Locus rs833061 of the VEGF Gene in Pregnant Women with Preeclampsia Is Associated with Newborn Weight

2021 ◽  
Vol 57 (9) ◽  
pp. 1100-1105
Author(s):  
O. V. Golovchenko ◽  
M. Y. Abramova ◽  
I. V. Ponomarenko ◽  
M. I. Churnosov
Keyword(s):  
Pregnant Women ◽  
Vegf Gene ◽  
Newborn Weight

scholarly journals Pengaruh Multiple Mikro Nutrien (MMN) Terhadap Berat Badan Bayi Baru Lahir Di Desa Pandes Klaten

2017 ◽  
Vol 2 (2) ◽  
Author(s):  
Dwi Retna Prihati ◽  
Gita Kostania
Keyword(s):  
Folic Acid ◽  
Birth Weight ◽  
Treatment Group ◽  
Vitamin B12 ◽  
Pregnant Women ◽  
Control Group ◽  
Metabolic System ◽  
Cross Sectional ◽  
Significant Difference ◽  
Newborn Weight

Abstract: MMN, Newborn Baby Weight. During pregnancy food is required with good quality and quantity to meet the nutritional needs of mother and baby. The low nutritional status of pregnant women during pregnancy can lead to various adverse effects for mothers and infants, such as those born with Low Birth Weight (LBW). LBW babies have a 10 to 20 times greater chance of dying than babies born with enough birth weight. Multiple Micro Nutrient (MMN) contains 15 types of vitamins and minerals most important for pregnant women, including vitamin A, vitamin E, vitamin D, vitamin B1, vitamin B2, niacin, Vitamin B6, vitamin B12, folic acid, vitamin C, Fe , folic acid, Zink, Copper, Selenium, and Iodine. MMN is one of the nutrients to prevent the occurrence of anemia because in MMN there are factors forming Hemoglobin ie Fe, Vitamin B12 and folic acid. The availability of adequate hemoglobin makes the metabolic system work well. Lack of hemoglobin not only affects the health of the mother but also affects the health of the fetus it contains, including the growth of the fetal inhibition (such as weight, body length). The purpose of this study was to prove the effect of MMN on newborn weight in Pandes Klaten village. This type of research is arestrospective study with cross sectional design. The subjects of this study were BBL (newborn) whose mother consumed MMN during pregnancy. Different test sing Independent T-test to compare control group and treatment group. Significant value in this study was p <0.05. The results of this study were no significant difference between birth weight between control group and MMN treatment group (P = 0.879). In conclusion MMN has no significant effect on newborn weight gain.

scholarly journals Newborn weight is associated with the maternal F13A1 gene rs5985 polymorphism

2021 ◽  
Vol 15 (3) ◽  
pp. 236-244
Author(s):  
O. V. Golovchenko ◽  
M. Yu. Abramova ◽  
I. V. Ponomarenko ◽  
M. I. Churnosov
Keyword(s):  
Pregnant Women ◽  
Factor Xiii ◽  
Polymorphic Locus ◽  
Molecular Genetic ◽  
Fetal Brain ◽  
Coagulation Factor ◽  
Clotting Factor ◽  
Nucleotide Polymorphisms ◽  
Newborn Weight

Aim: to evaluate a relationship between newborn weight and single-nucleotide polymorphisms rs5918 ITGB3, rs1126643 ITGA2, rs5985 F13A1 in pregnant women with preeclampsia (PE) and fetal growth retardation (FGR).Materials and Мethods. In this prospective comparative study, molecular genetic testing for the three polymorphic loci of hereditary thrombophilia candidate genes – rs1126643 ITGA2, rs5918 ITGB3, and rs5985 F13A1 was performed in 70 pregnant women with PE and FGR. Newborn somatometry was performed using standard methods. To assess functional effects of the rs5985 polymorphism of the F13A1 gene associated with newborn weight, we applied online bioinformatic programs GTEx Portal and HaploReg (assessing a relationship between polymorphism and level of gene transcription and related epigenetic effects).Results. The rs5985 polymorphism of the maternal F13A1 gene is associated with newborn weight according to allelic (â = 156.60; pperm = 0.05) and additive (â = 155.20; pperm = 0.05) genetic models. The polymorphic locus rs5985 of the F13A1 gene is characterized by pronounced pleiotropic regulatory effects in vivo: it determines the amino acid substitution in the A1 subunit of coagulation factor XIII (Val35Leu), associated with the activity of blood clotting factor XIII, localized in the DNase 1 hypersensitivity region, determines DNA affinity to 11 transcription factors (AP-2, CACD, EBF, ERalpha-a, ESR2, Hic1, Klf4, Klf7, SP1, ESR1 and TFAP2C), located in the region of modified histones, marking enhancers and promoters in the culture of ectoderm, endoderm and mesoderm cells, placenta, fetal brain and adrenal glands, progenitor cells and myoblasts in skeletal muscle, adipocytes, brain etc.Conclusion. The rs5985 polymorphism of the F13A1 gene in pregnant women with PE and FGR is associated with newborn weight.

scholarly journals BERAT BADAN IBU HAMIL TRIMESTER 3 DENGAN BERAT BADAN BAYI BARU LAHIR DI PUSKESMAS TANAH KALI KEDINDING SURABAYA

2019 ◽  
Vol 4 (2) ◽  
pp. 34
Author(s):  
Dewi Andriani
Keyword(s):  
Weight Gain ◽  
Pregnant Women ◽  
Fetal Growth ◽  
Post Partum ◽  
Sampling Technique ◽  
Normal Weight ◽  
Maternal Weight Gain ◽  
Maternal Weight ◽  
Cross Sectional ◽  
Newborn Weight

ABSTRAK Kenaikan berat badan ibu hamil merupakan adanya adaptasi ibu terhadap pertumbuhan janin, sedangkan berat badan bayi baru lahir merupakan bagian dari hasil pertumbuhan janin yang dapat dipengaruhi oleh kenaikan berat badan ibu selama hamil. Tujuan penelitian ini adalah untuk mengetahui hubungan serta badan ibu hamil trimester 3 dengan berat badan bayi baru lahir di Puskesmas Tanah KaliKedinding Surabaya.Jenis penelitian ini adalah korelasi dengan pendekatan cross sectional. Populasi dalam penelitian ini adalah ibu post partum yang melahirkan di Puskesmas Tanah KaliKedinding Surabaya dengan populasi 35 responden sampel sebanyak 32 responden. Teknik pengambilan sampling menggunakan Quota Sampling. Instrument penelitian ini menggunakan lembar observasi. Hasil yang didapat dari 32 responden terdapat berat badan ibu hamil yang normal sebanyak 17 orang (53,1%). Berat badan bayi baru lahir dengan berat sedang sebanyak 23 orang (71,9). Hasil analisis uji statistic Spierman Rho menunjukkan bahwa signifikan rho value sebesar 0,003 (α≤ 0,05) maka dengan ini H0 ditolak dan H1 diterima. Artinya terdapat Hubungan Berat Badan Ibu Hamil Trimester 3 Dengan Berat Badan Bayi Baru Lahir di Puskesmas Tanah KaliKedinding Surabaya. Pemantauan berat badan ibu hamil penting untuk mengetahui tumbuh kembang janin. ANC secara teratur merupakan upaya pemantauan yang efektif sehingga mengurangi resiko gangguan dalam persalinan.   Kata kunci :berat badan ibu hamil, berat badan bayi baru lahir, trimester 3   ABSTRACT Maternal weight gain is a maternal adaptation of fetal growth, while newborn weight is part of fetal growth that may be affected by maternal weight gain during pregnancy. The purpose of this study was to determine the relationship between body trimester pregnant mother 3 with newborn weight at Puskesmas Tanah KaliKedinding Surabaya. This research type is correlation with csoss sectional approach. The population in this research is post partum mother who gave birth at Puskesmas Tanah Kali Kedinding Surabaya with population of 35 sample respondents as many as 32 respondents. Sampling technique uses Sampling Quota. This research instrument uses observation sheet. Results obtained from 32 respondents had normal weight of pregnant women as many as 17 people (53.1%). Newborn weight with moderate weight as many as 23 people (71,9). The result of Spierman Rho statistic test shows that the significant rho value is 0,003 (α≤ 0,05) hence H0 is rejected and H1 accepted. This means that there is a Weight Pregnancy Trimester 3 Pregnant Wife With New Baby Weight Born in Puskesmas Tanah KaliKedinding Surabaya. Monitoring the weight of pregnant women is important to know the growth of fetal growth. ANCs are regularly an effective monitoring effort thus reducing the risk of impairment in labor.   Keywords: maternal weight, weight of newborn baby, trimester 3.

scholarly journals Factors associated with fetal macrosomia

2019 ◽  
Vol 53 ◽  
pp. 100
Author(s):  
Vanessa Agudelo-Espitia ◽  
Beatriz Elena Parra-Sosa ◽  
Sandra L Restrepo-Mesa
Keyword(s):  
Weight Gain ◽  
Gestational Diabetes ◽  
Pregnant Women ◽  
Gestational Weight Gain ◽  
Excess Weight ◽  
Fetal Macrosomia ◽  
Factors Associated ◽  
Gestational Weight ◽  
Newborn Weight ◽  
In Pregnancy

OBJECTIVE: To evaluate the clinical factors, as well as weight gain, in a group of pregnant women, associating them with fetal macrosomia in a public institution in Antioquia, Colombia, from 2010-2017. METHODS: A case-control study, using secondary information registries. Cases were defined using newborn weight of ≥ 4000g, while controls were defined as newborn weight between 3000– 3999g. A proportion ratio (PR) was established to evaluate factors associated with macrosomia, and a generalized linear model (GLM) of Poisson regression with robust variance was used to evaluate the aspects that best explained macrosomia in the neonate. RESULTS: 122 pregnant women participated in the study, of which 611 were cases and 61 were controls. Of the participants, 44.3% had pre-pregnancy overweight and 48.4% had excess gestational weight gain. Statistically significant differences were found between the groups in the following variables: pre-pregnancy BMI (p = 0.004), gestational weight gain (p = 0.000), gestational diabetes (p = 0.000), and type of delivery (p = 0.004). According to the regression model, a macrosomic newborn is 3.5 times more likely in women with excessive gestational weight gain (95%CI 1.78-7.18) and twice more likely in women who have gestational diabetes (95%CI 1.51-2.76). Of women with pre-pregnancy excess weight, 63% had excess gestational weight gain. CONCLUSIONS: Within this cohort, pre-pregnancy BMI, excess weight gain in pregnancy, and the presence of gestational diabetes were associated with an increased risk of neonatal macrosomia. pre-pregnancy BMI and weight gain in pregnancy are modifiable risk factors that are responsive to nutrition interventions, which can minimize adverse perinatal outcomes.

scholarly journals Factors Influencing Quality of Life during the First Trimester of Pregnancy: A Prospective Cohort Study

Medicina ◽  
2019 ◽  
Vol 55 (10) ◽  
pp. 666 ◽  
Author(s):  
Jakubauskiene ◽  
Jakubauskas ◽  
Mainelis ◽  
Buzinskiene ◽  
Drasutiene ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Prospective Cohort ◽  
First Trimester ◽  
Large For Gestational Age ◽  
Logistic Regression Models ◽  
Self Confidence ◽  
Factors Influencing ◽  
Sf 36 ◽  
Newborn Weight ◽  
First Trimester Of Pregnancy

Introduction: Pregnancy, delivery and postpartum periods are associated with fast changesleading to decreased self-confidence, anxiety, stress or even maternal depression impairing theirquality of life (QOL). Although considered important, QOL of women during pregnancy is poorlyunderstood. The aim of our study was to assess factors influencing QOL during first trimester ofpregnancy. The secondary goal of our study was to evaluate whether QOL during first trimester ofpregnancy is associated with newborn weight. Materials and methods: A prospective cohort studywas performed including pregnant women during the first trimester visit. Our questionnaireconsisted of the SF-36 QOL questionnaire, Wexner fecal incontinence scale, and other additionalinformation. The SF-36 questionnaire mental (MCS) and physical (PCS) health scores were used inorder to evaluate QOL of women during first trimester of pregnancy. Two multiple logisticregression models were created in order to determine independent variables that influence the QOL.Results: 440 pregnant women were included in the study. The two main domains that were used inthe study were MCS and PCS, their medians were 50.0 (25.0; 50.0) and 50.1 (39.4; 59.0) pointsrespectively. From the two logistic regression models we determined several independent factorsthat influence QOL of women during the first trimester of pregnancy. Additionally, we determinedthat women who reported worse QOL tended to give birth to newborns large for their gestationalage. Conclusions: We found several significant variables that influence QOL of women during thefirst trimester of pregnancy. We also found that that lower MCS and PCS scores during the firsttrimester are associated with newborns large for gestational age.

Maternal triglyceride levels and newborn weight in pregnant women with normal glucose tolerance

2005 ◽  
Vol 22 (1) ◽  
pp. 21-25 ◽  
Author(s):  
G. Di Cianni ◽  
R. Miccoli ◽  
L. Volpe ◽  
C. Lencioni ◽  
A. Ghio ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Pregnant Women ◽  
Normal Glucose Tolerance ◽  
Newborn Weight ◽  
Normal Glucose

scholarly journals Analysis of Vascular Endothelial Growth Factor (VEGF) -634C/G and +936C/T Polymorphisms and Serum VEGF Levels in Women Suffering From Preeclampsia

2021 ◽  
Author(s):  
Sayed hojjat Hosseini ◽  
Ata Ghadiria ◽  
Abdolah Mousavi Salehi ◽  
Saber Rokhafrooz ◽  
Mahin Najafian ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Control Group ◽  
Vascular Endothelial ◽  
Vegf Gene ◽  
Serum Samples ◽  
Significant Difference ◽  
Pcr Rflp ◽  
Gestational Week ◽  
And Control ◽  
Endothelial Growth Factor

Abstract Preeclampsia (PE) is a syndrome related with pregnancy and characterized by hypertension and proteinuria, occurring in approximately 6-8% of pregnancies and accounting for approximately 40% of premature births. This study aimed to investigate the polymorphisms of -634C/G and +936C/T in VEGF gene and their relationship with serum VEGF levels in pregnant women with PE. In this case-control study, peripheral blood samples were collected from 135 women with PE and 135 normal pregnant women as the control group. DNA was extracted using the phenol-chloroform method. Then, the polymorphisms of VEGF gene were detected by PCR-RFLP method using specific primers. Besides, VEGF concentrations were measured by ELISA method on serum samples and control subjects using ELISA kits. In this research, maternal age, gestational week, maternal hemoglobin and BMI were significantly correlated with the likelihood of PE, while the occurrence season variable was not effective in PE among the pregnant women. There was no significant difference in the two polymorphisms of -634C/G and +936C/T in VEGF gene between the two groups. Also, the serum VEGF level in PE patients was significantly higher than the normal group (P<0.001). Despite a significant increase in serum VEGF concentrations in women with PE, it seems that -634C/G and +936C/T polymorphisms of VEGF gene are not related with the onset of PE. Further studies are required to fully understand the risk factors related to preeclampsia syndrome.

scholarly journals Relationship Between Ferritin and Folic Acid Levels In Pregnant Women With Newborn Weight and Head Circumference

2018 ◽  
Vol 3 (2) ◽  
pp. 113
Author(s):  
Usna Maria Harahap ◽  
Fadil Oenzil ◽  
Desmawati Desmawati
Keyword(s):  
Body Weight ◽  
Folic Acid ◽  
Pregnant Women ◽  
Head Circumference ◽  
Sampling Technique ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
West Sumatra ◽  
Newborn Weight ◽  
Kolmogorov Smirnov

Iron deficiency and folic acid anemia cause decrease in ferritin and folic acid levels that can interfere with the intake of oxygen and nutrients to the fetus resulting in LBW and reduced brain growth during pregnancy. The aim of the study was to determine the relationship between ferritin and folic acid levels in pregnant women with newborn weight and head circumference.This study was a cross sectional study conducted on 55 pregnant women at 37-42 weeks who were taken by consecutive sampling technique. The study was carried out in the Working Area of the Puskesmas and the Regional Health Laboratory of the Merangin Regency, and the health laboratory of West Sumatra Province from May 25 to July 13, 2018. Test the normality with the Kolmogorov-smirnov test and the correlation test using Pearson and Spearman.The results showed ferritin mean 23,643±16,682 ng/ml, folic acid 14,093±4,578 ng/ml, newborn weight 3047,27±399,005 gram and head circumference 33,02±1,163 cm. Statistical test results showed no correlation between ferritin levels with body weight (r=0.063, p=0.648) and head circumference (r=0.018, p=0.895) and folic acid levels with body weight (r=-0.036, p=0.795) and head circumference (r=-0.098, p=0.477).The conclusions of the study were that ferritin and folic acid levels of pregnant women had no significant correlation with newborn weight and head circumference. By improving nutrition, socioeconomic, qualitative antenatal care, initial referral of risky cases and supplementation of iron and folic acid can reduce the incidence of anemia.

scholarly journals RELATIONSHIP AMONG MATERNAL, PRENATAL AND PREGNANCY OUTCOME IN RANGELI MUNICIPALITY OF NEPAL

2020 ◽  
Vol 8 (11) ◽  
pp. 204-210
Author(s):  
Asmita Mahato ◽  
Barsha Shrestha
Keyword(s):  
Heart Rate ◽  
Birth Weight ◽  
Pregnant Women ◽  
Gestational Age ◽  
Fetal Heart Rate ◽  
Maternal Age ◽  
Fetal Heart ◽  
Significant Difference ◽  
Newborn Weight ◽  
The Mean

Background: The incidence of pregnancy complications may be due to risk factors during pregnancy. Whether maternal parameters like age, gravida/ parity, gestational age, and fetal heart rate have any influence to the delivery outcome and newborn weight is a big quest. A young age at birth is more common in Nepal and carries a less social stigma, and hence enforces this study to understand the impact. Objective and methodology: The objectives of this retrospective study were to evaluate the maternal and prenatal outcomes of pregnancies and the effects of the age of the pregnancy, gravida, gestational age, and newborn weight. Pregnant women giving birth in Rangeli Hospital, Morang (Nepal) in 2019 were retrospectively screened. Pregnant women of all age group were included in this study. Results: Mean maternal age for delivery of child was 22.45 ±0.225 years. 41.9% of study subjects were primigravida (G1), while 58.1% were multi-gravida (G2-4). The mean age of primigravida is 20.57 ±0.025 years. Mean gestational week, fetal heart rate (FHR), and newborn weight were 38.18 ±0.11, 140.91 ±0.43, and 2870.65 ±26.13 g respectively. Almost one-third (32.1%) of the newborn were preterm babies. 20.9% of the newborn child was low birth weight. Spontaneous vaginal delivery was seen in 90.7% of the pregnancy while 7.9% had caesarean section. Conclusion: A significant positive correlation was seen of age with gravida, parity, and newborn weight. Newborn weight was significantly related to gestational age. There is no significant difference between the mean maternal age of mother delivering preterm baby or term-baby. No significant difference in the mean age of the mother or the mean gestational duration between male and female children could be established. Significant mean differences were seen in the maternal age of LBW child and normal birth weight child.

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