scholarly journals The effect of liver enzymes on body composition: a Mendelian randomization study

2019 ◽  
Author(s):  
Jun Xi Liu ◽  
Shiu Lun Au Yeung ◽  
Man Ki Kwok ◽  
June Yue Yan Leung ◽  
Lai Ling Hui ◽  
...  

AbstractBackgroundHigher alanine transaminase (ALT) is positively associated with diabetes but inversely associated with body mass index (BMI) in Mendelian randomization (MR) studies, suggesting liver function may affect body composition. To clarify, we assessed the association of liver function with muscle and fat mass observationally with two-sample MR as a validation.MethodsIn the population-representative “Children of 1997” birth cohort, we used multivariable linear regression to assess the adjusted associations of ALT and alkaline phosphatase (ALP) (IU/L) at ~17.5 years with muscle mass (kg) and body fat percentage (%). Genetic variants predicting ALT, ALP and gamma glutamyltransferase (GGT) (100% change in concentration) were applied to fat-free and fat mass (kg) in the UK Biobank (n=~331,000) to obtain unconfounded estimates using MR.ResultsObservationally, ALT was positively associated with muscle mass (0.11, 95% confidence interval (CI) 0.10 to 0.12) and fat percentage (0.15, 95% CI 0.13 to 0.17). ALP was inversely associated with muscle mass (−0.03, 95% CI −0.04 to −0.02) and fat percentage (−0.02, 95% CI −0.03 to −0.01). Using MR, ALT was inversely associated with fat-free mass (−0.41, 95% CI −0.64 to −0.19) and fat mass (−0.58, 95% CI −0.85 to −0.30). ALP was not clearly associated with body composition. GGT was positively associated with fat-free (0.30, 95% CI 0.01 to 0.06) and fat mass (0.41, 95% CI 0.10 to 0.71).ConclusionALT reducing fat-free mass provides a possible pathway for the positive association of ALT with diabetes, and suggests a potential target of intervention.

Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2493
Author(s):  
Clifton J. Holmes ◽  
Susan B. Racette

Body composition is a key component for maintaining good general health and longevity. It can be influenced by a variety of factors, including genetics, environment, and lifestyle choices. The assessment of body composition is an essential tool for nutrition specialists to effectively evaluate nutritional status and monitor progression during dietary interventions. As humans age, there is a natural increase in fat mass coupled with a gradual decline in lean mass, specifically in bone and muscle mass. Individuals with a high body fat percentage are at a greater risk of cardiovascular diseases, type 2 diabetes, several types of cancer, and early mortality. Significant decreases in bone mineral density signify osteopenia and osteoporosis, while reductions in skeletal muscle mass increase the risk of developing sarcopenia. Moreover, undernutrition exacerbates the effects of many medical conditions and is important to address. Though weight tracking and calculation of BMI are used commonly by clinicians and dietitians, these measures do not provide insight on the relative contributions of fat mass and fat-free mass or the changes in these compartments that may reflect disease risk. Therefore, it is important that healthcare professionals have a critical understanding of body composition assessment and the strengths and limitations of the methods available.


2008 ◽  
Vol 39 (5) ◽  
pp. 801-810 ◽  
Author(s):  
S. E. Saarni ◽  
S. I. Saarni ◽  
M. Fogelholm ◽  
M. Heliövaara ◽  
J. Perälä ◽  
...  

BackgroundThe literature suggests an association between obesity and schizophrenia but fat mass and fat-free mass, which have been shown to be more predictive of all-cause mortality than only waist circumference and obesity [body mass index (BMI) ⩾30 kg/m2], have not been reported in psychotic disorders. We examined the detailed body composition of people with different psychotic disorders in a large population-based sample.MethodWe used a nationally representative sample of 8082 adult Finns aged ⩾30 years with measured anthropometrics (height, weight, waist circumference, fat percentage, fat-free mass and segmental muscle mass). Psychiatric diagnoses were based on a consensus procedure utilizing the Structured Clinical Interview for DSM-IV (SCID)-interview, case-notes and comprehensive register data.ResultsSchizophrenia (including schizo-affective disorder) was associated with obesity [odds ratio (OR) 2.3, 95% confidence interval (CI) 1.5–3.6], abdominal obesity (waist circumference ⩾88 cm for women, ⩾102 cm for men) (OR 2.2, 95% CI 1.3–3.6) and with higher fat percentage (mean difference 3.8%, 95% CI 2.0–5.7%), adjusted for age and gender, than in the remaining sample. The associations between schizophrenia and low fat-free mass and decreased muscle mass on trunk and upper limbs became statistically significant after adjusting for BMI. After further adjusting for current antipsychotic medication, education, diet and smoking, schizophrenia remained associated with obesity (OR 1.9, 95% CI 1.1–3.6) and abdominal obesity (OR 3.8, 95% CI 1.5–9.4). Participants with affective psychoses did not differ from the general population.ConclusionsIndividuals with schizophrenia have metabolically unfavorable body composition, comprising abdominal obesity, high fat percentage and low muscle mass. This leads to increased risk of metabolic and cardiovascular diseases.


2020 ◽  
Vol 32 (1) ◽  
Author(s):  
Sacha Clael Rodrigues Rêgo ◽  
Samuel da Silva Aguiar ◽  
Filipe Manuel Clemente ◽  
Ricardo Franco Lima ◽  
Gustavo De Conti Teixeira Costa ◽  
...  

The present study aimed to check if there is an association between fitness performance variables and to analyze the variation of fitness levels between playing positions university soccer players. Twenty university soccer players were selected (20.95 ± 1.84 years; 71.60 ± 11.65 kg; 176.85 ± 7.28 m) divided into defenders, midfielders and attackers. Body composition was assessed in a cross-sectional analysis that correlated fat mass, lean mass and fat-free mass by DXA with the physical capacity tests. The main results of the present study revealed that both 10-m and 20-m accelerations had moderate-to-large correlations with agility tests across the playing positions, however these accelerations were largely inversely correlated with YoYo intermittent recovery test in defenders and largely positively in midfielders. The agility test was moderately correlated with YoYo intermittent recovery test across the different playing positions. In conclusion, there the acceleration and the agility had a positive association with the different positions of the soccer players.


2021 ◽  
Vol 1 (2021) ◽  
pp. 3-11
Author(s):  
Subhojit Chatterjee ◽  
◽  
Usra Hasan ◽  
Subhra Chatterjee ◽  
◽  
...  

Introduction: Physiological and body composition variables have important role for assessment of training status and evaluation of health status of athletes. Regular monitoring of these variables during training may provide valuable information to coaches for training and selection of players’ training protocol participating in both team sports and individual events. Purpose and objectives of the study: The aims of this study were to compare physiological and body composition variables between male athletes participating in team sports (football) and individual sprint event and also to correlate training duration (both in years and hours per week) of male athletes participating in both team sports as well as sprint with physiological and body composition variables. Applied Methodology: The study was carried out with thirty-year-old (n=30) and BMI matching male Indian athletes participating in team sports (football, n=16) and individual sprint event (n=14), having minimum 2 years of official training. They were in post competitive phase during the test. Several physiological and body composition variables were assessed such as height, weight, body mass index, training age (years), training time (hours/week), fat mass, fat-free mass, body cell mass, muscle mass, VO2 max, maximal power, training intensity and fatigue index following standard protocol. Achieved major results: The sprinters were found to possess significantly more fat free mass (p < .01), body cell mass (p < .01), muscle mass (p < .01), less fat mass (p < .05) and more average anaerobic power (p < .01) than their peers - football players. However, no significant correlation was found between any of the measured physiological and body composition parameters and the training status of these players. Conclusion: This study would provide useful information for assigning training protocols to the athletes participating in team sports and individual sprint events on the basis of physiological and body composition parameters.


Nutrients ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 478 ◽  
Author(s):  
Hamish Fernando ◽  
Jessica Zibellini ◽  
Rebecca Harris ◽  
Radhika Seimon ◽  
Amanda Sainsbury

Background: Ramadan involves one month of fasting from sunrise to sunset. In this meta-analysis, we aimed to determine the effect of Ramadan fasting on weight and body composition. Methods: In May 2018, we searched six databases for publications that measured weight and body composition before and after Ramadan, and that did not attempt to influence physical activity or diet. Results: Data were collected from 70 publications (90 comparison groups, 2947 participants). There was a significant positive correlation between starting body mass index and weight lost during the fasting period. Consistently, there was a significant reduction in fat percentage between pre-Ramadan and post-Ramadan in people with overweight or obesity (−1.46 (95% confidence interval: −2.57 to −0.35) %, p = 0.010), but not in those of normal weight (−0.41 (−1.45 to 0.63) %, p = 0.436). Loss of fat-free mass was also significant between pre-Ramadan and post-Ramadan, but was about 30% less than loss of absolute fat mass. At 2–5 weeks after the end of Ramadan, there was a return towards, or to, pre-Ramadan measurements in weight and body composition. Conclusions: Even with no advice on lifestyle changes, there are consistent—albeit transient—reductions in weight and fat mass with the Ramadan fast, especially in people with overweight or obesity.


2020 ◽  
Vol 5 (4) ◽  
pp. 72
Author(s):  
Austin Katona ◽  
Caroline Riewe ◽  
Angela Bruzina ◽  
Nicholas J Ollberding ◽  
Mary Ankrom ◽  
...  

Body composition plays a key role in overall health and sports performance and its assessment is an important part of many athletic programs. The purpose of this study was to describe longitudinal changes in body composition for collegiate female soccer players in order to provide data to inform future training and nutrition interventions for this population. A linear mixed-model (LMM) approach was used to analyze four years of pre- and post-season body composition data, including total mass, fat-free mass (FFM), fat mass, and body fat percentage (%BF) for 49 athletes. Athletes gained an average of 0.5 kg FFM during the season (p < 0.05) and increased total mass, FFM, fat mass, and %BF (2.5 kg, 1.1 kg, 1.7 kg, and 1.7%, respectively; p < 0.05) over four years. Freshmen experienced a 1.5 kg gain in total mass pre- to post-season (p < 0.05), while no changes in total mass or body composition were seen in other grade levels. Gains in %BF during the off season between Freshman and Sophomore years represented negative changes in body composition that should be addressed further. These results can help interdisciplinary athlete care teams optimize training programs in this population by understanding what changes are expected over multiple years. Normalizing these changes may also help the promotion of realistic body composition goals and the development of positive training and dietary habits.


2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Avivit Brener ◽  
Yarden Waksman ◽  
Talya Rosenfeld ◽  
Sigal Levy ◽  
Itai Peleg ◽  
...  

Abstract Background Physical growth during childhood and adolescence is influenced by both genetic and environmental factors. Heritability, the proportion of phenotypic variance explained by genetic factors, has been demonstrated for stature and weight status. The aim of this study was to explore the heritability of body composition. Methods A real-life, observational study of the children and adolescents referred to the Endocrine Unit in a tertiary medical center. In January 2018, body composition by means of bioimpedance analysis (BIA) was implemented as part of the standard intake assessment of subjects referred for endocrine consultation. The clinic BIA database was searched for subjects with the term “observation of growth” as the sole reason for referral. BIA of 114 triads of healthy subjects aged 5–18 years and their parents were analyzed. The BIA report included the following data: fat mass, fat percentage, truncal fat percentage and muscle mass. Calculated variables included: appendicular skeletal muscle mass (ASMM = the sum of muscle mass of four limbs), muscle-to-fat ratio [MFR = ASMM (kg)/fat mass (kg)] and sarcopenic index [(SI = ASMM(kg)/height (meter)²]. Data collection from medical files included pubertal stage and home address for socioeconomic position grading. Results There were sex differences in body composition parameters in both the prepubertal and pubertal subjects. The boys among the prepubertal subjects had a lower fat percentage on average than girls (p = 0.020). Among the adolescents, boys on average had lower fat percentage (p = 0.011), higher sarcopenic index (p = 0.021), and higher muscle-to-fat ratio (p < 0.001), than adolescent girls. Correlation analyses between body composition parameters of all participants revealed significant correlations in the sarcopenic index of prepubertal children and their parents (boys-fathers: r = 0.380, p = 0.050; boys-mothers: r = 0.435, p = 0.026; girls-fathers: r = 0.462, p = 0.012; girls-mothers: r = 0.365, p = 0.050) and adiposity indices (fat percentage, truncal fat percentage and muscle-to-fat ratio) of prepubertal boys and their mothers (r = 0.438, p = 0.025; r = 0.420, p = 0.033, and r = 0.478, p = 0.014, respectively). There were no associations between body composition parameters of adolescents and their parents. Socioeconomic position adversely affected fat percentage in adolescent girls and mothers. Conclusions Heritable body composition traits were demonstrated in childhood but not in adolescence, suggesting that environmental influence has a more telling effect during teenage years.


2018 ◽  
Vol 16 (1) ◽  
pp. 047
Author(s):  
Predrag Bićanin ◽  
Saša Milenković ◽  
Dragan Radovanović ◽  
Aco Gajević ◽  
Jelena Ivanović

This research included a sample of 79 pre-school boys aged 6 and 7 with 40 of them in the experimental group and 39 in the control group. Their current state of body composition was studied, as well as their relations after a 6-month fitness treatment that the experimental group of participants was involved in, in order to analyze its effects. The experimental group had two classes per week, in addition to regular programmed activities as part of the children’s sport school (three times per week), and as part of 48 of additional, six-month training lessons of exercising in sport (fitness) clubs. The following variables have been used to evaluate body composition with the application of bio-electric impedance In Body 230 such as: muscle mass, percentage of muscle mass, body fat mass, percentage of body fat mass, fat free mass, percentage of fat free mass. Although small to moderate effects were obtained by the double mixed ANOVA, the results show the experimental group’s achievements as significantly higher than those of the control group. Furthermore, with individual eta coefficient findings in comparison with each group measurements, it is clear that the value of the obtained effects is different between groups to the benefit of the experimental group. Permanent implementation of the proposed programme could contribute to an improvement on the studied body composition variables which can result in the better health status of children in future.    


2021 ◽  
Vol 224 (2) ◽  
pp. jeb219543
Author(s):  
Daniella E. Chusyd ◽  
Tim R. Nagy ◽  
Lilian Golzarri-Arroyo ◽  
Stephanie L. Dickinson ◽  
John R. Speakman ◽  
...  

ABSTRACTMany captive Asian elephant populations are not self-sustaining, possibly due in part to obesity-related health and reproductive issues. This study investigated relationships between estimated body composition and metabolic function, inflammatory markers, ovarian activity (females only) and physical activity levels in 44 Asian elephants (n=35 females, n=9 males). Deuterium dilution was used to measure total body water from which fat mass (FM) and fat-free mass (FFM) could be derived to estimate body composition. Serum was analyzed for progestagens and estradiol (females only), deuterium, glucose, insulin and amyloid A. Physical activity was assessed by an accelerometer placed on the elephant's front leg for at least 2 days. Relative fat mass (RFM) – the amount of fat relative to body mass – was calculated to take differences in body size between elephants into consideration. Body fat percentage ranged from 2.01% to 24.59%. Male elephants were heavier (P=0.043), with more FFM (P=0.049), but not FM (P>0.999), than females. For all elephants, estimated RFM (r=0.45, P=0.004) was positively correlated with insulin. Distance walked was negatively correlated with age (r=−0.46, P=0.007). When adjusted for FFM and age (P<0.001), non-cycling females had less fat compared with cycling females, such that for every 100 kg increase in FM, the odds of cycling were 3 times higher (P<0.001). More work is needed to determine what an unhealthy amount of fat is for elephants; however, our results suggest higher adiposity may contribute to metabolic perturbations.


2020 ◽  
Author(s):  
zenghui ding ◽  
Yubing Xu Dr ◽  
Yanyan Chen Dr ◽  
Xianjun Yang ◽  
Yining Sun ◽  
...  

Abstract Background: Prophylactic interventions against osteoporosis require a determination of the factors that influence the bone status during adulthood. This study aimed to investigate the associations between body composition parameters (body height (BH), body weight (BW), fat free mass (FFM), fat mass (FM), lower limb muscle mass (LLMM), lower limb fat mass (LLFM)), countermovement jump (CMJ) performance, and calcaneal bone stiffness (SI) in a population of young adults. Methods: The study population included 560 Chinese adults (369 females), aged 20-40 years. Body composition was obtained by bioelectrical impedance analysis (BIA). The CMJ performance (CMJ height (CMJH), the impulse of CMJ phase (ICMJ) and potential energy in the CMJ phase (ECMJ)) was obtained by 3 maximal CMJ trials on ZTJ-II system. Bone quality was measured by quantitative ultrasound (QUS). Results: The present study found BW, FFM and LLMM had significant correlations with SI both in males (r=0.20-0.24, p<0.05) and females (r=0.12-0.20, p<0.05). However, FM and LLFM had positive correlations with SI only in females (p<0.05). CMJ performances, including CMJH, ICMJ and ECMJ, had significant positive correlations with SI in men (r=0.415, p<0.01; r=0.32, p<0.01; and r=0.39, p<0.01, respectively) and women (r=0.248, p<0.01; r=0.26, p<0.01; r=0.3, p<0.01, respectively). Conclusions: This provides evidence that local muscle mass have greater positive associations with calcaneal bone quality than total FFM, and local muscle mass and power are the determinations of region bone quality in young adults. The bone–muscle relationship is more prominent in males than in females.


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