Low antibiotic resistance rates in Staphylococcus aureus, Escherichia coli and Klebsiella spp but not in Enterobacter spp and Pseudomonas aeruginosa: a prospective observational study in 14 Swedish ICUs over a 5-year period

2007 ◽  
Vol 51 (7) ◽  
pp. 937-941 ◽  
Author(s):  
H. Hanberger ◽  
L. G. Burman ◽  
O. Cars ◽  
M. Erlandsson ◽  
H. Gill ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Antibiotic Resistance ◽  
Observational Study ◽  
Prospective Observational Study ◽  
Resistance Rates ◽  
Klebsiella Spp

scholarly journals 2049. Trends in Antibiotic Use and Antibiotic Resistance among Veterans Affairs Community Living Centers from 2011 to 2017

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S690-S691
Author(s):  
Haley Appaneal ◽  
Aisling Caffrey ◽  
Stephanie Hughes ◽  
Vrishali Lopes ◽  
Robin L Jump ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Pseudomonas Aeruginosa ◽  
Antibiotic Resistance ◽  
Antibiotic Use ◽  
Veterans Affairs ◽  
Fluoroquinolone Resistance ◽  
Antibiotic Overuse ◽  
Community Living Centers ◽  
Resistance Rates ◽  
Klebsiella Spp

Abstract Background Antibiotic resistance is a global public health crisis, with antibiotic overuse contributing to selection pressure, and thus driving antibiotic resistance. Strategies to reduce antibiotic overuse may slow the development of resistance, but large-scale studies assessing trends in antibiotic use and resistance among nursing homes at the national level are limited. We describe trends in antibiotic use and resistance nationally among Veterans Affairs (VA) Community Living Centers (CLCs). Methods We assessed antibiotic use and microbiological cultures among VA CLC residents from 2011 to 2017. Antibiotics were grouped into eight drug classes and annual days of antibiotic therapy per 1,000 bed-days were calculated. Facility-weighted annual antibiotic resistance rates were calculated. Joinpoint Software was used for regression analyses of trends over time and to estimate annual average percent changes (AAPC) with 95% confidence intervals (CI). Results Over 7 years and among 146 CLCs, several significant trends in decreasing antibiotic use and corresponding reductions in resistance were identified. Fluoroquinolone use decreased by 9.9% annually (95% CI −11.6 to −8.2%) and fluoroquinolone resistance decreased by 2.3% per year for Escherichia coli, 5.1% for Klebsiella spp., 1.8% for Proteus mirabilis, 4.9% for Pseudomonas aeruginosa, 12.6% for Enterobacter spp., and 3.2% for Enterococcus spp. Anti-pseudomonal penicillin use decreased by 6.6% annually (95% CI −10.6 to −2.4%) and anti-pseudomonal penicillin resistance rates decreased each year by 7.9% for Escherichia coli, 8.9% for Klebsiella spp., 15.2% for Proteus mirabilis and 4.2% for Pseudomonas aeruginosa. Anti-staphylococcal penicillin use decreased by 5.4% annually (95% CI −10.0 to −0.5%) and resistance in Staphylococcus aureus decreased 1.7% per year. Conclusion Nationally among VA CLCs, we observed significant reductions in the use of several classes of antibiotics with corresponding reductions in antibiotic resistance, including an impressive decline in fluoroquinolone use and corresponding decreases in fluoroquinolone resistance among six organisms. Future research should assess whether reductions in antibiotic use predict later reductions in antibiotic resistance and improvements in resident outcomes. Disclosures All authors: No reported disclosures.

scholarly journals Comparative clinical characteristics and outcomes of patients with community acquired bacteremia caused by Escherichia coli, Burkholderia pseudomallei and Staphylococcus aureus: A prospective observational study (Ubon-sepsis)

2021 ◽  
Vol 15 (9) ◽  
pp. e0009704
Author(s):  
Ranjani Somayaji ◽  
Viriya Hantrakun ◽  
Prapit Teparrukkul ◽  
Gumphol Wongsuvan ◽  
Kristina E. Rudd ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Blood Culture ◽  
Observational Study ◽  
Organ Dysfunction ◽  
Burkholderia Pseudomallei ◽  
Prospective Observational Study ◽  
Proportional Hazards Model ◽  
Cox Proportional Hazards Model ◽  
Empirical Antibiotics

Background Community acquired bacteremia (CAB) is a common cause of sepsis in low and middle-income countries (LMICs). However, knowledge about factors associated with outcomes of CAB in LMICs is limited. Methodology/Principal findings A prospective observational study (Ubon-sepsis) of adults admitted to a referral hospital with community-acquired infection in Northeastern Thailand was conducted between March 1, 2013 and February 1, 2017. In the present analysis, patients with a blood culture collected within 24 hours of admission that was positive for one of the three most common pathogens were studied. Clinical features, management, and outcomes of patients with each cause of CAB were compared. Of 3,806 patients presenting with community-acquired sepsis, 155, 131 and 37 patients had a blood culture positive for Escherichia coli, Burkholderia pseudomallei and Staphylococcus aureus, respectively. Of these 323 CAB patients, 284 (89%) were transferred from other hospitals. 28-day mortality was highest in patients with B. pseudomallei bactaeremia (66%), followed by those with S. aureus bacteraemia (43%) and E. coli (19%) bacteraemia. In the multivariable Cox proportional hazards model adjusted for age, sex, transfer from another hospital, empirical antibiotics prior to or during the transfer, and presence of organ dysfunction on admission, B. pseudomallei (aHR 3.78; 95%CI 2.31–6.21) and S. aureus (aHR 2.72; 95%CI 1.40–5.28) bacteraemias were associated with higher mortality compared to E. coli bacteraemia. Receiving empirical antibiotics recommended for CAB caused by the etiologic organism prior to or during transfer was associated with survival (aHR 0.58; 95%CI 0.38–0.88). Conclusions/Significance Mortality of patients with CAB caused by B. pseudomallei was higher than those caused by S. aureus and E. coli, even after adjusting for presence of organ dysfunction on admission and effectiveness of empirical antibiotics received. Improving algorithms or rapid diagnostic tests to guide early empirical antibiotic may be key to improving CAB outcomes in LMICs.

scholarly journals Susceptibilidad antimicrobiana de cepas aisladas de muestras clínicas en el laboratorio del Hospital General Dr. Liborio Panchana Sotomayor

2019 ◽  
Vol 3 (2) ◽  
pp. 7
Author(s):  
Patricia Suárez González
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Tracheal Aspirate ◽  
Diffusion Method ◽  
Beta Lactamases ◽  
Hospital Patients ◽  
Tract Infections ◽  
Santa Elena ◽  
Klebsiella Spp

    La causa principal de la resistencia es el abuso de los antimicrobianos. El objetivo de este estudio fue determinar la resistencia antimicrobiana en aislamientos bacterianos de muestras biológicas de pacientes que acuden al hospital de Santa Elena (Ecuador) en 2017. Se efectuó un estudio retrospectivo correspondiente a los principales agentes infecciosos aislados de muestras de pacientes del área de la Península de Santa Elena. Las cepas aisladas fueron analizadas por el método difusión Kirby-Bauer. Escherichia coli se destacó como principal agente causal, seguida por Klebsiella spp. Se aislaron en mayor proporción de infecciones del tracto urinario tanto en pacientes hospitalarios como la comunidad. En el caso de los aislamientos de Pseudomonas aeruginosa provinieron de exudados óticos en pacientes ambulatorios, mientras que en pacientes hospitalizados se aislaron de muestras de aspirados traqueales. Staphylococcus aureus fue identificado en muestras de hemocultivo.   Palabras clave: Escherichia coli, sensibilidad, antibióticos, betalactamasas.   Abstract The main cause of resistance is the abuse of antimicrobials. The objective of this study was to determine the antimicrobial resistance in bacterial isolates from biological samples of patients who attended the Santa Elena hospital (Ecuador) in 2017. A retrospective study was carried out corresponding to the main infectious agents isolated from samples of patients in the area of the Santa Elena Peninsula. The isolated strains were analyzed by the Kirby-Bauer diffusion method. Escherichia coli stood out as the main causative agent, followed by Klebsiella spp. They were isolated in a higher proportion of urinary tract infections both in hospital patients and in the community. In the case of Pseudomonas aeruginosa isolates, they came from otic exudates in outpatients, while in hospitalized patients they were isolated from tracheal aspirate samples. Staphylococcus aureus was identified in blood culture samples.   Keywords: Escherichia coli, sensitivity, antibiotics, beta-lactamases.

Sub-lethal exposure to cold atmospheric plasma in vitro induces changes in bacterial antibiotic resistance profiles. A pilot study.

2019 ◽  
Vol 16 (1) ◽  
Author(s):  
Melina E. Martínez-Barrera ◽  
Jaime Bustos Martinez ◽  
Leonor Sánchez-Pérez ◽  
Aída Hamdan-Partida ◽  
A Enrique Acosta-Gio
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Antibiotic Resistance ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Atmospheric Plasma ◽  
Cold Atmospheric Plasma ◽  
Bacterial Antibiotic Resistance ◽  
Exposure To Cold

To evaluate the effect of sub-lethal exposure to cold atmospheric plasma (CAP) on their antibiotic resistance, Methicillin Resistant Staphylococcus aureus, S. epidermidis, Pseudomonas aeruginosa, Escherichia coli, Streptococcus mutans, and Candida albicans were exposed in vitro to a commercially available CAP. This antimicrobial CAP inhibited growth but changed survivors’ antibiotic resistance.

scholarly journals Etude bactériologique et pathologique de la pneumonie chez le dromadaire (Camelus dromedarius) en Jordanie

2001 ◽  
Vol 54 (2) ◽  
pp. 93 ◽  
Author(s):  
Y. H. Al Tarazi
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Mannheimia Haemolytica ◽  
Camelus Dromedarius ◽  
E Coli ◽  
Actinomyces Pyogenes ◽  
Klebsiella Spp

Les publications concernant la pneumonie chez le dromadaire sont en général rares. Dans cette étude, 284 poumons de dromadaires, abattus entre 6 mois et 10 ans d’âge et provenant du nord de la Jordanie, ont été examinés. La prévalence de la pneumonie a été de 10,2 p. 100. Les lésions pathologiques des poumons atteints de pneumonie ont été classées selon qu’elles indiquaient la présence de la bronchopneumonie proliférative chronique, de la pleuropneumonie chronique ou de la pneumonie interstitielle. Les abcès du poumon ont aussi été enregistrés. La broncho-pneumonie proliférative chronique (20,69 p. 100) et la pleuropneumonie chronique (6,9 p. 100) ont été plus fréquentes chez les dromadaires âgés (10 ans environ), alors que la pneumonie interstitielle (58,6 p. 100) et les abcès du poumon (10,34 p. 100) ont été plus fréquents chez les jeunes dromadaires (âgés de 6 mois à 4 ans). Mannheimia haemolytica et Pseudomonas aeruginosa ont été les espèces les plus fréquemment isolées dans le cas de broncho-pneumonie proliférative chronique et de pleuropneumonie chronique, alors que, dans les cas de pneumonie interstitielle, c’étaient Escherichia coli et Klebsiella spp. qui l’ont été le plus. Dans les cas d’abcès du poumon c’étaient Staphylococcus aureus, Actinomyces pyogenes et des streptocoques hémolytiques qui ont été le plus fréquemment observés. Au total, 75 espèces bactériennes ont été isolées de 29 poumons. Les plus fréquentes ont été E. coli (26,66 p. 100), Klebsiella spp. (14,66 p. 100), Pseudomonas aeruginosa (12 p. 100), Staphylococcus aureus (10,66 p. 100), Mannheimia haemolytica (6,66 p. 100) et Actinomyces pyogenes (6,66 p. 100). L’espèce la plus souvent observée parmi les Klebsiella identifiées a été Klebsiella ozaenae.

scholarly journals Antibacterial Susceptibility Patterns of Common Bacterial Species Associated with Urinary Tract Infections in Patients Attending Kam Medical and Diagnostic Centre, Kampala Uganda.

2021 ◽  
Author(s):  
◽  
Gerald Turyatunga
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Urinary Tract ◽  
Diffusion Method ◽  
Enterococcus Spp ◽  
Tract Infections ◽  
Klebsiella Spp ◽  
Diagnostic Centre ◽  
Susceptibility Patterns

Background: Urinary tract infection (UTI) is defined as the presence of microbial pathogens within the urinary tract. It is primarily caused by Escherichia coli (E.coli), accounting for 75% of all bacterial UTI cases. Bacteria such Klebsiella pneumonia, Proteus mirabilis, Staphylococcus aureus, Pseudomonas aeruginosa, and Enterococcus faecalis have also been reported as causative agents. The study aimed to determine the antibiotic susceptibility patterns of Uropathogenic bacteria in urine samples of patients with suspected UTI in Kam Medical and the diagnostic Centre.  Methodology: This was a cross-sectional study where 120 urinary samples from Kam Medical and Diagnostic Centre in 2019. The urine specimens were cultured on CLED (Cysteine Lactose Electrolyte – Deficient) and blood agar media. Kirby-Bauer’s standard disk diffusion method was applied to test the susceptibility of the drug for Mueller-Hinton culture agar plates. Results: All 120 patients suspected of UTI had bacterial pathogen causing UTI. Among the urinary pathogens, Escherichia coli was the most common in 85/120 (70.8%) of the patients followed by S.aureus 13/120 (10.8 %), Klebsiella spp 4/120 (9.2%), Enterococcus spp with 4/120 3.3 %), Pseudomonas aeruginosa with 4/120 (3.3%) and Proteus with 3/120 (2.5%). According to the results of the antibiogram, the highest resistance was observed for Nalidixic acid (64.2%), Ampicillin (61.7%), and Cotrimoxazole (54.2 %). The highest susceptibility (antibiotic sensitivity) was observed with imipenem (97.5%), Nitrofurantoin (49.2 %), Ciprofloxacin (45.8%), and Clotrimazole (44.2 %) Conclusion and recommendations:  The bacterial pathogens associated with UTIs in this study were E.coli species, Staphylococcus aureus, Klebsiella, Enterococcus species, Pseudomonas species, and Proteus species. E.coli was the most common isolate followed by S.aureus, Klebsiella spp, Pseudomonas spp, and Enterococcus spp, and lastly Proteus spp. The highest levels of bacterial resistance were recorded against first-generation antibiotic drugs. Bacterial isolates in this study were highly susceptible to broad-spectrum, second/ third generation antibiotics drugs.

STUDY ON ANTIBIOTIC RESISTANCE OF COMMON PATHOGENIC BACTERIA AT BINH AN HOSPITAL IN KIEN GIANG IN 2010

2013 ◽  
pp. 35-42
Author(s):  
Nguyen Ngoc Trac Mai
Keyword(s):  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Antibiotic Resistance ◽  
Pathogenic Bacteria ◽  
Antibiotic Use ◽  
Beta Lactamase ◽  
Cross Sectional ◽  
Highly Sensitive ◽  
Klebsiella Spp ◽  
Lactamase Inhibitor

Objective: Study on the distribution of common pathogens at Binh An hospital in 2010 and their antibiotic resistance. Methods: Retrospective, descriptive and cross-sectional methods were used. Data of bacterial identification and antibiogram results were collected at Binh An hospital from January to December 2010. Results: The top 5 bacterias were E.coli (33.93%), Streptococcus spp. (23.21%), Staphylococcus aureus (14.29%), Klebsiella pneumoniae (8.93%) and Pseudomonas aeruginosa (7.14%). E.coli strains were high resistant to Ampicillin (100%), Ticarcillin (100%), Trimethoprim/Sulfamethoxazol (85%) and highly sensitive to Imipenem (94%), Cefoperazone/Sulbactam (93%) and Piperacillin/Tazobactam (83%). Resistant rates for Streptococcus spp. were as follows: Oxacillin (100%), Gentamicin (77%), Amikacin (77%), Trimethoprim/Sulfamethoxazol (62%). Streptococcus spp. were sensitive to Vancomycin (100%), Imipenem (100%), Piperacillin and Cefoperazone/Sulbactam (100%). Staphylococcus aureus were high sensitive to Vancomycin (100%) and combinations of Betalactam/Beta-lactamase inhibitor (100%). Carbapenems and combinations of Betalactam/Beta-lactamase inhibitor were effective to Klebsiella spp. Imipenem is still a realistic selection for Pseudomonas aeruginosa Conclusion: Continuous surveillance of antibiotic resistance as well as reasonable antibiotic use are required to mitigate the progression of antibiotic resistance. Key words: antibiotic, common pathogens

Antibiotic Resistance in Intensive Care Unit Areas

1983 ◽  
Vol 4 (5) ◽  
pp. 382-387 ◽  
Author(s):  
F. Daschner ◽  
H. Langmaack ◽  
B. Wiedemann
Keyword(s):  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Antibiotic Resistance ◽  
Intensive Care ◽  
Klebsiella Pneumoniae ◽  
Staphylococcus Epidermidis ◽  
Nosocomial Pathogens ◽  
E Coli ◽  
Oxacillin Resistance ◽  
Resistance Rates

AbstractThe incidence of nosocomial infections and antimicrobial resistance rates of nosocomial pathogens vary considerably among countries and even among intensive care units (ICUs) within one hospital. Such differences might be partly due to the selection pressure exerted by certain antibiotics, since intensive care patients are given more antimicrobials than any other group of patients. We therefore compared resistance rates of four important nosocomial pathogens (Staphylococcus aureus, E. coli, Klebsiella pneumoniae, Pseudomonas aeruginosa) isolated from patients in general wards and ICUs. There were few trends toward higher resistance of ICU isolates, and most differences were found with Klebsiella pneumoniae.We also tried to relate antibiotic use in ICUs and frequency of antibiotic resistance of five selected nosocomial pathogens. The ampicillin and cephalosporin resistance of E. coli and Klebsiella pneumoniae arose along with an increase in usage of both drugs. Decreasing prescription of cotrimoxazole was not reflected by decrease in resistance of Staphylococcus aureus and Staphylococcus epidermidis. Increasing prescriptions of tetracyclines were followed by an increasing resistance of E. coli, but not of Staphylococci. The oxacillin resistance of Staphylococcus epidermidis almost paralleled the consumption, the opposite was true for Staphylococcus aureus. There seemed to be a rather close relationship between the incidence of resistant Staphylococcus aureus, Staphylococcus epidermidis and Pseudomonas aeruginosa strains and the quantities of gentamicin, tobramycin and azlocillin prescribed.The increase or decrease of prescriptions of certain antimicrobials increased or decreased their resistance rate to the respective drugs of only certain bacterial strains in one ICU, but not in the other. The findings in our hospital cannot necessarily be applied to other hospitals. Restriction of antimicrobial usage however decreased resistance rates in most situations.

scholarly journals Prevalence of symptomatic urinary tract infection and bacterial spectrum of diabetic and non-diabetic patients at the two teaching hospitals in Enugu, Nigeria

2021 ◽  
Vol 22 (4) ◽  
pp. 480-488
Author(s):  
C.C. Okwume ◽  
N.F. Onyemelukwe ◽  
I.N. Abdullahi ◽  
O.E. Okoyeocha ◽  
S.D. Asamota
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Bacterial Pathogen ◽  
Diabetic Patients ◽  
Isolation Rate ◽  
E Coli ◽  
Enterococcus Spp ◽  
Infections Urinaires ◽  
Klebsiella Spp

Background: Diabetes mellitus is a group of metabolic disorder characterized by relative or absolute lack of insulin. When this condition is not properly managed, it can lead to complications that make diabetic patients vulnerable to urinary tract infections (UTI). The objectives of this study are to determine the prevalence of microbiologically confirmed UTI and the spectrum of uropathogens in diabetic and non-diabetic patients with clinical features of UTI attending the two tertiary hospitals in Enugu State, Nigeria. Methodology: Clean catch specimen of single mid-stream urine sample was collected from each of 60 (22 males, 38 females) diabetic and 60 (22 males, 38 females) non-diabetic patients enrolled using stratified random sampling method. The samples were cultured on standard microbiological culture media (MacConkey and Blood agar plates) and incubated aerobically at 37◦C for 24 hours. Plates with significant bacteria growth (>105 CFU/ml) were processed further for bacterial identification using conventional biochemical test scheme. Antibiotic susceptibility test (AST) of each isolate to 17 selected antibiotics was performed by the modified disc diffusion method. Results: Of the total 120 patients enrolled, 101 had bacterial pathogens isolated from their voided urine samples; 51 of 60 (85.0%) diabetics and 50 of 60 (83.3%) non-diabetics (p=0.802). Bacteria were isolated in 59.1% (13/22) of diabetic and 54.5% (12/22) of non-diabetic male patients compared to 100% (38/38) isolation rate in diabetic and non-diabetic female patients. The most frequently isolated bacteria in the diabetic patients were Proteus spp (18.6%), Klebsiella spp (16.9%) and Escherichia coli (15.5%) while the most frequently isolated bacteria among the non-diabetic patients were E. coli (30.0%), Proteus spp (26.3%) and Enterobacter spp (14.0%). Apart from Klebsiella spp which was more frequently isolated from the diabetic (16.9%) than non-diabetic patients (6%) (p=0.039), the frequency other bacterial pathogen isolation such as Proteus spp, E. coli, Enterobacter spp, Pseudomonas aeruginosa, Staphylococcus aureus and Enterococcus spp was not significantly different between the two population groups (p>0.05). The Gram-positive and Gram-negative bacteria were highly sensitive to imipenem in both diabetic and non-diabetic patients, but the isolates from both study groups exhibited low susceptibility to amoxicillin, nitrofuran- toin, cefixime and cefuroxime. Conclusion: Although the overall frequency of bacterial pathogen isolation in the diabetic and non-diabetic patients was not significantly different, females had a higher pathogen isolation rate than the males, and diabetic females had a higher frequency of polymicrobial infections compared to non-diabetic females and the male population. The high antimicrobial resistance of the isolated bacteria pathogens underscores the need for clinical microbiology laboratory testings to optimize the management of UTI in diabetic patients.   French title: Prévalence des infections urinaires symptomatiques et spectre bactérien des patients diabétiques et non diabétiques dans les deux hôpitaux universitaires d'Enugu, au Nigeria   Contexte: Le diabète sucré est un groupe de troubles métaboliques caractérisés par un manque relatif ou absolu d'insuline. Lorsque cette condition n'est pas correctement gérée, elle peut entraîner des complications qui rendent les patients diabétiques vulnérables aux infections des voies urinaires (UTI). Les objectifs de cette étude sont de déterminer la prévalence des infections urinaires confirmées microbiologiquement et le spectre des uropathogènes chez les patients diabétiques et non diabétiques présentant des caractéristiques cliniques des infections urinaires fréquentant les deux hôpitaux tertiaires de l'État d'Enugu, au Nigeria. Méthodologie: Un échantillon de capture propre d'un seul échantillon d'urine à mi-jet a été prélevé sur chacun des 60 (22 hommes, 38 femmes) patients diabétiques et 60 (22 hommes, 38 femmes) patients non diabétiques inscrits à l'aide d'une méthode d'échantillonnage aléatoire stratifié. Les échantillons ont été cultivés sur des milieux de culture microbiologiques standard (plaques de gélose MacConkey et Blood) et incubés en aérobie à 37°C pendant 24 heures. Les plaques avec une croissance bactérienne significative (>105 CFU/ml) ont été traitées davantage pour l'identification bactérienne en utilisant un schéma de test biochimique conventionnel. Le test de sensibilité aux antibiotiques (AST) de chaque isolat à 17 antibiotiques sélectionnés a été réalisé par la méthode de diffusion sur disque modifiée. Résultats: Sur un total de 120 patients recrutés, 101 avaient des agents pathogènes bactériens isolés de leurs échantillons d'urine évacués; 51 des 60 (85,0%) diabétiques et 50 des 60 (83,3%) des non-diabétiques (p=0,802). Les bactéries ont été isolées chez 59,1% (13/22) des patients diabétiques et 54,5% (12/22) des hommes non diabétiques contre un taux d'isolement de 100% (38/38) chez les femmes diabétiques et non diabétiques. Les bactéries les plus fréquemment isolées chez les patients diabétiques étaient Proteus spp (18,6%), Klebsiella spp (16,9%) et Escherichia coli (15,5%) tandis que les bactéries les plus fréquemment isolées chez les patients non diabétiques étaient E. coli (30,0%), Proteus spp (26,3%) et Enterobacter spp (14,0%). Hormis Klebsiella spp qui était plus fréquemment isolé chez les diabétiques (16,9%) que les patients non diabétiques (6%) (p=0,039), la fréquence d'isolement d'autres agents pathogènes bactériens tels que Proteus spp, E. coli, Enterobacter spp, Pseudomonas aeruginosa, Staphylococcus aureus et Enterococcus spp n'étaient pas significativement différents entre les deux groupes de population (p>0,05). Les bactéries Gram-positives et Gram-négatives étaient très sensibles à l'imipénème chez les patients diabétiques et non diabétiques, mais les isolats des deux groupes d'étude présentaient une faible sensibilité à l'amoxicilline, à la nitrofurantoïne, au céfixime et à la céfuroxime. Conclusion: Bien que la fréquence globale d'isolement des agents pathogènes bactériens chez les patients diabétiques et non diabétiques n'était pas significativement différente, les femmes avaient un taux d'isolement des agents pathogènes plus élevé que les hommes, et les femmes diabétiques avaient une fréquence plus élevée d'infections polymicrobiennes par rapport aux femmes non diabétiques. et la population masculine. La haute résistance antimicrobienne des bactéries pathogènes isolées souligne la nécessité de tests de laboratoire de microbiologie clinique pour optimiser la gestion des infections urinaires chez les patients diabétiques.    

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