Genomic analysis of family UBA6911 (Group 18 Acidobacteria) expands the metabolic capacities of the phylum and highlights adaptations to terrestrial habitats

Approaches for recovering and analyzing genomes belonging to novel, hitherto unexplored bacterial lineages have provided invaluable insights into the metabolic capabilities and ecological roles of yet-uncultured taxa. The phylum Acidobacteria is one of the most prevalent and ecologically successful lineages on earth yet, currently, multiple lineages within this phylum remain unexplored. Here, we utilize genomes recovered from Zodletone spring, an anaerobic sulfide and sulfur-rich spring in southwestern Oklahoma, as well as from multiple disparate soil and non-soil habitats, to examine the metabolic capabilities and ecological role of members of the Family UBA6911 (group18) Acidobacteria. The analyzed genomes clustered into five distinct genera, with genera Gp18_AA60 and QHZH01 recovered from soils, Genus Ga0209509 from anaerobic digestors, and genera Ga0212092 and UBA6911 from freshwater habitats. All genomes analyzed suggested that members of Acidobacteria group 18 are metabolically versatile heterotrophs capable of utilizing a wide range of proteins, amino acids, and sugars as carbon sources, possess respiratory and fermentative capacities, and display few auxotrophies. Soil-dwelling genera were characterized by larger genome sizes, higher number of CRISPR loci, an expanded carbohydrate active enzyme (CAZyme) machinery enabling de-branching of specific sugars from polymers, possession of a C1 (methanol and methylamine) degradation machinery, and a sole dependence on aerobic respiration. In contrast, non-soil genomes encoded a more versatile respiratory capacity for oxygen, nitrite, sulfate, trimethylamine N-oxide (TMAO) respiration, as well as the potential for utilizing the Wood Ljungdahl (WL) pathway as an electron sink during heterotrophic growth. Our results not only expand our knowledge of the metabolism of a yet-uncultured bacterial lineage, but also provide interesting clues on how terrestrialization and niche adaptation drives metabolic specialization within the Acidobacteria. Importance Members of the Acidobacteria are important players in global biogeochemical cycles, especially in soils. A wide range of Acidobacterial lineages remain currently unexplored. We present a detailed genomic characterization of genomes belonging to the Family UBA6911 (also known as group 18) within the phylum Acidobacteria. The genomes belong to different genera and were obtained from soil (genera Gp18_AA60 and QHZH01), freshwater habitats (genera Ga0212092 and UBA6911), and anaerobic digestor (Genus Ga0209509). While all members of the family shared common metabolic features, e.g. heterotrophic respiratory abilities, broad substrate utilization capacities, and few auxotrophies; distinct differences between soil and non-soil genera were observed. Soil genera were characterized by expanded genomes, higher numbers of CRISPR loci, larger carbohydrate active enzyme (CAZyme) repertoire enabling monomer extractions from polymer side chains, and methylotrophic (methanol and methylamine) degradation capacities. In contrast, non-soil genera encoded more versatile respiratory capacities for utilizing nitrite, sulfate, TMAO, and the WL pathway, in addition to oxygen as electron acceptors. Our results not only broaden our understanding of the metabolic capacities within the Acidobacteria, but also, provide interesting clues on how terrestrialization shaped Acidobacteria evolution and niche adaptation.

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Quantitative and Qualitative Methods of Studying the Processes of Socialization of a Modern Teenager

Siberian Pedagogical Journal ◽

10.15293/1813-4718.2006.10 ◽

2020 ◽

pp. 102-109

Author(s):

Svetlana Alekseevna Raschetina ◽

Keyword(s):

Research Methods ◽

Interpersonal Relations ◽

Internet Communication ◽

Socialization Process ◽

Wide Range ◽

The Family ◽

Modern Family ◽

Making Friends ◽

Main Support

Relevance and problem statement. Modern unstable society is characterized by narrowing the boundaries of controlled socialization and expanding the boundaries of spontaneous socialization of a teenager based on his immersion in the question arises about the importance of the family in the process of socialization of a teenager in the conditions of expanding the space of socialization. There is a need to study the role of the family in this process, to search, develop and test research methods that allow us to reveal the phenomenon of socialization from the side of its value characteristics. The purpose and methodology of the study: to identify the possibilities of a systematic and anthropological methodology for studying the role of the family in the process of socialization of adolescents in modern conditions, testing research methods: photo research on the topic “Ego – I” (author of the German sociologist H. Abels), profile update reflexive processes (by S. A. Raschetina). Materials and results of the study. The study showed that for all the problems that exist in the family of the perestroika era and in the modern family, it acts for a teenager as a value and the first (main) support in the processes of socialization. The positions well known in psychology about the importance of interpersonal relations in adolescence for the formation of attitudes towards oneself as the basis of socialization are confirmed. Today, the frontiers of making friends have expanded enormously on the basis of Internet communication. The types of activities of interest to a teenager (traditional and new ones related to digitalization) are the third pillar of socialization. Conclusion. The “Ego – I” method of photo research has a wide range of possibilities for quantitative and qualitative analysis of the socialization process to identify the value Pillars of this process.

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A Review on the Anti-Viral Activity of Houttuynia cordata: A Possible Herb for the Management and Treatment of COVID-19

Current Research Journal of Pharmaceutical and Allied Sciences ◽

10.54059/2021.4(2)crjpas_190 ◽

2021 ◽

Vol 4 (2) ◽

pp. 3-10

Author(s):

Emdormi Rymbai ◽

Keyword(s):

Vital Role ◽

Viral Agent ◽

Houttuynia Cordata ◽

Traditional Medicines ◽

Virulent Newcastle Disease Virus ◽

Wide Range ◽

Anti Cancer ◽

The Family ◽

Anti Oxidant

Plants are an important source of natural products and they play a vital role in the field of medicinal chemistry and pharmaceutical science. Traditional medicines have been practiced and used for thousands of years, mostly in Asian countries, where plants are the main sources of medicine. Houttuynia cordata, a herb that belongs to the family Saururaceae, has a wide range of pharmacological activities and is used traditionally in conditions like anisolobis sores, heatstroke, lung carbuncles, malaria, scrotal abscess, tonsillitis, salammoniac poison and has also been widely accepted to possess anti-cancer, anti-oxidant, anti-hypertension, anti-inflammatory, anti-mutagenic, antibacterial, anti-viral and anti-purulent activity. Moreover, it is one of the herbs that was recognized during pandemic outbreaks, such as Severe Acute Respiratory Syndrome Coronavirus (SARS CoV) in China, virulent Newcastle Disease Virus (VNDV) in Java (Indonesia) and Newcastle (England). In this review, we briefly discuss the role of H. cordata as an anti-viral agent and the possibility of developing a dosage form against Coronavirus disease-19 (COVID-19).

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ETHNOBOTANICAL RESEARCH OF THE PERSPECTIVE MEDICINAL PLANT OFCISTANCHE SALSA (С.А. МEY.) G. BECK

Vestnik ◽

10.53065/kaznmu.2021.47.91.051 ◽

2021 ◽

pp. 252-255

Author(s):

Д.К. Айдарбаев ◽

А.Ж. Жарқынбек

Keyword(s):

Medicinal Plant ◽

Raw Materials ◽

Folk Medicine ◽

Climatic Conditions ◽

Pharmacological Properties ◽

Ecological Features ◽

Wide Range ◽

The Family ◽

Research Recommendations

В статье рассматриваются биологические и экологические особенности цистанхе, а также предусматривается этноботанические исследования, рекомендации по рациональному использованию. Выявлены некоторые значения Cistanchе, которое произрастает в Казахстане. Определена область использования в народной медицине цистанхе из семейства Orobanchaceae. В исследовании показана роль цистанхе, как растения с широким спектром фармакологических свойств. Проведен анализ маршрутно-рекогносцировочных исследований популяции цистанхе, определены распределение, запасы и объемы ежегодных заготовок по основным расположенным флористическим районам. Проведен расчет среднего суммарного объема заготовок сырья, собранных в Прибалхашье Алматинской области. В настоящее время в результате глобального потепления климатические условия меняются, и многие виды растений вымирают. Поэтому защита и эффективное использование растений является одной из самых актуальных проблем. Также важно изучить цистанхе, используемый в народной медицине как лекарственное растение. The article discusses the biological and ecological features of cistanche, as well as provides for ethnobotanical research, recommendations for rational use. Some values of Cistanche, which grows in Kazakhstan, are revealed. The scope of use in folk medicine of cistanha from the family Orobanchaceae is determined. The study shows the role of cistanche as a plant with a wide range of pharmacological properties. Conducted analysis of route-reconnaissance studies of cisterna populations, determined the distribution, stock and volumes of annual preparations for the main floristic areas. Calculated the average total volume of raw materials collected in the Balkhash region of Almaty region. As a result of global warming, climatic conditions are changing and many plant species are dying. Therefore, the protection and efficient use of plants is one of the most pressing problems. It is also important to study the tanks used in folk medicine as a medicinal plant.

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Characteristics and dynamics of the family of talented adolescents

Estudos de Psicologia (Natal) ◽

10.1590/s1413-294x2012000100003 ◽

2012 ◽

Vol 17 (1) ◽

pp. 15-23 ◽

Cited By ~ 1

Author(s):

Jane Farias Chagas Ferreira ◽

Denise de Sousa Fleith

Keyword(s):

Information Needs ◽

Leisure Activities ◽

Gifted Students ◽

Talent Development ◽

Family Characteristics ◽

Use Of Time ◽

Wide Range ◽

The Family ◽

Relevant Role

The purpose of this study was to describe family characteristics and dynamics of talented adolescents. Forty-two adolescents between 12 and 18 years old who attended a program for gifted students and their family participated in the data collection. A family characteristics questionnaire and the Parent Success Indicator Inventory, children's and parents' versions were used as instruments. The results indicated that more than half of the families with talented adolescents had a traditional figure: spouses with children born of their own conjugal union. These families prioritized education and the development of their children's talents. The family dynamics involved a wide range of routine and leisure activities, among which stand out those related to the rest, to school, watching television and movies and visiting relatives. Parents evaluated their parental performance in a more positive way when comparing to the adolescents considering all the categories measured by the PSI: communication, use of time, teaching, frustration, satisfaction, and information needs. The results of this study highlight the relevant role of the family regarding talent development.

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Novel Astroviruses in Insectivorous Bats

Journal of Virology ◽

10.1128/jvi.00857-08 ◽

2008 ◽

Vol 82 (18) ◽

pp. 9107-9114 ◽

Cited By ~ 173

Author(s):

D. K. W. Chu ◽

L. L. M. Poon ◽

Y. Guan ◽

J. S. M. Peiris

Keyword(s):

Virus Detection ◽

High Genetic Diversity ◽

Insectivorous Bats ◽

Detection Rates ◽

Human Astroviruses ◽

Wide Range ◽

The Family ◽

Apparently Healthy

ABSTRACT Bats are increasingly recognized to harbor a wide range of viruses, and in most instances these viruses appear to establish long-term persistence in these animals. They are the reservoir of a number of human zoonotic diseases including Nipah, Ebola, and severe acute respiratory syndrome. We report the identification of novel groups of astroviruses in apparently healthy insectivorous bats found in Hong Kong, in particular, bats belonging to the genera Miniopterus and Myotis. Astroviruses are important causes of diarrhea in many animal species, including humans. Many of the bat astroviruses form distinct phylogenetic clusters in the genus Mamastrovirus within the family Astroviridae. Virus detection rates of 36% to 100% and 50% to 70% were found in Miniopterus magnater and Miniopterus pusillus bats, respectively, captured within a single bat habitat during four consecutive visits spanning 1 year. There was high genetic diversity of viruses in bats found within this single habitat. Some bat astroviruses may be phylogenetically related to human astroviruses, and further studies with a wider range of bat species in different geographic locations are warranted. These findings are likely to provide new insights into the ecology and evolution of astroviruses and reinforce the role of bats as a reservoir of viruses with potential to pose a zoonotic threat to human health.

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The Role of TRP Channels in Migraine

The Open Pain Journal ◽

10.2174/1876386301306010037 ◽

2013 ◽

Vol 6 (1) ◽

pp. 37-49 ◽

Cited By ~ 10

Author(s):

Gerry Stephen Oxford ◽

Joyce Harts Hurley

Keyword(s):

Trp Channels ◽

Large Family ◽

Trigeminovascular System ◽

Peripheral Tissues ◽

Wide Range ◽

The Family ◽

The Status ◽

Physical Stimuli ◽

Pain Transduction

TRP channels are members of a large family of non-selective cation channels. The family which numbers over 30 is classified into 6 groups based on amino acid sequence homology. TRP channels are distributed in many peripheral tissues as well as central and peripheral nervous system. These channels are important in sensing a wide range of chemical and physical stimuli. Several TRP channels, including TRPV1 and TRPA1 are important in pain transduction pathways. This review will focus on the function of TRP channels in the trigeminovascular system and other anatomical regions which are relevant to migraine. We will discuss the possible role of TRP channels in migraine, including the potential role of TRPV1 in the hypersensitivity and allodynia frequently observed in migraine patients. We will review the status of TRP channel drugs in migraine therapeutics. We will also discuss the possible roles of TRP channels in triggering migraine attacks, a process which is not well-understood.

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The Role of Animated Characters in the Socialization of Children in the Russian Federation

International Journal of Engineering & Technology ◽

10.14419/ijet.v7i4.38.24621 ◽

2018 ◽

Vol 7 (4.38) ◽

pp. 551

Author(s):

Dina Kabdullinovna Tanatova ◽

Ivan Vladimirovich Korolev ◽

Marina Vladimirovna Nevskaya ◽

Liliya Rafaelevna Tairova

Keyword(s):

New Technologies ◽

Soviet Period ◽

The Public ◽

Wide Range ◽

Animated Films ◽

The Family ◽

The Usa ◽

Smart Tv ◽

Animated Characters

The studies of animated characters as a factor of socialization have virtually no theoretical or empirical interpretation in the Russian sociology. At the same time, cartoons have a huge potential for development and successful socialization of children. It is a well-known fact that animated films are widely used in pedagogy, psychology, and within the family circle. The public especially favors cartoons produced during the Soviet period, but gradually they become a thing of the past. This process is mainly due to the fact that visually and technologically they are inferior to modern cartoons and thus lose their appeal.As a result of the availability of the Internet and Smart TV, the number of young users watching videos and TV broadcasts has risen significantly. The leaders of ratings in terms of views and popularity are cartoons made in the USA, which reflect the values and characteristics of Western society.However, modern animated films boast a wide range of genres, plots, and characters created with the help of new technologies. Their pedagogical, cultural, and development potential is impressive, and their role in the socialization of children is still significant.

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“Post-Soviet sexual revolution”: history and modernity. Group Discussion

Inter ◽

10.19181/inter.2019.17.1 ◽

2019 ◽

Vol 11 (17) ◽

pp. 7-32

Author(s):

Olga M. Zdravomyslova

Keyword(s):

Group Discussion ◽

Sexual Revolution ◽

Soviet Bloc ◽

Reproductive Decisions ◽

The West ◽

Men And Women ◽

Wide Range ◽

The Family ◽

The Right

The group discussion at March 30, 2018 covers a wide range of problems related to modern sexuality, social norms that regulate it, and the historical circumstances that influenced these norms. In the speeches of the participants, three generations of the sexual revolution in Russia are designated: the generation of the behavioral revolution, the generation of the discursive revolution and the generation of the gender revolution. It considers the Bolshevik gender reforms, expressed in the adoption of laws aimed at changing the role of women in the family and society and changing the basis of relations between men and women due to legislative consolidation of gender equality. The authors point out fundamental differences in the pace and nature of gender modernization in Western countries and in Russia, expressed in the fact that in the West, the consequences of the “sexual revolution” of 1968 significantly changed the behavior of both men and women, in the countries of the Soviet bloc only female roles have changed. It is noted, however, that although men show a growing interest in active fatherhood, women in the majority reserve the right to make all reproductive decisions on their own.

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THE SPECIFIC CHARACTER OF THE ARCHETYPE OF HOME IN THE NOVEL “HOUSE OF DOCTOR DEE” BY P. ACKROYD

Наукові записки Харківського національного педагогічного університету ім. Г. С. Сковороди "Літературознавство" ◽

10.34142/2312-1076.2019.3.93.02 ◽

2019 ◽

Vol 3 (93) ◽

pp. 16-28

Author(s):

Н.Ю Бондар

Keyword(s):

Social Protection ◽

The Novel ◽

Specific Character ◽

Family Ties ◽

Wide Range ◽

The Family ◽

The World ◽

Family Generation ◽

External Corrosion

The article deals with the specific character of the archetype of home in the novel “The House of Doctor Dee” by P. Ackroyd. The novel of the English writer tells the story of the fate of the famous alchemist and scientist of the 16th century, Doctor John Dee and modern researcher Matthew Palmer. The purpose of the article is to determine the specific character of the archetype of home in the novel “The House of Doctor Dee” by P. Ackroyd in an individually-authored interpretation. The classical understanding of home is a connection with the family, generation, protection and support, shelter and spiritual comfort. In the second half of the 20th century the archetype of home is significantly problematic. “Home” ceases to be perceived as an exclusively “private” locus, even if it has absorbed all the wealth of the souls of its inhabitants, additional inclusions appear, most often of an existential universal plan. The literature of the postmodern era with its “sensitivity” to the world around it, i.e. with the desire to outline the problems of a wide range (philosophical, historical and others), continues to include “home” in the complex context of life. In this regard, P. Ackroyd’s novel “The House of Doctor Dee”, in which mysticism and reality are intertwined together, is of particular interest. The house of Doctor Dee seems to Matthew full of mystical phenomena and becomes a centre, including different time layers. The house in the novel “The House of Doctor Dee” by P. Ackroyd loses archetypal characteristics at all levels (despite the fact that Matthew is changing his attitude to his adoptive mother), from psychological (strong family ties, attention, understanding) to physical and social (protection, stability). All the fundamental mythological motifs of stability, which usually characterize the archetype of the house – the symbolic constancy of the place, the important role of higher female and male creatures (parents, teachers) as a kind of “good guardians” and mentors, the presence of children as a bastion of eternal renewal – are subjected to internal and external corrosion, destruction, and make the idea of returning home impossible. In addition, the house itself acquires the features of the homunculus, it disintegrates and reborn, but in each century in its own way.

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