively. The ratio of males to females was 1.4 in 2012 and 1.2 in 2013, respectively. Peak distribution was observed at ages 40s and 60s in males and females, respectively. The prevalence of the risk factors were steroid-associated: 39%, alcohol-associated: 30%, both: 4%, and none: 27%. Conclusions The DID database data showed a similar distribution of gender and age to that in other nationwide surveys but lower incidence and prevalence of ONFH. Sampling bias may affect the epidemiological characteristics of ONFH.

scholarly journals Otorhinolaryngological myiasis: the problem and its presentations in the weak and forgotten

2020 ◽  
Vol 54 (3) ◽  
pp. 173-178
Author(s):  
Amit Rana ◽  
Rohit Sharma ◽  
Vinit Sharma ◽  
Ashish Mehrotra ◽  
Rachana Singh
Keyword(s):  
Risk Factors ◽  
Health Care Professionals ◽  
Clinical Findings ◽  
International Travel ◽  
Humid Climate ◽  
Tropical Regions ◽  
Associated Risk Factors ◽  
Nasal Myiasis ◽  
Head Neck ◽  
Chrysomya Bezziana

Introduction: Myiasis is common in tropical regions, but now increasing incidence is seen in the west due to international travel. Otorhinolaryngological myiasis is uncommon and is seen in diabetics, alcoholics or patients unable in self-care.Objectives: To study presentations of otorhinolaryngological myiasis, identify associated risk factors and species of flies causing myiasis.Methods: Clinical findings and co-morbidities of 67 myiasis cases were noted. Maggots were identified, manually removed, and patients were managed with topical treatment, systemic ivermectin and antibiotics.Findings: Thirty-three nasal myiasis, 13 aural myiasis and 5 patients with oral myiasis were noted. Seven patients with head neck wounds myiasis and nine patients of tracheostome myiasis were recorded.Discussion: Warm humid climate of tropical regions is a major concern along with co-existing conditions like poor sanitation, alcoholism, psychiatric diseases and neuropathies. Hesitancy is seen in attendants and health care professionals to deal with myiasis.Conclusion: Awareness about risk factors is important in avoiding myiasis along with prompt treatment which reduces morbidity. Tracheostome myiasis is an under-documented entity rather than a rare presentation.Keywords: Myiasis, Ivermectin, screwworm, Chrysomya bezziana, Musca domestica, Lucilia sericata.Funding: None

scholarly journals Geographical distribution of the associated factors of osteonecrosis of the femoral head, using the designated intractable disease database in Japan

2021 ◽  
Author(s):  
Wataru Ando ◽  
Masaki Takao ◽  
Tetsuro Tani ◽  
Keisuke Uemura ◽  
Hidetoshi Hamada ◽  
...  
Keyword(s):  
Risk Factors ◽  
Femoral Head ◽  
Age Distribution ◽  
Female Ratio ◽  
Registry System ◽  
Registration Rate ◽  
The Mean ◽  
Associated Risk Factors ◽  
Epidemiological Characteristics ◽  
Male To Female

ABSTRACT Objectives Osteonecrosis of the femoral head (ONFH) is a designated intractable disease (DID) in Japan. The Ministry of Health, Labour, and Welfare launched an online registry system for DIDs. We aimed to investigate the epidemiological characteristics of patients with ONFH using the DID database. Methods Data of patients with ONFH registered in the DID database between January 2004 and December 2013 were extracted. The incidence of new cases and distributions of sex, age, and associated risk factors were investigated. The prevalence of the two categories, ‘steroid-associated’ and ‘alcohol-associated’ risk factors, was estimated for each prefecture. Results New 15,049 cases of ONFH were investigated. The mean registration rate-corrected annual ONFH incidence per 100,000 individuals was 1.77. The male-to-female ratio was 1.33. Age distribution peaked in the 40s and 50s for male and 60s for female. The prevalence of steroid-associated ONFH was lower in males (28.6%) than in females (49.8%), while that of alcohol-associated ONFH was higher in males (47.2%) than in females (9.3%). No clear region was identified for the steroids. The incidence of alcohol-associated ONFH was significantly higher in Tokyo and Okinawa, regardless of sex. Conclusions Alcohol-associated ONFH incidence varies geographically across Japan, suggesting that it has regional characteristics.

scholarly journals Analysis of the complications in patients undergoing an invasive mechanical ventilation program

2020 ◽  
pp. 151-157
Author(s):  
J. Gómez-de-Oña ◽  
C. De-la-Hoz-García ◽  
N. Utrilla-Cid ◽  
A. Cárdenas-Cruz
Keyword(s):  
Risk Factors ◽  
Mechanical Ventilation ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Invasive Mechanical Ventilation ◽  
Point Of View ◽  
Refractory Hypoxemia ◽  
Study Population ◽  
Associated Risk Factors ◽  
Epidemiological Characteristics

Objective: To analyze, from a qualitative and quantitative point of view, the different complications directly related to critically ill patients under invasive mechanical ventilation (IMV) as well as the main associated risk factors. Material and methods: It is a descriptive longitudinal study, which has as study population all patients under IMV program in the Intensive Medicine Unit (UMI) of Poniente Hospital in Almería throughout 2019, regardless of the cause that conditioned the use of this therapeutic resource. Results: 76% of patients were male. The mean age was 55.12 years. Cardiovascular risk factors were the most frequent (64.63%), followed by toxic habits (31%) and respiratory and infectious diseases (17.07% each) needing mechanical ventilation. The duration of the IMV was highly variable, its average was 8.63 days (51% less than 3 days). The most frequent complications found were adult respiratory distress syndrome (ARDS) and refractory hypoxemia (10.98% each). Conclusion: patients under IMV in the ICU of Poniente Hospital do not have a higher complication rate than those reported by other published series. ARDS and refractory hypoxemia are the main complications associated with IMV. Cardiovascular risk factors (CVRF) were the most frequent antecedents. The differences found with other series can be explained by differences in the methodology used to carry out the different studies and in the epidemiological characteristics of the studied population.

Clinical Factors Contributing to Anastomotic Leak After Mid-to-High Colorectal Anastomosis

2021 ◽  
pp. 000313482110415
Author(s):  
Amandeep Ghuman ◽  
Ramarao Ganga ◽  
Natalia Parisi Severino ◽  
Dimitri Krizzuk ◽  
Qiong Zhen Li ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Anastomotic Leak ◽  
Statistical Significance ◽  
Anal Verge ◽  
Colorectal Anastomosis ◽  
Multivariable Logistic Regression Analysis ◽  
Air Leak ◽  
Colorectal Anastomoses ◽  
Associated Risk Factors

Background Low colorectal anastomoses carry a high anastomotic leak (AL) rate (up to 20%) and thus are commonly diverted. Much less is known about mid-to-high colorectal anastomosis, which carries a leak rate of 2-4%. The objective of this study was to determine our AL rate after mid-to-high colorectal anastomosis and associated risk factors. Methods A single center retrospective cohort study of patients undergoing left colonic resections with mid-to-high colorectal anastomosis (≥7 cm from the anal verge) from January 2008 to October 2017 was utilized. Main outcome, AL, defined as clinical suspicion supported by radiological or intraoperative findings, was calculated and risk factors assessed using multivariable logistic regression analysis. Results 977 patients were included; 487 (49.9%) were male, with a mean age of 59.8 (+/−12.1) years. Mean BMI was 27.5 (+/−5.5) kg/m2. Diverticular disease (67.5%), malignancy (17.4%), and inflammatory bowel disease (2.2%) were the main indications for resection. Mean length of stay was 6.7 (+/−4.5) days. 455 (46.8%) colonic resections were performed by laparoscopy, 283 (29.1%) by hand assisted surgery, 219 (22.5%) by laparotomy, and 16 (1.6%) by robotics. Majority of patients had complete donuts (99.6%) and a negative air leak test (97.7%). 149 patients (15.3%) underwent construction of a diverting stoma. The overall AL rate was 2.1% (n = 20). Increased BMI (>30 kg/m2), P = .02, was an independent risk factor for AL and a trend observed for positive air leak tests ( P = .05), with other factors failing to achieve statistical significance. Conclusions Patients with mid-to-high colorectal anastomosis have a 2% AL risk. Increased BMI was a risk factor for AL.

Long term peripheral neuropathy symptoms in breast cancer survivors.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e21599-e21599
Author(s):  
Moaath Khader Mustafa Ali ◽  
Machelle Moeller ◽  
Lisa A. Rybicki ◽  
Halle C. F. Moore
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Peripheral Neuropathy ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Multivariable Analysis ◽  
Multivariable Logistic Regression Analysis ◽  
Patient Reported ◽  
Associated Risk Factors

e21599 Background: Peripheral neuropathy (PN) is a common complication from chemotherapy (CTX), associated with significant morbidity, and may improve with time. The prevalence of long-term PN symptoms in breast cancer survivors is not well known. We sought to explore PN symptoms and associated risk factors among breast cancer survivors at least 2 years out from diagnosis. Methods: We performed a cross-sectional retrospective study investigating the prevalence of patient-reported numbness/tingling symptoms as a surrogate for PN in breast cancer survivors at our institution. We included patients with stage 0-III breast cancer who completed a questionnaire about symptoms and life-style habits at a survivorship visit that occurred 2 or more years after initial diagnosis. We evaluated the prevalence of PN and associated risk factors using univariable and multivariable logistic regression analysis; results are shown as odds ratio (OR) and 95% confidence interval (CI). Results: 605 patients assessed between April 2009 and October 2016 met eligibility for analysis. Median age was 60 (31-93) years. Median number of years from diagnosis to assessment was 6.3 (2-21). All patients had surgery and 62% had CTX. Twenty-seven percent reported PN. On univariable analysis, obesity, stage II & III, mastectomy, PN before diagnosis, and receipt of taxane CTX were associated with PN (all p < 0.05). Patients who were older, exercised before diagnosis, had ER/PR-positive disease and who received endocrine therapy reported less PN (all p < 0.05). On multivariable analysis, only receipt of docetaxel (OR: 2.18, CI: 1.22- 3.88) or paclitaxel (OR: 4.07, CI: 2.54-6.50) and reporting PN symptoms before diagnosis (OR: 3.28, CI: 1.49-7.21) were associated with PN. Among patients without pre-existing PN symptoms, 15%, 19%, 28% and 43% reported long-term PN after no CTX, non-taxane CTX, docetaxel CTX and paclitaxel CTX respectively. Conclusions: At a median follow-up of 6.3 years from diagnosis, 28% of survivors in our cohort who had received docetaxel and 43% who had received paclitaxel report long-term PN symptoms compared with 15-19% in those who received no or non-taxane CTX. These data can help inform patients and clinicians regarding long-term PN risk following CTX.

Role of gut microbiota in travel-related acquisition of extended spectrum β-lactamase-producing Enterobacteriaceae

2021 ◽  
Author(s):  
Ye Peng ◽  
Suisha Liang ◽  
Kanchana Poonsuk ◽  
Hilda On ◽  
Sze Wang Li ◽  
...  
Keyword(s):  
Risk Factors ◽  
Random Forest ◽  
Gut Microbiota ◽  
Area Under The Curve ◽  
International Travel ◽  
Resistant Bacteria ◽  
Extended Spectrum ◽  
Related Risk ◽  
Associated Risk Factors

Abstract Background International travel could facilitate the spread of antimicrobial-resistant bacteria including extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E). Previous studies, which attempted to understand the role of gut microbiota in the acquisition of antimicrobial resistant bacteria during international travels, are limited to western travelers. Methods We established a prospective cohort of 90 Hong Kong travelers to investigate gut microbiota determinants and associated risk factors for the acquisition of ESBL-E. Baseline characteristics and travel-associated risk factors were gathered through questionnaires. Fecal samples were collected in 3–4 days before and after travel. Antimicrobial susceptibility of ESBL-E isolates was tested, and gut microbiota were profiled by 16S rDNA amplicon sequencing. Non-parametric tests were used to detect potential associations, and logistic regression models were used to quantify the associations. Random forest models were constructed to identify microbial predictors for ESBL-E acquisition. Results 49 (54.4%) participants were tested negative for ESBL-E colonization before travel and were followed up after travel. A total of 60 ESBL-E isolates were cultured from 20 (40.8%) participants. Having low Actinobacteria richness and low abundance of short-chain fatty acid-producing bacteria in the gut microbiota before travel increased the risk of acquiring ESBL-E and the risk can be further exacerbated by eating raw seafood during travel. Besides, post-travel ESBL-E positive participants had increased abundances of several opportunistic pathogens such as Staphylococcus, Enterococcus, Escherichia/Shigella and Klebsiella. The random forest model integrating pre-travel microbiota and the identified travel-related risk factor could predict ESBL-E acquisition with an area under the curve of 75.4% (95% confidence interval: 57.9%–93.0%). Conclusions In this study, we identified both travel-related risk factors and microbiota predictors for the risk of ESBL-E acquisition. Our results provide foundational knowledge for future developments of microbiota-based interventions to prevent ESBL-E acquisition during international travels.

scholarly journals High Burden of Self-Reported Sexually Transmitted Infections among Key Populations in Mozambique: The Urgent Need for an Integrated STI Surveillance System

2020 ◽  
Author(s):  
Makini A.S. Boothe ◽  
Charlotte Comé ◽  
Cynthia Semá Baltazar ◽  
Noela Chicuecue ◽  
Jessica Seleme ◽  
...  
Keyword(s):  
Risk Factors ◽  
Drug Use ◽  
Sex Work ◽  
Surveillance System ◽  
Self Report ◽  
Key Populations ◽  
Risk Behaviours ◽  
High Burden ◽  
Prevention Services ◽  
Associated Risk Factors

Abstract Background: Key populations - men who have sex with men (MSM), female sex workers (FSW) and people who inject drugs (PWID) – are at high risk for STI infection given their sexual risk behaviours along with social, legal and structural barriers to prevention, care and treatment services. The purpose of this secondary analysis is to assess the prevalence of self-reported STIs among participations of the first Biological Behavioural Surveillance (BBS) in Mozambique and to describe associated risk factors.Methods: Responses from the first BBS surveys conducted in 2011-2014 were aggregated across survey-cities to produce pooled estimates for each population. Aggregate RDS-weighted estimates were computed to analyse self-reported STI prevalence. Unweighted pooled estimates were used in multivariable logistic regression to identify associated risk factors. Results: The prevalence of self-reported STI was 11.9% (95% CI: 7.8-16.0), 33.6% (95% CI: 29.0-41.3), and 22.0% (95% CI: 17.0-27.0) among MSM, FSW and PWID, respectively. MSM who were circumcised, had HIV, reported drug use, reported receptive anal sex, and non-condom use with their last male partner had greater odds of STI self-report. STI-self report among FSW was associated with living in Beira, being married, employment aside from sex work, physical violence, sexual violence, drug use, access to comprehensive HIV prevention services, non-condom use with last client, and sexual relationship with a non-client romantic partner. Among PWID, risk factors for self-reported STI infection included living in Nampula, access to HIV prevention services, and sex work.Conclusion: The high-burden of STIs among survey participants requires integrated HIV and STI prevention, treatment, and harm reduction services that address overlapping risk behaviours, especially injection drug use and sex work. A robust public health response requires the creation of a national STI surveillance system for better screening and diagnostic procedures within these vulnerable populations.

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