scholarly journals Revisiting the heterogeneous global genomic population structure of Leishmania infantum

2021 ◽  
Vol 7 (9) ◽  
Author(s):  
Luz H. Patino ◽  
Adriana Castillo-Castañeda ◽  
Marina Muñoz ◽  
Carlos Muskus ◽  
Matilde Rivero-Rodríguez ◽  
...  
Keyword(s):  
Leishmania Infantum ◽  
Genomic Structure ◽  
Geographic Region ◽  
Global Level ◽  
Genome Sequences ◽  
Genomic Variability ◽  
The World ◽  
Genomic Relationships ◽  
Variable Sensitivity ◽  
Different Parts

Leishmania infantum is the main causative agent responsible for visceral leishmaniasis (VL), a disease with global distribution. The genomic structure and genetic variation of this species have been widely studied in different parts of the world. However, in some countries, this information is still yet unknown, as is the genomic behaviour of the main antigens used in VL diagnosis (rK39 and rK28), which have demonstrated variable sensitivity and specificity in a manner dependent on the geographic region analysed. The objective of this study was to explore the genomic architecture and diversity of four Colombian L. infantum isolates obtained in this study and to compare these results with the genetic analysis of 183 L. infantum isolates from across the world (obtained from public databases), as well as to analyse the whole rK39 and rK28 antigen sequences in our dataset. The results showed that, at the global level, L. infantum has high genetic homogeneity and extensive aneuploidy. Furthermore, we demonstrated that there are distinct populations of L. infantum circulating in various countries throughout the globe and that populations of distant countries have close genomic relationships. Additionally, this study demonstrated the high genetic variability of the rK28 antigen worldwide. In conclusion, our study allowed us to (i) expand our knowledge of the genomic structure of global L. infantum; (ii) describe the intra-specific genomic variability of this species; and (iii) understand the genomic characteristics of the main antigens used in the diagnosis of VL. Additionally, this is the first study to report whole-genome sequences of Colombian L. infantum isolates.

The Rule of Law: The New Leviathan?

1999 ◽  
Vol 12 (1) ◽  
pp. 151-168 ◽  
Author(s):  
Olufemi Taiwo
Keyword(s):  
Rule Of Law ◽  
Philosophical Tradition ◽  
Global Level ◽  
The Rule Of Law ◽  
The World ◽  
Social Ordering ◽  
Soviet Communism ◽  
Just Society ◽  
Different Parts ◽  
The Ideal

These are the best of times for the Rule of Law. In all parts of the world, states, governments, and individuals, have found in the rule of law, at various times, a rallying cry, a principle of social ordering that promises the dawn of a just society that its supporters in Euro-American democracies claim to be its crowning glory, or a set of practices that is a sine qua non of a good society. The pursuit of the ideal is nothing new: after all, even those states where it was observed more often in its breach always paid lip service to it. And the defunct socialist countries of Eastern Europe, while they existed, could not escape its lure even as they sought to give it a different nomenclature—socialist legality. The movement towards the rule of law has accelerated after the collapse of Soviet communism and its foster progeny in different parts of the world. Given the present momentum towards the rule of law and the widespread enthusiasm with which it is being embraced and pursued at the global level, some would consider it somewhat churlish for anyone to inject any note of doubt or caution. This is more so when such a note emanates from Marxist quarters. But that is precisely what I wish to do in this essay. Although I do not intend to rain on the rule of law’s entire parade, I surely propose to rain on a segment of it: the Marxist float. I propose to look at the issue within the context of the Marxist politico-philosophical tradition.

scholarly journals Globalization and Transnational Advance Fee Fraud: A Study of Perceptions of Undergraduates in Southeastern Nigeria

2009 ◽  
Vol 7 (1) ◽  
Author(s):  
Ngozi G. Egbue
Keyword(s):  
Law Enforcement ◽  
Global Level ◽  
Focus Group Discussions ◽  
Group Discussions ◽  
Southeastern Nigeria ◽  
Racial Identities ◽  
Self Employment ◽  
Advance Fee Fraud ◽  
The World ◽  
Different Parts

Transnational advance fee fraud has become a public issue since the 1980s, and has grown world wide within a background of corrupt dealings in foreign exchange and the transfer of illegally obtained money through foreign businesses and enterprises. In the Nigerian context, the general economic impoverishment with the attendant desperation of the educated to create self-employment and generate wealth, together with a tendency to get-rich-quick, constitute the background within which advance fee fraud has grown. At the global level, while contacts between different parts of the world have grown tremendously, with increasing potentials for personal, business and other forms of exchange, yet racial identities quite evidently tend to remain resilient, resulting in various forms of divisions and conflicts. This paper sought, with the use of a questionnaire, focus group discussions and interviews to examine the perception of undergraduates in southeastern Nigeria about certain aspects of this scam. This is because these youth are considered to be most predisposed, by virtue of their education, constant access to the internet, unsatisfied financial needs and the threat of imminent unemployment, to temptations to engage in advance fee fraud. The findings indicated that undergraduates were very familiar with advance fee fraud as a major economic activity. Furthermore, it was found that undergraduates generally viewed internet scam as less grievous than other irregular sources of income, largely because the victims were mainly foreigners, and also because there was usually no direct contact with victims. The study made recommendations for improved enlightenment of youth, stricter overall anti-corruption law enforcement, and increased employment opportunities for undergraduates.

scholarly journals An African origin for Mycobacterium bovis

2020 ◽  
Vol 2020 (1) ◽  
pp. 49-59 ◽  
Author(s):  
Chloé Loiseau ◽  
Fabrizio Menardo ◽  
Abraham Aseffa ◽  
Elena Hailu ◽  
Balako Gumi ◽  
...  
Keyword(s):  
Population Structure ◽  
West Africa ◽  
Mycobacterium Bovis ◽  
Evolutionary History ◽  
Whole Genome ◽  
Genome Sequences ◽  
The World ◽  
History Of ◽  
Global Population ◽  
Different Parts

Abstract Background and objectives Mycobacterium bovis and Mycobacterium caprae are two of the most important agents of tuberculosis in livestock and the most important causes of zoonotic tuberculosis in humans. However, little is known about the global population structure, phylogeography and evolutionary history of these pathogens. Methodology We compiled a global collection of 3364 whole-genome sequences from M.bovis and M.caprae originating from 35 countries and inferred their phylogenetic relationships, geographic origins and age. Results Our results resolved the phylogenetic relationship among the four previously defined clonal complexes of M.bovis, and another eight newly described here. Our phylogeographic analysis showed that M.bovis likely originated in East Africa. While some groups remained restricted to East and West Africa, others have subsequently dispersed to different parts of the world. Conclusions and implications Our results allow a better understanding of the global population structure of M.bovis and its evolutionary history. This knowledge can be used to define better molecular markers for epidemiological investigations of M.bovis in settings where whole-genome sequencing cannot easily be implemented. Lay summary During the last few years, analyses of large globally representative collections of whole-genome sequences (WGS) from the human-adapted Mycobacterium tuberculosis complex (MTBC) lineages have enhanced our understanding of the global population structure, phylogeography and evolutionary history of these pathogens. In contrast, little corresponding data exists for M. bovis, the most important agent of tuberculosis in livestock. Using whole-genome sequences of globally distributed M. bovis isolates, we inferred the genetic relationships among different M. bovis genotypes distributed around the world. The most likely origin of M. bovis is East Africa according to our inferences. While some M. bovis groups remained restricted to East and West Africa, others have subsequently dispersed to different parts of the world driven by cattle movements.

scholarly journals Identification of super-transmitters of SARS-CoV-2

2020 ◽  
Author(s):  
Xuemei Yang ◽  
Ning Dong ◽  
Edward Wai-Chi Chan ◽  
Sheng Chen
Keyword(s):  
Multiple Sources ◽  
Genome Sequences ◽  
High Quality ◽  
Mutation Profile ◽  
The Us ◽  
The World ◽  
Genetic Clusters ◽  
Phylodynamic Analysis ◽  
Insight Into ◽  
Different Parts

AbstractA newly emerged coronavirus, SARS-CoV-2, caused severe outbreaks of pneumonia in China in December 2019 and has since spread to various countries around the world. To probe the origin and transmission dynamics of this virus, we performed phylodynamic analysis of 247 high quality genomic sequences of viruses available in the GISAID platform as of March 05, 2020. A substantial number of earliest sequences reported in Wuhan in December 2019, including those of viruses recovered from the Huanan Seafood Market (HNSM), the site of the initial outbreak, were genetically diverse, suggesting that viruses of multiple sources were involved in the original outbreak. The viruses were subsequently disseminated to different parts of China and other countries, with diverse mutational profiles being recorded in strains recovered subsequently. Interestingly, four genetic clusters defined as Super-transmitters (STs) were found to become dominant and were responsible for the major outbreaks in various countries. Among the four clusters, ST1 is widely disseminated in Asia and the US and mainly responsible for outbreaks in the states of Washington and California in the US as well as those in South Korea at the end of February and early March, whereas ST4 contributed to the pandemic in Europe. Each ST cluster carried a signature mutation profile which allowed us to trace the origin and transmission patterns of specific viruses in different parts of the world. Using the signature mutations as markers of STs, we further analysed 1539 genome sequences reported after February 29, 2020. We found that around 90% of these genomes belonged to STs with ST4 being the dominant one and their contribution to pandemic in different continents were also depicted. The identification of these super-transmitters provides insight into the control of further transmission of SARS-CoV-2.

BIOASSAY CHARACTERISTICS OF INDIVIDUAL URINARY GONADOTROPHIN EXTRACTS

1963 ◽  
Vol 42 (2) ◽  
pp. 214-224
Author(s):  
Raymond C. Mellinger ◽  
Jalileh A. Mansour ◽  
Richmond W. Smith
Keyword(s):  
Reference Material ◽  
Young Women ◽  
Reference Standard ◽  
General Acceptance ◽  
Modifying Factors ◽  
Large Numbers ◽  
The World ◽  
Quantitative Bioassay ◽  
Different Parts ◽  
Age And Sex

ABSTRACT A reference standard is widely sought for use in the quantitative bioassay of pituitary gonadotrophin recovered from urine. The biologic similarity of pooled urinary extracts obtained from large numbers of subjects, utilizing groups of different age and sex, preparing and assaying the materials by varying techniques in different parts of the world, has lead to a general acceptance of such preparations as international gonadotrophin reference standards. In the present study, however, the extract of pooled urine from a small number of young women is shown to produce a significantly different bioassay response from that of the reference materials. Gonadotrophins of individual subjects likewise varied from the multiple subject standards in many instances. The cause of these differences is thought to be due to the modifying influence of non-hormonal substances extracted from urine with the gonadotrophin and not necessarily to variations in the gonadotrophins themselves. Such modifying factors might have similar effects in a comparative assay of pooled extracts contributed by many subjects, but produce significant variations when material from individual subjects is compared. It is concluded that the expression of potency of a gonadotrophic extract in terms of pooled reference material to which it is not essentially similar may diminish rather than enhance the validity of the assay.

Christianity in the Twentieth Century

2019 ◽  
Author(s):  
Brian Stanley
Keyword(s):  
Latin America ◽  
Racial Identity ◽  
Sub Saharan Africa ◽  
Central Importance ◽  
Regional Survey ◽  
History Of Christianity ◽  
The World ◽  
History Of ◽  
Sub Saharan ◽  
Different Parts

This book charts the transformation of one of the world's great religions during an age marked by world wars, genocide, nationalism, decolonization, and powerful ideological currents, many of them hostile to Christianity. The book traces how Christianity evolved from a religion defined by the culture and politics of Europe to the expanding polycentric and multicultural faith it is today—one whose growing popular support is strongest in sub-Saharan Africa, Latin America, China, and other parts of Asia. The book sheds critical light on themes of central importance for understanding the global contours of modern Christianity, illustrating each one with contrasting case studies, usually taken from different parts of the world. Unlike other books on world Christianity, this one is not a regional survey or chronological narrative, nor does it focus on theology or ecclesiastical institutions. The book provides a history of Christianity as a popular faith experienced and lived by its adherents, telling a compelling and multifaceted story of Christendom's fortunes in Europe, North America, and across the rest of the globe. It demonstrates how Christianity has had less to fear from the onslaughts of secularism than from the readiness of Christians themselves to accommodate their faith to ideologies that privilege racial identity or radical individualism.

THE 2019 NOVEL PANDEMIC OF CORONAVIRUS DISEASE (COVID-19): A STUDY OF EXISTING EVIDENCE IN THE INDIAN POPULATION

2020 ◽  
Vol 7 (2) ◽  
pp. 199-204
Author(s):  
Shrikant Verma ◽  
Mohammad Abbas ◽  
Sushma Verma ◽  
Syed Tasleem Raza ◽  
Farzana Mahdi
Keyword(s):  
Disease Transmission ◽  
Indian Population ◽  
Respiratory Infections ◽  
Clinical Signs ◽  
Case Fatality ◽  
Public Health Emergency ◽  
The World ◽  
And Control ◽  
General Wellbeing ◽  
Different Parts

A novel spillover coronavirus (nCoV), with its epicenter in Wuhan, China's People's Republic, has emerged as an international public health emergency. This began as an outbreak in December 2019, and till November eighth, 2020, there have been 8.5 million affirmed instances of novel Covid disease2019 (COVID-19) in India, with 1,26,611 deaths, resulting in an overall case fatality rate of 1.48 percent. Coronavirus clinical signs are fundamentally the same as those of other respiratory infections. In different parts of the world, the quantity of research center affirmed cases and related passings are rising consistently. The COVID- 19 is an arising pandemic-responsible viral infection. Coronavirus has influenced huge parts of the total populace, which has prompted a global general wellbeing crisis, setting all health associations on high attentive. This review sums up the overall landmass, virology, pathogenesis, the study of disease transmission, clinical introduction, determination, treatment, and control of COVID-19 with the reference to India.

Impact of Globalisation on Pandemics: A comparative study on SARS and Covid-19 (Preprint)

2020 ◽  
Author(s):  
Johann Johann And Devika
Keyword(s):  
Comparative Analysis ◽  
Comparative Study ◽  
Descriptive Analysis ◽  
Qualitative Comparative Analysis ◽  
Global Scale ◽  
Global Level ◽  
Economic Stability ◽  
The Past ◽  
The World ◽  
Close Relationship

BACKGROUND Since November 2019, Covid - 19 has spread across the globe costing people their lives and countries their economic stability. The world has become more interconnected over the past few decades owing to globalisation and such pandemics as the Covid -19 are cons of that. This paper attempts to gain deeper understanding into the correlation between globalisation and pandemics. It is a descriptive analysis on how one of the factors that was responsible for the spread of this virus on a global scale is globalisation. OBJECTIVE - To understand the close relationship that globalisation and pandemics share. - To understand the scale of the spread of viruses on a global scale though a comparison between SARS and Covid -19. - To understand the sale of globalisation present during SARS and Covid - 19. METHODS A descriptive qualitative comparative analysis was used throughout this research. RESULTS Globalisation does play a significant role in the spread of pandemics on a global level. CONCLUSIONS - SARS and Covid - 19 were varied in terms of severity and spread. - The scale of globalisation was different during the time of SARS and Covid - 19. - Globalisation can be the reason for the faster spread in Pandemics.

Jiangnan Style

2017 ◽  
Author(s):  
Chris Wickham
Keyword(s):  
Middle Ages ◽  
Economic Activity ◽  
Global Economy ◽  
Medieval Period ◽  
The World ◽  
Transnational Connections ◽  
New Research ◽  
Different Parts

Building on impressive new research into the concept of a ‘global middle ages’, this chapter offers insights into how economic formations developed around the world. Drawing on new research on both Chinese and Mediterranean economies in the ‘medieval’ period, it compares structures of economy and exchange in very different parts of the world. The point of such comparisons is not simply to find instances of global economic flows but to understand the logic of medieval economic activity and its intersections with power and culture; and, in so doing, to remind historians that economic structures, transnational connections, and the imbrications of economy and politics do not arrive only with modernity, nor is the shape of the ‘modern’ global economy the only pattern known to humankind.

The Struggle for Public Recognition: Understanding Early Marriage through the Lens of Honour and Shame in Six Countries in South Asia and West Africa

2020 ◽  
Vol 20 (4) ◽  
pp. 328-346
Author(s):  
Esther Miedema ◽  
Winny Koster ◽  
Nicky Pouw ◽  
Philippe Meyer ◽  
Albena Sotirova
Keyword(s):  
International Development ◽  
Female Sexuality ◽  
Social Economic ◽  
Early Marriage ◽  
Social Standing ◽  
Public Recognition ◽  
The World ◽  
Economic Future ◽  
Different Parts

There is a burgeoning body of research on the role of ‘shame’ and ‘honour’ in decisions regarding early marriage in different parts of the world. Conceptualizing shame and honour as idioms through which gendered socio-economic inequalities are created and maintained, we examine early marriage decisions in Bangladesh, Nepal, Pakistan, Ghana, Burkina Faso and Senegal. While we acknowledge the existence of important differences between countries in terms of the nature and manifestations of shame and honour, we argue that regardless of setting, neither shame and honour, nor female sexuality and chastity can be separated from the socio-economic hierarchies and inequalities. Thus, in this article we seek to identify the cross-cutting dynamic of marriage as a means to overcome the shame associated with young single women’s sexuality, protecting family honour and social standing, and/or securing young women’s social-economic future. Building on our data and available scholarship, we question the potential of emphasizing ‘choice’ as a means of reducing early marriage and advancing women’s emancipation in international development efforts. Instead, we argue in favour of initiatives that engage with young people and caregivers on the ways in which, at grassroot levels, communities may revise narratives of respectability, marriageability and social standing.

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