scholarly journals How to Flatten the post-lockdown epidemic trajectory

Author(s):  
Roschen Sasikumar ◽  
Ajit Haridas

AbstractPopulations are locked down during an epidemic to slow down the rate of infection so that epidemic trajectory is "flattened". This helps to keep cases at a manageable level. Given the enormous economic damage and misery caused by a lockdown, it is imperative to keep the lockdown period limited. A lockdown is useful only if it can be ensured that after the lockdown is lifted, the epidemic trajectory does not rise sharply again. We present here the results from a mathematical model of the epidemic which examines how the timing, strength and duration of the lockdown affects the post-lockdown epidemic trajectory. Our results show the following:A early lockdown (imposed when less than 1% of the population has been infected), of any reasonable duration, cannot prevent the return of the epidemic when the lockdown is lifted. The curve starts climbing soon after lifting the lockdown and reaches a peak of the same height as the no-lockdown curveThe post-lockdown trajectory can be flattened only if the lockdown is imposed after about 10% of the population has recovered after infection.The slope of the post-lockdown epidemic curve depends on the level of immunity built up in the population before and during the lockdown period. Application of lockdown around the inflexion point of the epidemic curve (the point of maximum slope of the curve) ensures that the post-lockdown curve is also flattened.

Author(s):  
Balvinder Singh Gill ◽  
Vivek Jason Jayaraj ◽  
Sarbhan Singh ◽  
Sumarni Mohd Ghazali ◽  
Yoon Ling Cheong ◽  
...  

Malaysia is currently facing an outbreak of COVID-19. We aim to present the first study in Malaysia to report the reproduction numbers and develop a mathematical model forecasting COVID-19 transmission by including isolation, quarantine, and movement control measures. We utilized a susceptible, exposed, infectious, and recovered (SEIR) model by incorporating isolation, quarantine, and movement control order (MCO) taken in Malaysia. The simulations were fitted into the Malaysian COVID-19 active case numbers, allowing approximation of parameters consisting of probability of transmission per contact (β), average number of contacts per day per case (ζ), and proportion of close-contact traced per day (q). The effective reproduction number (Rt) was also determined through this model. Our model calibration estimated that (β), (ζ), and (q) were 0.052, 25 persons, and 0.23, respectively. The (Rt) was estimated to be 1.68. MCO measures reduce the peak number of active COVID-19 cases by 99.1% and reduce (ζ) from 25 (pre-MCO) to 7 (during MCO). The flattening of the epidemic curve was also observed with the implementation of these control measures. We conclude that isolation, quarantine, and MCO measures are essential to break the transmission of COVID-19 in Malaysia.


2021 ◽  
Author(s):  
Alexander Sokolov ◽  
Lyubov Sokolova

AbstractA mathematical model is a reflection of knowledge on the real object studied. The paper shows how the accumulation of data (statistical data and knowledge) about the COVID-19 pandemic lead to gradual refinement of mathematical models, to the expansion of the scope of their use. The resulting model satisfactorily describes the dynamics of COVID-19 in Moscow from 19.03.2020 to 01.09.2021 and can be used for forecasting with a horizon of several months. The dynamics of the model is mainly determined by herd immunity. Monitoring the situation in Moscow has not yet (as of 01.09.2021) revealed noticeable seasonality of the disease nor an increase in infectivity (due to the Delta strain). The results of using balanced identification technology to monitor the COVID-19 pandemic are:models corresponding to the data available at different points in time (from March 2020 to August 2021);new knowledge (dependencies) acquired;forecasts for the third and fourth waves in Moscow.Discrepancies that manifested after 01.09.2021 and possible further modifications of the model are discussed


Author(s):  
Christian Alvin H. Buhat ◽  
Monica C. Torres ◽  
Yancee H. Olave ◽  
Maica Krizna A. Gavina ◽  
Edd Francis O. Felix ◽  
...  

ABSTRACTThe number of COVID-19 cases is continuously increasing in different countries (as of March 2020) including the Philippines. It is estimated that the basic reproductive number of COVID-19 is around 1.5 to 4. The basic reproductive number characterizes the average number of persons that a primary case can directly infect in a population full of susceptible individuals. However, there can be superspreaders that can infect more than this estimated basic reproductive number. In this study, we formulate a conceptual mathematical model on the transmission dynamics of COVID-19 between the frontliners and the general public. We assume that the general public has a reproductive number between 1.5 to 4, and frontliners (e.g. healthcare workers, customer service and retail personnel, food service crews, and transport or delivery workers) have a higher reproduction number. Our simulations show that both the frontliners and the general public should be protected or resilient against the disease. Protecting only the frontliners will not result in flattening the epidemic curve. Protecting only the general public may flatten the epidemic curve but the infection risk faced by the frontliners is still high, which may eventually affect their work. Our simple model does not consider all factors involved in COVID-19 transmission in a community, but the insights from our model results remind us of the importance of community effort in controlling the transmission of the disease. All in all, the take-home message is that everyone in the community, whether a frontliner or not, should be protected or should implement preventive measures to avoid being infected.


2020 ◽  
Vol 36 (6) ◽  
pp. 913-926
Author(s):  
Te Xi ◽  
Chao Li ◽  
Wei Qiu ◽  
Hui Wang ◽  
Xiaolan Lv ◽  
...  

HighlightsDroplet deposition behavior on pear leaf surfaces under wind-induced vibration was investigated.The factors and limiting conditions affecting the vibration and spreading of droplets were analyzed.A mathematical model of the vibration and spreading of droplets on pear leaves was constructed.Abstract. Pear trees, a kind of fruit tree prone to diseases and insects, are sprayed 7-8 times a year in northern China and 8-10 times a year in the hot and humid areas of southern China. Air-assisted spraying is also the mainstream application technique for pear trees at present. To study the deposition behavior of droplets on pear leaves under the effect of air flow, the movement states of fluorescent droplets at different initial leaf angles and different leaf positions were measured with a high-speed camera. Based on the combined effect of the microstructure and the vibration of pear leaves, the factors and limiting conditions affecting the vibration and spreading of droplets were analyzed, and a mathematical model of the vibration and spreading of droplets on pear leaves was constructed. The experiment showed that the degree of influence of each factor on the velocity and acceleration of the droplets is in turn the inflow velocity, the drop position and the initial leaf angle. For pear hydrophilic plants, it is necessary to meet both conditions that the droplet velocity is less than the critical velocity of 1.1 m/s and the droplet acceleration is less than the critical acceleration of 20 m/s2 so that the droplet can deposit on the leaf surface. An inflow velocity of 7 m/s better facilitates droplet deposition and spreading. Keywords: Deposition behavior, Pear leaf, Wind-induced vibration.


2014 ◽  
Vol 13 (4) ◽  
pp. 290-309 ◽  
Author(s):  
Claudio Maccone

AbstractIn a series of recent papers and in a book, this author put forward a mathematical model capable of embracing the search for extra-terrestrial intelligence (SETI), Darwinian Evolution and Human History into a single, unified statistical picture, concisely calledEvo-SETI. The relevant mathematical tools are:(1)Geometric Brownian motion (GBM), the stochastic process representing evolution as the stochastic increase of the number of species living on Earth over the last 3.5 billion years. This GBM is well known in the mathematics of finances (Black–Sholes models). Its main features are that its probability density function (pdf) is a lognormal pdf, and its mean value is either an increasing or, more rarely, decreasing exponential function of the time.(2)The probability distributions known asb-lognormals, i.e. lognormals starting at a certain positive instantb>0 rather than at the origin. Theseb-lognormals were then forced by us to have their peak value located on the exponential mean-value curve of the GBM (Peak-Locus theorem). In the framework of Darwinian Evolution, the resulting mathematical construction was shown to be what evolutionary biologists callCladistics.(3)The (Shannon)entropyof suchb-lognormals is then seen to represent the ‘degree of progress’ reached by each living organism or by each big set of living organisms, like historic human civilizations. Having understood this fact, human history may then be cast into the language ofb-lognormals that are more and more organized in time (i.e. having smaller and smaller entropy, or smaller and smaller ‘chaos’), and have their peaks on the increasing GBM exponential. This exponential is thus the ‘trend of progress’ in human history.(4)All these results also match with SETI in that the statistical Drake equation (generalization of the ordinary Drake equation to encompass statistics) leads just to the lognormal distribution as the probability distribution for the number of extra-terrestrial civilizations existing in the Galaxy (as a consequence of the central limit theorem of statistics).(5)But the most striking new result is that the well-known ‘Molecular Clock of Evolution’, namely the ‘constant rate of Evolution at the molecular level’ as shown by Kimura's Neutral Theory of Molecular Evolution,identifieswith growth rate of the entropy of our Evo-SETI model, because they both grewlinearlyin time since the origin of life.(6)Furthermore, we apply our Evo-SETI model to lognormal stochastic processesother than GBMs.For instance, we provide two models for the mass extinctions that occurred in the past: (a) one based on GBMs and (b) the other based on aparabolicmean value capable of covering both the extinction and the subsequent recovery of life forms.(7)Finally, we show that the Markov & Korotayev (2007, 2008) model for Darwinian Evolution identifies with an Evo-SETI model for which the mean value of the underlying lognormal stochastic process is acubicfunction of the time.In conclusion: we have provided a new mathematical model capable of embracing molecular evolution, SETI and entropy into a simple set of statistical equations based uponb-lognormals and lognormal stochastic processes with arbitrary mean, of which the GBMs are theparticular case of exponential growth.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yuanji Tang ◽  
Tamires D. A. Serdan ◽  
Amanda L. Alecrim ◽  
Diego R. Souza ◽  
Bruno R. M. Nacano ◽  
...  

AbstractWe propose herein a mathematical model to predict the COVID-19 evolution and evaluate the impact of governmental decisions on this evolution, attempting to explain the long duration of the pandemic in the 26 Brazilian states and their capitals well as in the Federative Unit. The prediction was performed based on the growth rate of new cases in a stable period, and the graphics plotted with the significant governmental decisions to evaluate the impact on the epidemic curve in each Brazilian state and city. Analysis of the predicted new cases was correlated with the total number of hospitalizations and deaths related to COVID-19. Because Brazil is a vast country, with high heterogeneity and complexity of the regional/local characteristics and governmental authorities among Brazilian states and cities, we individually predicted the epidemic curve based on a specific stable period with reduced or minimal interference on the growth rate of new cases. We found good accuracy, mainly in a short period (weeks). The most critical governmental decisions had a significant temporal impact on pandemic curve growth. A good relationship was found between the predicted number of new cases and the total number of inpatients and deaths related to COVID-19. In summary, we demonstrated that interventional and preventive measures directly and significantly impact the COVID-19 pandemic using a simple mathematical model. This model can easily be applied, helping, and directing health and governmental authorities to make further decisions to combat the pandemic.


Author(s):  
Manuel Adrian Acuña-Zegarra ◽  
Andreu Comas-García ◽  
Esteban Hernández-Vargas ◽  
Mario Santana-Cibrian ◽  
Jorge X. Velasco-Hernandez

AbstractWe present here several variants of a mathematical model to explore three main issues related to SARS-CoV-2 spread in scenarios similar to those present in Mexico and elsewhere in Latin America. We explore the consequences for travel inside a given region, in this case Mexico, particularly focusing on airplane transportation but attempting to give a gross approximation to terrestrial movement since this is the main form of population movement across geographical areas in the country; then we proceed to study the effect of behavioral changes required to lower transmission by lowering the contact rate and infection probability and lastly, we explore the consequences of disease spread in a population subject to social isolation.These models are not suitable for predictive purposes although some rough predictions can be extracted from them. They are presented as a tool that can serve to explore plausible scenarios of spread and impact, effectiveness and consequences of contention and mitigation policies. Given the early stage at which the epidemic is at the date of writing in Mexico, we hope these ideas can be helpful for the understanding of the importance of isolation, social distancing and screening of the general population.Key findingsWe have estimated the parameters of the epidemic curve (growth rate, carrying capacity and dispersion) as well as a first estimate of the basic reproduction number for Mexico.We provide expected trends of epidemic outbreaks depending upon of the number of imported cases per day arriving to a large airport. We illustrate this trends with data from Mexico City airport.We provide expected trends of disease dispersal depending upon of the number of exported cases per day either by airplane or bus. We illustrate this trends with data from Mexico City.We evaluate the effect of behavioral change to reduce the contact rate and compare diverse scenarios that evaluate the timing of initial enforcement of behavior, time horizon in which to diminish the contact rate and the proportion of people under isolation.We evaluate the effect of social isolation by itself with respect to two main parameters: the starting time for the enforcement of control measures, and the learning time to achieve the desired contact rate reduction. We stress the importance of quick and direct actions to isolate and reduce contact rate simultaneously.


2019 ◽  
Author(s):  
Joost Smid ◽  
Christian L. Althaus ◽  
Nicola Low ◽  
Magnus Unemo ◽  
Björn Herrmann

ABSTRACTObjectivesA new variant ofChlamydia trachomatis(nvCT) was discovered in Sweden in 2006. The nvCT has a plasmid deletion, which escaped detection by two nucleic acid amplification tests (Abbott/Roche, AR), which were used in 14 of 21 Swedish counties. The objectives of this study were to assess when and where nvCT emerged in Sweden, the proportion of nvCT in each county, and the role of a potential fitness difference between nvCT and co-circulating wild-type strains (wtCT).MethodsWe used a compartmental mathematical model describing the spatial and temporal spread of nvCT and wtCT. We parameterised the model using sexual behaviour data and Swedish spatial and demographic data. We used Bayesian inference to fit the model to surveillance data about reported diagnoses of chlamydia infection in each county and data from four counties that assessed the proportion of nvCT in multiple years.ResultsModel results indicated that nvCT emerged in central Sweden (Dalarna, Gävleborg, Västernorrland), reaching a proportion of 1% of prevalent CT infections in late 2002 or early 2003. The diagnostic selective advantage enabled rapid spread of nvCT in the presence of high treatment rates. After detection, the proportion of nvCT decreased from 30-70% in AR counties and 5-20% in counties that Becton Dickinson tests, to around 5% in 2015 in all counties. The decrease in nvCT was consistent with an estimated fitness cost of around 5% in transmissibility or 17% reduction in infectious duration.ConclusionsWe reconstructed the course of a natural experiment in which a mutant strain ofC. trachomatisspread across Sweden. Our modelling study provides support, for the first time, of a reduced transmissibility or infectious duration of nvCT. This mathematical model improved our understanding of the first nvCT epidemic in Sweden and can be adapted to investigate the impact of future diagnostic escape mutants.Key messagesThe dynamics of a new variant ofChlamydia trachomatis(nvCT) that escaped testing and treatment in Sweden can be reconstructed using a mathematical transmission model.Our study for the first time provides support of a reduced transmissibility or infectious duration of the nvCT in Sweden.This mathematical model improved our understanding of the nvCT epidemic in Sweden and can be adapted to investigate the impact of future diagnostic escape mutants.


2018 ◽  
Author(s):  
Yu-Wei Wu ◽  
Susan Gordleeva ◽  
Xiaofang Tang ◽  
Pei-Yu Shih ◽  
Yulia Dembitskaya ◽  
...  

AbstractAstrocytes express a complex repertoire of intracellular Ca2+ transients (events) that represent a major form of signaling within individual cells and in the astrocytic syncytium. These events have different spatiotemporal profiles, which are modulated by neuronal activity. Spontaneous Ca2+ events appear more frequently in distal astrocytic processes and independently from each other. However, little is known about the mechanisms underlying such subcellular distribution of the Ca2+ events. Here we identify the initiation points of the Ca2+ events within the territory of single astrocytes expressing genetically encoded Ca2+ indicator GCaMP2 in culture or in hippocampal slices. We found that most of the Ca2+ events start in thin distal processes. Our mathematical model demonstrated that a high surface-to-volume (SVR) of the thin processes leads to increased amplitude of baseline Ca2+ fluctuations caused by a stochastic opening of Ca2+ channels in the plasma membrane. Suprathreshold fluctuations trigger Ca2+-induced Ca2+ release (CICR) from the Ca2+ stores by activating inositol 1,4,5-trisphosphate (IP3) receptors. In agreement with the model prediction, the spontaneous Ca2+ events frequency depended on the extracellular Ca2+ concentration. Astrocytic depolarization by high extracellular K+ increased the frequency of the Ca2+ events through activation of voltage-gated Ca2+ channels (VGCC) in cultured astrocytes. Our results suggest that the morphological profile of the astrocytic processes is responsible for tuning of the Ca2+ event frequency. Therefore, the structural plasticity of astrocytic processes can be directly translated into changes in astrocytic Ca2+ signaling. This may be important for both physiological and pathological astrocyte remodeling.Main pointsMajority of spontaneous Ca2+ events start in thin astrocytic processesHigher surface-to-volume ratio of the process is responsible for larger intracellular Ca2+ fluctuationsLarger intracellular Ca2+ fluctuations trigger Ca2+-dependent Ca2+ release


Sign in / Sign up

Export Citation Format

Share Document