scholarly journals Tetrazoles as PPARγ ligands: A Structural and Computational Investigation

2021 ◽  
Author(s):  
Karina de Paula ◽  
Jademilson C. Santos ◽  
Ana Carolina Mafud ◽  
Alessandro S. Nascimento
Keyword(s):  
Adult Population ◽  
Binding Pocket ◽  
Binding Mode ◽  
World Health ◽  
Hypoglycemic Agents ◽  
Oral Hypoglycemic Agents ◽  
Beneficial Effects ◽  
Binding Conformation ◽  
The Us ◽  
Health Organization

AbstractDiabetes is an important chronic disease affecting about 10% of the adult population in the US and over 420 million people worldwide, resulting in 1.6 million deaths every year, according to the World Health Organization. The most common type of the disease, type 2 diabetes, can be pharmacologically managed using oral hypoglycemic agents or thiazolidinediones (TZDs), such as pioglitazone, which act by activating the Peroxisome Proliferated-Activated Receptor γ. Despite their beneficial effects in diabetes treatment, TZDs like rosiglitazone and troglitazone were withdrawn due to safety reasons, creating a void in the pharmacological options for the treatment of this important disease. Here, we explored a structure-based approach in the screening for new chemical probes for a deeper investigation of the effects of PPARγ activation. A class of tetrazole compounds was identified and the compounds named T1, T2 and T3 were purchased and evaluated for their ability to interact with the PPARγ ligand binding domain (LBD). The compounds were binders with micromolar range affinity, as determined by their IC50 values. A Monte Carlo simulation of the compound T2 revealed that the tetrazole ring makes favorable interaction with the polar arm of the receptor binding pocket. Finally, the crystal structure of the PPARγ-LBD-T2 complex was solved at 2.3 Å, confirming the binding mode for this compound. The structure also revealed that, when the helix H12 is mispositioned, an alternative binding conformation is observed for the ligand suggesting an H12-dependent binding conformation for the tetrazole compound.

scholarly journals Diabetes Mellitus and Its Associated Risk Factors among adult Population in Bisha Province, Southwest of Saudi Arabia

2016 ◽  
Vol 9 (6) ◽  
pp. 22 ◽  
Author(s):  
Abdullah M. Al-Shahrani ◽  
Mohammed A. Al-Saleem ◽  
Mohamed O’haj ◽  
Faleh Th. Mohammed ◽  
Mutasim E. Ibrahim
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Healthy Lifestyle ◽  
Adult Population ◽  
Cross Sectional Study ◽  
World Health ◽  
Cross Sectional ◽  
Married Individuals ◽  
Health Organization ◽  
Associated Risk Factors

OBJECTIVES: To determine the prevalence and associated risk factors of diabetes mellitus (DM) among the adult population in Bisha province, Saudi Arabia.METHODS: A cross sectional study was conducted during December, 2015 using the World Health Organization STEPS wise approach for data collection. Blood glucose level and anthropometric measurements of blood pressure, height, weight, and waist circumference were performed per standard methods.  Logistic regression analysis was used to assess the prevalence and risk of diabetes.RESULTS: Of 542 adult individuals included in the study, 13.3% (72) had diabetes, of which 8.1% were previously diagnosed and 5.2% represented new cases. The proportions of DM were 14.7% for men and 10.8% for women. Diabetes was significantly higher among married compared to unmarried individuals (19.3% vs 5.5 %; p<0.001) and among individuals aged ≥40 years old compared to those <40 years (31.3% vs 9.3%; p<0.001). The risk of diabetes was significantly increased with older age (Odds Ratio=4.470; 95% CI 2.264-7.614), married individuals (OR=4.097; 95% CI 2.188-7.672), weight/obesity (OR=2.827; 95% CI 1.567-5.072), hypertension (OR=4.383; 95% CI 2.085-9.214) and having a job (OR=2.327; 95% CI 1.347-4.02). The independent risk factors predicted diabetes were hypertension (Adjusted OR=2.897; 95% CI 1.269-66.13) and job patterns (Adjusted OR=2.793; 95% CI 1.064-7.329).CONCLUSION: Different risk factors alarming diabetes among adult population in Bisha province were detected.  Strategies aimed to improving a healthy lifestyle are necessary to reduce the burden of the disease. 

scholarly journals The Incidence of Bleeding and the Factors That Influence Its Development among Patients Admitted With Dengue Fever

2017 ◽  
Vol 9 (2) ◽  
pp. 23-28
Author(s):  
Krishna Bahadur Thapa ◽  
Namrata KC ◽  
T Koirala ◽  
A Bhatttarai
Keyword(s):  
Platelet Count ◽  
Dengue Fever ◽  
Medical Center ◽  
Adult Population ◽  
World Health ◽  
Chi Square ◽  
Factors Affecting ◽  
Female Sex ◽  
Unit Increase ◽  
Health Organization

Background: Dengue virus is now classified as a major global health threat by the World Health Organization. Bleeding is a common complication and is one of the most feared. There is an increase incidence in the adult population, hence, the focus of this study.Objectives: To determine the incidence of bleeding and the factors that influence its development among patients admitted with dengue fever at Fatima Medical Center, Phillipines from January 2009 to December 2011.Methods: This is a case control study using chart review. The incidence of bleeding is calculated using risk ratio. Factors affecting bleeding are determined using chi square for qualitative variables and T-test or ANOVA for quantitative variables. Simultaneous determination of factors association with bleeding will be analyzed using multiple logistic regression. Level of significance will be set at alpha = 0.05.Results: The female sex is significantly more prone to develop bleeding (p=0.044). There is no significant increase in bleeding in patients who have co-morbidities (p=0.447). In every one unit increase in WBC (1 x 109) the odds of bleeding decrease by 15%. For every one unit increase in hematocrit the odds of bleeding decreases by 6.8%. For every one unit increase in platelet count the odds of bleeding decreases by 3% that is every 10 unit increase in platelet count the odds of bleeding decrease by 22.9%.Conclusions: Female sex, a low initial WBC and platelet count will increase a patient’s propensity to develop bleeding.Journal of Gandaki Medical College Volume, 09, Number 2, July December  2016, page: 23-28

scholarly journals A framework for the assessment and implementation of diagnostics in outbreak situations

2016 ◽  
Vol 5 (3) ◽  
Author(s):  
Elliot P. Cowan
Keyword(s):  
Infectious Agent ◽  
World Health ◽  
The Us ◽  
Health Need ◽  
Health Organization ◽  
Test Requirements ◽  
Regulatory Evaluation ◽  
Development Assessment ◽  
Outbreak Situation

Observation: Outbreak situations require in vitro diagnostics (IVDs) to identify those who are infected and to track the infectious agent in the population. However, such IVDs are typically not available and must be developed. In addition, the process of IVD development, assessment, and implementation are very time and resource intensive. Recognising the extraordinary public health need for IVDs in an outbreak situation, streamlined processes are needed to provide tests that meet the standard of a reasonable assurance of safety and effectiveness in the shortest amount of time. These IVDs are designated for outbreak use.Addressing Issues: This paper presents a pathway to the outbreak use of IVDs that can be considered by countries experiencing an outbreak situation. It takes into account recognition of the outbreak, product development, regulatory evaluation, implementation, and monitoring of the outbreak-use test. Streamlined assessment programmes for emergency-use tests have been established by the US Food and Drug Administration and the World Health Organization. These programmes take into account test requirements for the country in which the outbreak exists. Therefore, countries can consider adopting these tests without the need to conduct expensive and time consuming assessments, such as performance studies. Key responsible parties are identified for each step of the pathway, recognising that transparency and communication among all parties are critical.

The elderly caregiver questionnaire for COVID-19 (ECQC-24)

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Hanif Abdul Rahman ◽  
Wegdan Bani Issa ◽  
Mohammad Rababa ◽  
Deeni Rudita Idris ◽  
Khadizah H. Abdul-Mumin ◽  
...  
Keyword(s):  
Factor Analysis ◽  
Design Methodology ◽  
Reliability And Validity ◽  
The Elderly ◽  
World Health ◽  
Psychometric Analysis ◽  
Content Type ◽  
The Us ◽  
Caregiver Questionnaire ◽  
Health Organization

Purpose The purpose of this paper is to introduce a new tool called the elderly caregiver questionnaire for COVID-19 (ECQC-24) that helps to assess caregiver attributes toward best possible care for elderly during this pandemic. Design/methodology/approach ECQC-24 was developed based on international team of experts and draw upon latest advice from reliable governing bodies such as World Health Organization and the US Centre of Disease Control. Psychometric analysis was applied to ensure the newly developed ECQC-24 is valid and reliable. Findings Cronbach’s alpha ranged from 0.72 to 0.87, and construct validity by exploratory factor analysis was acceptable. The results provide good estimates for the reliability and validity of ECQC-24. Originality/value More evidence is urgently needed to better inform clinicians, health and social policymakers and related stakeholders and organizations involved in caring for the elderly. ECQC-24, the manual to use and analyzing tools are freely available for download and use at https://sites.google.com/view/the-elderly-caregiver-covid19/home.

scholarly journals Is hydroxychloroquine beneficial for COVID-19 patients?

2020 ◽  
Vol 11 (7) ◽  
Author(s):  
Xing Li ◽  
Ying Wang ◽  
Patrizia Agostinis ◽  
Arnold Rabson ◽  
Gerry Melino ◽  
...  
Keyword(s):  
Public Health ◽  
Severe Acute Respiratory Syndrome ◽  
Emergency Care ◽  
Public Health Emergency ◽  
World Health ◽  
Beneficial Effects ◽  
The World ◽  
Health Organization ◽  
Almost All ◽  
Effective Drugs

Abstract The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in December 2019. As similar cases rapidly emerged around the world1–3, the World Health Organization (WHO) declared a public health emergency of international concern on January 30, 2020 and pronounced the rapidly spreading coronavirus outbreak as a pandemic on March 11, 20204. The virus has reached almost all countries of the globe. As of June 3, 2020, the accumulated confirmed cases reached 6,479,405 with more than 383,013 deaths worldwide. The urgent and emergency care of COVID-19 patients calls for effective drugs, in addition to the beneficial effects of remdesivir5, to control the disease and halt the pandemic.

scholarly journals Sodium and Potassium Intake, Knowledge Attitudes and Behaviour Towards Salt Consumption Amongst Adults in Podgorica, Montenegro

Nutrients ◽  
2019 ◽  
Vol 11 (1) ◽  
pp. 160 ◽  
Author(s):  
Lanfranco D’Elia ◽  
Mina Brajović ◽  
Aleksandra Klisic ◽  
Joao Breda ◽  
Jo Jewell ◽  
...  
Keyword(s):  
Salt Intake ◽  
Adult Population ◽  
World Health ◽  
Dietary Salt ◽  
Potassium Intake ◽  
Salt Consumption ◽  
Physical Measurements ◽  
Random Samples ◽  
Health Organization ◽  
Sodium And Potassium

Excess salt and inadequate potassium intakes are associated with high cardiovascular disease (CVD). In Montenegro, CVD is the leading cause of death and disability. There is no survey that has directly measured salt and potassium consumption in Montenegro. The aim is to estimate population salt and potassium intakes and explore knowledge, attitudes and behaviour (KAB), amongst the adult population of Podgorica. Random samples of adults were obtained from primary care centres. Participants attended a screening including demographic, anthropometric and physical measurements. Dietary salt and potassium intakes were assessed by 24 h urinary sodium (UNa) and potassium (UK) excretions. Creatinine was measured. KAB was collected by questionnaire. Six hundred and thirty-nine (285 men, 25–65 years) were included in the analysis (response rate 63%). Mean UNa was 186.5 (SD 90.3) mmoL/day, equivalent to 11.6 g of salt/day and potassium excretion 62.5 (26.2) mmoL/day, equivalent to 3.2 g/day. Only 7% of them had a salt intake below the World Health Organization (WHO) recommended target of 5 g/day and 13% ate enough potassium (>90 mmoL/day). The majority (86%) knew that high salt causes ill-health. However, only 44% thought it would be useful to reduce consumption. Salt consumption is high and potassium consumption is low, in men and women living in Podgorica.

scholarly journals Alcohol skin preparation causes surgical fires

2012 ◽  
Vol 94 (2) ◽  
pp. 87-89 ◽  
Author(s):  
B Rocos ◽  
LJ Donaldson
Keyword(s):  
Fire Risk ◽  
World Health ◽  
Training Curriculum ◽  
Skin Preparation ◽  
Us States ◽  
National Patient Safety Agency ◽  
The Us ◽  
National Patient ◽  
Health Organization ◽  
The Uk

INTRODUCTION Surgical fires are a rare but serious preventable safety risk in modern hospitals. Data from the US show that up to 650 surgical fires occur each year, with up to 5% causing death or serious harm. This study used the National Reporting and Learning Service (NRLS) database at the National Patient Safety Agency to explore whether spirit-based surgical skin preparation fluid contributes to the cause of surgical fires. METHODS The NRLS database was interrogated for all incidents of surgical fires reported between 1 March 2004 and 1 March 2011. Each report was scrutinised manually to discover the cause of the fire. RESULTS Thirteen surgical fires were reported during the study period. Of these, 11 were found to be directly related to spirit-based surgical skin preparation or preparation soaked swabs and drapes. CONCLUSIONS Despite manufacturer's instructions and warnings, surgical fires continue to occur. Guidance published in the UK and US states that spirit-based skin preparation solutions should continue to be used but sets out some precautions. It may be that fire risk should be included in pre-surgical World Health Organization checklists or in the surgical training curriculum. Surgical staff should be aware of the risk that spirit-based skin preparation fluids pose and should take action to minimise the chance of fire occurring.

scholarly journals Is COVID-19 the end of US hegemony? Public bads, leadership failures and monetary hegemony

2020 ◽  
Vol 96 (5) ◽  
pp. 1281-1303 ◽  
Author(s):  
Carla Norrlöf
Keyword(s):  
United States ◽  
Public Goods ◽  
The United States ◽  
World Health ◽  
The Public ◽  
The Us ◽  
Us Hegemony ◽  
Health Organization ◽  
Public Bads ◽  
The Relationship

Abstract COVID-19 is the most invasive global crisis in the postwar era, jeopardizing all dimensions of human activity. By theorizing COVID-19 as a public bad, I shed light on one of the great debates of the twentieth and twenty-first centuries regarding the relationship between the United States and liberal international order (LIO). Conceptualizing the pandemic as a public bad, I analyze its consequences for US hegemony. Unlike other international public bads and many of the most important public goods that make up the LIO, the COVID-19 public bad not only has some degree of rivalry but can be made partially excludable, transforming it into more of a club good. Domestically, I demonstrate how the failure to effectively manage the COVID-19 public bad has compromised America's ability to secure the health of its citizens and the domestic economy, the very foundations for its international leadership. These failures jeopardize US provision of other global public goods. Internationally, I show how the US has already used the crisis strategically to reinforce its opposition to free international movement while abandoning the primary international institution tasked with fighting the public bad, the World Health Organization (WHO). While the only area where the United States has exercised leadership is in the monetary sphere, I argue this feat is more consequential for maintaining hegemony. However, even monetary hegemony could be at risk if the pandemic continues to be mismanaged.

scholarly journals The impact of joining the Eurozone on nutrition habits in Lithuania

2019 ◽  
Vol 29 (Supplement_4) ◽  
Author(s):  
V Dobrovolskij
Keyword(s):  
Vegetable Oil ◽  
Eating Habits ◽  
Adult Population ◽  
Food Prices ◽  
World Health ◽  
Consumer Prices ◽  
Fresh Vegetables ◽  
Health Organization ◽  
The Impact ◽  
Nutrition Habits

Abstract Background Increases in the cost of food often leads to changes in the quantity and type of foods that are purchased. World Health Organization estimates that today’s global food prices rose to the highest level. Numerous research results show that the effect of the conversion of national currencies to the euro on the growth of consumer prices in euro area countries was generally mild and one-off. The aim - to explore the eating habits in 2019 of the Lithuanian population and compare it with results of an eating habits research which was made before the joining euro zone in 2013. Methods The sample under the survey included 1007 of the Lithuania’s population. The interviewing under a questionnaire was carried out in March 2019 using the questionnaire developed for this purpose. Statistical analysis was performed using SPSS program package. The results were compared with nutritional habits of the survey done in 2013. Results The results showed that only one-fifth of the Lithuanian adult population thinks about food choices for health benefits - 22 % (in 2013 - 21 %). Food choice is affected by the taste - 37 % (in 2013 - 28%), to a lesser extent - the food price, which represents 24 % (in 2013 - 37%). 67% of the Lithuanian population (in 2013 - 43%) do not always eat at the same time. 59% (in 2013 - 59%) of the adult population eats three times a day. The majority - 98% (in 2013 - 92.9%) of the respondents had a snack between main meals. It is recommended to eat fresh vegetables every day, but this recommendation is shared by 55% (in 2013 - 40%). The milk and milk products are used each day by 51% (37% in 2013) of the population. The majority - 42% (in 2013 - 82%) of adult Lithuanian population most frequently used vegetable oil. Conclusions More people started to choose food by taste, and a decreased number of those who choose by price. There is increased number of people who eat fresh vegetables every day and decreased number of people who use vegetable oil. Key messages There are differents in nutrition habits among Lithuania population before and after joining Eurozone. The study showed the impact of joining the Eurozone on the diet of the population.

scholarly journals Bioactive Compounds in Anti-Diabetic Plants: From Herbal Medicine to Modern Drug Discovery

Biology ◽  
2020 ◽  
Vol 9 (9) ◽  
pp. 252 ◽  
Author(s):  
Ngan Tran ◽  
Bao Pham ◽  
Ly Le
Keyword(s):  
Diabetes Mellitus ◽  
Traditional Medicine ◽  
World Health Organization ◽  
Morphological Data ◽  
World Health ◽  
Hypoglycemic Agents ◽  
Antidiabetic Activity ◽  
Insulin Production ◽  
Traditional Medicines ◽  
Health Organization

Natural products, including organisms (plants, animals, or microorganisms) have been shown to possess health benefits for animals and humans. According to the estimation of the World Health Organization, in developing countries, 80% of the population has still depended on traditional medicines or folk medicines which are mostly prepared from the plant for prevention or treatment diseases. Traditional medicine from plant extracts has proved to be more affordable, clinically effective and relatively less adverse effects than modern drugs. Literature shows that the attention on the application of phytochemical constituents of medicinal plants in the pharmaceutical industry has increased significantly. Plant-derived secondary metabolites are small molecules or macromolecules biosynthesized in plants including steroids, alkaloids, phenolic, lignans, carbohydrates and glycosides, etc. that possess a diversity of biological properties beneficial to humans, such as their antiallergic, anticancer, antimicrobial, anti-inflammatory, antidiabetic and antioxidant activities Diabetes mellitus is a chronic disease result of metabolic disorders in pancreas β-cells that have hyperglycemia. Hyperglycemia can be caused by a deficiency of insulin production by pancreatic (Type 1 diabetes mellitus) or insufficiency of insulin production in the face of insulin resistance (Type 2 diabetes mellitus). The current medications of diabetes mellitus focus on controlling and lowering blood glucose levels in the vessel to a normal level. However, most modern drugs have many side effects causing some serious medical problems during a period of treating. Therefore, traditional medicines have been used for a long time and play an important role as alternative medicines. Moreover, during the past few years, some of the new bioactive drugs isolated from plants showed antidiabetic activity with more efficacy than oral hypoglycemic agents used in clinical therapy. Traditional medicine performed a good clinical practice and is showing a bright future in the therapy of diabetes mellitus. World Health Organization has pointed out this prevention of diabetes and its complications is not only a major challenge for the future, but essential if health for all is to be attained. Therefore, this paper briefly reviews active compounds, and pharmacological effects of some popular plants which have been widely used in diabetic treatment. Morphological data from V-herb database of each species was also included for plant identification.

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