Educational level and chronic inflammation in the elderly - the role of obesity: results from the population-based CARLA study

2015 ◽  
Vol 5 (5) ◽  
pp. 256-265 ◽  
Author(s):  
D. Medenwald ◽  
H. Loppnow ◽  
A. Kluttig ◽  
S. Nuding ◽  
K. H. Greiser ◽  
...  
Keyword(s):  
Chronic Inflammation ◽  
Educational Level ◽  
The Elderly ◽  
Population Based

Intergenerational Education for the Psychological, Social and Educational Improvement of the Elderly

2019 ◽  
Vol 15 (1) ◽  
pp. 22-26
Author(s):  
Nazaret Martínez-Heredia
Keyword(s):  
Educational Level ◽  
Mixed Type ◽  
Healthy Aging ◽  
Social Role ◽  
Intergenerational Relationships ◽  
Daily Practice ◽  
The Elderly ◽  
Educational Improvement ◽  
Intergenerational Education

Introduction: Intergenerational education encourages cooperation and interaction between two or more generations through experiences, knowledge, skills, attitudes and values. Objective: The main objective of our research was to know the benefits at the psychological, social and educational level of intergenerational education. Methods: This is mixed-type research establishing relationships between young and old. The sample consists of a total of 94 people, 47 young people (aged between 21 and 40 years old) and 47 older (aged between 65 and 85 years). We promote the development of a mixed methodology to know if after the implementation of an intergenerational program we have obtained benefits in the elderly participants. Results: Considering the results we can say that the benefits at the psychological, social and educational level have been very remarkable of our elders. Conclusions: We must bet on intergenerational relationships as an ideal within our daily practice achieving a healthy aging, benefiting continuity in an active social role of our elders.

scholarly journals Chronic Inflammation as an Immunological Abnormality and Effectiveness of Exercise

Biomolecules ◽  
2019 ◽  
Vol 9 (6) ◽  
pp. 223 ◽  
Author(s):  
Katsuhiko Suzuki
Keyword(s):  
Chronic Inflammation ◽  
Pathological Condition ◽  
Inflammatory Cells ◽  
The Elderly ◽  
Healthy Life ◽  
Daily Lives ◽  
Food Ingredients ◽  
Tissue Degeneration ◽  
Age Related

Reduced levels of physical activity in people’s daily lives cause the development of metabolic syndromes or age-related disorders. Chronic inflammation is now understood to be an underlying pathological condition in which inflammatory cells such as neutrophils and monocyte/macrophages infiltrate into fat and other tissues and accumulate when people become obese due to overeating and/or physical inactivity. Pro-inflammatory mediators such as cytokines that are secreted in excess from inflammatory cells will not only lead to the development of arteriosclerosis when they chronically affect blood vessels but also bring tissue degeneration and/or dysfunction to various organs. Chronic inflammation is also involved in sarcopenia that brings hypofunction in the elderly, dementia, osteoporosis, or cancer and negatively affects many chronic diseases and people’s healthy life expectancy. In this paper, outlines of such studies are introduced in terms of homeostatic inflammation, which occurs chronically due to the innate immune system and its abnormalities, while focusing on the efficacy of exercise from aspects of immunology and oxidative stress. The preventative effects of functional food ingredients in combination with exercise are also introduced and described. The challenges and future directions in understanding the role of exercise in the control of chronic inflammation are discussed.

The role of surgical resection for hepatocellular carcinoma in octogenarians: A population-based analysis.

2014 ◽  
Vol 32 (3_suppl) ◽  
pp. 202-202
Author(s):  
Takintope Akinbiyi ◽  
Atuhani S. Burnett ◽  
Philip Ernst ◽  
Marisa Cevasco ◽  
Donald A. McCain ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Surgical Resection ◽  
Survival Benefit ◽  
The Elderly ◽  
Population Based ◽  
Seer Database ◽  
Significant Difference ◽  
Disease Stages ◽  
The Impact

202 Background: Hepatocellular carcinoma (HCC) is a significant source of morbidity and mortality amongst the elderly population. In appropriately selected patients, surgery is known to confer a survival advantage. Octagenarians, however, given their remaining life expectancy may receive limited benefit from surgery. Nevertheless, insufficient information is available in the literature on the survival benefit of surgery in octagenarians with HCC. Methods: Octogenarians with HCC were selected from the Surveillance, Epidemiology, and End Results (SEER) database between 1998 and 2009. We evaluated patients who underwent surgical resection and those that declined to assess the impact surgery has on overall survival in this population. Results: A total of 8,614 with HCC were identified in the SEER database, of which surgery was recommended for 3,529 (41%). A total of 1,002 patients (28%) underwent surgery and 2,497 (71%) declined. Although there was a trend towards improved survival in the surgery group (7.91 months) vs the non-surgical group (7.03 months), there was no statistically significant difference in survival between the two groups (p = 0.09). Conclusions: Our study demonstrates that octagenarians as a whole do not experience a survival benefit from surgical resection for HCC. Subgroup analysis, however, may ultimately identify benefit in specific disease stages or patients with fewer comorbidities.

scholarly journals Social Network Communications in Chilean Older Adults

2020 ◽  
Vol 17 (17) ◽  
pp. 6078
Author(s):  
Francisco Javier Rondán-Cataluña ◽  
Patricio E. Ramírez-Correa ◽  
Jorge Arenas-Gaitán ◽  
Muriel Ramírez-Santana ◽  
Elizabeth E. Grandón ◽  
...  
Keyword(s):  
Older Adults ◽  
Social Networks ◽  
Social Networking ◽  
Social Networking Sites ◽  
Educational Level ◽  
The Elderly ◽  
Population Based ◽  
And Gender ◽  
Gender Influences ◽  
Elderly Users

The growth of older adults in new regions poses challenges for public health. We know that these seniors live increasingly alone, and this impairs their health and general wellbeing. Studies suggest that social networking sites (SNS) can reduce isolation, improve social participation, and increase autonomy. However, there is a lack of knowledge about the characteristics of older adult users of SNS in these new territories. Without this information, it is not possible to improve the adoption of SNS in this population. Based on decision trees, this study analyzes how the elderly users of various SNS in Chile are like. For this purpose, a segmentation of the different groups of elderly users of social networks was constructed, and the most discriminating variables concerning the use of these applications were classified. The results highlight the existence of considerable differences between the various social networks analyzed in their use and characterization. Educational level is the most discriminating variable, and gender influences the types of SNS use. In general, it is observed that the higher the educational level, the more the different social networking sites are used.

scholarly journals Infusion therapy of an oncologic patient: pros and cons

2020 ◽  
pp. 123-125
Author(s):  
Yu.Yu. Kobeliatskyi
Keyword(s):  
Tumor Cells ◽  
Chronic Inflammation ◽  
The Elderly ◽  
Infusion Therapy ◽  
Electrolyte Balance ◽  
Target Values ◽  
Filling Time ◽  
Microcirculatory Disorders ◽  
Tract Infections

Background. The goals of infusion therapy (IT) include the restoration of adequate tissue perfusion, maintaining the quantity and quality of the body fluid sectors, correction of homeostasis parameters. In addition, IT can be used for parenteral nutrition, reducing the risk of thrombosis and urinary tract infections. Objective. To identify key IT parameters of a cancer patient. Materials and methods. Analysis of the available literature on this topic. Results and discussion. Indications for IT include hypovolemia, cellular and protein deficiency of blood, nutrition disorders, intoxication, disorders of hemostasis, hemorheological properties, fluid and electrolyte balance, acid-base status. Cancer patients often have the listed syndromes. The appropriate infusion volume should not be exceeded, as the hypervolemia is accompanied by edema, multiorgan dysfunction and worsening of the prognosis. On the other hand, dehydration is the most common fluid and electrolyte balance disorder in the elderly. It is an independent predictor of mortality and high healthcare costs. At any IT administration it is necessary to assess the volemia condition, to determine the cause of the deficiency, to choose the optimal solution and infusion rate, to set and to monitor target values. Capillary filling time, heart rate, blood pressure, jugular veins’ condition, skin turgor, pulmonary and cardiac auscultation data, edema control, diuresis rate, and weight changes are used to assess volemia. Peculiarities of the elderly and debilitated patients, which should be taken into account when prescribing IT, include the loss of thirst feeling, deterioration of renal function and worsening of hormonal regulation of fluid and electrolyte balance. Anticancer therapy has a number of side effects, and some of them can be eliminated with the help of IT. The amount of fluid required should be calculated based on physiological needs (30-40 ml/kg/day), deficiency severity and pathological losses (fever, blood loss, polyuria, perspiration, drainage losses). Plasma replacement solutions can be divided into crystalloids (iso- and hypertonic saline, Ringera lactate) and colloids (albumin, solutions of gelatin, dextranes, hydroxyethyl starch). Crystalloids are recommended for short-term interventions, while long-term therapy requires colloids or balanced solutions, as the introduction of unbalanced solutions is accompanied by such risks as hyperchloremia, dilutive acidosis, acute kidney damage, and systemic vasoconstriction. In settings of the chronic inflammation, which often accompanies oncological diseases, the role of thirst as a means of controlling osmolarity changes. Hyperosmolarity may also accompany central diabetes mellitus and tumor metastases to the hypothalamus. Hyperosmolarity leads to the microcirculatory disorders, increased inflammation, cachexia development and multiple organ failure. Another feature of IT in oncology settings is the disruption of tissue energy supply due to nutritional deficiencies and changes in metabolism. Xylitol (Xylate, “Yuria-Pharm”) can be used to eliminate this problem. Xylitol is a five-atom alcohol, which is directly included into the pentose phosphate cycle. The benefits of xylitol include metabolism stabilization in people with diabetes, promotion of slow but stable energy production, antiketogenic properties, improved metabolism of B vitamins, cholekinetic action, and high safety. Xylitol is not used by the tumor cells as an energy substrate. The role of xylitol (Xylate) in IT is to increase the volume of circulating plasma, to reduce the interstitial edema, to decrease the production of ketone bodies, to activate the antioxidant systems, and to increase alkaline blood reserve. It has been reported that xylitol infusion has an oncosuppressive effect due to its antioxidant effect and inhibition of glucose utilization by tumor cells. Conclusions. 1. IT is an important component of cancer treatment; it should be based on the individual features of the patient. 2. Rational IT eliminates chronic inflammation, endothelial dysfunction and microcirculatory disorders. 3. Rational IT is based on the correct choice of solution, its timely introduction and frequent evaluation of the infusion response. 4. Xylate (“Yuria-Pharm”) has a multifunctional effect in oncology: eliminates dehydration, corrects energy deficiency, and has a direct oncosuppressive effect.

scholarly journals Meningkatkan kemandirian pasien pasca stroke melalui in-house training kader pendukung lansia pasca stroke

2019 ◽  
Vol 1 (1) ◽  
pp. 95
Author(s):  
Nurul Aktifah ◽  
Wahyu Ersila ◽  
Lia Dwi Prafitri ◽  
Rifqi Sabita
Keyword(s):  
Community Service ◽  
Daily Living ◽  
Active Role ◽  
The Elderly ◽  
Population Based ◽  
Post Stroke ◽  
Field Practice ◽  
Before And After ◽  
Improve Health

AbstrakInsiden stroke mengenai populasi usia lanjut yang berusia 75-84 tahun sekitar 10 kali dari populasi 55-64 tahun. Berdasarkan Rencana Strategis Kementerian Kesehatan 2015-2019, maka perlu adanya upaya peningkatan promosi kesehatan dan pengabdian masyarakat, serta kegiatan promotif dan preventif, yang dapat dilakukan melalui peningkatkan peran aktif kader dalam upaya promotif dan preventif melalui praktik pendidikan kesehatan dengan tujuan untuk memandirikan klien dalam melakukan Activity Daily Living (ADL). Tujuan pengabdian masyarakat ini adalah menghasilkan kader yang terlatih melakukan pendidikan kesehatan dan praktik lapangan serta memberikan pencegahan pada lansia yang beresiko terhadap stroke di wilayah Puskesmas Buaran. Metode yang dilakukan dimulai dengan pembentukan kader pendukung lansia pasca stroke pada bulan September 2018, diikuti dengan pelatihan kader dan berakhir dengan monitoring dan evaluasi keterampilan kader secara mandiri di bulan Februari 2019. Hasil yang diperoleh yaitu terbentuknya 20 kader yang memiliki pengetahuan tentang konsep stroke dan cara melatih Activity Daily Living (ADL) sebelum dan setelah pelatihan (xˉ= 86) , praktik keterampilan (xˉ = 79.30), dan praktik lapangan (xˉ= 86,75). Kesimpulan dari pengabdian masyarakat ini adalah melalui pelatihan terstruktur dengan penyediaan keterampilan promosi kesehatan menejemen lansia pasca stroke akan mampu membentuk kader pendukung lansia pasca stroke yang terlatih. Kata kunci: Kader; lansia; stroke AbstractStroke incidence in the 75-84-year-old population is about 10 times that of the 55-64-year population. Based on the Ministry of Health's 2015-2019 Strategic Plan, it is necessary to improve health and community service promotion, as well as promotive and preventive activities, which can be done through increasing the active role of cadres in the field of health education and field practice on Activity Daily Living (ADL). The purpose of community service is to produce cadres who improve education and field practice and provide a budget for the elderly who are at risk of stroke in the Buaran health district. The method was begun with the formation of post-stroke supporting cadres in September 2018, followed by cadres training and ended by monitoring and evaluating cadre skills independently in February 2019. The results obtained were the formation of 20 cadres who were knowledgeable about the concept of stroke and methods training Activity Daily Living (ADL) before and after training (xˉ = 86), skill practice (xˉ = 79.30), and field practice (xˉ = 86.75). The conclusion of this community service is through structured training with the provision of health promotion skills for post-stroke elderly management will be able to form  supporting cadres for trained post-stroke elderly. Keywords: Cadre; elderly; stroke

scholarly journals Role of BMI in the Relationship Between Dietary Inflammatory Index and Depression: An Intermediary Analysis

2021 ◽  
Vol 8 ◽  
Author(s):  
Yuxia Ma ◽  
Ruiqiang Li ◽  
Wenqiang Zhan ◽  
Xin Huang ◽  
Zechen Zhang ◽  
...  
Keyword(s):  
Cohort Study ◽  
Large Population ◽  
Geriatric Depression Scale ◽  
Depression Scale ◽  
The Elderly ◽  
Population Based ◽  
Dietary Inflammatory Index ◽  
Multivariable Logistic Regression Model ◽  
Inflammatory Index

Introduction: This study investigated this association and the role of BMI in the inflammatory process in a large population-based observational study.Methods: A total of 1,865 elderly people (≥55 years) were followed from the Community Cohort Study of Nervous System Diseases (CCSNSD) cohort study from 2018 to 2019 (Mean [SD] age, 66.31 [0.32] years; 716 [38.4%] males). The semi-quantitative FFQ and geriatric depression scale (GDS) were used to evaluate the diet and depressive symptoms of the elderly, respectively. The multivariable logistic regression model estimated the OR and 95% CI between Empirical Dietary Inflammatory Index (E-DII) and depression. The interaction of E-DII and BMI on depressive events was tested, and the mediation analysis of BMI was performed.Results: As measured by E-DII, the mean (SE) value of the inflammatory potential of the diet in our study was 1.56 (0.12). E-DII ranged from 5.23 to 5.58. In comparison with the first quartile, the elderly from the second quartile (OR: 1.15 [95% CI: 1.09, 1.28]) to the fourth quartile (OR: 1.31 [95% CI: 1.16, 1.42]) have a higher risk of depression before adjustment for BMI. An interaction was observed between E-DII and BMI in terms of the risk of depression (PInteraction < 0.001). The whole related part is mediated by BMI (31.06%).Conclusion: Our findings indicate that the higher pro-inflammatory potential of diet is associated with a higher risk of depression, and this association may be mediated by BMI. Further research is needed to verify our findings and clarify the latent mechanism.

scholarly journals Interleukin 6 in aging and age­-related diseases

The Clinician ◽  
2021 ◽  
Vol 14 (3-4) ◽  
pp. 10-17
Author(s):  
S. V. Topolyanskaya
Keyword(s):  
Chronic Inflammation ◽  
Inflammatory Cytokines ◽  
Significant Role ◽  
Interleukin 6 ◽  
The Elderly ◽  
Low Grade ◽  
Special Role ◽  
Risk Of Death ◽  
Age Related

Modern concepts about the importance of subclinical inflammation in various age-associated pathology are described in the review. The term “inflammaging” (inflammation due to aging) refers to the special role of inflammation in the aging processes. This type of inflammation is low-grade, controlled, asymptomatic, chronic and systemic. Inflammaging determines the rate of aging and life expectancy. The balance of pro-inflammatory and anti-inflammatory cytokines plays a significant role in aging processes. The increased levels of pro-inflammatory cytokines such as interleukin-6 and tumor necrosis factor-α in the elderly are associated with different diseases, disability and mortality. Interleukin-6 is a multifunctional cytokine involved in the regulation of acute phase response and other immunological reactions, in the hematopoiesis and in chronic inflammation. This cytokine is important in the pathogenesis of chronic inflammation diseases, as well as different oncological disorders. Interleukin-6 is often called the “cytokine of gerontologists”, since it is one of the main signaling pathways associated with aging and age-related diseases. This cytokine also plays an important role in the pathogenesis of atherosclerosis, coronary artery disease, chronic heart failure and increases the risk of death from cardiovascular diseases and overall mortality. Interleukin-6 is a key proinflammatory cytokine responsible for the “metabolic inflammation”, obesity, insulin resistance and diabetes mellitus. This cytokine has a significant impact on the development of sarcopenia and frailty. The serum levels of interleukin-6 negatively correlate with muscle mass and skeletal muscle function in the elderly, so it is considered as a biomarker of sarcopenia and functional decline. Interleukin-6 may contribute to the development of osteoporosis by stimulating osteoclastogenesis and bone resorption. The modern data indicate the diverse effects of interleukin-6 and confirm the significant role of this cytokine in aging and in different age-associated pathology.

scholarly journals Interleukin 6 in aging and age-related diseases

The Clinician ◽  
2020 ◽  
Author(s):  
S. V. Topolyanskaya
Keyword(s):  
Chronic Inflammation ◽  
Inflammatory Cytokines ◽  
Significant Role ◽  
Interleukin 6 ◽  
The Elderly ◽  
Low Grade ◽  
Special Role ◽  
Risk Of Death ◽  
Age Related

Modern concepts about the importance of subclinical inflammation in various age-associated pathology are described in the review. The term “inflammaging” (inflammation due to aging) refers to the special role of inflammation in the aging processes. This type of inflammation is low-grade, controlled, asymptomatic, chronic and systemic. Inflammaging determines the rate of aging and life expectancy. The balance of pro-inflammatory and anti-inflammatory cytokines plays a significant role in aging processes. The increased levels of pro-inflammatory cytokines such as interleukin-6 and tumor necrosis factor-α in the elderly are associated with different diseases, disability and mortality. Interleukin-6 is a multifunctional cytokine involved in the regulation of acute phase response and other immunological reactions, in the hematopoiesis and in chronic inflammation. This cytokine is important in the pathogenesis of chronic inflammation diseases, as well as different oncological disorders. Interleukin-6 is often called the “cytokine of gerontologists”, since it is one of the main signaling pathways associated with aging and age-related diseases. This cytokine also plays an important role in the pathogenesis of atherosclerosis, coronary artery disease, chronic heart failure and increases the risk of death from cardiovascular diseases and overall mortality. Interleukin-6 is a key proinflammatory cytokine responsible for the “metabolic inflammation”, obesity, insulin resistance and diabetes mellitus. This cytokine has a significant impact on the development of sarcopenia and frailty. The serum levels of interleukin-6 negatively correlate with muscle mass and skeletal muscle function in the elderly, so it is considered as a biomarker of sarcopenia and functional decline. Interleukin-6 may contribute to the development of osteoporosis by stimulating osteoclastogenesis and bone resorption. The modern data indicate the diverse effects of interleukin-6 and confirm the significant role of this cytokine in aging and in different age-associated pathology.

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