Acoustic determination of early stages of intravascular blood coagulation

2008 ◽  
Vol 366 (1880) ◽  
pp. 3649-3661 ◽  
Author(s):  
Svetlana G Uzlova ◽  
Konstantin G Guria ◽  
Georgy Th Guria
Keyword(s):  
Blood Coagulation ◽  
Early Stage ◽  
Simultaneous Detection ◽  
Coagulation System ◽  
Complex Biological System ◽  
Ultrasonic Methods ◽  
Non Invasive ◽  
Early Stages ◽  
Major Disadvantage ◽  
Set Up

The blood coagulation system (BCS) is a complex biological system playing a principal role in the maintenance of haemostasis. Insufficient activity of the BCS may lead to bleeding and blood loss (e.g. in the case of haemophilia). On the other hand, excessive activity may cause intravascular blood coagulation, thromboses and embolization. Most of the methods currently used for BCS monitoring suffer from the major disadvantage of being invasive. The purpose of the present work is to demonstrate the feasibility of using ultrasonic methods for non-invasive registration of the early stages of blood coagulation processes in intensive flows. With this purpose, a special experimental set-up was designed, facilitating the simultaneous detection of optical and acoustic signals during the clotting process. It was shown that (i) as microemboli appear in the flow during the early stage of blood coagulation, the intensity of the Doppler signal increases twofold, and (ii) microemboli formation in the early stages of blood clotting always reveals itself through an acoustic contrast. Both of these effects are well defined, so we hope that they may be used for non-invasive BCS monitoring in clinical practice.

scholarly journals Simultaneous Detection of Colorectal Cancer Mutations in Stool Samples with Biochip Arrays

2009 ◽  
Vol 28 (4) ◽  
pp. 285-292
Author(s):  
Helena Murray ◽  
Mark Latten ◽  
Andrew Cartwright ◽  
Damien McAleer ◽  
Stephen Fitzgerald
Keyword(s):  
Colorectal Cancer ◽  
Early Stage ◽  
Simultaneous Detection ◽  
Occult Blood ◽  
Western World ◽  
Non Invasive ◽  
Invasive Test ◽  
Cancer Mutations ◽  
Dna Alterations ◽  
Stool Samples

Simultaneous Detection of Colorectal Cancer Mutations in Stool Samples with Biochip ArraysColorectal cancer (CRC) is the second main cause of cancer-related death in the Western world and like many other tumours is curable if detected at an early stage. Current detection options include faecal occult blood testing and invasive direct visualisation techniques such as flexible sigmoidoscopy, colonoscopy and barium enema. The availability of a more simple, non-invasive test that detects tumour specific products with optimal analytical performance might overcome barriers among patients who are not willing to undergo more sensitive but invasive tests. One such emerging technology, which has shown promise in recent years, is the analysis of DNA alterations exfoliated from tumour cells into stool. Here we report an analytical platform for non-invasive detection of 28 common mutations within CRC-related genesAPC, TP53, K-rasandBRAFin stool samples based on biochip array technology and applied to the semi-automated Evidence Investigator analyser. Mutation detection was possible in 1000-fold excess of wildtype DNA and analysis of 10 CRC-positive patient samples showed presence of targeted mutations with equivalent mutations also identified by an alternative method. This application represents an excellent tool for the multiplex detection of CRC-specific mutations using a single platform.

scholarly journals Non-Invasive versus Invasive Samples for Zika Virus Surveillance: A Comparative Study in New Caledonia and French Guiana in 2015–2016

2021 ◽  
Vol 9 (6) ◽  
pp. 1312
Author(s):  
Marie-Alice Fraiture ◽  
Wim Coucke ◽  
Morgane Pol ◽  
Dominique Rousset ◽  
Ann-Claire Gourinat ◽  
...  
Keyword(s):  
Zika Virus ◽  
French Guiana ◽  
New Caledonia ◽  
Early Stage ◽  
Simultaneous Detection ◽  
Clinical Signs ◽  
Added Value ◽  
Serum Samples ◽  
Presenting Symptoms ◽  
Non Invasive

Zika virus, an arbovirus responsible for major outbreaks, can cause serious health issues, such as neurological diseases. In the present study, different types of samples (serum, saliva, and urine), collected in 2015–2016 in New Caledonia and French Guiana from 53 patients presenting symptoms and clinical signs triggered by arbovirus infections, were analyzed using a recently developed, and in-house validated, 4-plex RT-qPCR TaqMan method for simultaneous detection and discrimination of the Zika and Chikungunya viruses. Subsequently, statistical analyses were performed in order to potentially establish recommendations regarding the choice of samples type to use for an efficient and early stage Zika infection diagnosis. On this basis, the use of only urine samples presented the highest probability to detect viral RNA from Zika virus. Moreover, such a probability was improved using both urine and saliva samples. Consequently, the added value of non-invasive samples, associated with a higher acceptance level for collection among patients, instead of serum samples, for the detection of Zika infections was illustrated.

A Re-Appraisal of the Role of Blood Coagulation and Platelets in the Generalized Shwartzman Phenomenon

1966 ◽  
Vol 15 (03/04) ◽  
pp. 519-538 ◽  
Author(s):  
J Levin ◽  
E Beck
Keyword(s):  
Blood Coagulation ◽  
The State ◽  
Coagulation System ◽  
Renal Lesions ◽  
Intravascular Coagulation ◽  
Renal Glomeruli ◽  
Coagulation Mechanism ◽  
Shwartzman Phenomenon ◽  
Do So

SummaryThe role of intravascular coagulation in the production of the generalized Shwartzman phenomenon has been evaluated. The administration of endotoxin to animals prepared with Thorotrast results in activation of the coagulation mechanism with the resultant deposition of fibrinoid material in the renal glomeruli. Anticoagulation prevents alterations in the state of the coagulation system and inhibits development of the renal lesions. Platelets are not primarily involved. Platelet antiserum produces similar lesions in animals prepared with Thorotrast, but appears to do so in a manner which does not significantly involve intravascular coagulation.The production of adrenal cortical hemorrhage, comparable to that seen in the Waterhouse-Friderichsen syndrome, following the administration of endotoxin to animals that had previously received ACTH does not require intravascular coagulation and may not be a manifestation of the generalized Shwartzman phenomenon.

The Emergence of Rabbinic Culture from the Perspective of Qumran

2015 ◽  
Vol 6 (2) ◽  
pp. 253-274
Author(s):  
Vered Noam
Keyword(s):  
Early Stage ◽  
Second Temple ◽  
Test Case ◽  
Literary Works ◽  
Jewish Culture ◽  
The Bible ◽  
Set Up

The rabbinic halakhic system, with its many facets and the literary works that comprise it, reflects a new Jewish culture, almost completely distinct in its halakhic content and scope from the biblical and postbiblical culture that preceded it. By examining Jewish legislation in the area of corpse impurity as a test case, the article studies the implications of Qumranic halakhah, as a way-station between the Bible and the Mishnah, for understanding how Tannaitic halakhah developed. The impression obtained from the material reviewed in the article is that the direction of the “Tannaitic revolution” was charted, its methods set up, and its principles established, at a surprisingly early stage, before the destruction of the Second Temple, and thus at the same time that the Qumran literature was created.

CURRENT APPROACH ON CUTANEOUS MELANOMA DIAGNOSTICS

2019 ◽  
Vol 65 (5) ◽  
pp. 638-644
Author(s):  
Mariya Ebert ◽  
Georgiy Gafton ◽  
Grigoriy Zinovev ◽  
I. Gafton
Keyword(s):  
Physical Examination ◽  
Cutaneous Melanoma ◽  
Growth Dynamics ◽  
Current Approach ◽  
Clinical Diagnostics ◽  
Skin Tumors ◽  
Steady Increase ◽  
Non Invasive ◽  
Early Stages ◽  
Other Information

Melanoma is on the first place in mortality among all skin tumors. Over the past 50 years, there has been a steady increase in the incidence of cutaneous melanoma compared to other types of tumors. Rates of 5-year survival are fairly high, if melanoma is diagnosed in the early stages, which requires adequate diagnostics and treatment. Melanoma diagnostic, especially in the early stages, can be problematic even for an experienced dermatologist. However, primary contact doctor can be any specialty. Melanoma and other skin tumors can be detected by physical examination during treatment for another disease. Phenotypic risks factors, anamnestic data, and physical examination data are important in cutaneous melanoma diagnostics. The sensitivity of clinical diagnosis during a visual examination by an experienced dermatologist is approximately 70 percent. However, dermascopy can significantly increase the accuracy of a clinical diagnostics. In recent years there has been an active research for new non-invasive methods and algorithms for cutaneous melanoma diagnostics. The main goal of non-invasive diagnostics is to determine need for biopsy. This decision should be based on a combination of clinical and dermascopic examinations and other information, including growth dynamics, symptoms and medical history. Thus, an adequate diagnostic of cutaneous melanoma, including non-invasive and invasive methods, is a simple and economically viable way to early detection of cutaneous melanoma and to reduce mortality from this aggressive disease.

Review of Various Tasks Performed in the Preprocessing Phase of a Diabetic Retinopathy Diagnosis System

2020 ◽  
Vol 16 (4) ◽  
pp. 397-426
Author(s):  
Muhammad Nadeem Ashraf ◽  
Muhammad Hussain ◽  
Zulfiqar Habib
Keyword(s):  
Diabetic Retinopathy ◽  
Blood Vessels ◽  
Early Stage ◽  
Spherical Shape ◽  
Cost Effective ◽  
Lesion Detection ◽  
Diabetic Patients ◽  
Cad System ◽  
Non Invasive ◽  
Optic Discs

Diabetic Retinopathy (DR) is a major cause of blindness in diabetic patients. The increasing population of diabetic patients and difficulty to diagnose it at an early stage are limiting the screening capabilities of manual diagnosis by ophthalmologists. Color fundus images are widely used to detect DR lesions due to their comfortable, cost-effective and non-invasive acquisition procedure. Computer Aided Diagnosis (CAD) of DR based on these images can assist ophthalmologists and help in saving many sight years of diabetic patients. In a CAD system, preprocessing is a crucial phase, which significantly affects its performance. Commonly used preprocessing operations are the enhancement of poor contrast, balancing the illumination imbalance due to the spherical shape of a retina, noise reduction, image resizing to support multi-resolution, color normalization, extraction of a field of view (FOV), etc. Also, the presence of blood vessels and optic discs makes the lesion detection more challenging because these two artifacts exhibit specific attributes, which are similar to those of DR lesions. Preprocessing operations can be broadly divided into three categories: 1) fixing the native defects, 2) segmentation of blood vessels, and 3) localization and segmentation of optic discs. This paper presents a review of the state-of-the-art preprocessing techniques related to three categories of operations, highlighting their significant aspects and limitations. The survey is concluded with the most effective preprocessing methods, which have been shown to improve the accuracy and efficiency of the CAD systems.

Innovation in Indian Business Groups

2018 ◽  
Author(s):  
Prashant Kale ◽  
Harbir Singh
Keyword(s):  
Risk Taking ◽  
Business Groups ◽  
Formal Learning ◽  
Internal Markets ◽  
Early Stages ◽  
Innovation Culture ◽  
External Sources ◽  
Set Up ◽  
Organizational Mechanisms ◽  
Learning Interventions

Innovation is a critical to the success of large, diversified Indian business groups and this chapter explores the specific organizational mechanisms they have adopted to enable and foster innovation in their organizations. First, these groups provide internal markets for much needed capital and talent necessary for innovation to make up for sufficient lack of these institutions externally. In addition, they have pursued the following actions: (a) significantly upped their investments in R&D and innovation, (b) created internal leadership councils to oversee and promote innovation, (c) created an innovation culture that encourages and celebrates entrepreneurship, risk-taking, and tolerance for failure, (d) undertaken formal learning interventions to build the innovation capabilities of their managers, and (e) set-up formal units to in-source innovation from external sources. Indian companies are yet in the early stages of this journey and will have to sustain these practices to demonstrate durable success with innovation.

scholarly journals Increasing Electric Vehicles Reliability by Non-Invasive Diagnosis of Motor Winding Faults

Energies ◽  
2021 ◽  
Vol 14 (9) ◽  
pp. 2510
Author(s):  
Konrad Górny ◽  
Piotr Kuwałek ◽  
Wojciech Pietrowski
Keyword(s):  
Electric Vehicles ◽  
Diagnostic Method ◽  
Induction Motors ◽  
Early Stage ◽  
Short Circuit ◽  
Damage Classification ◽  
Non Invasive ◽  
Signal Features ◽  
Empirical Wavelet Transform ◽  
Simulation Results

The article proposes a proprietary approach to the diagnosis of induction motors allowing increasing the reliability of electric vehicles. This approach makes it possible to detect damage in the form of an inter-turn short-circuit at an early stage of its occurrence. The authors of the article describe an effective diagnostic method using the extraction of diagnostic signal features using an Enhanced Empirical Wavelet Transform and an algorithm based on the method of Ensemble Bagged Trees. The article describes in detail the methodology of the carried out research, presents the method of extracting features from the diagnostic signal and describes the conclusions resulting from the research. Phase current waveforms obtained from a real object as well as simulation results based on the field-circuit model of an induction motor were used as a diagnostic signal in the research. In order to determine the accuracy of the damage classification, simple metrics such as accuracy, sensitivity, selectivity, precision as well as complex metrics weight F1 and macro F1 were used.

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