scholarly journals Acquisition and Colonization Stability of Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in Children

2000 ◽  
Vol 38 (3) ◽  
pp. 1196-1199 ◽  
Author(s):  
Celeste W. Lamell ◽  
Ann L. Griffen ◽  
Dawn L. McClellan ◽  
Eugene J. Leys
Keyword(s):  
Risk Factor ◽  
Porphyromonas Gingivalis ◽  
Actinobacillus Actinomycetemcomitans ◽  
Healthy Children ◽  
Cross Sectional ◽  
Initial Acquisition ◽  
History Of ◽  
Cross Sectional Studies ◽  
The Stability ◽  
Apparently Healthy

The presence of Porphyromonas gingivalis has been shown to be a risk factor for periodontitis in adults, andActinobacillus actinomycetemcomitans has been implicated as a pathogen in early-onset periodontitis. Both species have been shown to establish stable colonization in adults. In cross-sectional studies, both A. actinomycetemcomitans and P. gingivalishave been detected in over one-third of apparently healthy children. Information on the stability of colonization with these organisms in children could help to elucidate the natural history of the development of periodontitis. For this purpose, samples previously collected from a cohort of 222 children between the ages of 0 and 18 years and previously examined for the presence of P. gingivalis with a PCR-based assay were examined for the presence of A. actinomycetemcomitans. It was detected in 48% of subjects and, like P. gingivalis, was found at similar frequencies among children of all ages (P = 0.53), suggesting very early initial acquisition. One hundred one of the original subjects were recalled after 1 to 3 years to determine the continuing presence of both A. actinomycetemcomitans and P. gingivalis. The prevalence of both species remained unchanged at resampling. However, in most children both species appeared to colonize only transiently, with random concordance between the results of the first and second sampling. Stability of colonization was unrelated to age for A. actinomycetemcomitans, but P. gingivalis was more stable in the late teenage years.

scholarly journals Prevalence and Predictors of Undiagnosed Hypertension in an Apparently Healthy Western Indian Population

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Anand N. Shukla ◽  
Tarun Madan ◽  
Bhavesh M. Thakkar ◽  
Meena M. Parmar ◽  
Komal H. Shah
Keyword(s):  
Blood Pressure ◽  
Risk Factor ◽  
Cardiovascular Diseases ◽  
Odds Ratio ◽  
Indian Population ◽  
Total Population ◽  
Undiagnosed Hypertension ◽  
History Of ◽  
Major Illness ◽  
Apparently Healthy

This epidemiological study was designed to evaluate the prevalence of undetected hypertension in an apparently healthy western Indian population having no history of major illness. 3629 individuals of ≥18 years of age were included in the study. Hypertension (HTN) was defined as systolic blood pressure (SBP) ≥ 140 mmHg or diastolic blood pressure (DBP) ≥ 90 mmHg and prehypertension (PHTN) as SBP ≥ 120–139 mmHg or DBP ≥ 80–89 mmHg, but without HTN. The prevalence of undiagnosed HTN in the total population was 26% and was 11% and 40% in the young (≤40-year) and old (>40-year) populations, respectively. The prevalence of PHTN, 40% in the overall population, was nearly the same in the young (39%) and the old population (42%). The risk factor most strongly associated with PHTN and HTN was obesity, showing the highest odds ratio in the overall (PHTN 2.14; 95% CI 1.20–3.81; HTN 2.72; 95% CI 1.53–4.85), the young (PHTN 2.29; 95% CI 1.25–4.21; HTN 2.92; 95% CI 1.59–5.35), and the old (PHTN 1.13; 95% CI 0.65–1.96; HTN 1.38; 95% CI 0.79–2.4) populations. Hypertension is a major risk factor for cardiovascular diseases which must not be ignored, especially in the western Indian population.

Detection of Human Parvovirus B19 Infection in Children with Chronic Haemolytic Anaemia in Benha University Hospitals

2021 ◽  
Vol 30 (2) ◽  
pp. 51-58
Author(s):  
Amal M. Matta ◽  
Elsayed M. Abd-Elghany ◽  
Abeer A. Aboelazm ◽  
Osama Abo. Zaki, ◽  
Doaa Abd. Shaker
Keyword(s):  
Hemolytic Anemia ◽  
Parvovirus B19 ◽  
Control Group ◽  
P Value ◽  
Healthy Children ◽  
Igg Antibodies ◽  
University Hospitals ◽  
History Of ◽  
Chronic Hemolytic Anemia ◽  
Apparently Healthy

Background: Due to the tropism of human parvovirus B19 to erythroid progenitor cells, infection in patients with an underlying hemolytic disorder such as thalassemia, hereditary spherocytosis, sickle cell disease and Glucose-6-phosphate dehydrogenase deficiency leads to suppression of erythrocyte formation, referred to as transient aplasia crisis (TAC), which may be life-threatening. Objectives: Detection of parvovirus B19 DNA and its IgG antibodies in the serum of children with chronic hemolytic anemia and in apparently healthy children in Benha University Hospitals. Methodology: The study was conducted on 80 children. Forty of them with chronic hemolytic anemia, they were subdivided into 2 groups, Group (1a) included 20 patients without history of aplastic crisis, Group (Ib) included 20 patients with a history of aplastic crisis and 40 age and sex-matched apparently healthy children representing control (Group II). All patients were subjected to full history taking, clinical examination and laboratory investigations. Parvovirus B19 IgG was measured using anti-parvovirus B19 ELISA kits (SUNRED), and parvovirus B19 DNA was detected by using nestedpolymerase chain reaction. Results: The seroprevalence of parvovirus B19 IgG was significantly higher (P value =0.016) in Group Ia (50%) (10 out of 20) and Group Ib (45%) (9 out of 20) than the control group (Group II) (17.5%) (7 out of 40). There was a significant positive correlation between anti-parvovirus B19 IgG and age of all patients, frequency of blood transfusion. The prevalence of parvovirus B19 DNA was 10% (2 out of 20) in group Ia and 30% (6 out of 20) in group Ib and no viral DNA was detected in the controls (P value=0.001). Although 42.3% (11 out of 26) of children with β thalassemia major had a detectable level of antiparvovirus B19 virus IgG antibodies, only (23.1%) (6 out of 26) of them had B19 DNA. Anti-parvovirus B19 IgG antibodies were detected in 4 children out of 5 children of sickle cell anemia (80%) but the the prevalence of Parvovirus B19 DNA was 20% among them. Conclusion: Measures to keep away from iatrogenic and nosocomial infection transmission should be implemented including screening of donated blood for parvovirus B19 especially blood given to patients with blood disorders. Recommendation: Data from this study support the need for introduction of an approved vaccine that mainly protects children with chronic hemolytic anemia against that infection.

scholarly journals Changes in Quality of Life in Elementary School Children—The Health Oriented Pedagogical Project (HOPP)

Sports ◽  
2019 ◽  
Vol 7 (1) ◽  
pp. 11
Author(s):  
Per Fredriksen ◽  
Helene Olsen ◽  
Trine Meza
Keyword(s):  
Quality Of Life ◽  
Life Quality ◽  
Cross Sectional Study ◽  
Healthy Children ◽  
Cross Sectional ◽  
Children And Parents ◽  
Parental Reports ◽  
Cross Sectional Studies ◽  
Average Average

Background: Quality of life (QoL) studies may provide information of change in health status in the population. Few studies have followed up previous cross-sectional studies to investigate any change in the QoL status of healthy children. The aim of the current study is to compare QoL in children 6–12 years old in two large cross-sectional studies of healthy children completed a decade apart. Methods: In the current study children and parents from nine elementary schools (n = 2816) were included in a cross-sectional study investigating children’s QoL. Using the Life Quality in Children and Adolescents (ILC), completed by both children and parents, the global QoL-score was estimated for 2297 children and 1639 parental reports. These results were compared to a similar study performed in 2004. The scores from both studies were divided into categories of below average, average and above average QoL. The percentage change of QoL between the two studies is presented. Results: Our results show that parents report that more children have below and above average QoL in 2015 compared to 2004. In contrast, more children scored in the average and above average QoL category in 2015 than in 2004. Conclusion: Parents reported lower QoL and children higher QoL in 2015 compared to 2004.

scholarly journals Trends of Prevalence of Uncontrolled Risk Factors for Cerebrocardiovascular Disease: Southern Italy from 1988/9 to 2008/9

Cholesterol ◽  
2016 ◽  
Vol 2016 ◽  
pp. 1-7
Author(s):  
Vincenzo Capuano ◽  
Norman Lamaida ◽  
Ernesto Capuano ◽  
Rocco Capuano ◽  
Eduardo Capuano ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Risk Factor ◽  
Southern Italy ◽  
Cross Sectional ◽  
Targeted Interventions ◽  
Risk Factor Prevalence ◽  
Cross Sectional Studies ◽  
Prevention Of Cardiovascular Disease

The aim of this study was to determine the trends of cardiovascular risk factor prevalence between 1988/9 and 2008/9 in the 25–74-year-old population in an area of Southern Italy. We compared three cross-sectional studies conducted in random population samples, in 1988/9, 1998/9, and 2008/9 in Salerno, Italy. The methodology of data collection (lipid profile, systolic and diastolic blood pressure, glycaemia, and smoking) and conducting tests which the population underwent during the three phases was standardized and comparable. Prevalence of diabetes, hypertension, hypercholesterolemia, and smoking was calculated and standardized for age. A total of 3491 subjects were included. From 1988/9 to 2008/9, in males, the prevalence of all four risk factors was reduced. In women, there was a clear reduction of hypertension, a similar prevalence of hypercholesterolemia, and an increase of smoking and diabetes. In the area of Salerno, our data confirm that the global prevalence of the major risk factors is decreasing in men, but their absolute values are still far from optimization. In women, diabetes and smoking showed a negative trend, therefore requiring targeted interventions. These data are now used as a base for executive targeted programs to improve prevention of cardiovascular disease in our community.

scholarly journals OVERUSE INJURIES IN LONG DISTANCE RUNNING - A LITERATURE REVIEW ON RISK FACTORS

2019 ◽  
pp. 1-3
Author(s):  
G Vijayan
Keyword(s):  
Risk Factors ◽  
Clinical Trials ◽  
Overuse Injuries ◽  
Distance Running ◽  
Long Distance ◽  
Cross Sectional ◽  
Recreational Athletes ◽  
Long Distance Running ◽  
History Of ◽  
Cross Sectional Studies

INTRODUCTION: In the past three decades, the incidence of running-related overuse injuries has signicantly increased because of the increasing number of recreational athletes and higher training intensity in competitive athletes. Long distance running has gained popularity in recent years, but between 19.4 and 79.3% of runners sustain a running related injury every year. Various risk factors contribute to the occurrence of this issue and shoe modications are thought to be an efcient tool in managing runningrelated over use injuries. The aim of this study was to collect and review information about the risks factors of overuse injuries long distance running. METHODOLOGY:Asystematic search of the electronic database of PUBMED, Bireme and PEDro which were selected that addressed clinical trials, control cases, prospective and cross-sectional studies. RESULTS: The search yielded 246 references. A predened inclusion criteria (case studies, clinical trials, prospective studies, cross sectional studies that addressed adult runners either amateur or professional) was used and 51 articles remained. 18 citations were excluded and 20 articles were after reading the abstract and full text. Therefore 13 studies that met the criteria for analysis were included. CONCLUSION:The overuse injuries are very much prevalent in long distance runners and the ethology is multifactorial. The distance, terrain, weekly sessions and history of previous injuries are the risk factors that inuence the occurrence of these injuries.

scholarly journals Protracted Cardiovascular Impairments After Anterior Cruciate Ligament Injury: A Critically Appraised Topic

2020 ◽  
Vol 29 (5) ◽  
pp. 680-683
Author(s):  
Cody R. Butler ◽  
Kirsten Allen ◽  
Lindsay J. DiStefano ◽  
Lindsey K. Lepley
Keyword(s):  
Physical Activity ◽  
Anterior Cruciate Ligament ◽  
National Football League ◽  
Cruciate Ligament ◽  
Acl Injury ◽  
Cross Sectional ◽  
History Of ◽  
Cross Sectional Studies ◽  
Anterior Cruciate ◽  
Cv Disease

Clinical Scenario: Anterior cruciate ligament (ACL) tear is a devastating knee injury with negative long-term consequences, such as early-onset knee osteoarthritis, biomechanical compensations, and reduced physical activity. Significant reduction in physical activity is a powerful indicator of cardiovascular (CV) disease; therefore, those with a history of ACL injury may be at increased risk for CV disease compared with noninjured individuals. Focused Clinical Question: Do individuals with a history of ACL injury demonstrate negative CV changes compared with those without a history of ACL injury? Summary of Key Findings: Three articles met the inclusion criteria and investigated CV changes after ACL injury. Both cross-sectional studies compared participants with ACL injury with matched controls. Bell et al compared time spent in moderate to vigorous physical activity and step count, whereas Almeida et al compared maximum rate of oxygen consumption, ventilatory thresholds, isokinetic quadriceps strength, and body composition. Collectively, both quantitative studies found that individuals with a history of ACL injury had less efficient CV systems compared with matched controls and/or preoperative data. Finally, a qualitative study of 3506 retired National Football League athletes showed an increased rate of arthritis and knee replacement surgery after an ACL injury when compared with other retired National Football League members, in addition to a >50% increased rate of myocardial infarction. Clinical Bottom Line: A history of ACL injury is a source of impaired physical activity. Preliminary data indicate that these physical activity limitations negatively impair the CV system, and individuals with a history of ACL injury demonstrate lower maximum oxygen consumption, self-reported disability, and daily step count compared with noninjured peers. These complications support the need for greater emphasis on CV wellness. Strength of Recommendation: Consistent findings from 2 cross-sectional studies and 1 survey study suggest level IIB evidence to support that ACL injury is associated with negative CV health.

scholarly journals Tuberculin sensitivity among inmates of children’s home

2017 ◽  
Vol 4 (5) ◽  
pp. 1581
Author(s):  
Usha Kiran C. B. ◽  
Sowmya J. ◽  
Jayamala R.
Keyword(s):  
Early Diagnosis ◽  
Nutritional Status ◽  
Vaccination Status ◽  
Healthy Children ◽  
Sensitivity Testing ◽  
Feasible Method ◽  
Tuberculin Sensitivity ◽  
Children's Home ◽  
History Of ◽  
Apparently Healthy

Background: Tuberculin sensitivity and its relationship to nutritional status in inmates of children's home.Methods: Tuberculin sensitivity was checked in 180 apparently healthy orphan children and its relationship with nutritional status, previous vaccination status was studied. setting: children's home run by NGOs participants: all inmates of children's home aged 2-15 years who meet inclusion and exclusion criteria.Results: Out of 180 apparently healthy children 27 (15%) were tuberculin positive. 109 (60.5%) were undernourished children out of which 15 (55.56%) were tuberculin positive. Out of 71 normal nourished children, 12 (44.4%) were tuberculin positive. BCG scar was present in 120 (66.6%) children out of which 19 were tuberculin positive and BCG scar was absent in 60% children out of which 8 were tuberculin positive. 8 children had history of contact with TB and 6 of them were tuberculin positive.Conclusions: Tuberculin sensitivity testing using 5 TU PPD-RT23 is a simple feasible method to screen inmates of children home at the time of entry and it is not influenced by nutritional status or previous BCG vaccination. Early diagnosis and treatment of TB will go a long way in reducing the burden of TB in our country.

Obesity

2014 ◽  
Author(s):  
Garreth R. Dutton ◽  
Belinda L. Needham
Keyword(s):  
Risk Factor ◽  
Immune Responses ◽  
Hpa Axis ◽  
Severe Obesity ◽  
Positive Association ◽  
Leptin Resistance ◽  
Future Research ◽  
Comorbid Depression ◽  
Cross Sectional ◽  
History Of

Cross-sectional and longitudinal studies indicate a positive association between obesity and depression. While some evidence suggests that depression is a risk factor for obesity, other findings indicate that obesity is a risk factor for depression. Therefore the directionality of this relationship remains unclear. Alternatively, there may be common mediating biological or environmental contributors accounting for this association. Potential biological mediators include dysregulation of the HPA axis, leptin resistance, and inflammatory immune responses. Environmental and psychological mediators may include a history of abuse and binge eating. It is also possible that the association between obesity and depression is most pronounced among particular subsets of individuals (e.g., women, those with more severe obesity). A better understanding of this depression-obesity association is needed to guide treatment recommendations for obese clients with comorbid depression. Future research is also needed to determine who is most vulnerable to experiencing comorbid depression and obesity.

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